Combinational Multidomain Mesoporous Chips and a Method for Fractionation, Stabilization, and Storage of Biomolecules

A new fractionation device shows desirable features for exploratory screening and biomarker discovery. The constituent MSCs may be tailored for desired pore sizes and surface properties and for the sequestration and enrichment of extremely low abundant protein and peptides in desired ranges of the mass/charge spectrum. The MSCs are effective in yielding reproducible extracts from complex biological samples as small as 10 III in a time as short as 30 minutes. The MSC-based device may serve as a diagnostic tool to complement histopathology, imaging, and other conventional clinical techniques. The MSCs mediated identification of disease-specific protein signatures may help in the selection of personalized therapeutic combinations, in the real-time assessment of therapeutic efficacy and toxicity.

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Patents:
WO 2,011,025,602

Inventor(s): FERRARI MAURO [US]; LIU XUEWU [US]; TASCIOTTI ENNIO [US]; BOUAMRANI ALI [FR]; HU YE [US]

Type of Offer: Sale



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