Carriers are provided for transport of a substance across the blood-brain barrier. The carriers comprise an antibody specific for a target antigen, in particular, antibodies capable of binding to prion proteins. The antibodies are produced via methods which include adding a target antigen stabilising agent to a sample containing a target antigen, allowing the stabilising agent to stabilise the target antigen, incubating the stabilised target antigen with a conventional antibody immobilised on a solid support to form a complex, wherein the immobilised antibody is specific for the target antigen, immunising a host with the complex, and isolating antibodies specific for the target antigen from the host. Also provided are use of the carriers in treatment and diagnosis of disease, e.g. prion diseases.

Attached files:
WO 2010038035.jpg

WO 2,010,038,035


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