Treatment of Fibrosis

The present invention relates to methods and compositions for treating fibrosis. In one aspect the invention provides the use of an agent capable of increasing the number of stem cells and/or progenitor cells available to and/or engraftment at a site of fibrosis in the manufacture of a medicament for use in conjunction with an anti- fibrotic agent for the treatment of fibrosis. The anti-fibrotic agent can be supplied to the subject before, at the same time, or after the agent capable of increasing the number of stem cells and/or progenitor cells available to and/or engraftment at a site of fibrosis. The fibrosis may be idiopathic pulmonary fibrosis. The anti-fibrotic agent can be a modulator of RhoA, RhoA GTPases, TGF-ssl or CTGF, or any other member of the RhoA signalling pathway; or can modulate the effect of suppressor of cytokine signalling 1 (SOCS 1), suppressor of cytokine signalling 3 (SOCS 3) or TLR9; or can be a statin compound or derivative thereof.

Patents:
WO 2,008,040,967

Inventor(s): SPITERI MONICA SILVERSTONE [GB]; WATTS KEIRA LOUISE [GB]

Type of Offer: Sale



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