INHIBITORS OF THE NITRATION OF AMYLOID ss PEPTIDES AND THEIR USES IN THE DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE
The present invention relates to a method for identifying an inhibitor of the aggregation of amyloid-ss peptide (Ass), comprising the steps of a) contacting at least one Ass-peptide and/or the nitrated forms thereof with at least one candidate inhibitor that potentially specifically binds to a region in said Ass-peptide capable of being nitrated, and b) detecting said inhibitor specifically binding to said region in said Ass-peptide through detecting a lack of or a reduced aggregation of said at least one Ass-peptide. The present invention is further directed at improved methods for treating neuronal degradation and particularly Alzheimer's disease, based on said inhibitor. The present invention is further directed at methods for diagnosing the aggregation of Ass-peptide in the context of neuronal degradation and particularly Alzheimer's disease.
HENEKA MICHAEL THOMAS [DE]; KUMMER MARKUS PETER [DE]
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