Healthcare Patents for Sale or License

Method for Linking Insurance Policies

Method for Linking Insurance Policies

By linking health insurance with life insurance, etc., a new type of insurance product can yield a win-win-win situation for the insurance company, the physician and the insured individual.
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Early Measurement of Insulin Insensitivity

This invention is a simple means of measuring insulinemia and is simple to administer. It makes it possible to detect pre-diabetic individuals (pre-pre-diabetics) much earlier than any existing technique.
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Elliptical Prone Exerciser

Elliptical Prone Exerciser

The main goal of the present invention is to provide a prone exerciser in which the user can simulate a real crawling movement to offser the negative effects of gravity.
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Early Measurement of insulin insensitivity and detection of early pre-diabetics by non invasive measurement of calciuria

Insulin insensitivity has been shown to occur long before it can be observed using a Glucose Tolerance Test, Fasting blood sugar test or the Glycated hemoglobin (A1C) test. This is because very eraly pre-diabetics can maintain noraml blood glucose levels by producing higher than noraml serum insulin levels. Such individuals can be identified in their early twenties. The standard measurement of insulin levels using the "hyperinsulinemic euglycemic clamp" is invasive and invoves blood sample and
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Elliptical Prone Exerciser

Fitness/physical therapy equipment The invention relates to a horizontal exerciser, in particular to an elliptical prone exerciser. Gravity has negative effects on human body, as long as human body posture keeps in a vertical position with ground, whatever we are walking, running even standing or sitting, where it results in problems with our spine, circulation, height loss, prolapsed organs, flexibility and other general body functions. The negative effects of gravity are greatly reduced wh
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Tee Shirt

The shirt is designed to snap closed on the shoulder and down the side for easier ability to dress after shoulder surgery. The shirt is versatile and can be used for patients who had surgery on either shoulder. It can be used by men, women and children also who may have a disability.
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Sanitary Hygiene Door Handle

Sanitary Door Handle for pull doors for ultimate Hygiene solution No disinfective spray or solution or motorised system, or cumbersome door linkages. Simple and ready to install on pull doors. No external or internal power source is required. Each pull and release of the handle dispenses a fresh paper/film so that any contaminated handle is never touched by hand. Cross-contamination by hand of bacteria, yeast and hazardous micro-germs present in high traffic areas is minimized.
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Method For Linking Insurance Policies

Whether you prefer tai chi, chi tea, or both, everyone can gain by linking their health to their wealth including one’s physician and insurance company. I believe that the CHAI Insurance Consulting Group LLC insurance patent portfolio may be of great interest to you in these areas with regard it’s potential for helping insurance companies to improve their marketing, sales and savings in health insurance, life insurance and many other types of insurance products. Essentially, CHAI c
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Auto-Flex Knee Brace

This product is the world’s first off-loader knee brace with full girth, flexible steel cuffs that unloads both osteoarthritic knee compartments simultaneously for the entire knee extension range, not just at heel strike (the spring pillars change their bending central axis location automatically and accommodate the entire knee flexion range). This device provides open space in damaged compartments for re-seeding and re-growth. After the patient removes the brace, the articulating, i.e. grin
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Machine and or a process that will provide self cleaning advanced hot tubs, baths, and pools, with dispensing functions and automatic scrubbing systems

A self-cleaning advanced hot tub-bath tub, pool with dispensing functions for providing a hot tub with the functionality to automatically cleanse itself and to inject bath oils, perfumes, soaps, bubble baths, medications, and or other items to the hot tub as desired either automatically through memory circuits or manually. A consumer can release bath oils, perfumes, soaps, bubble baths, medications, and or other luxury items to the hot tub as are desired either manually for each individual item
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"Liver Dysfunction-Jaundice"

HIPATONE® Why Hipatone and what it can make difference than other related medication MOST IDEAL SUPPLEMENT FOR LIVER FACT SHEET: 1. Safe and effective. 2. Small molecule and easy to digest. 3. Natural source of medicine. 4. No side effects or adverse effect even taken with conventional drug therapy. 5. It helps to improve Liver Cirrhosis conditions, Hepatitis, Jaundice, Indigestion, Hepatomegaly, Loss of Appetite, Hepatoprotective and Immunomodulatory effect. 6. It helps to remove
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Adjustable Orthotic Brace

System for strain detection and subsequent material contraction or expansion for counteraction of strain in wearable injury prevention device or rehabilitation device. System is based on: A sensor for strain (compression or tension) detection which sends signals to a logic circuit programmed to initiate discharge of a battery or capacitor if the logic circuit determines that the sensor signal indicates an injury inducing force or if it is beyond the programmed permissible range of motion for a
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Bed and Rail Cover

The Bed and Rail Cover prevents confused patients from injuring themselves with hospital bed rails. Currently, health care professionals cannot position bed rails in the upward position because confused patients may injure themselves. Confused patients can still fall our of bed, so health care professionals lower the bed and place a mat next to the bed. My health care experience has shown me that this is ineffective because when a patient stands up they can push the mat away, try to stand up, fa
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Leg Support Accessory for a Shower Chair

A leg support accessory that can be modified to fit many currently used shower room chairs. At the present time if you are in the hospital, rehab, veterans hospital, retirement home, and you have one leg that is immobile they will put that leg on a trash can or what ever is available to give you your shower. This patent is the perfect solution for people who have had knee or hip replacements, foot surgery, immobile legs due to paralysis, stroke, accidents, or other causes. This patent provides a
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Tractal Erectile Device

Male Erectile Dysfunction (ED) is a condition that affects many men and can have a negative physical and psychological impact on their lives. Stimulation of the penis may be difficult for men suffering from ED, and although attempts have been made to treat ED, those attempts have failed to provide a safe and effective non-drug related treatment. Health clinic research has revealed that starting an erection with a partial vacuum can be a simple and effective way of reducing the impact of male
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Sun block applicator

Skin cancer is the most common form of cancer in the United States. Here are the American Cancer Society’s estimates for melanoma in the United States for 2014: About 76,100 new melanomas will be diagnosed (about 43,890 in men and 32,210 in women). About 9,710 people are expected to die of melanoma (about 6,470 men and 3,240 women). The rates of melanoma have been rising for at least 30 years. This simple invention could help protect and save lives. How it works; It looks a little bit
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"The Royal Headrest" Ultimate Hairstyle Protecting Therapeutic Pillow

A adjustable hairstyle protecting pillow unit complete (FIG. 1) , design and function for providing adjustability to the user due to the many different comfort levels of consumers. A user of this invention can with a push of a button adjust the unit to their desired comfortable position at any comfort level when sleeping or relaxing anywhere the user desire. The unit provides to the user a high density triple layer extremely soft memory foam to sleep and relax on which conforms to the neck ,face
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MagnaStone, sinusoidal magnetic field therapy, alternative medicine.

MagnaStone US patents 7648454, 7803104, 8202192, 7915846, 8050059, 8257242, 8469872 is a instrument designed to generate a sinusoidal magnetic field that has been proven to have therapeutic value. This therapy has been effective in the field of orthopedics and depression. This is believed to stimulate cellular repair by concentrating the hemoglobin (the blood protein that carries oxygen) to the cellular damaged area. The exact mechanism of how it works is not fully understood. The design of t
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A Hands-Free, Wearable, and Fully Automatic Tooth Brush

I am an inventor and the patent-owner of a proprietary design of a HANDS-FREE, WEARABLE, and AUTOMATIC tooth-brush. The patented design that I would like to present to you is an innovation that has the potential to be developed into a new product line suitable to both niche and the mass market. The design is simple enough to be customized into variations, so that it can cater to potential future product developments. I believe that with the right amount of attention and development, the desig
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Flossing Device with Internal Floss Feed

A flossing device having internal floss feed in which floss is advanced from a storage chamber inside the handle of the device, through feed gears, to a pair of spaced apart tines. Spent floss is returned through the return gears, the return drive gear having a greater diameter than the feed drive gear, thus ensuring the floss remains taut between the tines. An integral cutter allows the spent floss to be cut off and discarded. One significant advantage of this device over similar designs is
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Vaginal cream applicator.

The new Gentle-Comfort vaginal cream applicator is easier to use, more comfortable to use, safer to use and more hygienic for women to use than the standard syringe type applicator is. Details of this device may be viewed at http://www.gentlecomfort.com US D457,627S, a United States Design Patent covering this device is also available for sale, or license with royalties, as are: US 7,172,573 B1, a US patent for a vaginal tablet applicator; US 7,815,593 B2, a device for inserting vaginal
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Joint Heat

An electric heating device that is constructed in a unique fashion that allows it to be drapeable so that its three-dimensional, `scoop-like` shape fits the curvature of a relaxed shoulder, a crooked knee, crooked elbow, fetal-positioned hip or ankle and is held in place by an adjustable strap whose ends are attached to the device. The heating element configuration that is contained within a singular, sealed, water-tight vinyl envelope that is produced as one piece, with the three panels briefly
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Magic Cone (Female Standing Urination Cone)

Magic Cone is a patented disposable funnel shaped, waterproof cardboard device which allows women to urinate in a standing position without any hassle.Magic Cone can be a life saver when one has no access to a clean and hygienic toilet facility. Magic Cone is here to help travellers, sport enthusiasts, women with different debilitating medical conditions and any women who has ever been faced with the inconvenience of having to use an unsanitary toilet.
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Vaporization Lighter

Tobacco or other herbs are typically smoked by burning and inhaling the smoke. The smoke may be harmful to the smoker's health and may also affect those around the smoker. In response to these issues, many cities, states and the federal government have passed laws or created ordinances or rules that prohibit smoking in public places. Vaporization may provide many benefits over traditional smoking. However, few smokers may vaporize because vaporization may be difficult to perform with the pre
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Device for Giving Liquid Medicine to Children

We own one US Patent #7654977 that we are interested in selling/auctioning. The protected device product has been developed and sold in Europe for delivering liquid medicines to infants and toddlers under the mark “MEDICINUS”. Please see some pictures below.
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Rescur Device for Marooned Victims

FIELD OF INVENTION This invention relates to a rescue device for a person trapped at an isolated and helpless spot as in flood waters, earthquakes etc. It can also be applied in rescue works from rooftops, crevasses in glaciers, ravines etc. where similar situations of emergency develop. BACKGROUND OF THE INVENTION Floods have become a common phenomenon nowadays. Rivers, canals and other water bodies often get flooded with increasing frequency due to sudden excessive rains and other
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Toothbrushing tablets (toothpaste in tablets)

SOME ADVANTAGES OF «DENTAMETE» TOOTHTABLETS OVER TOOTHPASTES: - no preservatives (toothpastes contain preservatives, whereas DENTAMETE have a stable (dehydrated) form, and are thus not liable to changes) - unlimited use (toothpastes have a limited shelf life, mostly two years) - hygienic packaging (with toothpastes, a so-called «ping-pong» infection can occur if more people are using the same tube: as toothpaste is sqeezed out, the tube touches different toothbrushes. In this
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Biostimul Pharma

BIODEX:500mg Patent claim BIODEX: calcium clusters (calcium peptide complexes) with modified calcium clusters (calcium peptide complexes)- with enhanced biochemical and biological features, that are extracted by non-chemical, patented process is handled by microscopic particles and they are absorbed by the body fast. As a result, is obtained and a mixture of calcium clusters (calcium peptide complexes), including a group of 27microelements: mainly copper, iron, manganese, molybdenum, phosp
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Nasal Cleaning Insert

January 14, 2013 Nasal Cleaning Insert Patent -USA 5,895,408 A device is used as a daily nasal cleaning insert. Use to clean remotes areas in nasal cavities. Is intended to use a daily hygiene to dialog Nasal cavities from mucus substances and germs as the same time reaching farther areas that could not be reached by other cleaning devises. Is a device that is designed to use with different substances to kill germs inside nasal cavities. One of the objects is to avoid germs to penetra
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Computer peripherals sterilization system

A KEYBOARD ADD-ON THAT PROVIDES A RULES-BASED, CONTROLLED PROCESS OF ELIMINATING BACTERIA AND GERMS FROM ANY EXISTING KEYBOARD, MOUSE, CELLPHONE, IPAD OR SIMILAR DEVICES IN 10 SECONDS OR LESS. EXISTING KEYBOARD CAN BE DISABLED TO GUARANTEE THE NEXT USER A FULLY STERILE ENVIRONMENT. FULLY USB CONTROLLED, IN IDLE MODE THE ADD-ON PROVIDES A UNIQUE ORGANIZER / USB HUB FUNCTIONALITY. VARIOUS MODES AS WELL AS FULL USAGE REPORTS ARE AVAILABLE FOR TRACKING. IDEAL FOR PUBLIC USE OR MEDICAL FACILITIES
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Lockable Specimen Transporter

Patent Number: US6354104 Portable Medical Device: Suited for the collection of Urine and Blood Specimens both inner office and in field. Industry: Health/Medical fulfilling World Health Organization, Center for Disease Control and Health and Human Services guidelines specific to Chain of Custody in specimen collections. Market: Drug Testing Industry, Blood Banks, Hospitals, Specimen Collections sites, etc.
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Methods and apparatus for determining body weight and fat content using computed tomography data

Methods and apparatus for determining body weight and fat content using computed tomography data are provided. One method (60) includes acquiring (62) a pre-scan image using a computed tomography imaging system (10) and segmenting (66) the pre-scan image into pixels representing imaged fat and pixels representing imaged tissue. The method (60) further includes determining (70) a lean body weight based on the segmented pixels representing imaged fat and imaged tissue.
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Device for Osteosynthesis

The aim of the invention is to provide an osteosynthesis plate (100) or a kit for osteosynthesis that clearly reduces the risks associated with the treatment of a bone fracture using the osteosynthesis of a bone plate, in particular the danger of infections and pressure necrosis compared to those of prior art. Said osteosynthesis plate (100) comprises at least one deformation area that is adequate for the load and at least two through openings (10) for introducing securing means, one side of sai
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Bioequivalence Dialysis

The present invention relates to a method for treating blood disorders and blood disorders compensation. This includes steps in which one blood or blood plasma of a patient outside the body brings with a second liquid (bioequivalent) in contact with the second liquid blood or blood is modified, which includes at least granulocytes, platelets and red blood cells.The invention further relates to devices for implementing this method and the use of such a device or modified by blood or blood that gr
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Magnetically Mounted Artificial Joint

The invention relates to a prosthesis for replacing a joint compound in the same magnetic fields of joint head 10, socket 12 and pivot collar 14 can be superimposed so that the repulsive forces produce a state of suspension of the joint head 10 in the bearing and the damping effect is maximal.The invention also provides a method for replacing a bone connection of a mammal in which the prosthesis is attached to the bones in the joint and cause repulsive forces to a state of levitation, the joint
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Method for Determining the Clamping Force on a Mechanical Joint Connection Connecting At Least Two Components

The invention relates to a method for determining the clamping force on a mechanical joint connection connecting at least two components by coupling sound waves into the joint connection. The invention is characterized by the combination of the following method steps: exciting the mechanical joint connection in order to generate oscillation, capturing the oscillations made by the joint connection due to the excitement, and analyzing the oscillations of the joint connection on the basis of refere
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Precursors of Lipid Metabolism for the Diagnosis and Treatment of Cancer

The present invention pertains to methods for the treatment and diagnosis of cancer employing prodrugs for targeting of lipid metabolism comprising either a detectable label or a therapeutic residue. The invention is based on the finding that the present prodrugs are specifically enriched in tumor tissue, in which they may be detected by suitable imaging techniques. Alternatively, a prodrug comprising a therapeutic residue, such as a suitable radioactive residue, may be used for the treatment of
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Prevennting the Occurrence of Obesity

Administration of autophagy inhibitor (e.g. 400 mg chloroquine daily) prevents occurrence of obesity and insulin resistance in human subject on prolonged high-fat diet.
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Method for Treating Obesity

The present invention relates, in general, to obesity, and, in particular, to a method of treating obesity and minimizing metabolic risk factors associated therewith using, for example, zonisamide or other weight-loss promoting anticonvulsant either alone or in combination with bupropion or other compound that enhances the activity of norepinephrine and/or dopamine via uptake inhibition or other mechanism.
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Human and physical asset movement pattern analyzer

A system of tracking and analyzing the movement of human subjects. UWB is used to track the location of all persons and/or physical objects (assets) occupying a defined area, giving their location with an accuracy of under twenty centimeters, their acceleration, their path, and a time/date-stamp for each observation. The system then uses artificial intelligence to detect variations in patterns of movement of designated individuals and movable physical objects in the defined space. The extracted
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Folding Armrest Tray for Wheelchairs

A tray assembly mounted on a wheelchair. A housing containing the tray is mounted along the side of the chair arm. The tray assembly has a tray surface moveable between a stowed and unstowed position.
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Pharmaceutical Compounds Comprising Abasic Oligonucleotides

The present invention relates to compounds which are capable of modulating Toll-like receptor (TLR) activity.
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Pyrimidinium Derivatives for Use in the Treatment Or Prevention of Diabetes

The present invention relates to methods and compositions for preventing or treating diabetes. The invention in particular discloses compounds according to formula (I) for use in the prevention and treatment of type II or I diabetes.
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N-terminally Modified Tetrapeptide Derivatives Having a C-terminal Arginine Mimetic

The invention relates to multi-base, N-terminally modified tetrapeptide mimetics having a C-terminal P1 arginine mimetic, to a method for producing the same and to the use thereof in the therapy and prophylaxis of diseases that are caused by bacterial pathogens or viruses, and in the therapy and prophylaxis of diabetes, arteriosclerosis, cancer, Alzheimer's or the development of overweight, and to the use of the compounds as inhibitors of proprotein convertases which cleave downstream of basic P
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Use of Hat Inhibitors and TMPRSS2 Inhibitors As Medicaments

The invention relates to the use of inhibitors of the general formula (I) where R1 is a substituent, P3 is a mono- or polysubstituted or unsubstituted, natural or unnatural a-amino acid or a-imino acid in the D configuration, P2 is a mono- or polysubstituted or unsubstituted, natural or unnatural a-amino acid or a-imino acid in the L configuration, and P1 is an arginine mimetic, the basic group of which may optionally also be present as a prodrug, for inhibition of the serine proteases HAT and T
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Monoclonal Antibodies Against Claudin-18 for Treatment of Cancer

The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLDl 8, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, cancer of the gallbladder, and the metastases thereof.
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Use of RNA for Reprogramming Somatic Cells

The present invention provides methods for de-differentiating somatic cells into stem-like cells without generating embryos or fetuses. More specifically,-the present invention provides methods for effecting the de-differentiation of somatic cells to cells having stem cell characteristics, in particular pluripotency, by introducing RNA encoding factors inducing the de-differentiation of somatic cells into the somatic cells and culturing the somatic cells allowing the cells to de-differentiate.
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Antibodies Specific for Claudin 6 (CLDN6)

The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing Claudin-6 (CLDN6), including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, an
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Dietary Compositions and Related Methods of Use

The present invention provides dietary compositions for mammalian consumption. In particular, the present invention provides compositions comprising pectin, a component comprising electrolytes, thickening agents, a sweetening agent, and water, and methods for making such compositions. In some embodiments, the dietary compositions are used for preventing and/or treating malabsorption dysfunction and associated disorders (e.g., short bowel syndrome, Crohn s disease). In some embodiments, the dieta
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Method for Detecting the Existence of Renal Calculi And/or Inflammation of the Excretory Urinary Tracts

The invention relates to methods for detecting diseases of the excretory urinary tracts. The aim of the invention is to provide a method for detecting the existence of diseases of the excretory urinary tracts, which can be carried out non-invasively, thus allowing first indications of disease, e.g. in relation to the existence of renal calculi and/or inflammation (e.g. after urinary tract infections) of the excretory urinary tracts, to be rapidly and cost-effectively detected, in order to resolv
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Marking Clip for an Area of the Inside Wall of the Stomach Or Intestine

The invention relates to marking clips for an area of the inside wall of the stomach or intestine. These are characterized in particular by the fact that damaged or treated areas of the inside wall of the stomach or intestine can be easily identified and in this way can be easily found again. For this purpose, a housing accommodates at least one lighting means interconnected with a primary element via a contactlessly actuatable switch, wherein the primary element housing made of metal is at the
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Method for Detecting the Existence of Renal Calculi And/or Inflammation of the Excretory Urinary Tracts

The invention relates to methods for detecting diseases of the excretory urinary tracts. The aim of the invention is to provide a method for detecting the existence of diseases of the excretory urinary tracts, which can be carried out non-invasively, thus allowing first indications of disease, e.g. in relation to the existence of renal calculi and/or inflammation (e.g. after urinary tract infections) of the excretory urinary tracts, to be rapidly and cost-effectively detected, in order to resolv
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X-ray Marker for Visually Comparing and for Controlling the Image Processing in Digital X-ray Recordings, in Particular for a Thorax X-ray Recording for a Patient Lying Down

The invention relates to an X-ray marker (1) that is also to be X-rayed in an X-ray recording of an organ of a patient (3) to be examined. The X-ray marker (1) has such a geometric X-ray weakening structure, so that the associated X-ray image (R) approximately shows the expected X-ray image structure of the organ to be examined after photographic development of an X-ray film, after digitalization and digital image processing of an X-ray storage film (6), or after digital recording and image proc
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Device for Determining Vertebral Distances of the Spinal Column of a Patient

The invention relates to devices for determining vertebral distances of the spinal column of a patient. The devices are characterized in particular in that vertebral distances of the patient while walking in a building or outdoors can be easily detected. For this purpose, at least two marks are applied to the skin of the patient at the height of the transverse processes while the patient is at rest, each mark being at least two lined representations arranged at a distance from each other. Furthe
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Biologically Active Molecules, Particularly Based on PNA and siRNA, Method for the Cell-specific Activation Thereof, and Application Kit to Be Administered

Biologically active molecules are inactivated for selective activation by target cells by being covalently bonded to one or more peptides each of which has one or more specific amino acid sequences that are selected in respect of enzymes cell-specific for target cells. The bonds, which are broken exclusively by the enzymes cell-specific for the target cells in order to biologically activate the molecules, allow the molecules to remain biologically inactive in cells other than the target cells. T
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Stimulation of Cpt-1 As Means to Reduce Weight

PROBLEM TO BE SOLVED: To provide a method and composition for inducing weight loss and maintaining optimum weight. ; SOLUTION: An agent is administered that stimulates carnitine palmitoyl transferase-1 (CPT-1) activity. The method does not require inhibition of fatty acid synthesis. The method selectively enhances fatty acid oxidation, increases energy production, and reduces adiposity while preserving lean body mass through pharmacological stimulation of (CPT-1) activity. Preferably, the agent
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Skin and Surface Disinfectant Compositions Containing Botanicals

The present invention relates to a skin or surface disinfectant composition with broad spectrum antimicrobial activity comprising one or more essential oil (and/or one or more component thereof) and one or more fruit acid. The compositions of the invention may be used as non-toxic alternatives to conventional disinfectants or may be added to other antimicrobial agents to enhance their activity. The invention provides effective alternatives to harsher products which may be particularly useful in
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Prolonged Effect Disinfectant Cleanser.

The present invention relates to cleanser compositions, and their uses, wherein the cleanser compositions comprise one or more cationic antiseptic agents, a film-forming cationic emulsifying agent, a dispersing auxiliary solvent, a solvent system, and optionally an alkanediol.
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Obesity Controlling Method

A method of controlling obesity by injecting bio-compatible bulking material into the pyloric sphincter area of the stomach. The injection of this material bulks the pyloric sphincter, retarding stomach emptying and producing a feeling of satiation in the patient. The method may be supplemental and augmented by inducing flacid paralysis of the stomach by injecting botulinum toxin into the muscle tissue of the antrum or fundus of the stomach.
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Real-time X-ray Vision for Healthcare Simulation

A medical procedure training system and method for using is provided. The system includes a sensing system structured to detect the position and motion of a medical device inserted into a simulated body, a processor structured to generate images of the medical device and relevant anatomical structures based on the detected position and motion of the medical device, and a display system structured to display the images in a correct registration on the outer surface of the simulated body.
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Method for Structural Health Monitoring Using a Smart Sensor System

The structural health monitoring method of the present invention utilizes a sensor system to determine information about deformation, stress and/or damage in structural elements. The sensor system and the method employ at least one sensor which comprises a material having fully-reversible nonlinear elasticity. The method comprises associating at least one sensor including a material having fully-reversible nonlinear elasticity with a structural element in a manner whereby stress is transferred f
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Natural Polypeptides for Oral Health Care.

Tlic present invention relates generally to dental diseases, caries and periodontal disease. More specifically, the invention relates to Lactoferrin and Stathcrin fusion proteins (STAT-LF) along with therapeutic, diagnostic and research uses for these polypeptides. The present invention also provides methods of treating dental diseases, caries and periodontal disease.
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A Multiple Degree of Freedom Rehabilitation System Having a Smart Fluid-based, Multi-mode Actuator

A rehabilitation system that combines robotics and interactive gaming to facilitate performance of task- specific, repetitive, upper extremity/hand motor tasks, to enable individuals undergoing rehabilitation to improve the performance of coordinated movements of the forearm and hand is disclosed. More specifically, the rehabilitation system includes a two degree-of -freedom (DOF) robotic, upper limb rehabilitation system and interactive gaming hardware that is coupled to a computer, to provide
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Lysine-specific Demethylase 1 (lsd1) Is a Biomarker for Breast Cancer

The present invention relates to novel biomarker for breast cancer, namely LSD1 and its application in inter alia the diagnosis of breast cancer. Furthermore, the present invention discloses a method of determining the LSD1 protein amount and the effect of LSD1 inhibitors on cancer cells selected from breast cancer, lung carcinoma and sarcoma.
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Method for Obtaining Human Microglial Precursor Cells from Pluripotent Stem Cells

The present invention relates to a method for obtaining human microglial precursor cells, comprising: (a) providing a ceil population comprising neural precursor cells, wherein the cell population is obtainable from embryoid bodies differentiated from human pluripotent stem cells; (b) differentiating the cell population comprising neural precursor cells into microglial precursor cells by culturing in medium comprising a growth factor selected from the group consisting of insulin and insulin-like
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Anticancer Agent

The present invention relates to a pharmaceutical composition for the therapeutic and/or prophylactic treatment of cancer and/or metastasis thereof comprising an amino acid sequence related to a Wech protein and/or a nucleic acid sequence of the gene encoding for the Wech protein.
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Apparatus and Method for Detecting Triacetone Triperoxide

The present invention relates to an apparatus and method for fast and secure online detection of triacetone (TATP).
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INHIBITORS OF THE NITRATION OF AMYLOID ss PEPTIDES AND THEIR USES IN THE DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE

The present invention relates to a method for identifying an inhibitor of the aggregation of amyloid-ss peptide (Ass), comprising the steps of a) contacting at least one Ass-peptide and/or the nitrated forms thereof with at least one candidate inhibitor that potentially specifically binds to a region in said Ass-peptide capable of being nitrated, and b) detecting said inhibitor specifically binding to said region in said Ass-peptide through detecting a lack of or a reduced aggregation of said at
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Cytohesin Inhibitors

The present invention relates to a pharmaceutical preparation comprising as an active ingredient a primary amide according to the general formula (1) and/or a secondary amide according to the general formula (2) and their use as a medicament.
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Method and Device for Gravity Like Simulation of Natural Balance Movements

We present a tool that can enhance the concept of BWS training by allowing natural APAs to occur mediolaterally. While in a supine position in a 90 degree tilted environment built around a modified hospital bed, subjects wear a backpack frame that is freely moving on air-bearings, as a puck on an air hockey table, and attached through a cable to a pneumatic cylinder that provides a load that can be set to emulate various G-like loads. Veridical visual input is provided through two 3-D automultis
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Cross-linked Biopolymers, Related Compositions and Methods of Use

The present invention provides stabilized oil-in-water emulsions with an extended range of chemical, thermal and/or mechanical stabilities, and method(s) for their preparation. Such preparations provide an environmentally-protective biopolymer component exhibiting improved adherence to the dispersed phase, reducing or eliminating dissociation therefrom under such conditions, for use in the context of a range of food, pharmaceutical, personal care, health care, cosmetic and other end-use applicat
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Portable Device and Method for Measurement and Calculation of Dynamic Parameters of Pedestrian Locomotion

The invention relates to a portable and autonomous device and corresponding method for the measurement, recording and calculation of dynamic parameters of the pedestrian locomotion of its bearer (1). The method hereby disclosed allows determining the distance effectively travelled, the velocity of displacement and the pressures exerted on the contact surface of the lower limb (2) with the ground, during the pedestrian locomotion, according to its different phases. Through sensors strategically p
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Proteins That Stimulate the Secretion of Satiety Hormones

The invention is in the field of weight management, in particular in the field of weight management by influencing the mechanisms of body-weight regulation. Intact pea protein and intact wheat protein were found to be effective in reducing appetite or inducing or increasing satiety when brought into contact with their receptors in the duodenum. Since it is known that intact proteins hydrolyse in the gastrointestinal tract, intact pea protein and intact wheat protein will not exhibit their satiat
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A Prosthesis Or Orthosis

A prosthesis or orthosis comprising a first body and a second body rotatable to one another, comprising a passive mechanical converting mechanism comprising a third body arranged movably with respect to the first body, an elastic element arranged between the third and the second body, the mechanical converting mechanism arranged for converting an angular change between the first body and the second body into a change of load on the elastic element, further comprising ratio adapting means interac
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Inhibitors of Anorexic Lipid Hydrolysis for the Treatment of Eating Disorders

Compounds, pharmaceuticals, cosmetic or dietary supplements for the treatment of overweight, obesity and/or type II diabetes in a mammal (e.g. human) comprising a compound with formula I or formula II for example ceramidase-inhibitor, such as (1S,2R)-D-erythro-2-(N-myristoylamino)-1- phenyl-1-propanol, alone or in combination with an anorexic lipid (or other appetite-inhibiting acylamides or oleoyl-estrone), and methods of treatment comprising administration of said compounds, pharmaceuticals, c
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A walking aid with a means for effectively varying its length during use

A walking aid 10 having a means for varying its length being configured to maintain a substantially constant vertically resolved distance between the user and the ground when the aid is tilted from a substantially vertical orientation during normal use. The crutch comprises a shaft member 12 having a foot portion 20 at an end of the shaft member, and a grip portion 16 distal the foot portion, with the foot portion being arranged to contact the ground, and the grip portion being configured to sup
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Small Molecule Intervention for Obesity.

Methods and compositions for activating PLTP gene expression include administering an effective amount of a limonoid.
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Trunk Rotation

This trunk rotation device uses dynamic movement of one's body such as, shoulder, hip, knee, back, thigh, and abdominal musculature. The device provides a method for exercising the spinal column and the muscles of the torso, including those in the abdominal lumbar and thoracic regions involving rotational torque. In a preferred embodiment, the device is a golf exercise and flexibility apparatus. The golf exercise apparatus provides resistance to a golfer during a golf swing to strengthen and con
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Wireless apparatus with proximity sensor switches allowing a disabled person to control an electronic device.

Disclosed is a proximity sensor switch operated control unit for electronic devices to be used by disabled persons with limited motor skills. The control unit consists of switches that sends signals to electronic units which process the signals and send secondary signals wirelessly to a computing device eg a home computer, a mobile phone or a PDA. The computing device is coupled to a visual display which displays text, icons and other visual cues to show the user the current function setting of
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Male Contraceptive

A compound having formula I. R1, R2, R3 and R4 are independently H or lower alkyl. R5 is aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryloxy, heteroaryloxy, cycloalkyloxy, heterocycloalkyloxy, arylamino, heteroarylamino, cycloalkylamino, heterocycloalkyl amino, arylthio, heteroarylthio, cycloalkylthio, heterocycloalkylthio, or cyclic olefin, any of which may be substituted or non-substituted; or substituted alkyl, substituted alkyl oxy or substituted alkyl amino wherein the substituent is an
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Method of Stratifying Breast Cancer Patients Based on Gene Expression

The present invention assists in prospectively predicting the metastatic likelihood, and thereby, the likely clinical outcome of breast cancer patients, based on the genotype of the patient, in particular, by determining the relative expression level of a set of genes, or subsets thereof. The present invention provides use of an expression level of a gene set for the identification of animals, optionally patients, likely to progress to an invasive phenotype, the gene set comprising at least some
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Copolymer for use in corneal bandages

A copolymer for use in corneal bandages comprises of units -(A)- and -(B)- in which the units A are derived from aminoalkyl (alkyl)acrylates, such as 2-(diethylamino)ethyl methacrylate (DEAEMA), 2-(diethylamino)ethyl acrylate (DEAEA), 2-(dimethylamino)ethyl methacrylate (DMAEMA) or 2-(dimethylamino)ethyl acrylate (DMAEA) and the units B are derived from aryloxy, alkoxy or hydroxyalkyl (alkyl)acrylates, such as hydroxyethylmethacrylate (HEMA), hydroxypropylmethacrylate (HPMA), hydroxylbutylmethac
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Hydrating Composition

The present invention relates to methods and compositions for enhancing the ability of the body to absorb ingested water and retain water in the tissues. Compositions and methods of the invention may be used for increasing athletic performance in the heat, as well as for preventing and treating dehydration. The compositions contain creatine for increasing intracellular body water and glycerol for increasing extracellular body water. Carbohydrate may also be included in order to increase absorpti
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Assessment of Functional Status

This invention relates to methods of neurocognitive assessment and, in particular, to methods for assessing the ability of individuals, in particular, memory- impaired individuals, to perform daily activities (i.e. functional status).
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Closed loop diabetes management system

Diabetes management apparatus comprising a sensor 12 providing measurements of glucose level in a human or animal; an insulin pump 16 for delivering a dose of insulin to said human or animal; and a processor 14. The processor 14 is adapted to perform the following steps: receive said measurements of glucose level from said sensor 12; calculate a insulin dose to be delivered by said insulin pump 16 based on said received measurement; assess the validity of the status of the apparatus; and send a
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Overnight Closed-loop Insulin Delivery with Model Predictive Control and Glucose Measurement Error Model

A closed-loop system for insulin infusion overnight uses a model predictive control algorithm ("MPC"). Used with the MPC is a glucose measurement error model which was derived from actual glucose sensor error data. That sensor error data included both a sensor artifacts component, including dropouts, and a persistent error component, including calibration error, all of which was obtained experimentally from living subjects. The MPC algorithm advised on insulin infusion every fifteen minutes. Sen
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Transport device for attachment to a wheelchair or similar

A transport device, an in particular sliding assistance or a stair riser to the cultivation at a wheelchair or such a thing, comprehensively a grasp device (2), a drive device (3) and a liaison vehicle (5), whereby the grasp device (2) and the drive device (3) is connectable with one another, the grasp device (2) a control element exhibits, with which the drive device (3) over electrical means is movable, and whereby the grasp device (2) over the liaison vehicle (5) with the drive device (3) is
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A Novel Method for the Treatment of Obesity

Isis Project No 3593 Isis Innovation, the technology transfer arm of the University of Oxford, releases a new causal-link, with potential in the treatment of obesity. Cysteine levels have been shown to be related to and causal of body fat mass. Marketing Opportunity Obesity is one of the major health challenges facing the developed world today, with over 1 billion adults overweight and at least 300m clinically obese. In the US alone, over 65% of adults are obese or overweight and approximat
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Onion preparation

Onion phenolics and flavonoids are types of phytochemicals, which are antioxidant chemicals that protect plants against bacteria, viruses and fungi. Phenolics and flavonoids, like other antioxidants, help prevent cancer by mopping up cell-damaging free radicals and inhibiting the production of reactive substances that could damage normal cells.In the research,water immersion extraction, was used to extract flavonoid compounds from onion. The content of total flavonoids in onions was determined b
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Low Level Laser battery operated medical devise

Medical Device: A low level hand held battery operated medical laser device has been developed and clinically tried with proven good results on almost all medical conditions encountered in a medical office including diabetes, strokes uncontrolled pain obesity and many others. Easy to learn techniques for applications have been developed and used. In a complimentary manner utilizing ancient acupuncture principles the device can help in many problems where medications and other western medical
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Novel Simple Organic Compounds for Treating Obesity

Highlights Novel small organic compounds derived from fatty acids , for treating obesity by regulating feeding and body weight Experiments in mice showed decreased food consumption and increased activity resulting in decrease in weight Improved cognitive function due to increased Norepinephrine levels There is a clear opportunity for an effective and well-tolerated anti-obesity drug. Our Innovation Novel derivatives of fatty acids injected into mice caused reduction in2-Arachidonoyl glyce
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Marine natural products as active anti-cancer agents

Marine natural products have gained increasing importance as a source of potential anticancer agents in the last few decades. Drs. C Ireland and L Barrows are exploring the possibilities to identify novel medicinal compounds having anti-cancer activity. They have identified makaluvamines, a series of cytotoxic marine metabolites, derived from sponges which act as DNA topoisomerase-II inhibitors and sensitized tumor cells, both in cellular based models and mouse tumor model. Naamidine A, also iso
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Lower Extremity Feedback System; In-Shoe Sensors; Incline & Step Counts

Today an inactive lifestyle is seen in children as well as adults. Lack of physical activity affects early onset diabetes, obesity, heart disease, and other chronic illnesses. These illnesses have a negative effect on an individual�s quality-of-life and functional status. However, it is difficult to fix a problem that cannot be measured well. Current motion monitors for measuring physical activity are expensive ($400-500/each) and ill-suited to many forms of physical activity. Motion-monitors
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Protein Kinase C-d in combination therapy with Bortezomib

Bortezomib is a targeted cancer drug which acts by blocking proteasomes, clusters of proteins necessary for tumor cell growth. It induces mitochondrial damage in cancer cells. Dr.Ray Lee and co-researchers have identified PKC-d as the downstream effector molecule which mediates the mitochondrial damage and apoptosis in these cancer cells. This invention has shown that identification of molecular targets in the apoptotic pathway which have ability to directly induce cell death and minimize the de
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"To Thirty and Beyond" a Ventilator Associated Pneumonia Prevention CD-Rom

This is a 20 minute educational CD-Rom designed to teach physicians, respiratory therapists, and nurses, how to overcome barriers to maintaining the head of the bed at an angle of thirty degrees or higher in mechanically-ventilated patients, in order to prevent ventilator-acquired pneumonia. Based on interview data from practicing intensivists, it addresses the barriers that prevent physicians, respiratory therapists, and nurses in intensive care from raising the head of the bed to thirty degree
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System for Providing Emergency Medical Care with Real-Time Instructions and Associated Methods

This disclosure describes the Basic Life Support System (BLSS) and a just-in-time training procedure for a first responder who must administer cardio pulmonary resuscitation (CPR). Just-in-time support (JITS) provides responders with advanced technology to provide effective CPR. The BLSS provides just-in-time support (using audio prompts and graphical animations) on key treatment procedures to resuscitate a sudden cardiac arrest victim. The BLSS consists of support devices, with embedded sensors
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Melatonin System for Regulating Immune Response Following Trauma (e.g., Injury, Stress, Transplantation)

This invention is a method of stimulating post-trauma immune response in warm-blooded animals, including humans. This method employs exogenous melatonin to moderate cytokine production in response to injury and to promote cellular response that enhances resistance to infection and healing. White blood cells produce cytokines, chemical messengers that stimulate or inhibit immune-system activity. Following trauma, the body releases interleukin-6 (IL), a pro-inflammatory cytokine family; and i
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Bioluminescence Based Lab-on-a-Disc

Due to the rising cost of health care, hospitals have been driven to reduce the amount of diagnostic tests being performed, compromising patient treatment. In addition, central chemistry labs are often off-site from the hospital, so when diagnostic test are performed there is often a time delay of anywhere from 4 to 72 hours to get results, again compromising patient treatment. Consequently there is a need for rapid, accurate, small scale sample analysis at the point-of-care (POC). Centrifuge
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Wheelchair Advantage Mobility System (WAMS)

WAMS is a bolt-on system with hand-actuated levers and disc/caliper system to propel, brake and securely park a manual wheelchair. It incorporates a set of ergonomic handles that enables users with reduced grip strength to propel or stop the wheelchair. Other interesting features of the invention include a) a lever system that allow the use of larger muscle groups with greater pushing strength and better stamina b) a disc brake system that provides solid clamping power to lock the chair in pla
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Navigational System for Persons with Varying Physical Disabilities

This technology is a Web-based navigational tool to assist people of varying physical ability levels in identifying shortest feasible routes through urban environments. There are several limiting factors in determining the correct and feasible path of travel for people with disabilities (PWDs), but an individual�s physical ability level is the essential consideration in determining a feasible route. The present invention incorporates different resources, devices, and programs to effectively
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Physician Time Tracking System

This system consists of a central database accessible through web interface for tracking information required by the Accreditation Council of Graduate Medical Education (ACGME) for resident physicians to graduate from their residency programs, and for the programs themselves to remain credentialed. It contains administrative tools and algorithms for analyzing data, documenting compliance, and warning of impending inadequacies or violation of standards. Residents may enter data by PC web bowser o
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A Dual Catheter System for Confocal Imaging of Cardiac Microstructure for Diagnosis of Diseases and Evaluation of Therapeutic Interventions

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Database and Knowledge-base Enhancements

Healthcare costs continue to escalate at a steep rate. Cost increases have occurred in all areas, including insurance premiums, medical equipment, medicines and costs for visits to doctors. A great deal of energy has gone into finding ways to reduce healthcare costs, from government control of aspects of health care to insurance company managed care plans to control patient utilization of the healthcare system and provider actions. The present invention provides protocols and environment for
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Instrumented Model of the Human Torso for Ballistic Impact

Effective body armor minimizes injury by transferring the kinetic energy of a projectile over an extended time-scale or surface area. Body armor that accomplishes such energy transfer using lightweight materials that are comfortable to wear involves sophisticated technology and engineering. To better assess the quality of new body armor designs, new injury criteria are needed to quantify the damage of different non-penetrating munitions to the internal organs. Therefore there is a need for a hum
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Wheelchair Toileting Module and Method

The invention provides for a toileting module which can be used in a standard wheelchair and consists of straps and a tensioning mechanism therefor attached to a support structure. The straps run under the wheelchair-bound person and, when tightened, raise the person above the seat cushion permitting its removal and the insertion of a waste receptacle for toileting. Patent Status: U.S. patent(s) 5,039,165 issued.
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Apoptosis and Self-destruct: Mechanisms for Management of Autonomic Systems (GSC-14968)

Abstract: Autonomic Computing is an emerging area for research and practice that is being promoted by IBM and others. The idea is to borrow principles from the human autonomic system and apply them to computer systems. For example, the human body self heals after an injury, and ideally computer systems would do the same. Our idea is to apply the principle of cell apoptosis and self-destruct to computer systems. That is, like cells in nature, computer systems have predetermined expirations and m
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Resistive Exercise Equipment (MSC-23196)

Abstract: While NASA scientists created the technology to offset the adverse effects of long-term microgravity exposure, including muscle atrophy and loss of bone mineral density, the devices are adaptable to home and commercial use. All of the devices are more compact than similar exercise equipment. Other potential uses for the devices include home use, physical therapy and rehabilitation and use at clubs, in hotels and on cruise ships. The equipment is economic and durable and is more lightw
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Rehydration Beverage ()

Abstract: This novel rehydration beverage contains sodium chloride, sodium citrate and aspartame useful for rapid restoration of hydration homeostasis. The beverage is particularly useful for restoration of normal body fluid volumes and their intracellular and extracellular distribution during a hypohydration state observed in astronauts and air passengers.
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A Method of Operation for the Quadrupole Ion Trap in the Resonance Ejection Mode with Linear Dependence of the mlz Ratio of Ejected Ions upon the Trapping RF Voltage

A method for producing precise linear mass calibration and accurate mass measurements in the resonance ejection mode of an ion trap mass spectrometer using modulation of the endcap voltage amplitude proportional to the amplitude of the fundamental RF frequency.
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Device and Method for Measuring Spinal Reposition Sense (20013)

Proprioception is used by the body to communicate position sense and appreciation of movement of body parts. Receptors located in muscles, ligaments, tendons, capsules, menisci and the skin provide proprioceptive input about the body's static and dynamic position sense in space. A growing body of research supports that injury or disease (degenerative disc disease, DDD) affecting the spine may disrupt spinal proprioception. In turn, the resulting proprioceptive impairment may further place spinal
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Automated Alignment System for Prosthetic Feet (20030)

Different types of prosthetic feet necessitate different alignment. Dynamic Alignment of prosthetic feet is currently accomplished using empirical, iterative methods. A clinician tentatively aligns the foot, the client walks with the foot/prosthesis system, and the clinician makes necessary changes to the alignment. This process is repeated until an agreeable alignment is found that satisfies both the client and the clinician. The adjustments are made to a "pylon" that will remain in the patient
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Method and Apparatus for Measuring Limb Position Sense During Cyclic Limb Movement (20086)

INVENTION: Limb position sense (LPS) is the ability of a subject to detect the position of his/her arm or leg in space. During locomotion, limb position sense is regulated by sensory feedback to the nervous system from proprioceptors, which include cutaneous, vestibular, muscle and joint receptors. These propioceptors respond to locomotion and provide information on spatial positioning of the limbs. Such feedback is essential for the generation of the normal motor pattern, and can influence norm
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Marionet (26033)

INVENTION: MARIONET is a “robotic assist” device for home use in rehabilitation. Unlike currently available robotic-assist devices, MARIONET is: Small & lightweight Inexpensive Safe & compliant Highly portable Intended for home use MARIONET remotely actuates robotic joints via a system of cables, varying the torque applied to a joint in a controlled manner. It accomplishes this by varying the moment-arm of a cable relative to the joint, rather than by varying cable tension. The MARI
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NUberwalker

INVENTION: The NUberwalker is a 2006 winner of the Davinci award that “honors outstanding engineering achievements relative to design process, product design and applied research related to accessibility and universal design issues ” (See 2006 Davinci Award). The NUberwalker is a body weight supported treadmill training system designed for home use. It can be used by those suffering from obesity or recovering from orthopedic surgery, stroke and other ailments to accelerate rehabilitation and
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Adaptable Ankle-Foot Prosthesis

INVENTION: The Adaptable Ankle-Foot Prosthesis automatically adapts to different surface slopes and to shoes of different heel heights. Current prosthetic ankle-foot mechanisms cannot automatically adapt to these conditions on the first step. Unlike current prosthetic ankle-foot mechanisms, the Adaptable Ankle-Foot Prosthesis: Automatically adapts to changing slopes on the first step Automatically adapts to different heel heights Mimics the able-bodied ankle-foot mechanism in the perio
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The Write Away

INVENTION: The Write Away is an easy-to-use writing aid for individuals with physical impairment such as arthritis or stroke. Unlike currently available writing aids, The Write Away: Is easy to grasp Supports the hand Is ambidextrous Securely grips writing implements Easily changes writing implements Glides easily Looks great Through extensive user testing, the inventors learned that users are most comfortable resting their hand on a solid device that supports their hand in the natura
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Prosthetic Foot with Adjustable Flat Region

INVENTION: The invention is a prosthetic foot that presents a flat region for standing but that has flexibility for walking. The foot can assume a stable position during standing and a "rollover shape" during walking. The rollover shape mimics the natural gait of an able-bodied ankle-foot mechanism. The invention enables the user to set the length of the flat region according to his preferences. The ability to adjust the flat region can be useful when the user first learns to use a prostheti
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Bi-Modal Prosthetic Foot

INVENTION: The Bi-Modal Prosthetic Foot presents a flat foot during standing and a flexible foot during walking. It can assume a stable position during standing and a "rollover shape" during walking. The rollover shape mimics the natural gait of an able-bodied ankle-foot mechanism. The Bi-Modal Prosthetic Foot achieves this via. a locking mechanism in the ankle joint, as shown below. Northwestern University seeks a licensing partner to commercialize this invention. A patent application h
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SMART Reimbursement and Contract Modeling Tool

The software application includes a web interface which allows users to define the expected (health insurance) reimbursement rate for an unlimited number of commercial third party payers (e.g. Blue Cross Blue Shield, EHP, CareFirst, Helix). The application then allows the user to run reports to identify where received payments do not meet the defined contract expectations. The detailed files produced can be sent to the third party payer to request additional payments and the system allows the us
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Methods and Protein Biomarkers Predictive of Toxic Exposure, Health Status and Disease

The present work describes a list of novel and specific biomarker targets and a novel data analysis strategy for determining current health status, the occurrence of past exposures to toxic chemicals, and associated adverse health outcomes. Biomarkers are specific physiological, biochemical and biological parameters to establish, quantify or predict genetic dispositions, environmental stresses and their effects on health status and/or development of specific diseases. Biomarkers have been propos
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Mechanism for Input, Transmission, and Analysis Mechanism of Self-assessed Pain Level for Patient Monitoring and Diagnostics

a. The device offers a novel method of monitoring pain in patients. The design allows doctors/nurses to track the pain levels felt by the patient much like heart rate and other metrics are currently viewed. By coupling the increase or decrease in pain with other events, better diagnosis�s can be made. b. Several different methods are outlined, including the use of a button, slider, touch pad, or trigger. Furthermore, the scale could be either based on pressure, a 1-10 scale, or even descriptio
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Hospital at Home Care Model

Acute hospital care can be burdensome for elderly patients. Providing acute hospital-level care to a patient in his home in lieu of an acute hospital admission may improve patient outcomes and be less expensive. As a result, Dr. Bruce Leff has developed a Hospital at Home model of care that includes protocols for admission, treatment, discharge standards, care protocols, staffing requirements, and economic models to assist health care systems understand financial effects of this care model. The
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Web-Based Diabetes Data Management Application

Intensive control of blood glucose levels may delay the onset and progression of microvascular complications that contribute to the morbidity and mortality of patients with type 1 and type 2 diabetes melltus. Treatment regimens targeting intensive control rely on the administration of multiple doses of different preparations of insulin. These regimens are monitored and adjusted on the basis of frequent self-measured blood glucose readings. Patients who keep track of their own blood glucose meas
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Improved Production of Clavulanic Acid by Genetic Engineering of Streptomyces Clavuligerus

Clavulanic acid is a potent beta-lactamase inhibitor used to combat resistance to penicillin and cephalosporin antibiotics. There is a demand for high-yielding fermentation strains for industrial production of this valuable product. This invention describes genetic engineering of the glycolytic pathway in Streptomyces clavuligerus to partially block the flux of D-glyceraldehyde-3-phosphate (G3P) into the Krebs cycle. G3P is one of two primary metabolic precursors of clavulanic acid biosynthesis,
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Johns Hopkins Diabetes Management Program

The invention encompasses a team of health care professionals who directly manage the pharacologic, nutritional and educational components of the medical care plan for hospitalized patients with diabetes mellitus. The director of the team wil be a board certified endocrinologist, who wil be responsible for oversight, algorithm development and interfacing with other disciplines (administrative, nursing, pharacy, case managers etc). A nurse practitioner(s) wil provide the day-to-day management of
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Removing Insult from Injury: Disclosing Adverse Events

Abstract (Set) Researchers at Johns Hopkins developed 25-minute training video, Removing Insult from Injury: Disclosing Adverse Events that helps to educate physicians and hospitals in how to disclose adverse events to their patients and their families. The video features short vignettes of doctors talking with patients to illustrate the best methods for disclosing medical errors. This program is helpful tool for physicians, risk managers and health care organizations. Description (Set) http:
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Wild-Type Amyloid Precursor Protein Yeast Artificial Chromosome Transgenic Line Py8.9

Researchers at Johns Hopkins and Case Western Reserve University have generated a transgenic mouse (Py8.9) line that expresses the wild-type human Amyloid Precursor Protein (APP). This mouse was generated through the insertion of a Yeast Artificial Chromosome encompassing the entire human APP gene, thus providing all the transcriptional regulatory elements required for the correct spatial and temporal expression of APP, and the splice donor/acceptor sites necessary to generate all alternatively
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Hand Held Patient Tracking, Education and Decision Support (TEDS) Tool

This product is a computerized handheld decision support device that would be used by a physician-led team od Community Health Workers working in the field to constantly monitor AND address patient healthcare needs and outcomes. This system will employ an enterprise-level Geographical Information System (GIS) software and relational database to enable the capture of community level data and promote better health education targeting by CHW�s. Risk factor and healthcare utilization algorithms wr
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Web-based Heparin Management System

Thrombotic disorders (myocardial infarction, unstable angina, stroke, deep venous thrombosis, pulmonary embolism) are among the most common reasons for hospital admission. (1) Anticoagulation plays an important role in the management of these illnesses. Although low molecular weight heparins are playing an increasingly important role in the management of thrombotic disease, the longer half-life, increased cost and renal elimination oflow molecular weight heparins limit their application in many
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High Resolution Three-dimensional (3D) Iterative Pinhole Image Reconstruction Methods

The invention is a three-dimensional (3D) iterative pinhole image reconstruction method and its software implementation for use in high-resolution pinhole SPECT imaging. The method and software is particularly useful in high-resolution microSPECT imaging of small animals including mice and rats. In addition, the invention allows further improvement and enhancement of hte image reconstruction method.
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IHC Software

A comprehensive software program has been developed to aid in immunohistochemical laboratory studies. At present, no such comprehensive and integrated software program with equal or similar capabilities is available in the marketplace. Some vendors offer rudimentary software as part of their proprietary staining machines and reagent systems, but their capabilities are limited. Description (Set) The IHC software application is a proprietary product written using the (M)UMPS programming languag
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The JHU Sleep Center's Interactive Training Module for Polysomnogram (PSG) Scoring

Abstract (Set) This interative computer program represents the first fully interactive tool that allows one to score sleep studies that can be checked against board certified and eligible sleep specialists and a certified sleep technologist based on the APSS 2007 PSG scoring guidelines. The product(s) will consist of (Part1: Normal Sleep , Part2: Respiratory Scoring, Part3: Leg movements Part4: Sleep Disorders (i.e. apneas, narcolepsy, circadian disorders, parasomnias), and Unusual Sleep Phenom
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Home Link System for Daily Monitoring of Outpatients

Despite landmark basic and clinical research advances in our understanding of the pathophysiology and treatment of CHF, the majority of patients are not receiving or applying optimal pharmacologic therapy or dietary and physical activity regimens. Effective management of congestive heart failure (CHF) is one of the most important challenges and opportunities confronting our health care delivery system. The Johns Hopkins Medical Institutions, Division of Cardiology and The Johns Hopkins Applied P
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Method to Assess Vascular Endothelial Function using Phase-Contrast Magnetic Resonance Angiography

Endothelial function is crucial in maintaining cardiovascular health. FMD is a noninvasive method of evaluating endothelial function. Impaired FMD measured by ultrasound correlates with cardiovascular risk factors, predicts the presence and severity of coronary artery disease, and predicts adverse cardiovascular events. Intense and widespread interest exists in developing FMD for use by practitioners to predict cardiovascular risk and to guide therapy in individuals. The ultrasound FMD technique
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Method for Measuring Myocardial Motion

A method of magnetic resonance imaging of myocardial motion includes positioning a portion of a patient such as a patient's heart within a main magnetic field and employing a plurality of RF signals to establish a plurality of parallel plane tags through the portion. In imaging heart motion, a first minimum spacing between adjacent tags is employed in a region where the tags will decrease their separation over systole and a second initial tag separation will be employed for portions wherein the
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A Dipole Antenna for Magnetic Resonance Imaging and Spectroscopy

The invention provides a method for magnetic resonance imaging and spectroscopic analysis of a specimen which includes positioning the specimen within a main magnetic field and introducing an antenna having a loopless antenna portion in close proximity to the specimen. Radio frequency pulses are provided to the region of interest to excite magnetic resonance signals, gradient magnetic pulses are applied to the region of interest with the antenna receiving magnetic resonance signals and emitting
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Sickness Impact Profile" a/k/a "SIP (Copyright Only)

Sickness Impact Profile (SIP) is an assessment tool that consists of 136 questions and measures behaviorally-based health status. It has been validated and used for over 30 years. The SIP can be self- or interviewer-administered and asks respondents to endorse items that describe their everyday activity and are related to their health. Scoring is based on the number and type of items endorsed.
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Child Health & Illness Profile - Child Edition (CHIP-CE), Child Report Form & Parent Report Form

The Child Health and Illness Profile (CHIP) is a family of self-report questionnaires designed to assess the health of children (Child Edition-CE) and adolescents (Adolescent Edition-AE) ages 6 through 17 years. The CHIP-CE is a generic child health status questionnaire that comprehensively describes all aspects of child health that can be influenced by the health care and school systems - satisfaction, discomfort, resilience, risk avoidance, achievement, and disorders. The Child Report Form (CH
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Screening instrument (PraPlus)

Pra and PraPlus are screening tools that identify elders who are at high risk for using healthcare services heavily in the future. Pra is 8-item questionnaire and PraPlus has additional 9 items that evaluate older persons� medical conditions, functional ability, living circumstances, nutrition and depression. Proposed Use (Set) Risk screening instrument
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Skills Trainer for Robotic Surgery

Robotic surgery is becoming increasingly popular with the advent of robotic technology in medicine. With this, there arises a need to extensively train the surgeons to effectively use these devices. Surgeons using these robotic systems need to be tra ined for a large number of procedures before being considered proficient. There is a large time and monetary cost involved with such training and therefore there is a need to reduce time spent on training on these systems. Currently commercially opt
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Composition of Liposomal GM-CSF

Pharmaceutical and immunological scientists at the University at Buffalo have developed novel formulations for cytokine and growth factor drugs, including recombinant interleukin-12 (rhIL-12), GM-CSF and VEGF-C. Depending on the preferred method of a dministration, these formulations can be customized to either remain localized at the site of injection or prolong circulation time, and in either case with minimal or no loss of biological activity. One of these formulations, liposomal rhIL-12, app
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CPAP titration using artificial neural network

For 18 million Americans suffering from Obstructive Sleep Apnea (OSA) this is as frustrating as a dog chasing its tail. Lack of proper sleep can lead to severe health problems and increased risk of accidental death. Continuous Positive Airway Press ure (CPAP) provides effective treatment. However, determining the CPAP pressure for treatment involves multiple steps and guess work which drives up cost and delays treatment. This invention eliminates much of the guess work. The sleep technician obta
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Method for Inhibiting Proteases in the Oral Cavity

Sensitive teeth, a condition which affects more than 45 million Americans each year, likely results from exposed dentinal tubules. A number of products have been developed that either occlude the exposed dentinal tubules or desensitize the nerves r esponsible for transmitting signals that the brain interprets as pain. Unfortunately, these products suffer from a number of drawbacks including but not limited to low pH, increased risk for developing kidney stones with long-term use, and/or are kn o
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Composition and method of preparation of liposomal microparticulate IL-12 for immunotherapy

Pharmaceutical and immunological scientists at the University at Buffalo have developed novel formulations for cytokine and growth factor drugs, including recombinant interleukin-12 (rhIL-12), GM-CSF and VEGF-C. Depending on the preferred method of a dministration, these formulations can be customized to either remain localized at the site of injection or prolong circulation time, and in either case with minimal or no loss of biological activity. One of these formulations, liposomal rhIL-12, app
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CryoTissue Conditioner (Conditioner Solution for Frozen Tissue Sections for Histological Examination)

Microscopic examination of tissue morphology and intracellular protein content is one of the major methods of assessing disease states in tissue samples. Current techniques often result in damage to the tissue section either during the cryostat sect ioning or as the sections are subjected to shear stress during labeling and washing. Damaged frozen sections appear either with no texture or with damaged and rough surfaces causing the loss of valuable sample material. This CryoTissue Conditioner is
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Intestinal Coupling Device

Esophageal atresia with tracheal esophageal fitula occurs in approximately 1 in 1500-5000 newborns. This is a congenital defect in which the esophagus does not form a continuous connection to the stomach and instead ends in a pouch. Without treatme nt, the condition is fatal. Current treatments involve extensive surgery which can have lifelong effects on the patient and a significant mortality risk. Described within is a novel method and device that could be used as a minimally invasive metho d
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Esophageal Coupling Rings

Esophageal atresia with tracheal esophageal fitula occurs in approximately 1 in 1500-5000 newborns. This is a congenital defect in which the esophagus does not form a continuous connection to the stomach and instead ends in a pouch. Without treatme nt, the condition is fatal. Current treatments involve extensive surgery which can have lifelong effects on the patient and a significant mortality risk. Described within is a novel method and device that could be used as a minimally invasive metho d
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Esophageal Coupling Device

Esophageal atresia with tracheal esophageal fitula occurs in approximately 1 in 1500-5000 newborns. This is a congenital defect in which the esophagus does not form a continuous connection to the stomach and instead ends in a pouch. Without treatme nt, the condition is fatal. Current treatments involve extensive surgery which can have lifelong effects on the patient and a significant mortality risk. Described within is a novel method and device that could be used as a minimally invasive metho d
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Composition of the reconstitution medium for protein and peptide formulations

Pharmaceutical scientists at the University at Buffalo have developed a rational strategy to design compositions for the reconstitution of freeze-dried protein/peptide formulations. These compositions confer stability to otherwise unstable protein p roducts such as replacement therapies (i.e. factor VIII, interferon-beta, etc.) and vaccines. Other applications include use as a delivery vehicle or as adjuvants for therapeutic and prophylactic vaccines. The strategy allows for the selection of ap
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MUC7 20-mer Peptide: Novel and Promising Antifungal and Antibacterial Therapeutic Agent

This invention encompasses peptide derivatives of a naturally occurring protein found within the human body. These peptides have been shown to posses potent antifungal and antibacterial activity comparable to that of currently used antimicrobial age nts. The microbes used within those studies include but are not limited to both resistant and non-resistant strains of C. albicans, C. glabrata, C. neoformans, S. mutans, E. coli, and P. aeruginosa. Preliminary data demonstrates that these peptides p
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A Method to Distinguish Organisms Causing Exacerbations of Chronic Bronchitis

The invention provides a simple, quick and inexpensive test for discriminating between bacterial and non-bacterial exacerbations of chronic lung disease. The test is based on the strong correlation between bacterial AECB (acute exacerbations of chro nic bronchitis) and sputum elastase. The test comprises obtaining a sputum sample from a patient such that it contains secretions of the lower respiratory tract and testing it for the presence of elastase. In addition, for some pathogens a correlat i
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CryoTissue Conditioner (Conditioner Solution for Frozen Tissue Sections for Histological Examination)

Microscopic examination of tissue morphology and intracellular protein content is one of the major methods of assessing disease states in tissue samples. Current techniques often result in damage to the tissue section either during the cryostat sect ioning or as the sections are subjected to shear stress during labeling and washing. Damaged frozen sections appear either with no texture or with damaged and rough surfaces causing the loss of valuable sample material. This CryoTissue Conditioner is
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A Method to Distinguish Organisms Causing Exacerbations of Chronic Bronchitis

The invention provides a simple, quick and inexpensive test for discriminating between bacterial and non-bacterial exacerbations of chronic lung disease. The test is based on the strong correlation between bacterial AECB (acute exacerbations of chro nic bronchitis) and sputum elastase. The test comprises obtaining a sputum sample from a patient such that it contains secretions of the lower respiratory tract and testing it for the presence of elastase. In addition, for some pathogens a correlat i
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Skills Trainer for Robotic Surgery

Robotic surgery is becoming increasingly popular with the advent of robotic technology in medicine. With this, there arises a need to extensively train the surgeons to effectively use these devices. Surgeons using these robotic systems need to be tra ined for a large number of procedures before being considered proficient. There is a large time and monetary cost involved with such training and therefore there is a need to reduce time spent on training on these systems. Currently commercially opt
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CPAP titration using artificial neural network

For 18 million Americans suffering from Obstructive Sleep Apnea (OSA) this is as frustrating as a dog chasing its tail. Lack of proper sleep can lead to severe health problems and increased risk of accidental death. Continuous Positive Airway Press ure (CPAP) provides effective treatment. However, determining the CPAP pressure for treatment involves multiple steps and guess work which drives up cost and delays treatment. This invention eliminates much of the guess work. The sleep technician obta
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Intestinal Coupling Device

Esophageal atresia with tracheal esophageal fitula occurs in approximately 1 in 1500-5000 newborns. This is a congenital defect in which the esophagus does not form a continuous connection to the stomach and instead ends in a pouch. Without treatme nt, the condition is fatal. Current treatments involve extensive surgery which can have lifelong effects on the patient and a significant mortality risk. Described within is a novel method and device that could be used as a minimally invasive metho d
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Esophageal Coupling Rings

Esophageal atresia with tracheal esophageal fitula occurs in approximately 1 in 1500-5000 newborns. This is a congenital defect in which the esophagus does not form a continuous connection to the stomach and instead ends in a pouch. Without treatme nt, the condition is fatal. Current treatments involve extensive surgery which can have lifelong effects on the patient and a significant mortality risk. Described within is a novel method and device that could be used as a minimally invasive metho d
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Esophageal Coupling Device

Esophageal atresia with tracheal esophageal fitula occurs in approximately 1 in 1500-5000 newborns. This is a congenital defect in which the esophagus does not form a continuous connection to the stomach and instead ends in a pouch. Without treatme nt, the condition is fatal. Current treatments involve extensive surgery which can have lifelong effects on the patient and a significant mortality risk. Described within is a novel method and device that could be used as a minimally invasive metho d
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Composition of Liposomal GM-CSF

Pharmaceutical and immunological scientists at the University at Buffalo have developed novel formulations for cytokine and growth factor drugs, including recombinant interleukin-12 (rhIL-12), GM-CSF and VEGF-C. Depending on the preferred method of a dministration, these formulations can be customized to either remain localized at the site of injection or prolong circulation time, and in either case with minimal or no loss of biological activity. One of these formulations, liposomal rhIL-12, app
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Composition and method of preparation of liposomal microparticulate IL-12 for immunotherapy

Pharmaceutical and immunological scientists at the University at Buffalo have developed novel formulations for cytokine and growth factor drugs, including recombinant interleukin-12 (rhIL-12), GM-CSF and VEGF-C. Depending on the preferred method of a dministration, these formulations can be customized to either remain localized at the site of injection or prolong circulation time, and in either case with minimal or no loss of biological activity. One of these formulations, liposomal rhIL-12, app
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Composition of the reconstitution medium for protein and peptide formulations

Pharmaceutical scientists at the University at Buffalo have developed a rational strategy to design compositions for the reconstitution of freeze-dried protein/peptide formulations. These compositions confer stability to otherwise unstable protein p roducts such as replacement therapies (i.e. factor VIII, interferon-beta, etc.) and vaccines. Other applications include use as a delivery vehicle or as adjuvants for therapeutic and prophylactic vaccines. The strategy allows for the selection of ap
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Biomarkers for Cardiovascular Disease

Introduction Cardiovascular disease (CVD) is the leading cause of death among both men and women in the United States and, as such, is associated with high costs in terms of health care, morbidity, and mortality. An important aspect of the fight to reduce CVD is the development of diagnostic tests to identify people who are at increased risk of CVD and who will thus benefit from treatment. As such, there is a pressing need to identify markers for the rapid, accurate and non-invasive diagnosis an
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Calcipressins: Lead Targets for Autoimmune, Inflammatory, and Cardiovascular Disease

Summary The development of more selective immunosuppressive agents to mitigate transplant rejection and autoimmune diseases requires effective strategies of blocking signaling pathways in T cells. Current immunosuppressive strategies use cyclosporin A (CsA) or FK506 to inhibit calcineurin, which dephosphorylates and promotes the nuclear import of nuclear factor of activated T cells (NFAT) transcription factors. These nuclear NFATs then transactivate cytokine genes that regulate proliferative res
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Efficient Air Purification and Lighting

Introduction According to the CDC, one third of the world’s population is infected with tuberculosis (TB) with nearly 9 million newly infected and nearly 2 million related deaths each year. This respiratory disease is passed through the air, and these germs can stay active in an environment for hours. TB and other respiratory diseases pose a serious global health concern, especially in the developing world. Technology Description Professor Abernethy at the University of Washington has develop
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Wearable Low Vision Aids Using Retinal Light Scanning Technologies

Introduction Severe visual impairment (those persons classified as legally blind) affects over 1 million Americans currently. With the aging of the U.S. population, this visually impaired segment is expected to rise at 10 times the rate of general population growth. Technology description Researchers at the UW have developed a wearable low vision aid (WLVA). This new technology does not require bulky pixel arrays so there is high potential for miniaturization to a form factor compatible with the
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SirT1 Conditional Knockout Mice

Introduction SirT1 is a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase capable of modifying the activity of many transcription factors that have been implicated in the physiology and pathology of multiple organs. Researchers at the University of Washington have developed a strain of SirT1 conditional knockout mice (SirT1co/co mice). By crossing SirT1co/co mice with CMV-Cre transgenic mice, they generated SirT1-deficient mice and uncovered the function of SirT1 in modulation of est
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Fluorescent Microglial Cell Lines

Introduction Microglial cells are the resident immune cells of the central nervous system. Upon brain damage, these cells are rapidly activated and transform from a resting state into activated microglia. They share many properties with peripheral tissue macrophages, one of them being their inherent difficulty to be transfected or transduced. Currently there is no stable transgenic microglia cell line at all. Researchers at the University of Washington have developed a viral-based transduction s
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Automated laboratory system and analytical module

Our invention: Fast Lab Technology is a cornerstone in preventive and lower cost health care of USA Government program: http://www.codebuildingblocks.com/Michael/FastSpin Our technology intends to decrease time and cost of routine and esoteric tests and comprises some new engineering methods and devices. Project fits with existent testing technology and does not require changing analyzing methods. Reduction in medical errors will reduce health care cost by several $Billions per year and
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Piezoelectric Structural Health Monitoring Systems

Introduction All engineered works suffer the damages of time, intended use, and disaster. Skyscrapers, bridges, dams, aircraft, and freight trucks are just a few examples of constructs where structural integrity is important to monitor for safety, social, environmental, and economic reasons. With the proper monitoring system in place, the impact of both the gradual strain of normal wear and tear and the sudden damage from disaster, such as earthquakes, can be quickly assessed and mitigated. Tech
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Diabetes Food Additive, Neutraceutical & Drug

Project 1: We currently are marketing / outlicensing a diabetic food additive / neutraceutical. Possible Drug development aspects. Project 2: We are looking for a grant, an angel investor(s) and/or venture capital group to bring to NCE status a new drug to treat and prevent Alzheimers. If you really want to cure Alzheimers, Call us.
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Neuroprotective Agent for the Treatment of Ischemic Stroke

Novel neuroprotective peptide agent capable of reducing the amount of ischemic brain injury. Description Researchers at the Centre for Addiction and Mental Health have developed a novel neuroprotective peptide agent capable of reducing the amount of ischemic brain injury. This is accomplished by disrupting a unique extracellular interaction between the AMPA receptor (AMPAR) and the enzyme, GAPDH. Our agent disrupts this AMPAR-GAPDH interaction resulting in cell survival and preservation of
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University of Nebraska-Lincoln Technology Out-Licensing Opportunities

The Lincoln, Nebraska-based Office of Technology Development (OTD): http://otd.unl.edu/ manages the intellectual property assets of the University of Nebraska-Lincoln. OTD’s mission is to help turn academic research into tangible products and services, while returning income to the inventors and to the University to support further research and education. OTD has recently partnered with the Consulate General of Canada Minneapolis to offer Canadian companies access to technologies enabling the
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NH-7211 – a Broad Acting Anti-Alzheimer’s Compound

Novel small chemical compounds capable of disrupting the three key misfolded proteins responsible for Alzheimer’s disease (AD) and other CNS disorders Description Our researchers have created novel small chemical compounds capable of disrupting the three key misfolded proteins responsible for Alzheimer’s disease (AD) and other CNS disorders. Our lead compound, NH-7211 has been extensively tested in both in vitro and in vivo models and has shown a unique ability to inhibit ABeta40/ABeta4
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Epilepsy, Alzheimers & Parkinson's Drug Development

Upsher-Smith Laboratories, Inc., is a privately held, specialty pharmaceutical company with headquarters in Minneapolis, MN (www.upsher-smith.com). The company is seeking collaborative partners and out-licensing opportunities for improved drug therapies that treat epilepsy, Parkinson's and Alzheimer's disease. Background Upsher-Smith Laboratories, Inc., a privately held, specialty pharmaceutical company with headquarters in Minneapolis, MN (www.upsher-smith.com), is pursuing improved drug
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Drug Delivery Technologies

Upsher-Smith Laboratories, Inc., a privately held, specialty pharmaceutical company with headquarters in Minneapolis, MN (www.upsher-smith.com), is actively seeking Canadian companies or research organizations with technology or expertise in various areas of drug delivery. Background Upsher-Smith Laboratories, Inc., a privately held specialty pharmaceutical company with headquarters in Minneapolis, MN (www.upsher-smith.com), is pursuing improved drug therapies to empower people suffering
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Women's Healthcare

Upsher-Smith Laboratories, Inc., a privately held specialty pharmaceutical company with headquarters in Minneapolis, MN (www.upsher-smith.com), would like to augment its current portfolio with marketed or near-to-market women’s health products. Upsher-Smith Laboratories, Inc., a privately held specialty pharmaceutical company with headquarters in Minneapolis, MN (www.upsher-smith.com), is pursuing improved drug therapies to empower people suffering from diseases to lead healthy, productive li
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Feiter a New Method of Brain Scanning

BACKGROUND A number of techniques are available for brain scanning and imaging including CT scanners, MRI, fMRI and PET. All require large expensive fixed installations and cannot be made available in all hospitals. Their imaging speed does not allow measuring brain activity or functional responses in the millisecond region.. The University of Manchester is a Centre of Excellence in the field of industrial tomography and image reconstruction and has exploited these skills to develop fEITER (Func
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Novel Synthesis of Iduronate a Heparan Sulphate Subunit

BACKGROUND Heparan sulphate and heparin play a central role in a large number of processes including anti-coagulation, angiogenesis, cell growth and migration. A new class of medicinal drugs can be envisaged that would either promote or inhibit the function of heparan sulfate/heparin by mimicking or competitively inhibiting the function of heparan sulphate/heparin. These types of complex heparan sulphate molecules have historically been difficult to synthesise and the majority could be obtained
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Zero Bias Switch

ZBS (Zero Bias Switch) patent # 7,106,188 A long range radio receiver without an amplifier (no battery drain) This RF receiver is acitvated by the incoming signal no stand-by power is needed. Make new hybrdid RFID tags that need no battery replacements and much more
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