Tricyclic Compounds Having Cytostatic And/or Cytotoxic Activity and Methods of Use Thereof

The present invention provides tricyclic compounds having cytostatic and cytotoxic activity in a single molecule having receptor tyrosine kinase(s), dihydrofolate reductase, thymidylate synthase and/or dihydroorotate dehydrogenase inhibitory activity, which are useful as anti-angiogenic and anti-tumor agents. Also provided are methods of utilizing these inhibitors to treat tumor cells and other proliferative diseases and disorders.

Patents:
WO 2,009,029,473

Inventor(s): GANGJEE ALEEM [US]

Type of Offer: Licensing



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