Nitrated-fatty Acids Modulation of Type Ii Diabetes

Nitro oleic acid and related metabolites are agonists of PPAR-?. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-?, relative to nitro linoleic acid. Thus, nitro oleic acid and its metabolites, as well as their pharmaceutically acceptable salts and prodrug forms, are candidate therapeutics for the treatment of type-2 diabetes, which results from insulin resistance accompanying the improper functioning of PPAR-?.

Attached files:
O 2009017802.jpg

WO 2,009,017,802

Inventor(s): FREEMAN BRUCE A [US]

Type of Offer: Licensing

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