Delivery of Dna or Rna Via Gap Junctions from Host Cells to Target Cells and a Cell-Based Delivery System for Antisense or siRna
A method of delivering an oligonucleotide or a plasmid expressing an oligonucleotide into a target cell comprises introducing an oligonucleotide into a donor cell, particularly a stem cell, and contacting the target cell with the donor cell under conditions permitting the donor cell to form a gap junction with the target cell, whereby the oligonucleotide or a product of the oligonucleotide is delivered into the target cell from the donor cell.
BRINK PETER R [US]; ROSEN MICHAEL R [US]; ROBINSON RICHARD B [US]; COHEN IRA S [US]; GROLLMAN ARTHUR [US]
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