STAT3 Agonists and Antagonists and Therapeutic Uses Thereof
The present invention relates to methods for modulating, i.e., agonizing or antagonizing, Stat3 (Signal Transducer and Activator of Transcription3) signaling activity for use in gene therapy. Inhibition and/or activation of Stat3 signaling is an effective approach to modulate angiogenesis and the immune response for treatment and/or prevention of inflammation, infection, inflammation, immune disorders, and ischemia.
YU HUA [US]; PARDOLL DREW [US]; JOVE RICHARD [US]; DALTON WILLIAM [US]
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