Integrated Biomedical Multimodality Imaging Probe - Optical Coherence Tomography/Ultrasound/Photoacoustics Imaging System
Background: In clinical applications for the examination of cardiovascular, cerebrovascular, leg and other vessels, ultrasound imaging (USI) and optical coherence tomography (OCT) are two of the most widely used imaging modalities. USI and OCT both measure cross-sectional tissue profile. OCT measures tissue surface profile and cross-sectional image within a few millimeter depth range under the skin with a superior image resolution of 10 micrometers; high frequency USI also measures cross-sectional tissue image with a much deeper depth but with lower resolution, on the order of 100 micrometers. Conventional USI performs relatively poorly in blood vessel imaging due to the weak echogenicity of blood. Technology: Researchers at the University of California Irvine have developed a multimodality imaging probe by combining OCT, USI and photoacoustic imaging (PAI) technology to provide morphological as well as functional imaging of tissue and blood vessels with high spatial resolution and imaging contrast. The imaging probe can construct 2D or 3D cross-sectional tissue imaging. Application: By combining these imaging modalities into a single imaging probe, high-resolution tissue image (by OCT and USI) and high-resolution blood vessel image and functional imaging (by PAI) can be accomplished. Clinical imaging applications might include tissue physiological parameter monitoring (oxi-hemoglobin/deoxi-hemoglobin), blood vessel measurements or early tumor and dysplasia monitoring.
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