Human Islet Amyloid Polypeptide transgenic mice

Introduction Amyloid deposits are found in the pancreatic islets of most individuals with non-insulindependent diabetes mellitus (NIDDM). The major component of islet amyloid is a 37-amino acid peptide, islet amyloid polypeptide (IAPP; amylin), which is a normal secretory product of the pancreatic β cell. Formation of islet amyloid deposits from IAPP may contribute to the progressive deterioration of β cell function observed in this disease. Technology description To study the role the inherent amyloidogenicity of human IAPP plays in the formation of islet amyloid deposits and to investigate a possible hormonal role for IAPP, transgenic mice expressing hIAPP were developed. The transgene was composed of a fragment of an hIAPP cDNA linked to the rat insulin II promoter. One line of transgenic mice expressed the transgene and synthesized hIAPP in their pancreatic islets. IAPP-like immunoreactivity in pancreatic extracts and plasma were twoto threefold greater in the transgenic mice compared with nontransgenic control mice. Related Publication(s)
Diabetes. 1994 Dec;43(12):1457-61 Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3492-6

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