A Novel Class of Proteosome Inhibitors
Summary Harvard Medical School investigators has discovered a number of anticancer small molecules, termed ubistatins, that inhibit cell cycle machinery through interference with the ubiquitin-proteasome system. Lead ubistatins were able to arrest cyclin B proteolysis in Xenopus extract assays, and were found to prevent proteasome recognition by attaching to Lys-48-linked ubiquitinated chains. The ubistatins were discovered in a rapid miniaturized assay measuring cyclin B in Xenopus cell cycle extracts, followed by verification in a reconstituted proteasome system, and in-vivo testing in mammalian cells. Strong inhibition of ubiquitin-proteasome interaction suggests that ubistatins represent a novel class of proteasome inhibitors with promising therapeutic potential.
Applications Ubistatins may likely have broad anti-cancer applications. Clinical use may eventually address multiple myeloma, prostate cancer, non-small cell lung cancer, pancreatic cancer, ovarian cancer and breast cancer. For Further Information Please Contact the Director of Business Development Katie Gordon Email:
[email protected] Telephone: (617) 432-0920
Inventor(s):
King, Randall W
Type of Offer:
Licensing
« More Pharmaceutical Patents« More Medical Patents