Surface-Bound Double-Stranded DNA Protein Arrays
Summary Developed at Harvard Medical School, this invention provides nucleic acid arrays specifically designed for the assay of DNA-dependent protein:protein binding and/or physical interactions between proteins and nucleic acid molecules. Intermolecular analyses enabled by this technology are advantageously performed in massively-parallel fashion under uniform reaction conditions. This technology enables researchers to:
- Screen for polypeptides that bind nucleic acid sequences of interest.
- Highlight potential gene regulatory elements.
- Identify candidate co-regulated genes based upon their affinity for a given trans-regulator.
- Identify nucleotides or amino acids that mediate specific DNA:protein or protein:protein interactions.
The invention is covered by U.S. Patent No. 6,548,021, which is available for non-exclusive license for:
- Internal research use
- Commercial service use
- Sale of information generated through use of methods
Applications Proteomics and pharmacogenomics research; drug development; clinical diagnostic, food and environmental testing. For Further Information Please Contact the Director of Business Development Maryanne Fenerjian Email: firstname.lastname@example.org Telephone: (617) 432-0920
Church, George M
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