Methods for Improved Viability of Cells at Low Temperature

Summary Discovery of the linkage between the expression of Trigger Factor, a protein of previously-unknown function, and resistance of living cells to cold-shock has led to development of methods that enable prokaryotic and eukaryotic cells to remain viable at temperatures at- or below which they would not normally proliferate or survive. Controlled expression of Trigger Factor enables cells to maintain essential activities at low, typically lethal, temperatures; of particular use are Trigger Factor fragments having peptidyl proline isomerase activity.


- Expand geographical range for cultivation of warm weather plants. - Provide agricultural diversity in high latitudes or mountainous regions.

- Extend growing season to maximize crop production in existing farmlands.

- Improve tolerance of plants or plant products (i.e., fruits, vegetables, flowers and seeds) to extended cold storage.

Clinical and/or Research Applications:

- Extend the life of cells, tissues or organs during cold storage prior to transplantation, implantation or grafting.

- Enable cold-dependent laboratory manipulation of otherwise cold-sensitive cells, tissues or organs.


Kandror and Goldberg (1997), "Trigger factor is induced upon cold shock and enhances viability of Escherichia coli at low temperatures", Proc. Natl. Acad. Sci. U.S.A. 94(10): 4978-81

The invention is protected by U.S. Patent No. 6,027,932 and is available for exclusive or non-exclusive license.

Applications Enhanced production of cold-tolerant cells for research, therapeutic, vaccine and manufacturing uses; improved agricultural methods. For Further Information Please Contact the Director of Business Development Katie Gordon Email: Telephone: (617) 432-0920

Inventor(s): Goldberg, Alfred L

Type of Offer: Licensing

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