Methods for Improved Viability of Cells at Low Temperature

Summary Discovery of the linkage between the expression of Trigger Factor, a protein of previously-unknown function, and resistance of living cells to cold-shock has led to development of methods that enable prokaryotic and eukaryotic cells to remain viable at temperatures at- or below which they would not normally proliferate or survive. Controlled expression of Trigger Factor enables cells to maintain essential activities at low, typically lethal, temperatures; of particular use are Trigger Factor fragments having peptidyl proline isomerase activity.

Agriculture/Horticulture:

- Expand geographical range for cultivation of warm weather plants. - Provide agricultural diversity in high latitudes or mountainous regions.

- Extend growing season to maximize crop production in existing farmlands.

- Improve tolerance of plants or plant products (i.e., fruits, vegetables, flowers and seeds) to extended cold storage.

Clinical and/or Research Applications:

- Extend the life of cells, tissues or organs during cold storage prior to transplantation, implantation or grafting.

- Enable cold-dependent laboratory manipulation of otherwise cold-sensitive cells, tissues or organs.

Reference:

Kandror and Goldberg (1997), "Trigger factor is induced upon cold shock and enhances viability of Escherichia coli at low temperatures", Proc. Natl. Acad. Sci. U.S.A. 94(10): 4978-81

The invention is protected by U.S. Patent No. 6,027,932 and is available for exclusive or non-exclusive license.

Applications Enhanced production of cold-tolerant cells for research, therapeutic, vaccine and manufacturing uses; improved agricultural methods. For Further Information Please Contact the Director of Business Development Katie Gordon Email: katherine_gordon@hms.harvard.edu Telephone: (617) 432-0920

Inventor(s): Goldberg, Alfred L

Type of Offer: Licensing



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