Keratinocytes Derived from Human Embryonic Stem Cells

Summary The investigator has discovered a method for isolating and propogating keratinocytes from human embryonic stem (ES) cells. Production of an isolated keratinocyte culture proceeded step-wise from ES cell implantation in scid mice, followed by colony fragmentation of the embryoid body, circumferential migration and detection of temporal biomarkers in-vitro. During keratinocyte differentiation, biomarkers that could be detected included transcription factor p63 followed by biomarkers of a more mature keratinocyte lineage including K14, basonuclin, and involucrin.

Applications Wide clinical uses of hES derived kerotinocytes include treatment of skin damage related to burn trauma, physical injury, cosmetic surgery, or ulcers. This represents the first successful isolation of keratinocytes from ES cells. A chief advantage of the technology may be timing and speed to treatment. Autologous culturing requires at least 16 days from the time of biopsy, in addition to patient trauma during skin sampling. Keratinocyte production using ES cells may eventually sidestep such an individualized process and enable accelerated recovery through earlier surgical grafting following severe burns and trauma. For Further Information Please Contact the Director of Business Development Katie Gordon Email: katherine_gordon@hms.harvard.edu Telephone: (617) 432-0920

Inventor(s): Green, Howard

Type of Offer: Licensing



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