cDNA for B1 subunits of human sodium channels

Introduction Voltage-gated sodium channels in the brain are composed of a central, pore-forming α subunit and one or two β subunits. Sodium channel β1 subunits modulate α subunit gating and cell surface expression and participate in cell adhesive interactions in vitro. β1 subunits play important roles in the regulation of sodium channel density and localization, are involved in axo-glial communication at nodes of Ranvier, and are required for normal action potential conduction and control of excitability in vivo. Technology description Dr William Catterall’s laboratory has generated cDNA for B1 subunits of human sodium channels. This cDNA will be useful for production of cell lines expressing human sodium channels for pharmacological screening and for mapping of the human ß1 subunit genes. Related Publication(s)
J Neurosci 2004 24(16):4030–4042. For more information on this technology contact:
Ariadna Santander Agreements Manager, Invention Licensing [email protected] 206-543-3970

Type of Offer: Licensing



« More Medical Patents

---