A Novel Cancer Drug Screen Based on Cell Cycle Uncoupling

Precise coordination of the S and M phases of the eukaryotic cell cycle is critical not only for normal cell division, but also for effective growth arrest under conditions of stress. When damaged, a cell must communicate signals to both the mitotic and DNA synthesis machineries so that a mitotic block is not followed by an extra S phase, or vice versa. The biochemical mechanisms regulating this coordination, termed checkpoints, have been identified in lower eukaryotes, but are largely unknown in mammalian cells.sup.1-3. DNA-damaging agents are used in the clinic to preferentially kill cancer cells. However, there is a need in the art to discover additional therapeutic agents which are selectively toxic to cancer cells. Description (Set) Proposed Use (Set)
Patent (Set) 6,511,818; 7,148,099; 5,882,865; 5,879,889; 5,888,735; 5,897,999; 6,214,616

Patents:
US 6,511,818

Inventor(s): Vogelstein, Bert

Type of Offer: Licensing



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