Generation of Soluble Divalent Heterodimeric Analogs of Proteins involved in Immune Responses

This invention is directed to compositions comprising soluble divalent and multivalent heterodimeric analogs of proteins that are involved in immune regulation and methods of making and using the same. The high affinity that these complexes have for their cognate ligands enables them to be effective competitors to T cell receptors and MHC molecules normally involved in transplant rejection and autoimmune disease. Molecules such as divalent T cell receptors may also have an impact on the diagnosis and treatment of cancer in that they may be used to augment antitumor responses, or may be conjugated to toxins which may then be used to help eliminate tumors. Use of such compositions will allow one to accomplish selective immune modulation without compromising the general performance of the immune system. Patent (Set) 6,458,354; 729406; 331688; 0544449; 6,140,113; 770938; 6,015,884; WO 97/35991; 6,448,071

Patents:
US 6,458,354

Inventor(s): Schneck, Jonathan

Type of Offer: Licensing



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