Blocker of Hedgehog Signalling

A Sonic hedgehog (Shh) response element was identified in the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) promoter that binds to a factor distinct from Gli, a gene known to mediate Shh signaling. Although this binding activity is specifically stimulated by Shh-N (amino-terminal signaling domain), it can also be unmasked with protein phosphatase treatment in the mouse cell line P19, and phosphatase inhibitors can block induction by Shh-N. Thus, Shh-N signaling may result in dephosphorylation of a target factor that is required for activation of COUP-TFII islet1 and Gli response element-dependent gene expression. This finding identifies another step in the Shh-N signaling pathway.
Patent (Set) 6,733,971; 6,277,566; 7,049,090

Patents:
US 6,733,971

Inventor(s): Beachy, Philip A.

Type of Offer: Licensing



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