MR Imaging of Vascular Gene Therapy
Our current knowledge about the bio-distribution and/or in vivo pharmacokinetics of gene therapy is incomplete and relies mainly on staining of biopsied or post-mortem tissues. Modern imaging techniques provide a unique opportunity to monitor and control gene therapy. Johns Hopkins University researchers have developed a new technique for the MRI of vascular gene therapy. Advantages of this technology include: (1) high-resolution images of the vessel, (2) multiple diagnostic evaluations of organ function and morphology, and (3) multiple image planes with no risk of ionizing radiation. This technology should allow for the in vivo monitoring of vascular gene therapy for the treatment of diseases such as restenosis.
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