J HIN, J RASSF1A, J TWIST, J HIC Plasmids

Abstract (Set) Plasmid DNAs incorporating human gene-specific promoter sequences altered by sodium bisulfate treatment. The plasmids contain sequences hybridizing to external QM-MSP regions within gene promoters of RASSF1A, TWIST1, NIN1, and HIC1. These areas bracket cloned DNA from non-human sources to serve as reference control for novel methylation approaches, including studies of blood. Each region cloned into an individual plasmid. Description (Set) Proposed Use (Set) Their use includes serving as reagents, standards, or controls for assays of gene methylation (e.g. for determining methylated or methylated gene copy number or for calibration of assay parameters or equipment).

Inventor(s): Sukumar, Saraswati V. ,Fackler, Mary Jo

Type of Offer: Licensing



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