Screening Method to Predict Donor Organ Function after Transplantation

Abstract (Set) Transplantation represents an established procedure in end-stage organ failure patients and results in satisfying long-term results. However, this surgical therapy is continuously limited by severe and progressive organ shortages. Therefore, many transplant programs have to extend their ?standard? donor criteria by accepting organs from ?Marginal Donors?. These include advanced age, deterioration of function in the dying donor, and long preservation times. However, by doing so, they are faced with a portion of kidneys, which function poorly or not at all. At present, there are no diagnostic methods to measure acute intracellular injury allowing surgeons to discard damaged kidneys. JHU scientists have identified important parameter to screen potential donor organs to predict their function after transplantation. Description (Set) ? Predicts donor organ function after transplantation; ? Uses small tissue samples obtained by the standard needle biopsy; ? Tremendous market opportunity due to progressive organ shortages. Proposed Use (Set) This technology will be used to screen donor organs to predict which ones are acceptable for transplantation and which are not.

Inventor(s): Inventor (Set) Sun, Zhaoli ,Williams, G. Melville

Type of Offer: Licensing

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