In Vitro and in Vivo Induction of Potent Bystander Anti-Tumor Effects Through Inhibition of Stat3 Signaling

The present invention relates to methods for modulating, i.e., agonizing or antagonizing, Stat3 (Signal Transducer and Activator of Transcription3) signaling activity for use in gene therapy. Inhibition and/or activation of Stat3 signaling is an effective approach to modulate angiogenesis and the immune response for treatment and/or prevention of inflammation, infection, inflammation, immune disorders, and ischemia.

Patent (Set) WO 02/20032

US 220,032

Inventor(s): Pardoll, Drew M

Type of Offer: Licensing

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