The Cysteine Noose of the Attachment Protein of Respiratory Syncytial Virus Inhibits the Effects of the Endotoxin and the Innate Immune Response

Both endotoxin and RSV protein F stimulate CD14/TLR4 receptor in monocyte/macrophages resulting in a strong inflammatory response. In the case of endotoxin, this response has a direct pathogenic role in septic shock, autoimmune diseases, HIV, and asthma. And, it is the first response of the immune system against many pathogens and also a critical mechanism of disease for numerous processes. JHU Researchers have found, that within the conserved region of the protein G present in all wild type isolates of RSV, the presence of an amino acid noose that can inhibit the inflammatory response. This inhibitory effect has been demonstrated in both in vitro and in vivo (mice) by the decrease in inflammation elicited by RSV F protein. JHU Researchers have also confirmed an anti-inflammatory role of this noose with endotoxin-induced inflammation in-vitro. Description (Set) Proposed Use (Set) Potential drug to treat a vast array of acute and chronic illnesses, from septic shock and HIV progression to modulation of the immune system during transplantation, autoimmune disease, etc. Possible replacement therapy for steroid modulation of innate immunity.

Inventor(s): Polack, Fernando Pedro

Type of Offer: Licensing

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