High Fidelity DNA Display for the Evolution of Combinatorial Libraries

This invention relates to a method of producing combinatorial libraries from non-biological molecules coupled with replication of selected compounds. Individual molecules used to construct the library are attached to specific DNA sequences that are assembled as polymers, and so each combinatiorial compound has a DNA template that provides a set of instructions for its synthesis. Therefore, this technology allows non-biological compounds to undergo iterative rounds of screening and selection in order to enrich for compounds of interest, followed by resynthesis of selected compounds after each round of selection. In addition, the number of molecules that can be used for each combinatorial step is essentially unrestricted and the format is extremely flexible. When coupled with the high fidelity of DNA replication, libraries with diversities approaching 10 to the power of 18 can be produced using this invention, which is much larger than for existing biological libraries. Description (Set) Proposed Use (Set) This invention can be used to create non-biological combinatorial libraries in order to screen for functional chemical compounds with any specified property, such as new drugs, catalysts and substrates.

Inventor(s): Merryman, Charles Everett

Type of Offer: Licensing

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