N171-82Q Huntington's Disease (HD) Mouse Model

This transgenic line expresses an N-terminally truncated human huntingtin cDNA that encodes 82 glutamines and encompasses the first 171 amino acids. The altered huntingtin cDNA is under the control of a mouse prion protein promoter. Expression is observed in neurons of the central nervous system. Description (Set) Proposed Use (Set) This mouse model provides an important research tool for studying the pathogenesis of Huntington?s disease.

Inventor(s): Ross, Christopher A.

Type of Offer: Licensing

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