Homogenous bioassays and biosensors.

This invention discloses a novel system that involves the use of a short peptide antigen doubly-labeled with fluorescent dye for use in homogenous bioassays and biosensors. Fluorescent energy transfer dyes, which are capable of moving between a more stacked configuration to exhibit fluorescent quenching and a more spaced configuration to exhibit fluorescence can be conjugated to a peptide epitope for use in the detection of an unknown antibody in bulk solution. The resulting labeled peptide reagent can be used in an immunoassay procedure by placing it in bulk solution along with the unknown antibody to be detected. When the antibody binds to the peptide epitope, the pair of dyes carried by the peptide epitope will have their configuration altered from a stacked to an unstacked configuration and will exhibit a fluorescent increase in response.

Useful in clinical diagnostics, enzyme assays (e.g. protein kinases) and immunoassays.

Stage of Development
U.S. Patents: 6,482,655 and 6,576,419
International Patents Issued: Austria, Belgium, Denmark, France, Germany, Italy, Sweden, Switzerland, United Kingdom and the Netherlands
Patents Pending: Canada

Additional Info

Type of Offer: Licensing

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