Polypeptides Including Modified Constant Regions

Disclosed are processes for producing a variant polypeptide (e.g. antibodies) having increased binding affinity for an Fc[gamma]R, which processes comprise modifying the polypeptides by substitution of the amino acid at position 268 of a human IgG CH2 region for a non-native polar or charged amino acid e.g. Gln, Asn, Glu, or Asp. also provided are corresponding polypeptides, nucleic acids, and methods of use of the same e.g. in improved lytic therapies.

Patents:
US 20,100,247,431

Inventor(s): ARMOUR KATHRYN LESLEY [GB]; CLARK MICHAEL RONALD [GB]

Type of Offer: Sale



« More Chemistry Patents
« More Metallurgy Patents

---