Modulation of miRNA Activity

Provided is a method of identifying a compound which modulates miRNA activity comprising (i) determining the ability of a test compound to alter the polyuridylation activity of a ZCCHC polypeptide wherein a test compound which alters the polyuridylation activity is useful in modulating miRNA activity; or (ii) determining the ability of a test compound to alter the binding of a ZCCHC polypeptide to a LIN28 polypeptide, wherein a test compound which alters said binding may be useful in modulating miRNA activity; or (iii) determining the ability of a test compound to bind to a ZCCHC polypeptide, wherein a test compound which binds to the ZCCHC polypeptide may be useful in modulating miRNA activity.

Patents:
WO 2,011,015,829   [MORE INFO]

Inventor(s): MISKA ERIC [GB]; LEHRBACH NIC [GB]; ARMISEN-GARRIDO JAVIER [GB]; BALASUBRAMANIAN SHANKAR [GB]

Type of Offer: Sale



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