A Method for Treating Obesity

A method and pharmaceutical composition for treating a disease or condition associated with elevated hypothalamic T cell protein tyrosine phosphatase (TCPTP) such as obesity, weight gain, type 2 diabetes mellitus, insulin sensitivity, impaired glucose tolerance, and inflammation is disclosed. The method involves administering a subject with an agent which inhibits the activity or expression of TCPTP, wherein the agent is administered, adapted and/or formulated in a manner ensuring that an effective amount of said agent is delivered to the hypothalamus and inhibits the activity and/or expression of hypothalamic TCPTP. Also disclosed is a method for alleviating or preventing leptin resistance in an obese or overweight subject, a method for sensitising a subject to weight loss through dieting, and a dieting kit.

WO 2,011,057,331


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