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TC-1 (Po)
This cell line "was developed to circumvent the confounding issue of negatively selecting nonessential tumor markers in cancer vaccine experiments. Primary lung epithelial cells from C57BL/6 mice were immortalized with HPV-16 E6 and E7 and then transformed with the activated ras oncogene. This trans
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MR Safe Coaxial Cables
This invention is a novel coaxial cable design that will reduce the induced currents and hence the risk of excessive heating or burns in MR scanner. Compact resonance circuits/structures are placed along the length of a coaxial cable with short intervals in a way that an external field could not ind
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Biosynthetic Engineering of Cell Surface Sialic Acids
Surrounding every cell is a halo of glycoproteins, glycolipids and proteoglycans termed the glycocalyx. On these structures, the most common terminus is the sugar sialic acid which is unique in its 9-carbon structure and tissue specific derivatization. Because of its location and potential for diver
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Antisera to Pax-6 Protein
A rabbit polyclonal antisera which recognizes the developmentally important protein marker, Pax-6, in both histological sections and cultured cells. The localized protein identifies neuronal progenitor cells and specific types of differentiated cells in the retina. Description (Set) Proposed Us
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Neutralization of HIV-1 by Bacterial Toxins
Aerolysin is a channel-forming toxin secreted by Aeromonas spp. that binds to glycosyl phosphatidylinositol (GPI)-anchored proteins, such as Thy-1, on sensitive target cells. Receptor binding is followed first by oligomerization of the toxin and then by insertion of the oligomers into the membrane t
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Homer Regulates Cellular Calcium Signaling: a Novel Target for Pharmaceutical Development
A method is provided for identifying a compound that modulates a cellular response associated with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for identifying a compound that modulates receptor-activated calcium mobilization associated with Homer.
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Methylated CpG Island Amplification (MCA)
Aberrant methylation of promoter region CpG islands is associated with transcriptional inactivation of tumor-suppressor genes in neoplasia. JHU scientists have developed a novel method of understanding patterns of CpG island methylation called Methylated CpG island Amplification (MCA). MCA is a PCR
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Referenceless Interleaved Echo Planar Imaging
The patent below describes a method for obtaining magnetic resonance images using ?echo planar imaging? and related techniques, without the use of ?reference scans?. The patent describes a method for calibrating a scanner for time delays and phase shifts and using this a priori knowledge to avoid th
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Fiber Reconstruction Method using Data Acquired by Magnetic Resonance Imaging
This is a technique that allows reconstructing three-dimensional trajectories of axonal fiber bundles in human brain white matter. The technique, called diffusion tensor imaging (DTI) is based on magnetic resonance imaging. Specifically, it monitors orientation of water diffusion, which tends to dif
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Injectable Bag Intraocular Lens System
Featured is an injectable intraocular lens system including an insertion and injection device and an injectable intraocular lens. In its broadest aspects, the injectable intraocular lens is a deflated flexible bag that is disposed within the insertion and injection device prior to insertion into the
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ATM Kinase Assay
The present invention relates to identification of the consensus sequence phosphorylated by ATM kinase. This, in turn, permitted identification of ATM kinase target proteins, and development of a convenient assay system for ATM kinase phosphorylation using fusion polypeptides as substrates. The assa
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Immunotherapy of Autoimmune Disease by co-transfection of Antigen Presenting Cells
Immunologic tolerance to self antigens is a necessary mechanism for protecting an organism from destruction by its own immune system. A number of diseases such as Multiple Sclerosis, Lupis, Myathenia Gravis, and Rheumatoid Arthritis have been shown to result from malfunctions in the mechanisms that
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Yeast Strain S288C
A yeast strain based on Saccharomyces cerevisiae S288C in which commonly used selectable marker genes are deleted by design, dependent upon the yeast genome sequence of interest. Description (Set) Proposed Use (Set) Deletion mutations are valuable because they never revert back to the wild-type
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Phenylalkenoic Acid-Mediated Corection of Aberant Protein Trafficking
This discovery encompasses the compound 4-phenyl-delta3-transbutenoic acid, which restores normal biosynthetic trafficking to the CFTR mutation deltaF508 The mechanism centers on butyrate-mediated down-regulation of the chaperone protein Hsc70. The compound 4-phenyl-delta3-transbutenoic acid is rela
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Biodegradable and Biocompatible Lactide-Phosphate Copolymers, Compositions, Articles and Methods for Making the Same
The growing need for new polymer-based drug delivery materials continues to stimulate polymer research. Although several classes of synthetic polymers have been studied for controlled drug delivery and tissue engineering, polylactide (PLA) and poly (lactide-co-glycolide) (PLGA) still remain the most
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Narp is a Synaptogenic Factor for Excitatory Glutamate Receptors
A novel neuronal cell growth factor, neuronal-activity regulated pentraxin or NARP and its encoding cDNA sequence is provided in this invention. Narp induces dendritic neurite outgrowth, promotes neuronal migration, may modulate intermediate early gene expression in neuronal tisue and facilitates ag
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Non-traumatic Infusion Cannula
In preferred aspects, the present invention features a non-traumatic cannula for use in connection with eye surgery, such as retinal tear and/or detachment surgery. The non-traumatic cannula of the present invention is particularly configured so as to minimize or avoid the potential for damage to th
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Synphilin-1, a Protein which Associates with Alpha-Synuclein and Promotes the Formation of Cytostolic Inclusions
Complementary DNA encoding the neural protein ?synphilin-1? was cloned via the protein?s interaction with synuclein, a previously identified product which has been genetically linked to Parkinson?s Disease. Though synphilin-1 shares little similarity with other proteins in the public database, synph
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Intraventricular Injection of Urokinase or other Thrombolytics
An experimental therapy that could accelerate the resolution of the blood clot and thus reduce the clot-related pathological events associated with the clinical management of intraventricular hemorrhage. Description (Set) Proposed Use (Set) In terms of patients with intraventricular hemorrhage
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Human BARX2 Gene
Surprisingly, it has been found that the Barx2 gene is mutated in ovarian cancer. The invention provides methods of diagnosis, prognosis and treatment of cancer related to the Barx2 gene. Description (Set) Proposed Use (Set) This technology could be commercialized as diagnostic and prognostic k
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Mass-Correlated Pulsed Extraction for a Time-of-Flight Mass Spectrometer
This method and apparatus provides improved focusing and mass resolution over a broad mass range for a time-of-flight mass spectrometer. This is accomplished in a two-source extraction scheme in which the second field is dynamic and compensates for the mass dependency of pulsed extraction methods. T
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Rapid Chest Tube Inserter
Key issues for chest tube insertion include location, penetration angle, control of depth of insertion (to minimize the risk of injury to internal structures), and effective evacuation of air/blood from the pleural space. In addition, the chest tube should be well secured to the chest wall such that
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Cardiac Sock Electrode and Implantable Defibrillator System
An object of this invention is to provide an implantable cardioverter defibrillator (ICD) system and/or method that is less painful to a patient than one or more conventional ICD systems/methods. Another object of this invention is to provide a flexible array including a plurality of electrodes for
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Surgical Device for Enhanced Perception
Featured are surgical devices that provide enhanced perceptual feedback to a medical practitioner in the form of e.g. tactile sensations or auditory feedback, and methods of use of the devices. The devices and methods of the present invention are particularly suitable for microsurgery applications i
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Intraoperative Microsurgical Ultrasound Device
Featured is a device that provides a mechanism for imaging structure and/or tissue of a surgical site during and after performing a microsurgical procedure such as ophthalmic surgical procedures. Also featured are methods and systems related thereto. In the imaging method of the present invention u
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Fusion of Heat Shock Protein 70 to Antigens Enhances the Potency of DNA Vaccines
Increasing evidence has suggested that CD8+ T cell mediated immune responses are important in controlling both intracellular pathogens and tumors. Using human papillomavirus E7 as a model antigen, we have developed several strategies targeting the MHC class I processing pathway to enhance the CD8+ T
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Genetic Engineering of Autologous Vein Grafts with thrombomodulin-Expressing Vectors to Resist thrombosis, Neointimal Hyperplasia and Atherosclerosis
Autologous vein grafts are the most widely used conduits for coronary and peripheral arterial bypass surgery. Compared to arterial grafts, vein grafts suffer significantly higher failure rates that limit their clinical efficacy. The pathophysiology of graft occlusion varies with graft age, with acut
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Techniques Using Heat Flow Management, Stimulation, and Signal Analysis to Treat Medical Disorders
This invention pertains to methods of treating a brain disorder using heat transfer, electrical stimulation, or delivery of medication so as to stop or prevent seizures or to improve function of the brain. The method includes surgically implanting a heat pump, stimulating electrodes, or drug deliver
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A Visual Color Detection System to Identify Agents that Induce Mitochondrial Dysfunction.
Mitochondrial dysfunction can lead to many diseases and can effect any organ at any age. The number of diseases associated with mitochondrial dysfunction has grown tremendously within the past decade and include common maladies as diverse as cancer, diabetes, heart disease, blindness, deafness, kidn
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Anti-HIF-1B Antibodies
Polyclonal antibodies were raised in rabbits and monoclonal antibodies were raised in mice that recognize hypoxia-inducible factor-1? Description (Set) Proposed Use (Set) These antibodies can be used for biomedical research to detect expression of HIF-1�in immunoblot, immunoprecipitation, and
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Method for Parallel Spatial Encoded Magnetic resonance Imaging
In a MR imaging system spins in a selected slice of the object are excited by RF excitation pulse and the signal is then received by an array of RF detectors. The phases of signals from multiple channels are uncorrelated and a Fourier-Hilbert Transform method analytically restores the phase coherenc
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Facilitation of the Expression in Eukaryotic Cells of Exogenous Genes by an Exogenous Compound
Scriptaid is a histone deacetylase inhibitor that provides a simple means of increasing the efficiency of plasmid-based reporter and expression constructs. When added to mammalian cells in culture Scriptaid confers a 10 to 15-fold augmentation of gene expression. Scriptaid can be used with exogenous
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The Analgesic and Anesthetic Roles of CGMP-Dependent Protein Kinase Ia Inhibitor
IA selective, potent and cell-permeable inhibitor of cGMP-dependent protein kinase Ia, without effects on cAMP-dependent protein kinase or cGMP-regulated phosphodiesterases, has been found to reduce response to nociceptive stimulation and requirement of inhalational anesthetics. Advantages of this
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Method to Assess Vascular Endothelial Function using Phase-Contrast Magnetic Resonance Angiography
Endothelial function is crucial in maintaining cardiovascular health. FMD is a noninvasive method of evaluating endothelial function. Impaired FMD measured by ultrasound correlates with cardiovascular risk factors, predicts the presence and severity of coronary artery disease, and predicts adverse c
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Novel Strategy to Enhance the DNA Vaccine Potency
Nucleic acid vaccines represent an attractive approach to generating antigen-specific immunity because of their stability and simplicity of delivery. However, there is still a need to increase the potency of DNA vaccines. Using human papillomavirus type 16 (HPV-16) E7 as a model antigen, we evaluate
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Integrated Multidimensional Molecular Tissue Bioinformatics Research, Lab Management and Publishing Databases
PELICAN is an integrated, web-based database application for integrating clinical and life sciences data. Description (Set) Proposed Use (Set) Life Science Laboratory Management Platform. Used to integrate molecular data in functional genomic context. Link clinical data to molecular data
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A Flexible Retinal Vessel Cannulation Device
A microcatheter system that allows for vascular infusion into retinal veins for extended periods of time. The microcatheter system includes a flexible cannula that is inserted into the retinal vein lumen and that remains stably within the retinal vein lumen without being held by a robot, micromanipu
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Transgastric Peritoneoscopy
A novel approach to diagnostic and therapeutic interventions in the peritoneal cavity is described. More specifically, a technique for accessing the peritoneal cavity via the wall of the digestive tract is provided so that examination of and/or a surgical procedure in the peritoneal cavity can be co
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Gastric Reduction Endoscopy
Methods and devices for partitioning or plicating a region of a hollow body organ are described herein. These methods and devices relate generally to medical apparatus and methods and more particularly to devices and methods for affecting a change in the function of a hollow body organ, particularly
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Circumferential Pulmonary Vein Ablation using a Laser and Fiberoptic Balloon Catheter
The purpose of this invention is to deliver near-infrared laser radiation radially from a diffusing optical fiber through an optically transparent distendable balloon to create complete circumferential thermal lesions at the pulmonary vein ostia or orifice. Electrical isolation of the pulmonary vein
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Transgenic Mice Expressing a Truncated Mutant of Rat Cardiac Troponin
Stunned myocardium is a reversible contractile failure secondary to coronary artery disease. It has been found that selected proteolysis of the protein troponin is associated with stunned myocardium and this effect has been modeled using transgenic mice expressing the major degradation product of tr
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Fusion of Calreticulun (CRT) to Antigens Enhances the Potency of DNA Vaccines
Antigen-specific cancer immunotherapy and anti-angiogenesis have emerged as two attractive strategies for cancer treatment. An innovative approach that combines both mechanisms will likely generate the most potent anti-tumor effect. In this study, we tested this notion using calreticulin (CRT) since
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Monoclonal Antibodies to Gangliosides Raised in Ganglioside-Deficient Knockout Mice
Knock-out mice lacking complex gangliosides were found to be improved hosts for raising high affinity, high titer monoclonal IgG anti-ganglioside antibodies. Gangliosides are major cell surface determinants in the vertebrate nervous system. Although their functions have not been fully defined, gangl
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Enhancement of DNA Vaccine Potency by Linkage of Antigen Gene to the Extracellular Domain of FLT3-Ligand Gene
professional antigen presenting cells (APCs), particularly dendritic cells (DCs). A recombinant chimera of the extracellular domain of Flt3-ligand (FL) linked to a model antigen may potentially target the antigen to DCs and their precursor cells. Using HPV-16 E7 as a model antigen, we evaluated the
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Bisubstrate Analog Inhibitors for Protein Kinases
A new approach for the design of protein kinase inhibitors is disclosed. Using this approach a potent insulin receptor protein tyrosine kinase inhibitor has been produced. In principle, this method is general and could be applied to any protein kinase. Previous bisubstrate analog compounds have been
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Near-field Radio Frequency Planar Strip Array Antenna for NMR Imaging
A device for detecting electromagnetic signals, more specifically, the magnetic resonance signals from excited nuclei as well as related apparatuses, systems and methods is provided. This detection device includes a planar strip array antenna including a plurality, and in more particular embodiments
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GDF-1 Knockout Mouse
Transgenic knockout mouse serves as a useful tool to identify the developmental activity associated with the expression of the growth/differentiation protein, GDF-1. Description (Set) Proposed Use (Set) Diagnostic application for left-right pattern pathologies in birth defects and the upstream
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Enhancement of Sindbis Virus Self-Replicating RNA Vaccine Potency by Linkage of Mycobacterium Tuberculosis Heat Shock Protein 70 Gene to an Antigen Gene
Self-replicating RNA vaccines (RNA replicons) have emerged as an effective strategy for nucleic acid vaccine development. Unlike naked DNA vaccines, RNA replicons eventually cause lysis of transfected cells and therefore do not raise the concern of integration into the host genome. We evaluated the
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Home Link System for Daily Monitoring of Outpatients
Despite landmark basic and clinical research advances in our understanding of the pathophysiology and treatment of CHF, the majority of patients are not receiving or applying optimal pharmacologic therapy or dietary and physical activity regimens. Effective management of congestive heart failure (CH
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Rapid PCR-based blood test for Detection of Bacteria
An innovative technique that establishes a unique and highly specific assay, which eliminates ubiquitous background DNA in all PCR reagents (Taq polymerase, primers, dNTP's, PCR buffer, MgC12) by employing the use of a carefully selected restrivtion enzyme digest. This protocol thus allows for conta
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The Analgesic and Anesthetic Effects of Inhibiting the Interaction of the NMDA Receptor Subunits 2A/2B with Neuronal Nitric Oxide via PDZ Domain of PSD95/SAP90
PSD-95/SAP90 is a molecular scaffold protein that, through interactions involving its PDZ domains, couples the NMDA receptor to cellular signaling pathways at neuronal synapses. PSD-95/SAP90?s mRNA and protein are enriched in the spinal cord and selectively distributed in the superficial dorsal horn
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Establishing Genomic Imprinting by Cell Differentiation: a Model System Using Embryonic Germ Cells
The purpose of the invention is to develop the first in vitro model system for studying genomic imprinting. This model system is based upon the development of pluripotent embryonic germ (EG) cells that are capable of differentiating into virtually any somatic cell lineage, with the exception of plac
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Oral Gene Delivery for Hemophilia
This invention is a non-viral trans gene delivery system developed for the long-term treatment of genetic disease. A recombinant plasmid construct with a cDNA of the gene implicated in hemophilia B was used to form nanospheres. Complex coacervation of the recombinant constrct with chitosan, a bioplo
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LuSIV Cells: a Highly Sensitive Detection System for Infectious HIV and Related Retroviruses
JHU researchers constructed a reporter cell line, derived from human CEMx174 cells, that can be used to readily identify cells that are infected with HIV and related retroviruses. This cell line, designated LuSIV, contains a reporter construct comprising the firefly luciferase reporter gene under th
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CAIN Antibody
A novel protein which is a calcineurin inhibitor (CAIN) has been identified, cloned, and characterized. Description (Set) Proposed Use (Set) Calcineurin is a widely distributed protein phosphatase involved in the mediation of certain immunosuppressive drugs and also has been shown to be involv
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Gene Responsible for Stargardt-like Dominant Macular Dystrophy
The gene responsible for Stargardt-like macular dystrophy has been identified, along with its normal allelic form. The mutant gene encodes a mutant protein containing a frameshift mutation, resulting in abnormal fatty acid synthesis and transport in the retina. Also disclosed are assays for Stargard
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Application of Photochemotherapy for the Treatment of Cardiac Arrhythmias
Atrial fibrillation (very rapid random heartbeats) is the most common and debilitating electrical abnormality of the heart that affects nearly 2 million Americans and is responsible for 150,000 strokes per year. When drug therapies fail to control the heartbeat, patients require an invasive open che
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Enhancement of Nucleic Acid Vaccine Potency by Intercellular Spreading and Enhancement of MHC Class I Presentation of Antigen Linked to Herpesvirus VP22 Protein
The potency of naked DNA vaccines is limited by their inability to amplify and spread in vivo. VP22, a herpes simplex virus type 1 (HSV-1) protein, has demonstrated the remarkable property of intercellular transport and may thus provide a unique approach for enhancing vaccine potency. We therefore
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A Single Image Registration Method for Image Guided Interventions
The purpose of this invention is to determine the three-dimensional position and orientation of an effector (a needle, probe, etc.) relative to a subject using single cross sectional images (e.g. from a CT or MRI scanner). Minimally invasive image guided interventions are an attractive option for lo
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Recombinant Ehrlichia Phagocytophila AnkA Protein (EPANK1 Protein) from Clone pHGE-D
Recombinant E. phagocytophilia MSP is a major immunodominant protein antigen derived from the human E. phagocytophilia (HE agent) strain BDS. The clone was initially selected based upon reactivity with monoclonal antibody to E. phagocytophilia group antigens and the gene sequenced and subcloned into
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Recombinant Ehrlichia Phagocytophila Major Surface Protein (MSP) from Clone p20H13
Recombinant E. phagocytophilia MSP is a major immunodominant protein antigen derived from the human E. phagocytophilia (HE agent) strain BDS. The clone was initially selected based upon reactivity with monoclonal antibody to the major 44kDa surface antigen and the gene sequenced and subcloned into t
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Prevention and/or Treatment of Neurodegenerative Diseases by Elevation of Glutathione and Phase Detoxification Enzymes
A wealth of data has unambiguously showed that cellular glutathione (GSH) protects neurons against degeneration (possibly by preventing apoptosis). Phase 2 enzymes such as GSH transferase that also help reduce cellular oxidative stress may play an important role in preventing neurodegerenation as we
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A Method for Monitoring Protein S-Nitrosylation
S-nitrosylation is the addition of a nitric oxide group to a cysteine group in a protein sequence to form an S-nitrosothiol derivative. JHU scientists developed a method in which a test sample comprising at least one protein substrate is treated with an alkylthiolating agent to block free thiol gro
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Auscultation Diagnostic Support Device
This invention is a screening tool for heart and lung aliments. Advanced signal processing techniques have been applied to heart and lungs sounds as an aid to diagnoses. A database containing patient demographics, relevant health information, physical exam results, ECG traces, echocardiograph diagno
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Neuroprotection and Inhibition of Apoptosis by Mitrochondrial Potassium Channel Openers
Mitochondria can either enhance or suppress cell death. Cytochrome C release triggers apoptosis, but activation of mitochondrial ATP-sensitive potassium (mitoPotassiumATP) channels prevents lethal ischemic injury in vivo. To clarify the mechanism of the protection against ischemia, Johns Hopkins Uni
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Online Mendilian Inheritance in Man (OMIM TM Database)
This database is a catalog of human genes and genetic disorders authored and edited by researchers at Johns Hopkins and elsewhere, and developed for the World Wide Web by NCBI, the National Center for Biotechnology Information. The database contains textual information, pictures, and reference infor
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Controllable Motorized Device for Accurate Percutaneous Needle Placement in Soft Tissue Target
The invention is a motorized controllable needle driver for percutaneous delivery of needles and devices of circular cross section profile to soft tissue targets inside the body. The device can be used with flouroscopy, X-ray or CT (CAT-scan, or computed tomography) guidance in image guided surgery,
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PICK1 Antibody and GluR2 Phospho-specific Antibody
Antibodies to analyze the levels of the PICK1 protein and the phosphorylation of Ser880 of the AMPA receptor GluR2 subunit. Description (Set) Proposed Use (Set) PICK1 has been shown to regulate the synaptic targeting of the AMPA receptors, thus the use of these novel antibodies may allow the m
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A Method for Generating Constitutively Active Transmembrane Proteins
The present invention related to methods and reagents for generating and using activating mutations of receptors and ion channels.
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Use of Fluorescence Resonance Energy Transfer to Directly Monitor the Receptor-Mediated Activation of Heterotrimeric G-proteins in Living Cells
Techniques to visualize heterotrimeric G-protein signaling in cells has not proven effective thus far. The best technique to date, calcium imaging, requires cells to be loaded with a fluorescent calcium-sensitive dye. Activation of certain G-protein coupled receptors. Can elicit transient increases
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Determinants of ShhN required for signaling
The invention relates to hedgehog proteins that are involved in signaling developmental processes. The proteins of the invention modulate differentiation of neural plate. Also provided are methods for identifying compounds that modulate early events in development and more particularly to methods to
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CTD110.6 monoclonal antibody
O-linked N-acetylglucosamine (O-GlcNAc) is a newly described but ubiquitous dynamic modification of key regulatory proteins in side virtually all multi-cellular eukaryotic cells. Recently, this sugar modification has been shown to be as abundant as protein phosphorylation, often competing with this
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Practical Tunable Planar and Cylindrical Multi-element Magnetic Resonance Detector Arrays
The invention is a detector for MRI signals, and is used in conjunction with an MRI scanner. More specifically, the invention is a tunable strip array for providing multi-channel detection of MRI signals from an object. The detector is comprised of one or preferably more conducting strips insulated
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A Novel Rapid Quantitative Assay for the Simultaneous Detection of Microbial Infection and Speciation
Current methods for determining whether a patient has a bacterial infection are time-consuming and may lead to delays in diagnosis and/or treatment. Real-time PCR is an emerging molecular technique, which rapidly amplifies small amounts of selected DNA regions, offering the potential for expedited i
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Beta - Secretase (BACE1) Knockout Mice
Two beta-secretases termed BACE1 and BACE2 have been shown to generate the Alzheimer's disease Abeta peptides. To examine the physiological roles of BACE1 and to determine whether BACE1 is the major beta-secretase in neurons, Johns Hopkins University researchers have created mice with targeted inact
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Analysis of Cardiac MR Relaxation Time Images with Application to Quantifying Myocardial Perfusion Indexes
The present invention is a method and apparatus for semi-automatically registering low signal to noise ratio relaxation-time images, with particular application to tracking motion in moving organs and quantifying myocardial perfusion reserve. For each image acquired in a time series, a corresponding
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Methods for Identifying Gene Regulatory Sequences, and the Identity of such Sequences
A barrier to advances in understanding the mechanisms and regulation of imprinting of a genomic region is our poor understanding of the organization of genes and the cis regulatory factors located in 97% of the non-exonic genome. Sequence analysis offers an effective approach for the identification
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Cancer Immunotherapy using a DNA Vaccine Encoding the Translocation Domain of a Bacterial Toxin Linked to a Tumor Antigen
DNA vaccines are an attractive approach for tumor immunotherapy. One concern about DNA vaccines is their potency since they do not amplify themselves. Domain II of Pseudomanas Exotoxin A (ETA(dII))has been shown to translocate from extracellular and vesicular compartments into the cytoplasm, which p
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Enhancement of Suicidal DNA Vaccine Potency by Linkage Mycobacterium Tuberculosis Heat Shock Protein 70 to an Antigen
Naked DNA vaccines represent an attractive approach for generating antigen-specific immunity because of their stability and simplicity of delivery. There are particular concerns, however, such as potential integration into the host genome, cell transformation, and limited potency. The usage of DNA-b
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Digital Optical Imaging for Tracking Vascular Gene Expression and Early Diagnosis of Atherosclerosis
Atherosclerotic cardiovascular disease remains the leading cause of mortality in the United States. Gene therapy is a rapidly expanding field with great potential for the treatment of atherosclerotic cardiovascular diseases. Several genes have been shown to be useful for preventing acute thrombosis,
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The Cardiac Ausculatory Recording Database (CARD): an Internet-based software Program and Digital Heart Sound Recording Database for Teaching and Study of Cardiac Auscultation
The Cardiac Auscultatory Recording Database (CARD) was also developed. Developed using the Microsoft Access relational database program, CARD is available online through the World Wide Web. CARD contains digitized heart sound recordings collected from patients at the Pediatric Cardiology Echocardiog
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Phosphatonin-Related Gene: FRP - 4
This invention provides methods for modulating phosphate homeostasis and renal phosphate transport by delivering agents that alter the expression of the FRP-4 gene or alter the activity of the FRP-4 protein. The methods of the invention are useful for modulating bone mineralization, renal phosphate
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Oncogenic Osteomalacia-Related Gene 1: MEPE
This invention provides isolated polynucleotides encoding an oncogenic osteomalacia-related factor and polypeptides encoded by this polynucleotide. Expression systems, including gene delivery vehicles such as liposomes and vectors, and host cells containing the polynucleotides are further provided b
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Genetic Disruption of PPAR(delta) Decreases Tumorigenicity of Human Colon Cancer Cells
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are involved in many normal and disease related processes, such as lipid metabolism and cancer. Specifically, isotype PPAR�as been proposed as a downstream target in the adenomatous polyposis coli (APC)/�atenin pa
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Identification of DNA Sequences Differentially Methylated in Pancreatic Cancer
Researchers at Johns Hopkins University have used the techniques of methylated CpG island amplification (MCA) coupled with representational difference analysis (RDA) to isolate 42 clones, which were shown to be differentially methylated in a panel of 8 pancreatic cancer cell lines compared to normal
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Fas Ligand-Expressing Hematopoietic Cells for Transplantation
Rejection of allografts is mediated by activated T cells that recognize alloantigen presented by dendritic and other antigen presenting cells. To decrease the immune response against allografts, Johns Hopkins University researchers have genetically modified dendritic cells with retroviral vectors to
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MR Imaging of Vascular Gene Therapy
Our current knowledge about the bio-distribution and/or in vivo pharmacokinetics of gene therapy is incomplete and relies mainly on staining of biopsied or post-mortem tissues. Modern imaging techniques provide a unique opportunity to monitor and control gene therapy. Johns Hopkins University resear
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Simulator for cardiovascular Image Guided Therapy
An embedded and integrated system is disclosed for augmented reality based simulation of image-guided cardiovascular interventional therapeutic procedures for training, education and certification and patient specific pre-treatment planning. The system provides users with a training and pre-treatmen
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A Simulation Method for Designing Customized Interventional Medical Device During Pretreatment Planning
This invention, provides a method to design and evaluate the potential performance and/or clinical application of medical devices for interventional cardiovascular applications. The design and evaluation process is based on quantitative analysis of volume rendered images, followed by a derivation of
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MoPrP. Xho Vector
This plasmid expression vector was developed to direct the expression of foreign genes in the brains of transgenic mice. The vector, which is transcriptionally dependent on the mouse prion protein promoter, was derived from segments of genomic DNA that compose the mouse prion protein gene, specifica
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Clinician's Portable, Digital, Intelligent Assistant (Pain Informatics Program)
The input devices are mobile pen-based computers and palm pad systems that will emulate and expand the clinician's present paper patient system. The system will provide for semi-automation of the collection, archiving, and retrieval of patient information. The Pain Informatics system provides medica
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Accessing the Scala Media of the Inner Ear with Robot Assistance
Accessing the scala media of the cochlea would permit the delivery of drugs, growth factors, gene therapy vectors and cells in order to treat hearing loss of cochlear origin. Many forms of hearing loss begin with trauma to the acoustic hair cell receptors, which in turn, initiates a downstream casca
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R-3327-AT6.1
Somatic cell hybrids created from highly metastatic rat prostatic cancer cells and human chromosome 11 were created using micro cell-mediated chromosome transfer. The introduction of human chromosome 11 into the highly metastatic rat prostate cancer cells suppressed the metastatic ability of the ce
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R-3327-AT-1 (Rat Prostatic Cancer Cell Line)
AT-1 originates from the spontaneous tumor (R3327) of the prostate identified by W.F. Dunning in a 22 month-old inbred Copenhagen male rat (1961). R3327 has been maintained by continuous serial passage in rats for many years. In 1974, a variant was characterized at Johns Hopkins (i.e. H for Hopkins)
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R-3327-3.1
AT-3 originates from the spontaneous tumor (R3327) of the prostate identified by W.F. Dunning in a 22 month-old inbred Copenhagen male rat (1961). R3327 has been maintained by continuous serial passage in rats for many years. In 1974, a variant was characterized at Johns Hopkins (i.e. H for Hopkins)
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R-3327 MAT-LyLu
This cell line was derived from the "H" subline and upon passage to the AT-1 subline (JHU-29) of the parental R3327 tumor The "H" subline is a heterogeneous cell line as it is comprised of androgen-dependent and androgen-independent tumor cells. Passing this heterogeneous tumor cell population in in
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R-3327 AT.2
AT-2 originates from the spontaneous tumor (R3327) of the prostate identified by W.F. Dunning in a 22 month-old inbred Copenhagen male rat (1961). R3327 has been maintained by continuous serial passage in rats for many years. In 1974, a variant was characterized at Johns Hopkins (i.e. H for Hopkins)
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Modulation of systemic Immune Responses by Transplantation of Hemotopoietic Stem Cells Transduced with Genes Encoding Antigens and Antigen Presenting Cell Regulatory Molecules
The initiation of T cell-dependent immune responses depends on presentation of antigens by bone marrow-derived antigen-presenting cells such as dendritic cells. Tolerance induction depends on expression of antigens by tolerizing antigen presenting cells. Immunotherapy approaches are aimed at introdu
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Identification of P53-activating Compounds for Cancer Research and Therapy
An exciting,new invention from the laboratory of Dr. Scott Kern at The Johns Hopkins University School of Medicine for the identification of p53 activating compounds that I thought would be of interest to In Vitro Technologies. As you are aware, the status of p53 varies among human tumors and has be
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Design and Fabrication of High Performance AFM Cantilivers
High performance cantilevers with optimal combinations of high resonant frequency and low force constant are provided. AFM cantilevers with spring constants in the range 1-10-6 N/m with fundamental resonant frequencies in aqueous solutions of 0.1-100 MHz are provided. The high performance cantilever
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