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Laser-based CT and MR Registration
A simple method for robot and precise instrument registration in computer tomography and magnetic resonance imaging systems. The method uses the laser markers readily available on any CT or MR scanner. It does not require imaging thus eliminating radiation exposure in the CT case. Its accuracy is in
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BDNF Polymorphism and Association with Bipolar Disorder
Methods for diagnosing and treating neuropsychiatric disorders, especially bipolar disorder, and to methods for identifying compounds for use in the diagnosis and treatment of neuropsychiatric disorders are disclosed. Also disclosed are novel compounds and pharmaceutical compositions for use in the
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ABACUS: an Automated Algorithm for Determining Genotypes from Quantitative Probe Hybridization Data
An automated statistical method has been developed to determine genotypes of individual DNA samples from quantitative hybridization assays to DNA probes. This method was validated using Affymetrix Variation Detection Arrays (VDAs). The method provides a quality score (i.e. confidence score) to indiv
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Beta-Secretase (BACE1) Knockout Fibroblast Cells
We have developed BACE1 knockout cells to further facilitate our understanding of physiological consequences of the lack of BACE1 in cells. We have established BACE1 knockout immortalized cell lines by transforming the primary fibroblasts derived from BACE1 knockout mice. Description (Set) Prop
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Use of Proaerolysin Toxins Modified to Contain Tissue Specific Protease Activation Sequences as Targeted Therapy for Cancer
Proaerolysin is a bacterial toxin that is normally activated by furin protease to produce the pore forming toxin aerolysin which is toxic to prostate cancer cells at picomolar concentrations. We have removed the furin activation site and replaced it with a site that is recognized by the serine prote
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Macaca Mulatta CCR8 cDNA
Both simian and human immunodeficiency viruses (SIV and HIV) utilize chemokine receptors with or without CD4, as portals for entry into susceptible cells. JHU researchers have cloned 11 rhesus macaque chemokine receptors and receptor-like proteins (CCR1, CCR2b, CCR3, CCR5, CCR8, CXCR4, STRL33, GPR1,
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Use of Isogenic Human Cancer Cells for High-throughput Screening and Drug Discovery
A novel high-throughput drug screening strategy is described using isogenic human cancer cell lines that are genetically identical except for the presence or absence of a key cancer causing gene. Isogenic cell lines are ?tagged? with two different colored fluorescent proteins so that the growth and
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Enhancement of DNA Vaccine Potency by Linking Marek's Disease Virus Type 1 VP22 to an Antigen
We have previously employed an intercellular spreading strategy using herpes simplex virus type 1 (HSV-1) VP22 protein to enhance DNA vaccine potency because DNA vaccines lack the intrinsic ability to amplify in cells. Recently, studies have demonstrated that the protein encoded by UL49 of Marek?s d
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Inhibition of Retroelement Replication with Divalent Cations
AIDS is a devastating disease caused by the HIV-1 virus. Happily, there are now highly active antiviral drug cocktails available that allow many patients to control the disease. Nevertheless, many patients continue to have problems because of viral resistance and because of side effects. Thus there
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Association of Dopamine Beta-Hydroxylase Polymorphisms with Bipolar Disorder
A central role for the gene encoding dopamine beta-hydroxylase in neuropsychiatric disorders is disclosed. Use of single nucleotide polymorphisms in the dopamine beta-hydroxylase gene for diagnosis, prediction of clinical course and treatment response, development of new treatments and development o
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ViewGene: a Graphical Tool for SNP Visualization and Characterization
The Human Genome Project has produced an enormous amount of sequence data, based on which single base changes between individuals are being identified. Unfortunately, computer tools that were adequate for sequence assembly are less than ideal for the characterization of single nucleotide polymorphi
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14-3-3sigma is Required to Prevent Mitotic Catastrophe After DNA Damage
14-3-3Sigma knockout in human colorectal cancer cell line HCT116. Details are described in the paper by Chan et al., 1999 Description (Set) Proposed Use (Set) 14-3-3Sigma promotes pre-mitotic cell cycle arrest following DNA damage. In 14-3-3Sigma knockout cell lines, cells are unable to maintai
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Disruption of p53 in Human Cancer Cells Alters the Responses to Therapeutic Agents
p53 knockout in human colorectal cancer cell line HCT116. Details are described in the paper by Bunz et al., 1999 Description (Set) Proposed Use (Set) The p53 gene is inactivated in the majority of human cancers. JHU scientists determined that p53 knockout cell lines have altered responses to t
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Carcinogen-specific Induction of Genetic Instability
The researchers created two H3 colorectal cancer cell lines. One cell line has chromosomal instability (CIN) and resistance to 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP). The other cell line has microsatelite instability (MIN) and resistance to methylating agent N-methyl-N'-nitro-N-nitr
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A Multiple-projection DXA Scanner for Improved Accuracy and Precision in the Measurement of Bone Cross-sectional Geometry and Body Composition
Osteoporosis and a number of other diseases and conditions alter the mechanical strength of the skeleton such that bones fracture easily. A number of treatments exist that can mitigate the loss of bone strength, hence accurate diagnosis and assessment of the effects of treatment are critical. Bone-w
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Beta-Secretase (BACE1) Polyclonal Antisera
To facilitate our understanding of the physiological role of BACE1 and its involvement in the generation of the Alzheimer?s disease (AD) Ab peptides, we generated a rabbit polyclonal antibody against BACE1. Our BACE1 antisera will be useful in the BACE1 levels and expression patterns in brains of no
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Targeting CD4+ Cells to Treat Ischemia Reperfusion Injury
There is currently no specific therapy for ischemic acute renal failure. We have recently identified that CD4+ T cells directly participate in the pathogenesis of the injury. Furthermore, modulating CD4+ T cells improves the course of ischemic acute renal failure. With rapid developments in immunolo
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Simultaneous DNA Sequencing Technique (SimulSeq) and Combined PCR/sequencing (AmpliSeq)
We report two novel methods for DNA sequencing. AmpliSeq permits combined PCR and cycle sequencing in a single reaction. This can be bi-directional (e.g. for mutation confirmation) or unidirectional. Full-length sequencing can be achieved. A second method, SimulSeq, permits simultaneous sequencing o
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3-BROMOPYRUVIC ACID As a Potent Anticancer Agent Delivered Intraarterially
Liver cancer is one of the most common fatal cancers in the world and may reach epidemic levels in the future due to increased viral hepatitis. Current treatment options are rarely successful indicating a real need for alternative therapies. We have developed a new approach based on delivering the c
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In Vitro and in Vivo Induction of Potent Bystander Anti-Tumor Effects Through Inhibition of Stat3 Signaling
The present invention relates to methods for modulating, i.e., agonizing or antagonizing, Stat3 (Signal Transducer and Activator of Transcription3) signaling activity for use in gene therapy. Inhibition and/or activation of Stat3 signaling is an effective approach to modulate angiogenesis and the im
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Extraction and Purification of carotenoid compounds from biomass
Commercial opportunity:
A proven process technology for the removal of carotenoid and other pigments from biomass, concentration, purification and packaging in accordance with EU specifications.
What is it that is novel and inventive about the invention?
New low cost system, mutliple products,
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Rabbit Serum 5690: Antibodies Against Rat Lmo7
Abstract (Set) Nuclear lamina is a dense fibrillar network inside the nucleus of eukaryotic cells composed of intermediate filaments (lamins) and membrane associated proteins called lamin-associated membrane proteins. The nuclear lamina provides mechanical support, regulates important cellular even
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Rabbit Serum 5688: Antibodies Against Rat Lmo7
Abstract (Set) Nuclear lamina is a dense fibrillar network inside the nucleus of eukaryotic cells composed of intermediate filaments (lamins) and membrane associated proteins called lamin-associated membrane proteins. The nuclear lamina provides mechanical support, regulates important cellular even
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Rabbit Serum 5045: Antibodies Against Human BAF`
Abstract (Set) Nuclear lamina is a dense fibrillar network inside the nucleus of eukaryotic cells composed of intermediate filaments (lamins) and membrane associated proteins called lamin-associated membrane proteins. The nuclear lamina provides mechanical support, regulates important cellular even
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Rat Serum 4279: Antibodies Against Human MAN1
Abstract (Set) Nuclear lamina is a dense fibrillar network inside the nucleus of eukaryotic cells composed of intermediate filaments (lamins) and membrane associated proteins called lamin-associated membrane proteins. The nuclear lamina provides mechanical support, regulates important cellular even
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Rabbit Serum 4278: Antibodies Against Human MAN1
Abstract (Set) Nuclear lamina is a dense fibrillar network inside the nucleus of eukaryotic cells composed of intermediate filaments (lamins) and membrane associated proteins called lamin-associated membrane proteins. The nuclear lamina provides mechanical support, regulates important cellular even
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Rabbit Serum 3273: Antibodies Against Human BAF
Abstract (Set) Nuclear lamina is a dense fibrillar network inside the nucleus of eukaryotic cells composed of intermediate filaments (lamins) and membrane associated proteins called lamin-associated membrane proteins. The nuclear lamina provides mechanical support, regulates important cellular even
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Rabbit Serum 2999: Antibodies Against Human Emerin
Abstract (Set) Nuclear lamina is a dense fibrillar network inside the nucleus of eukaryotic cells composed of intermediate filaments (lamins) and membrane associated proteins called lamin-associated membrane proteins (LAPs). The nuclear lamina provides mechanical support, regulates important cellul
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Rabbit Serum 2807: Antibodies Against Xenopus LAP2
Abstract (Set) Nuclear lamina is a dense fibrillar network inside the nucleus of eukaryotic cells composed of intermediate filaments (lamins) and membrane associated proteins called lamin-associated membrane proteins (LAPs). The nuclear lamina provides mechanical support, regulates important cellul
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Rabbit Serum 2805: Antibodies Against Human LAP2
Abstract (Set) Nuclear lamina is a dense fibrillar network inside the nucleus of eukaryotic cells composed of intermediate filaments (lamins) and membrane associated proteins called lamin-associated membrane proteins (LAPs). The nuclear lamina provides mechanical support, regulates important cellul
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Rabbit Serum 2804: Antibodies Against Human LAP2
Abstract (Set) Nuclear lamina is a dense fibrillar network inside the nucleus of eukaryotic cells composed of intermediate filaments (lamins) and membrane associated proteins called lamin-associated membrane proteins (LAPs). The nuclear lamina provides mechanical support, regulates important cellul
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JH-EsoAd1- Esophageal Cancer Cell Line
Abstract (Set) Esophageal adenocarcinoma currently has one of the most rapidly increasing tumor incidences in the United States, with the vast majority of cases occurring on the backdrop of metaplastic epithelium (Barrett esophagus). The availability of appropriate cell line models is essential for
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COA360.org - Cultural Competency Organizational Assessment
Abstract (Set) Today, four states in U.S. are minority-majorities (California, Texas, New Mexico, and Hawaii) and by 2010 there could be as many as eight. Nearly 18% of Americans speak a language other than English at home. These demographic characteristics have major implications for the healthcar
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A Malaria Vaccine to Stop Malaria Transmission
Abstract (Set) Malaria is a disease caused by parasites of the genus Plasmodium. It affects near 2 billion people worldwide and results in 1-2 million deaths every year. Transmission-blocking vaccines (TBV) have received attention as potentially effective strategy in the fight against malaria. Surf
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DLD-Chk1 S317A Cells
Abstract (Set) Chk1 kinase acts downstream of ATM/ATR kinase and plays an important role in DNA damage checkpoint control, embryonic development and tumor suppression. JHU scientists have engineered a somatic cell knock in that is deficient for the DNA damage induced activation of the Chk1 kinase.
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Collagen Mimetic Peptides for Imaging and Therapy
Abstract (Set) Collagens, the most abundant protein in mammals, provide a structural framework during tissue development and repair. Functionalized collagen that incorporates exogenous compounds may offer new and improved biomaterials applications, especially in drug delivery, multifunctional impla
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Glutaminase Inhibition to Treat Cancer, Cardiac Ischemia and Stoke
Abstract (Set) A common occurrence in cancer is altered glucose metabolism where cells take up glucose avidly and convert it primarily to lactate, despite available oxygen. These cells also depend on continued mitochondrial function for metabolism, specifically glutaminolysis that catabolizes gluta
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Floating Chamber Set for Multi-Well Tissue Culture Plate
Abstract (Set) Description (Set) Clear, precise immunohistochemistry data is reliant on the quality of immunolabeling and the structural integrity of the tissue being examined. Most tissue processing techniques require multiple reagent changes and physical manipulation of small, delicate samples
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Known Drug found to have applicability in the area of glaucoma, optic nerve diseases, and other neurodegenerations
Abstract (Set) According to the World Health Organization, glaucoma is the second leading cause of blindness in the world. One approach to treat glaucoma, and optic nerve diseases as well as other neurodegenerations, is to develop ?neuroprotective? agents that promote the survival of neurons. JHU s
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Plasmid pProEX-hOtu1
Abstract (Set) The plasmid pProEX-hotu1 was constructed using vector pProEX and cDNA of human otubain 1. The plasmid was created for expression and purification of recombinant human otubain 1 in E.coli. Description (Set) Proposed Use (Set) The plasmid was created for expression and purificatio
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Selective Prodrug Activation in Cancer Cells Using Protein Switches
Cancer is a major health problem in the world and is the second leading cause of death in the U.S. An estimated 1.3 million new cases of cancer are reported in the U.S. each year. Current chemotherapeutic agents and gene-directed enzyme prodrug therapy (GDEPT; also known as "suicide gene therapy"),
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Johns Hopkins Approved Wireless Portable Polysomnography Monitoring Device
Abstract (Set) Currently there are no clinically proven portable devices that objectively measure and record sleep activity in a reliable fashion at minimal inconvenience to the patient. While portable sleep testing may currently be used to diagnose obstructive sleep apnea (OSA), the inability to c
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J HIN, J RASSF1A, J TWIST, J HIC Plasmids
Abstract (Set) Plasmid DNAs incorporating human gene-specific promoter sequences altered by sodium bisulfate treatment. The plasmids contain sequences hybridizing to external QM-MSP regions within gene promoters of RASSF1A, TWIST1, NIN1, and HIC1. These areas bracket cloned DNA from non-human sourc
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Diagnostic Biomarkers of Kidney Transplant Dysfunction
Abstract (Set) Johns Hopkins University is currently seeking licensees for a panel of biomarkers for kidney transplant dysfunction. Kidneys are the most frequently transplanted organ in the U.S. Kidney transplant recipients can experience a variety of problems including delayed graft function and a
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Improved Method of Human Embryonic Stem Cell Embryoid Body Formation
Description (Set) JHU scientists have developed an optimized method for culturing and differentiating human embryonic stem (hES) cells. Obtaining sufficient numbers of viable differentiated cells from human embryonic stem cells is a recognized challenge in stem cell culture. It is a critical limiti
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Screening Method to Predict Donor Organ Function after Transplantation
Abstract (Set) Transplantation represents an established procedure in end-stage organ failure patients and results in satisfying long-term results. However, this surgical therapy is continuously limited by severe and progressive organ shortages. Therefore, many transplant programs have to extend th
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System for Refibrillation of the Heart for Treatment of Post Countershock Pulseless Electrical Activity and Asystole
A method and/or system for inducing ventricular fibrillation (VF) of the heart for treatment of post-countershock pulseless electrical activity (PEA) or asystole. In certain example embodiments, it has been found that reinduction of ventricular fibrillation, followed by restoration of blood flow wit
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Ambulatory Raynaud's Monitor
Monitoring a person?s response to cold by recording their skin temperature is a key physiological response parameter for identifying Raynaud?s. This device would provide the means for physicians to definitively diagnose the disease without having to rely solely on a patient?s subjective feedback. Ac
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Prostate Cancer Cells Derived from Familial Prostate Cancer Tumor and Methods of Use
A cell line has been generated from a culture of prostate epithelial cells taken from a prostate cancer patient with a strong family history of prostate cancer. This is the first cell line to be generated and characterized from such a patient. Description (Set) Proposed Use (Set) This in vitro
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Use of Polymer-based Gene Delivery Systems for Molecular and Cellular Labeling, and pH Monitoring with MRI and MR Spectroscopy (MRS)
There is great interest in magnetic resonance imaging (MRI) contrast agents that are capable of visualizing small concentrations of molecular or cellular labels in vivo. The present invention relates to some existing polyamides (dendrimers, poly-lysine, and polyglutamate) that are extremely suitable
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Magnetic Resonance Imaging and Spectroscopic Imaging of pH
In situ MR imaging and spectroscopy method to detect the effect of pH and/or protein content changes on the intensity of the water signal in MRI. This is done by selectively irradiating and saturating the broad amide proton resonance of the endogenous mobile proteins centered around 8.3 ppm in the p
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Methods of Generating Primate Pluripotent Stem Cells from Non-Embryonic Sources
Abstract (Set) Currently, the efficiency of generating human induced pluripotent stem (iPS) cells is low. JHU scientists have found a way to improve it by supplementing an additional gene or bioactive molecules to generate iPS cells from human adult as well as fetal fibroblast. This is the first ti
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Combination device and solution for efficient removal of insect from the ear canal
Abstract (Set) Johns Hopkins University is seeking a licensee for a combination solution and device for efficient removal of insects from the ear canal. A JHU Emergency department study showed that insects were found in 85% of adults with ear foreign bodies. The hard outer shell and legs of an inse
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miRNA Microarray Analysis in Barrett's Esophagus and Esophageal Adenocarcinoma
Description (Set) JHU scientists have discovered independent microRNA specific for Barrett?s esophagus (BE) and Esophageal adenocarcinoma (EAC). These EAC and BE microRNA could be used as diagnostic and prognostic biomarkers. EAC is a lethal condition with a very low 5-year survival rate. EAC and i
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Noninvasive System for Assessing Cardiac Filling Pressure
Abstract (Set) The invention is a system for assessing cardiac filling pressure noninvasively. It consists of a device and method that can be used at the bedside, in clinic, in the emergency department, an intensive care unit, or at home. It can be used repeatedly and conveniently, and is inexpensi
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The New Culture Method of Rat Distal Pulmonary Vein Smooth Muscle Cell
Description (Set) Isolation of primary cell populations is complex and requires a significant amount of technical expertise to produce purified and viable cultures. JHU scientists have developed an optimized method to produce a highly purified population of mammalian intrapulmonary vein smooth musc
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The JHU Sleep Center's Interactive Training Module for Polysomnogram (PSG) Scoring
Abstract (Set) This interative computer program represents the first fully interactive tool that allows one to score sleep studies that can be checked against board certified and eligible sleep specialists and a certified sleep technologist based on the APSS 2007 PSG scoring guidelines. The product
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Novel Neuromorphic Signal Cross-Correlation Device
Abstract (Set) The Johns Hopkins University seeks a partner to commercialize a novel signal cross-correlation engine. Utilizing silicon neurons, the engine significantly reduces the computational resources and time required to extract motion or to separate sound sources. Cross-correlation is a usef
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Potential Biomarker for Use in Targeted Drug Delivery Applications as well as Other Therapeutic Strategies
Abstract (Set) According to the World Health Organization (WHO), malignant tumors accounted for around 12% of deaths worldwide, and more than 10 million new cases of cancer emerge each year. JHU scientists have identified that protein expressed by colon carcinoma cells possesses specific selectin b
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Prevention and Treatment of Bacterial and Fungal Meningitis
Description (Set) Johns Hopkins University is currently seeking licensees for a method of preventing meningitis caused by bacterial or fungal infection. Meningitis is a serious and often deadly inflammation of the central nervous system. The most susceptible populations for fungal meningitis are th
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A New in Vitro Assay for Evaluating Anti-viral Drug Activity
Abstract (Set) JHU scientists have developed an efficient in vitro single-round virus infectivity assay with a high correlation to clinical outcomes of drug treatment. This reporter virus assay is an accurate, fast way to screen and evaluate anti-viral drugs including anti-HIV therapeutics. Anti-vi
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Anopheles Gambiae Densonucleosis Virus Expression System
Abstract (Set) Densonucleosis viruses (DNVs) are single-stranded non-enveloped viruses in the family parvoviridae. This invention is the novel Anopheles gambiae densonucleosis virus (AgDNV), and the use of AgDNV as a heterologous system for gene expression, gene silencing and genetic manipulation o
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Software Tools for Analysis of Chromosomal Abnormalities in Pedigrees Using High Density Genomic Data.
Description (Set) The SNP software analysis tools use a novel "reverse pedigree" method to detect genetic differences between siblings. This reversed pedigree method reveals how regions of chromosomes have been inherited between siblings. Paternal versus maternal inheritance for each region will al
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Three Software Tools for Analysis of Chromosomal Abnormalities in High Density Genomic Data
Abstract (Set) High density single nucleotide polymorphism (SNP) data have been used to identify chromosomal changes in DNA samples. A current challenge is to identify disease associated changes such as deletions and duplications as well as inheritance patterns. JHU scientists have developed a soft
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Software Tools for Analysis of Chromosomal Abnormalities in Pedigrees Using High Density Genomic Data SNPtrio
Abstract (Set) Description (Set) Chromosomal DNA alterations can be detected using high density single nucleotide polymorphism (SNP) microarrays. These include deletions and duplications (assessed by observing changes in copy number) and regions of homozygosity. The analysis of SNP data from tri
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Cell Line 2V6.11
Abstract (Set) The human adenovirus E4 ORF 6 34 kDa oncoprotein (E4 34k), in concert with the 55 kDa product of E1b, prevents concatenation of viral genomes in infected cells, inhibits the repair of double strand breaks (DSBs) in the viral genome, and inhibits V(D)J recombination in a plasmid trans
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Molecular Characteristics of Non-small Cell Lung Cancer
expression (SAGE) in a total of nine normal lung epithelial cells and non-small cell lung cancers (NSCLC). Separation of normal and tumor samples, as well as histopathological subtypes, was evident using the 3,921 most abundant transcript tags. This distinction remained when just 115 highly differen
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N-Methyl-D-aspartate (NMDA) Receptor NR1 Subunit Polyclonal Antibody
JHU scientists have developed a polyclonal antibody to the NR1 Subunit of the N-Methyl-D-aspartate (NMDA) Receptor. Proposed Use (Set) This technology encompasses an antibody specific for the NR1 Subunit of the NMDA Receptor. It has the potential to be commercialized as a biomarker for therapeutic
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Enhancing DNA Potency By Co-administration of DNA Encoding Anti-apoptotic Proteins
Intradermal vaccination via gene gun efficiently delivers DNA vaccines into dendritic cells (DCs) of the skin, resulting in activation and priming of antigen-specific T cells in vivo. However, DCs have a limited lifespan, hindering their ability to prime antigen-specific T cells. We reason that a st
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1. a Family of Novel Flavoenzymes, 151, that Binds Actin and Regulates Repulsive Axon Guidance Through Oxidation-Reduction Mechanisms and 2. a Role for Oxdidation of Actin in Limiting Axonal Outgrowth
We have identified a class of proteins containing members which directly binds to the cytoplasmic domains of plexin receptors in both invertebrates and vertebrates, and we have shown that these proteins are essential for plexin signaling events in the developing nervous system. We have also identifi
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Adjustable Remote Center of Motion Robotic Module
The invention is a robotic module that can be used to orient an end-effector about two axes intersecting at a fixed geometric point located distal to the mechanism materializing a pivot point or a Remote Center of Motion (RCM). A robotic tool (or end-effector) mounted on an RCM module will rotate ab
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Claudins As markers for Early Detection, Diagnosis, Prognosis and as Targets of Therapy for breast Cancer
We have recently identified Claudins 1, 3, 4, and 7 as differentially expressed in breast cancer relative to normal breast tissue. Further studies have shown Claudins 1 and 7 to be down-regulated in primary breast cancers relative to normal breast epithelium. We have generated a rabbit anti-peptide
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Non-invasive Diagnostic Imaging Technology for Mitochondria Dysfunction in Man By Using Lipophilic Cations Labeled with F-18 and I-123
In the last decade a new field of ?Mitochondrial Medicine? has been created from the discovery that a wide array of diseases in humans are associated with mitochondrial dysfunction. A partial list of diseases includes Cancer, Autoimmune Disorders, Alcoholic Liver Disease, Cardiomayopathies, Ecphalom
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Simulation System for Training and Pre-treatment Planning of Image Guided Needle Placement Proceedures for Vertebroplasty and Other Orthopedic and Soft Tissue Diagnostic & Therapeutic Medical Applicat
The invention is designed to provide physicians and paramedical medical personnel with a simulation system that will allow them to train, practice and or pre-plan image guided needle placement procedures that have both diagnostic and therapeutic medical applications. The user can interactively manip
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pNB1 + pNB3
These molecular biology research tools are recombinant yeast plasmids that were designed for use with an in vitro Tn7 transposition system Description (Set) Proposed Use (Set) Genome analysis, characterization and manipulation.
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Mutations in Macrophage Scavenger Receptor 1 Gene Increase Risk of Prostate Cancer, Asthma, and Cardiovascular Disease
The present invention discloses methods of screening a subject for increased likelihood or risk of certain diseases or disorders. This method comprises detecting the presence or absence of at least one mutation in the MSR1 gene wherein the presence or absence of such mutation indicates an increased
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Specific Ablation of STAT3(beta) Distorts the Pattern of STAT3-Responsive Gene Expression and Impairs Recovery from Endotoxic Shock
Stat3 is one of seven mammalian signal transducer and activator of transcription molecules that are activated by the Janus Kinases in response to cytokines. Although originally identified as an acute-phase response factor activated by interleukin (IL)-6, Stat3 is now known to be activated in respons
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inhibition of Tumor Growth Through Reduction of Peroxiredoxin 3 levels
The primary transforming activity of MYC is thought to arise through transcriptional regulation of numerous target genes. Scientists at Johns Hopkins have demonstrated that PRDX3, which encodes a mitochondrial protein of the peroxiredoxin gene family, is a direct target of MYC and is required for MY
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Tracker Robot for CT-Guided Interventions
A new robotic system for CT-guided operations has been developed to perform precise manipulation of a needle or other surgical instrument in the confined space of the imager without interfering with the imager functionality. This device is connected to the mobile table of the CT, allowing the patien
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Device, Method, and System for Needle Insertion Inside a Medical Imager, from Within Body Cavity
The Invention is a device, computerized system, and methods for entering a needle into the body inside a medical imager such as a MRI scanner, CT, X-ray fluoroscopy, and ultrasound imaging, from within a body cavity (such as the rectum, vagina, or laparoscopically accessed cavity). A three degree-of
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Combined Chemical/Biological Agent Mass Spectrometer Detector
detection and identification of both chemical and biological agents. Specifically, it provides both conventional mass spectra of volatile chemicals and tandem, or MS/MS, measurements to characterize chemical structures for obtaining identification. As a I biological detector it provides measurements
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Miniaturized Sample Scanning Mass Analyzer
This mass spectrometer is being developed as a compact analytical instrument capable of handling large sample arrays, such as the 96 and 384 microtiter sample formats. It is aimed at both research and high throughput screening applications. Description (Set) Proposed Use (Set) Protein research
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A Chitosan-DNA Mucosal Vaccine for Respiratory Syncytial Virus Infection
A gene expression vaccine (GXV) comprising of a cocktail of pDNAs encoding nine immunogenic antigens was developed in the form of chitosan-DNA nanospheres. This GXV was tested in a BALB/c model of RSV infection. Results demonstrate that an intranasal GXV is safe and effective against RSV and signifi
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Modulators of hedgehog Signaling
Members of the Hegdehog (Hh) family of secreted signaling proteins play critical roles in coordinating cell growth and differentiation. Impaired pathway function in embryogenesis can produce severe malformations, such as cyclopia and other midline defects of the face and forebrain associated with de
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Johns Hopkins Point of Care Information Technology (POC-IT)
Johns Hopkins Point of Care Information Technology (POC-IT) has undertaken development ofa series of electronic medical specialty guides to assist physicians in raising the standards of care. In keeping with the educational mission, a system has been created to compress complex clinical guidelines i
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Cell Lines for Evaluation of 'Beta'-Catenin Function
Mutation in the beta-catenin/APC pathway are responsible for over 90% of all colon cancers in humans. Mutations in the beta-catenin gene activate the activity of this oncogene and cause uncontrolled growth of the affected cells that harbor this mutation. Using our gene targeting technology, we have
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Hypoxia-induced Mitogenic Factor
JHU researchers have discovered a novel cytokine named Hypoxia- Induced Mitogenic Factor (HIMF; also known as FIZZ1/RELM? a secreted protein that is highly up regulated in the lungs as a result of hypoxia-induced pulmonary hypertension. HIMF profoundly constricts the pulmonary vasculature and partic
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A Nucleotide Factor Kappa-B Promoter Polymorphism is associated with Increased Risk for Ulcerative Colitis
We have been investigating genes that are associated with inflammatory bowel disease. Recently, we have identified a novel IBD risk polymorphism in a regulatory region of a gene that is associated with multiple different types of inflammatory diseases. This polymorphism increases risk for ulcerative
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Expanding Human Embryonic Stem Cells Using human Adult (Marrow) Cells or Derived Molecules
All the existing human embryonic stem cells (hESCs) are derived and propagated on mouse embryonic fibroblasts (MEFs). We established a method to derive and expand human cells (from adults) that can fully substitute MEFs in support of the growth of undifferentiated hESCs. The first type of human cell
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Non-linear Time-of-flight Mass Spectrometer
This is a unique approach to the design of time-of-flight mass spectrometers that utilizes non-linear electrostatic fields throughout the instrument. Specifically, the instrument does not include a field-free drift region. The aim of this technology is the development of miniaturized analytical inst
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Generation of HLA-Ig based Artificial Antigen Presenting Cells
Adoptive immunotherapy involves stimulation of viral- or tumor-specific T cells, ex vivo, followed by transfer of expanded numbers of activated autologous T cells back into patients. While adoptive immunotherapy holds promise as a treatment for both infectious diseases in immunocompromised patients
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Time-of-Flight Mass Spectrometer Combining Fields Non-linear in Time and Space
This companion to project DM4077 adds time dependency to the non-linear electostatic fields in a time-of-flight mass spectrometer. The specific aim is the development of miniaturized laboratory and diagnostics instruments with high resolving power. Description (Set) Proposed Use (Set) Researc
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Enhancement of Adenoviral Oncolytic Activity by Modification of the E1A Gene Product
The present invention relates to compositions and methods for enhancing the oncolytic activity of replication-competent, target cell-specific adenovirus vectors by modification of the E1A gene product. The target cell-specific replication-competent adenovirus vectors comprise a chimera of an adenovi
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Boronic-Chalcone Analogs as MDM2 Inhibitor
A series of boronic-chalcone derivatives were synthesized and tested for antitumor activity against human breast cancer cell lines. The results show the boronic-chalcones are more toxic to breast cancer cells compared to normal breast cells than other known chalcones. Description (Set) Propose
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Boronic-Chalcone Analogs as MDM2 Inhibitor
A series of boronic-chalcone derivatives were synthesized and tested for antitumor activity against human breast cancer cell lines. The results show the boronic-chalcones are more toxic to breast cancer cells compared to normal breast cells than other known chalcones. Description (Set) Proposed
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Polyamine Analogues with Significant Antitumor and Antiparasitic Activity
Johns Hopkins researchers have synthesized a novel series of terminally alkylated polyamines that have significant biological activity. Some of the analogues have impressive antitumor activity against cultured tumor cells (ling, breast, prostate, and melanoma), while others have excellent activity a
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A Molecular Mechanism for Action of Immunophilins and a Method to Identify Novel Pharmaceuticals
The immunophilins are a family of proteins that are functionally related by their rotamase activity (ie they are peptidylprolyl isomerases, PPIase) and their ability to bind immunosuppressive drugs such as FK-506, rapamycin, and cyclosporin A. Immunophilin ligands also hold great promise for the tre
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Design and Synthesis of Renal Dipeptidase Inhibitors
Colon cancer is a deadly disease with a 6% average lifetime risk in the United States. When detected in the earliest stages, patients have a 90% survival rate. In the early stages of colon cancer, however, patients are generally asymptomatic. Therefore, colon cancer is often diagnosed in the late st
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Disulfide Constrained Peptides for Targeting the Prostate Specific Membrane Antigen
Utilizing a standard phage display methodology, we have screened a hepta-peptide disulfide bridge constrained phage display library for binding to the prostate specific membrane antigen (PSMA). PSMA is a prostate specific cell surface marker which is up regulated in aggressive prostate cancer and is
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Combined Chemical/Biological Agent Detection by Mass Spectrometry
This is a mass spectrometer for combined chemical/biological agent detection and identification that comprises (a) a combined electron impact and MALDI ionization source for volatile and non-volatile sample analyses, respectively, (b) a mode in which both EI and MALDI sources are operating simultane
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