PATENTS
For Sale or License
Notify me of New Entries
Receive an email whenever a new patent is added.
You can unsubscribe at any time.
4D Digital Extended Cardiac-Torso (XCAT) Phantom
The four-dimensional (4D) NURBS-based cardiac-torso (NCAT) phantom, previously developed to provide a realistic model of the human anatomy and physiology for nuclear medicine imaging research, currently lacks anatomical details and accurate physiological functions for application to high resolution
...
Immune Modulation Through Targeting of the MINOR Gene
this gene will induce apoptosis in dendritic cells, thereby limiting immune responses. Inhibition of the gene will prevent dendritic cell death, thereby enhancing immune responses. Dendritic cells are critical to the initiation of the immune response, thus this will provide a central tool to manipul
...
Mutations of the PIK3CA Gene in Human Cancers
Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that regulate signaling pathways important for neoplasia, including cell proliferation, adhesion, survival and motility. To determine if PI3Ks are genetically altered in tumorigenesis, JHU researchers sequenced PI3K genes in human cancers and
...
293 EcR Shh
Cell line for ecdysone-inducible expression of Shh. Description (Set) Proposed Use (Set) This cell line can be used to discover compounds that block activation of the Hh response pathway and abnormal cell growth associated with both types of oncogenic mutation
...
Shh Light2 Cells
Cell line derived from the NIH/3T3 cell line transfected with GLI-responsive Firefly luciferase reporter from H. Sasaki and a constituitive Renilla-luciferase expression vector. Description (Set) Proposed Use (Set) Useful as a cell-based research tool for the quantitative assay of biologicall
...
pFex: an Adenoviral Fiber Exchange Shuttle System
The value of re-targeted adenoviral vectors is becoming apparent in the current age of gene therapy. However, the large size and complex organization of adenoviral vectors makes construction of re-targeted viral genomes difficult. The described invention, pFex, provides a very flexible system for th
...
PXA1, PXA2, PXA3, PXA4, PXA5, PXA6
The invention consists of low-passage cell lines generated from primary pancreatic cancers established as nude-mice xenografts, and subsequently passaged in vitro. Description (Set) Proposed Use (Set) Due to their low-passage, these cell lines are more representative of the alterations in the p
...
A Synthetic Torso for Training and Evaluation of Laparoscopic Skills
We report the development a new synthetic torso for urologic laparoscopy training allowing the placement of animal organs in situs. The trainer, Lapman, has the exact shape of a human torso, presenting abdominal and thoracic cavities. Animal and/or synthetic models of the abdominal organs can be rea
...
Potent, Simplified Derivatives of Immunosuppressive Agents
Pateamine A (PatA), a metabolite from the marine sponge Mycale, is a potent inhibitor of the intracellular signal transduction pathway that emanates from the T-cell receptor and leads to the transcription of cytokines such as interleukin-2 (IL-2). Researchers at Johns Hopkins and Texas A&M have ide
...
TH - Cre Mouse
A transgenic mouse, which produces the Cre Recombinase in Catecholaminergic Neurons. Description (Set) Proposed Use (Set) This mouse is a useful tool to study, at the molecular level, neuronal cell degeneration, protection and other related causes for neural cell disorders. This mouse is uniqu
...
TH, Bcl Conditional KO mouse
Transgenic mouse that lacks expression of Bcl-x in Tyrosine Hydroxylase-positive Neurons. Description (Set) Proposed Use (Set) This mouse is a useful tool for the molecular study of neural disorders, which include neuronal degeneration, protection and response activation. This animal (Bcl-x Mo
...
TMAJ: Database and Software Tools to Manage Tissue Microarrays (Copyright only)
Tissue micro-array based biomarkers studies involve large datasets of clinical, specimen, and image data that require effective data entry, storage, management, and querying tools. An integrated set of software tools have been developed to manage clinical data, pathology data, and image data for arr
...
Genetic Modification of Cells Prior to Delivery to the Heart so as to Improve Electrical and Contractile Function
Heart failure (HF) is a major public health problem in the United States. Despite great strides in the management of HF, it is still associated with high mortality and morbidity. Cardiac transplantation is the only definitive treatment for end stage heart failure, but is limited by the availability
...
Hypomorphic Mouse Mutant of PASG, an SNF2L factor, that leads to growth retardation and premature aging that is associated with replicative senescence, genetic instability, decreased stem cell expansi
Researchers at JHU have shown that PASG (Proliferation Associated SNF2-Like gene, also termed lsh or SMARCA6) is essential for properly maintaining DNA methylation and gene expression patterns which are required for normal growth and longevity. PASG, a facilitator of DNA methylation, causes global D
...
Identification of a Specific Ligand for Siglec-8
JHU scientists have created a unique, carbohydrate-based chemical structure that binds to the cell surface protein Siglec-8, which is expressed by human eosinophils, basophils and mast cells. Siglec-8 reduces the activity of these cells and when bound by modulators, Siglec-8 signals eosinophils to r
...
Mutational analysis of the tyrosine phosphatome in colorectal cancers
JHU researchers have performed a comprehensive mutational analysis of the protein tyrosine phosphatases super gene family in colorectal tumors and other cancers. It was discovered that the mutated tyrosine phosphatases are tumor suppressor genes, regulating pathways that may be amendable to therapeu
...
A Novel, Robust Method for Ultrasound Probe Calibration
Abstract (Set) The Johns Hopkins University seeks a partner to commercialize a novel, robust method for calibration of an ultrasound probe. The technique relies on a unique closed-form solution that provides real-time quality assurance for two-dimensional and three-dimensional ultrasound data. By u
...
Method for Targeting Motor Neurons
Amyotrophic Lateral Sclerosis and Spinal Muscular Atrophy are disorders of motor neurons for which there is presently no effective treatment. As understanding of the mechanisms of these conditions increases, the possibility for therapy involving delivery of genes to the motor nerve cell bodies is be
...
System for Clinical Workflow and Information Management
Problem-Driven Order Entry (PDOE) is a novel process for computerized physician order entry (CPOE) that dynamically generates problem-specific CPOE pick-lists without the need for static order sets or a formal, pre-determined knowledge base. Through its simple yet unique workflow, it provides highly
...
Control of Proliferation and Apoptosis in Cancer Cells
pp32 (ANP32A) is a protein expressed in stem-like normal cellular compartments and in human cancers, such as breast and prostate, that exerts multiple complex functions. Collectively appear to control whether a cell retains proliferative capacity, terminally differentiates, or undergoes apoptosis. T
...
HMG-1 transgenic mouse
The HMG-I/Y gene is overexpressed in human cancer, although a direct role for this gene in transformation had not been established. JHU researchers have generated transgenic mice with HMG-I targeted to lymphoid cells. All 7 informative founder HMG-I mice developed aggressive lymphoma by a mean age o
...
A New Ultrasound Imaging Method for Prostate Visualization
The Johns Hopkins University seeks a partner to commercialize a new method of ultrasound strain imaging for prostate therapies.
Click here to view high-quality marketing materials. Description (Set) • A major problem in prostatic interventions and therapies is localizing and tracking of the pr
...
A Highly Accurate Ultrasound-Guided Interstitial Intervention
The Johns Hopkins University seeks a partner to commercialize a new approach to dramatically increase the accuracy of image-guided intervention systems, with the use of interstitial ultrasound.
Click here for high-quality marketing materials. Description (Set) • Interstitial ultrasound (ISUS)
...
A System for Macro-micro Distal Dexterity Enhancement in Microsurgery of the eye
The system is a system for providing dexterity inside the eye for micro-surgical procedures. The system includes a remote center of motion unit (RCM) and a Macro-Micro Distal Dexterity (MMDD) unit. the MMDD unit is of several unique design variants that provide dexterity, deliver a micro robot close
...
The Use of Cerebralspinal Fluid as Inter-subject Normalization Reference Standard for Magnetization Transfer Weighted Imaging
This invention describes the use of cerebrospinal fluid (CSF) as an inter-subject reference standard for magnetization transfer (MT) imaging. This is useful in cases where the standard MT referencing approach (MT ratio or MTR) does not work properly, for instance as demonstrated for the spinal cord
...
Interventional Devices for Chronic Total Occlusion Recanalization Under MRI Guidance
Recanalization of chronic total occlusion (CTO) is a chanllenging clinical procedure traditionally conducted under x-ray guidance to improve blood flow to patients with symptomatic ischemia. X-ray guidance generally does not provide satisfactory imaging nor geometric information about the artrtial c
...
Monitoring Functional Kinetics of Vesicular Trafficking - Evidence for "Sleeping" Membrane Receptors on Cell Surface
The present inventive method is designed to measure the rate of protein trafficking to cell surface. Such measurement may be used to determine the physiological state of cells under different conditions including but not limited to pathological states, drug treatments, and genetic modifications. D
...
Modification of Professional Antigen-Presenting Cells with Small Interfering RNA (siRNA) Targeting BAK and/or BAX Can Enhance DNA Vaccine Potency
dendritic cell survival by co-administering DNA encoding antigen with DNA encoding inhibitors of apoptosis to DCs. We previously tested a variety of anti-apoptotic factors for their ability to enhance DC survival and antigen -specific CD8+ T cell immune responses when co-administered with DNA encodi
...
Cloning and Isolation of the Large Ribosomal Subunit Proteins from E. coli for the in vitro Reconstitution of functional 50S Subunits
For the first time, JHU researchers have cloned, expressed and purified each of 34 individual large ribosomal subunit proteins for E. coli for use in vitro ribosome reconstitution reactions. The ready manipulation of ribosomes assembled from their component substituents will permit fine-tuning of th
...
Attendance Tracking System
The Attendance Tracking System is a web-based application which records the attendance of working professionals for educational and divisional conferences and meetings. Equipped with a web-based administrative backend, the system is completely customizable according to the individual user. The syste
...
Method for the Detection of Schistosome Parasites
Schistosomes cause serious disease in humans and warm-blooded animals by living parasitically in the blood vessels draining the gut and bladder where they produce eggs that are passed out in the urine and feces. In man and animal hosts (dogs, cats, livestock), infection can produce severe debilitati
...
OS-9 Interacts with Hypoxia-inducible Factor 1(alpha) and Prolyl Hydroxylases to Negatively Regulate HIF-1 Activity
Hypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen homeostasis in metazoan species and mediates changes in gene transcription in response to changes in cellular oxygenation. The half-life of the HIF-1a subunit is determined by oxygen dependent prolyl hydroxylation, which is
...
The Cysteine Noose of the Attachment Protein of Respiratory Syncytial Virus Inhibits the Effects of the Endotoxin and the Innate Immune Response
Both endotoxin and RSV protein F stimulate CD14/TLR4 receptor in monocyte/macrophages resulting in a strong inflammatory response. In the case of endotoxin, this response has a direct pathogenic role in septic shock, autoimmune diseases, HIV, and asthma. And, it is the first response of the immune s
...
New Inhibitor of HIV-1 Replication, Ubiquitin Like Protein ISG15
The AIDS epidemics are still not limited, especially in the developing countries. The antiviral therapy used in this country is not affordable in the undeveloped countries. In the United States, current technology is ineffective against the generation of drug resistant HIV-1 variants. As such, an al
...
LOI of lgf2 Increases Intestinal Stem Cell Compartment and Adenoma Formation
This invention provides a strategy for identifying patients at risk of colorectal cancer, and likely other tumor types, by the discovery and identification of an expanded stem cell population in such patients, as well as methods for its detection. Description (Set) Proposed Use (Set) Rapid tes
...
Modified 0.8 mm-tipped Laparoscopic Dissecting Clamps used to Aid in Cavernous Nerve Preservation During Nerve-Sparing Laparoscopic Radical Prostatectomy
Laparoscopic radical prostatectomy has recently been proposed as a less invasive technique as compared to conventional open radical prostatectomy for the surgical management of prostate cancer. Preservation of the cavernous nerves during radical prostatectomy is a delicate surgical technique that is
...
Fluorescence Assay for Type IB DNA Topoisomerases for Use in High-Throughput Screening of Small Molecule Libraries
This invention describes the first continuous spectroscopic assay for DNA topoisomerase IB that allows monitoring of the reaction under multiple turnover conditions. As these enzymes are established targets for anticancer and antiviral drug therapies, this assay allows the rapid screening of chemic
...
Imaging Tissue Deformation Using Strain Encoded (SENC) Magnetic Resonance Imaging (MRI
Strain Encoded (SENC) MRI is a novel technique for the direct imaging of regional deformation (contraction and stretching) or elasticity of tissues. Deformation of tissue results in changes in intensity of the resulting strain-encoded (SENC) images that is observed as contrast in the images. Also, d
...
Transgenic Mice that Express Human Superoxide Dismutase 1 with the Following Mutations (1) a Double Mutation at Residue 46 and 48 with Histidine 46 Mutated to Arginine and Histidine 48 Mutated to Glut
Mutations in superoxide dismutase 1 cause familial forms of amyotrophic lateral sclerosis (ALS). To investigate potential mechanisms of disease pathogenesis, transgenic mice that express human superoxide dismutase 1 with the following mutations were generated: (1) a double mutation at residue 46 and
...
PACE 4 Antisera and Cells
Rabbit antibodies against the proprotein processing enzyme PACE4; cell lines stably secreting PACE4
...
Emission Ratiometric Indicators of Intracellular Cyclic AMP and Epac Activation
The classic second messenger, cAMP, coordinates many cellular functions via its effectors such as Epac (exchange proteins directly activated by cAMP) and PKA (cAMP-dependent protein kinase). JHU inventors have developed a series of emission ratiometric reporters as research tools for measuring the p
...
Hypothermia Induction Device
JHU researchers have developed a device that cools the heart and brain from normal temperature to mild hypothermia (35-32?C) within a few minutes. The device cools blood extracorporealy. It requires only venous access and thus suitable for uses in an out-of-hospital environment. The device is not de
...
Use of Amniotic Fluid (AF) in Ocular Disease
Human amniotic membrane (HAM) has been used successfully in recent years to treat various ocular ailments such as ocular chemical burns, corneal ulcers, and persistent corneal epithelial defects. The efficacy of HAM stems from its mechanical properties as a bandage and the presence of various intrin
...
Use of Amniotic Fluid (AF) in Ocular Disease
Human amniotic membrane (HAM) has been used successfully in recent years to treat various ocular ailments such as ocular chemical burns, corneal ulcers, and persistent corneal epithelial defects. The efficacy of HAM stems from its mechanical properties as a bandage and the presence of various intrin
...
Transgenic Frog Lines to Study Retina Degeneration
A JHU researcher has developed lines of transgenic frogs in which transgenes induce photoreceptor degeneration in vivo and can visibly reveal the viability status of the photoreceptors through a fluorescent reporter. These frog lines produce thousands of progeny that can be used to screen therapeuti
...
Disposable Sleep and Breathing Monitor
The apparatus consists of two parts, 1.) a calibrated flowmeter for measuring breathing and 2.) electrical sensors attached to the mask for measuring biomedical signals such as, but not limted to, oxygen saturation, head position as well as bioelectrical signals. The flow meter unit delivers a stabl
...
Point-of-care Mass Spectrometer
The invention is an apparatus for clinical diagnostics using a point-of-care approach to mass spectrometry technology to provide a single broad-based assessment of viral infection, HIV, and/or cancer. The approach records a survey mass spectrum that can be compared with patients' baseline data to de
...
Nanowire Transport, Assembly, and Rotation in Suspension by AC Electric Fields
A variety of low dimensionality entities, such as nanospheres, nanodisks, nanowires, and nanotubes, have recently been explored due to their unique attributes and capabilities to bind chemical and biological targets. Nanowires posses a large aspect ratio and geometrical shape, and multi-component na
...
A Dwarf Mouse with Growth Hormone Deficiency Due to Targeted Ablation (Knock Out) of the GHRH Gene
The proliferation of pituitary somatotroph cells and the synthesis and secretion of GH are under the stimulatory control of the hypothalamic peptide GHRH. GHRH is initially synthesized as pre-prohormone and then enzymatically cleaved to its mature form (44 amino acids in humans and 42 in mice). Alth
...
Development of Novel Approaches to Combinatorial Antifungal Drug Therapy
This invention relates to a method of treating fungal infections. Fungal infections can be life-threatening to transplant patients, cancer chemotherapy patients, AIDS patients and others in immunocompromised conditions. Pathogenic fungi represent an increasing clinical challenge because existing ant
...
Pyruvate Dehydrogenase Kinases as Therapeutic Targets for Cancer and Ischemic Diseases
This invention addresses two desired outcomes relating to cells exposed to ischemic or low oxygen tension by modulating the activity of a mitochondrial matrix enzyme. Tumor cells that have low oxygen tension survival mechanism may be thwarted and killed and critical cells for survival may be treated
...
Implantable Microstimulators for Gastrointestinal Tract
This technology constitutes implanting neuromuscular micro-stimulators with an endoscope into the gastrointestinal tract. The micro-stimulators are targeted to areas of dysfunction, and stimulate or inhibit the gastrointestinal tract. The micro-stimulators can be controlled by the patient using a ?
...
Pleiotrophin is a Neurotrophic Factor for Spinal Motor Neurons and Dorsal Root Ganglion
This invention utilizes pleiotrophin (PTN), a growth factor of the cytokine family, as a neurotrophic factor for both the motor and the sensory neurons of the PNS. In animal and tissue culture models, PTN has been shown to protect motor and sensory neurons from death and promote regeneration of thei
...
Hand Held Patient Tracking, Education and Decision Support (TEDS) Tool
This product is a computerized handheld decision support device that would be used by a physician-led team od Community Health Workers working in the field to constantly monitor AND address patient healthcare needs and outcomes. This system will employ an enterprise-level Geographical Information Sy
...
Multi-turn Element RF Coil Array for Multiple Channel MRI
An RF coil assembly for use in a multiple receive-channel MRI system is provided. The RF coil assembly is configured as a multi-turn-element RF coil assembly 200 to operate as a surface-coil array in cooperation with the MRI system 100 which is configured to operate in a multiple-channel receive mod
...
Microarray Gene Expression Profiling of IBD from Endoscopic Biopsy Tissues
This invention relates to the identification of biomarkers for ulcerative colitis (UC) and Crohn's disease (CD) and methods of screening. UC and CD are two highly prevalent inflammatory bowel diseases (IBDs) of the Western World. Almost all IBD patients require lifelong treatments and frequently nec
...
Rapid Identification of Microbial Genotypes and Phenotypes
Apparatus, systems, and methods for detecting, screening and sampling of cells are disclosed. Patent (Set) PCT/US05/003369
...
Medical Device for Treatment of Ulnar Neuropathy
UlnarGuardTM is a non-invasive medical device used for treating pain and disability due to ulnar neuropathy. It is designed to worn under clothing so that patients can undergo treatment day and night. Background Ulnar nerve abnormalities are found in as many as 40% of adult Americans. Often due to e
...
BACE2 Knockout Mice
Two beta-secretases termed BACE1 and BACE2 have been shown to generate the Alzheimer's disease Abeta peptides. To examine the physiological roles of BACE2 and to determine whether BACE2 is the major beta-secretase in neurons, Johns Hopkins University researchers have created mice with targeted inac
...
Methods and Compositions for Treatement of Intraepithelial Neoplasia
The present invention provides for compositions, kits and methods for treatment of intraepithelial neoplasia, where the compositions include catecholic butanes, which include NDGA derivatives
Patent (Set) PCT/US05/25639
...
Diagnostic Tool for Diagnosing Benign Versus Malignant Thyroid Lesions
Thyroid cancer represents 1% of all malignant diseases and it is estimated that 5-10% of the population will develop a clinically significant thyroid nodule during their lifetime. The best available test for thyroid nodule is fine needle aspiration biopsy (FNA). The diagnosis of malignant thyroid tu
...
Method for the direct extraction of isothiocyanates into the seed oil from glucosinolate-containing plant seeds
JHU researchers have developed a methodology for simple, reliable, stable, and inexpensive incorporation of plant isothiocyanates into oils such as natural plant seed oils. Some plant isothiocyanates are cancer chemoprotective, antibiotic, or insect repellents. These oils are ideal for topical derm
...
Facile Modification of Collagen Directed by Synthetic Peptides
mechanical properties. Such modification may allow attachment of bioactive agent that can bring in designed bioactivity to natural collagen. Most of the techniques practiced today for collagen modification involves simple "blending method" which results in weak attachment of the target molecules or
...
A method for high-efficiency clonal isolation and expansion of human embryonic stem cells
JHU researchers have developed a method and identified growth factors for high efficiency cloning, clonal expansion and subculture of human embryonic stem (hES) cells. The invention further describes a method for rapid, high-throughput screening (including genetic screening) for agents (genes, growt
...
Novel Diagnostic and Prognostic Markers, and Therapeutic Targets for Melanoma
The incidence of melanoma is increasing at the highest rate for any form of cancer in the United States and the current lifetime risk in the US is 1 in 68. Presently there are few effective systemic therapies to treat advanced stages of melanoma and the key to improved survival in all affected indi
...
PDE Inhibitors in Immunotherapy
Defects in the immune system of tumor-bearing hosts can dramatically preclude effective immune-therapy. JHU researchers and others have previously described some of the cellular and molecular mechanisms responsible for these defects and have shown that the inhibition of these pathways can facilitat
...
A High Throughput Screen Utilizing Newly Discovered Intramolecular Neuronal Calcium Channel interactions to Discover New Analgesics
This invention incorporates a newly discovered peptide which inhibits neural N-type calcium channels and the specific inter-molecular interaction that mediates the inhibitory effect of the peptide. This prototype peptide promises a beneficial profile for producing analgesia akin to opiates like morp
...
Function of GDE Protein Family in Cellular Differentiation
This technology describes a novel retinoid-inducible gene, GDE2 (glycerophosphodiester phosphodiesterase 2) that encodes a 6 TM protein and is necessary to drive spinal motor neuron differentiation in vivo. A single amino acid mutation in the extracellular catalytic domain removes protein function a
...
Wild-Type Amyloid Precursor Protein Yeast Artificial Chromosome Transgenic Line Py8.9
Researchers at Johns Hopkins and Case Western Reserve University have generated a transgenic mouse (Py8.9) line that expresses the wild-type human Amyloid Precursor Protein (APP). This mouse was generated through the insertion of a Yeast Artificial Chromosome encompassing the entire human APP gene,
...
High Fidelity DNA Display for the Evolution of Combinatorial Libraries
This invention relates to a method of producing combinatorial libraries from non-biological molecules coupled with replication of selected compounds. Individual molecules used to construct the library are attached to specific DNA sequences that are assembled as polymers, and so each combinatiorial
...
Platelet Endothelial Cell Adhesion Molecule-1 Gene Polymorphism and its Soluble Level are Associated with Severe Coronary Artery Stenosis in Chinese and Asian Indians
Many established risk factors in atherosclerosis and Coronary Artery Disease (CAD) have been defined for Caucasians but not for other ethnic groups. For example, the Asian Indians have 4 times higher prevalence of CAD compared to Caucasians. Thus, there is an urgent need to find novel risk factors/g
...
High Fidelity DNA Display for the Evolution of Combinatorial Libraries
This invention relates to a method of producing combinatorial libraries from non-biological molecules coupled with replication of selected compounds. Individual molecules used to construct the library are attached to specific DNA sequences that are assembled as polymers, and so each combinatiorial c
...
Strategies for Designing Drugs that Target the Sir2 Family of Enzymes to Treat Multiple Diseases
Sir2 enzymes comprise a unique class of NAD+ -dependant protein deacetylases that are involved in a broad range of biological processes including transcriptional silencing, aging, fat mobilization and regulation of the p53 tumor suppressor gene. The Sir2 proteins catalyze NAD+ -dependant acetylatio
...
New Analogs of the Hormone 1(alpha)25-Dihydroxyvitamin D with Side Chain Carbonyl Groups
Medicinal chemists are designing analogs to be at least as potent as, but less calcemic than, the natural hormone la, 25-dihydroxyvitamin D3 (calcitriol) for chemotherapy of diverse human illnesses. Scientists at JHU have previously shown that some new vitamin D analogs, even though lacking the clas
...
O/E2 and O/E3 Knockout Mice
The mammalian Olf1/EBF (O/E) family of repeated helix-loop-helix (rHLH) transcription factors has been implicated in olfactory system gene regulation, nervous system development and B-cell differentiation. Ebf (O/E1) mutant animals showed defects in B-cell lineage and brain regions where it is the o
...
Unexpected Cross-neutralization of Cutaneous & Mucosal Papillomavirus Types with Anti-Sera to a Novel Epitopes
High risk Human Papillomavirus (HPV) infection is a common cause of cervical cancer. Researchers at JHU have found that vaccination with the N terminus of HPV16 and bovine papillomavirus 1 can induce cross neutralizing antibodies that inhibit in vitro generated pseudovirus infection of both cutaneou
...
Identification of PSCA as an Immune Relevant Target of Antitumor Immune Responses
Prostate Stem Cell Antigen (PSCA) was previously identified as a biomarker for pancreatic and prostate cancer. JHU researchers have shown that a pancreatic cancer vaccine induced immune responses against PSCA in patients who demonstrated a positive clinical response, identifying PSCA as a candidate
...
A "Wireless" Scleral Search Coil for the Measurement of Eye Movements
The present invention improves upon the existing scleral search coil system by introducing a new ?wireless? contact lens. The new system uses a similar scleral contact lens on the eye but without the connecting wire leading to the amplifier system. Additionally, the transmitter/receiver coils are pr
...
Malaria Diagnosis in Urine
Scientists at JHU have developed a urine test for malaria, the first of its kind. The test will detect aldolase and pfhistidine-rich protein using an immunoassay design. The infectious agent, Plasmodium falciparum, may also be detected using PCR methodologies. Description (Set) Proposed Use (Set
...
B(subscript 1)-Insensitive T(subscript 2) Magnetization Preparation for Magnetic Resonance Imaging at High Field
T2 magnetization preparation is a commonly used MRI technique that enhances the contrast between arteries and surrounding tissues. Recently, high field imaging has shown promising results in acquiring high signal-to-noise images with sufficient spatial resolution suited for clinical diagnosis. Howev
...
New Class of Reporter Genes for MRI Based on Chemical Exchange Saturation Transfer (CEST)
Among the clinically applied 3D imaging modalities, magnetic resonance (MR) imaging has the highest resolution and is therefore the preferred method for detection of cellular gene expression. However, because of the low sensitivity of MR, no suitable reporter genes exist. This invention comprises a
...
Inversion Recovery with On-Resonant Water Suppression
JHU researchers have developed a new technology entitled, "IRON", which stands for Inversion Recovery ON-resonant water suppression. IRON is a magnetic resonance imaging (MRI) method that is designed to image magnetic susceptibility gradients primarily associated with non-diamagnetic objects such as
...
A Novel Genetic Approach to inhibit or Eliminate the Tumorgenicity of Human Embryonic Stem Cells and/or their Derivatives After Transplantation
Pluripotent embryonic stem cells have enormous potential for providing an unlimited supply of multipotent and specialized cells, such as brain and heart cells, for transplantation and cell-based therapies that are otherwise limited by donor availability. However, this promising application is hamper
...
A Method of Assessing Vascular Reactivity Using Magnetic Resonance Imaging
precision, using magnetic resonance imaging. The most commonly used noninvasive technique for assessing arterial endothelial function employs ultrasound. There are several improvements using this invention. One problem with the ultrasound-based method is that shear rate during hypermia, the stimulus
...
Generation of Isogenic Lines Differing Only in MLH1 Status
JHU researchers have created matched cell lines which are isogenic, differing only in the MLH1 alleles. One line has two defective alleles, the other has one defective allele and one normal (wild-type) allele, which was generated by targeted homologous recombination ("knock-in"). One wild-type allel
...
Use of Consensus Sequence as Vaccine Antigen to Enhance Recognition of Virulent Viral Variants
Vaccines for diverse viruses will be most effective when they direct the recipient?s response to recognize the most virulent form of the organism. Scientists at JHU have found that circulating strains of hepatitis C virus (HCV) contain substitutions that render the virus less fit. Therefore, the use
...
A Novel Method for Fabricating Ultrahigh Density MRAM
The Johns Hopkins University seeks a partner to commercialize a new technique for fabricating Magnetoresistive Random Access Memory (MRAM). The fabrication method creates asymmetric ferromagnetic nanorings, a novel nanotechnology with unique properties. The nanorings form the basis for MRAM chips t
...
Selectively Targeted Histone Deacetylase Inhibitors
Inhibitors of histone deacetylases (HDAC) are regarded as an important approach to cancer chemotherapy, since they disrupt the aberrant cellular metabolism that occurs in many tumor types. The HDAC inhibitors currently in clinical trials and typified by compounds such as trichostatin (TSA) and MS-27
...
MTAP KO Lines for Drug Discovery
Methylthioadenosine phosphorylase (MTAP) plays an important role in the salvage pathway for the synthesis of adenosine. The loss of MTAP function has been implicated in a variety of cancers. JHU researchers have created MTAP knock out cell lines. Description (Set) Proposed Use (Set) The cell l
...
PTEN KO Lines for Drug Discovery
PTEN is a tumor suppressor gene that is frequently mutated or deleted in a variety of human cancers . PTEN functions primarily as a lipid phosphatase and plays a key role in the regulation of the PI3 kinase/Akt pathway, thereby modulating cell proliferation and cell survival. JHU researchers have c
...
p16 KO Lines for Drug Discovery
p16 tumor suppressor gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are described in the paper by Bachman et al., 2003 Description (Set) Proposed Use (Set) The cell lines described in this invention can be used in screens for novel molecules that target the DNA meth
...
SMAC KO Lines for Drug Discovery
Second mitochondrial-derived activator of caspase (SMAC; also known as Diablo) gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are described in the paper by Kohli et al., 2004 Description (Set) Proposed Use (Set) The cell lines described in this invention can be used
...
PIK3CA KO Lines for Drug Discovery
PIK3CA knockouts in human colorectal cancer cell lines HCT116 and DLD1. Details are described in the paper by Samuels et al., 2005 Description (Set) Proposed Use (Set) JHU scientists have recently discovered that mutations in PIK3CA occur in a significant fraction of cancers. Knockout lines ind
...
Dicer KO Lines for Drug Discovery
Dicer RNase gene knockouts in human cell lines. Description (Set) Proposed Use (Set) The cell lines described in this invention can be used in screens for novel molecules that target the miRNA pathway in human cancer cells or to confirm the specificity of siRNA-based drugs discovered through
...
RAF KO Lines for Drug Discovery
BRAF kinase gene knockouts of human cancer cell lines. Description (Set) Proposed Use (Set) The cell lines described in this invention can be used in screens for novel molecules that target the RAF pathway in human cancer cells or to confirm the specificity of drugs discovered through other ap
...
CHK2 KO Lines for Drug Discovery
Chk2 protein kinase gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are described in the paper by Jallepalli et al., 2003 (see below). Description (Set) Proposed Use (Set) The cell lines described in this invention can be used in screens for novel molecules that tar
...
DEC1 KO Lines for Drug Discovery
Deleted in esophageal cancer 1 (DEC1) gene knockouts of the human keratinocyte cell line, HaCaT. Details are described in the paper by Zawel et al., 2002 Description (Set) Proposed Use (Set) The cell lines described in this invention can be used in screens for novel molecules that target the TG
...
XIAP KO Lines for Drug Discovery
X-linked inhibitor of apoptosis protein (XIAP) gene knockouts of human colon cancer cell lines. Details are described in the paper by Cummins et al., 2004 (see below). Description (Set) Proposed Use (Set) The cell lines described in this invention can be used in screens for novel molecules tha
...
HAUSP KO Lines for Drug Discovery
HAUSP (also known as USP7) deubiquitinase gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are described in the paper by Cummins et al., 2004a (see below) Description (Set) Proposed Use (Set) The cell lines described in this invention can be used in screens for nove
...
Targeting of Stat-3 Signaling in the Hematopoietic System Evokes Multicomponent Therapeutic Antitumor Immunity
The immune system can act as an extrinsic suppressor of tumors. Therefore, tumor progression depends in part on mechanisms that down modulate intrinsic immune surveillance. Identifying these inhibitory pathways may provide promising targets to enhance antitumor immunity. Scientists at Johns Hopkins
...
Page: 1 - <10 - 34 35 36 37 38 39 40 - 10> - 118 Next»