PATENTS
For Sale or License

Crowdsell Your Patent

Notify me of New Entries

Receive an email whenever a new patent is added.
You can unsubscribe at any time.



Sort by category

Nuclear Magnetic Resonance Spectroscopy Data Acquisition Schemes for Phase-Sensitive Detection of Pure Absorption Mode Signals Devoid of Dispersive Components Arising from Phase Errors

The methodology described in this disclosure enables one, for the first time, to remove dispersive components arising from phase errors (inevitably) introduced during acquisition of multi-dimensional spectra. This enables one to measure NMR paramete rs such as chemical shifts more accurately, and au
...

Coordinate independent, consistent and high level dual-gene transgenesis from a single lentiviral vector

Expression of multiple genes within the same target cells is required for certain gene delivery and therapeutic applications. In spite of such need, reaching independent, coordinate and high level dual-gene expression is still a challenging task. Non -uniform transfer, promoter interference, and poo
...

A Parameterized VLSI Architecture for Binary Multipliers based on Optimal Partitioning and Redundancy Removal

A parameterized VLSI architecture for performing binary multiplication on signed and unsigned binary numbers or variable widths is the invention. The archictecture consists of two basic units. The first unit optimally paritions the computations that are involved in the multiplication of two binary n
...

Calcium Sulfate (sulphate)-Based Nanoparticles: Synthesis and Modification Methods and Application in Bone Regenerative Therapy

Bone regeneration within critical size defects, both in the oral cavity and throughout the rest of the body, occurs very slowly in the absence of bone stabilizing agents to act as scaffolds. Though autogenous and allogenic bone grafts have been used to address this limitation, each faces its own set
...

Compositions Accelerating the Setting Time of Cements

Portland cement has long been used as a component in various endodontic filling procedures. Newer Portland-type cements such as Mineral Trioxide Aggregate (MTA) have been developed specifically for clinical applications but their long setting times a re viewed as a clinical shortcoming. As a result,
...

Identification of a new Type II Heat-labile Enterotoxin

One of the factors limiting the commercial development of mucosal vaccines is the availability of appropriate, safe and effective adjuvants and antigen delivery systems that promote the desired kinds of immune responses. In addition, many of the new subunit vaccine candidates lack sufficient immunog
...

Compressed Sensing Camera

Advantages . Design enables simultaneous sensing and compression of images. . Compression is part of the analog acquisition process, so the need for data compression algorithms is eliminated. . The image or video sequence is automatically encrypted without additional computational expense. . Des
...

Integrated single embedded processor based laser spectroscopic sensor

This is an ultra-compact laser based gas sensor with fully integrated hardware, software, and optics. This device can automatically adjust laser wavelength and optical output, convert sensor power, measure and control target parameters, and communicate and/or process the acquired data for analysis.
...

EtherFuse: an Ethernet Watchdog

This invention is a device that can be inserted into existing Local Area Networks (Ethernet) to significantly enhance its reliability. The functionality of this device can be integrated into existing Ethernet switches to eliminate the need for adding new devices. However, implementing the EtherFuse
...

Continuous Remote Control and Authentication of Integrated Circuits

This invention is a new approach for remote enabling, disabling and metering of integrated circuits. The approach leverages inherent manufacturing variability of modern and pending Si technologies. The key conceptual novelty is that designers can control ICs remotely, continuously, and concurrently
...

Remote Hardware Enabling/Disabling Techniques Using Manufacturing Variability

This invention proposes the first active hardware metering scheme that symmetrically protects the IP designer and the foundry by providing a key-exchange mechanism. The active metering method uniquely locks the IC at the fabrication house by utilizing the unclonable variability-based ID of each sili
...

Fair Asynchronous Random Access with Probabilistic Antenna Allocation in MIMO Multihop Networks

This invention is the first asynchronous multiple input/multiple output media access control (MIMO MAC) protocol that counters starvation and provides fairness. The invention exploits antenna selection and uses standard network utility maximization to find the number of used antennas per link in a g
...

Throughput Maximization in Wireless Communications Systems

Current theory tells us the ultimate throughput, or ergodic capacity, of an idealized communications system. The ergodic capacity is achieved in idealized systems by using codewords that are infinitely long and thus averaged over an infinite number of instances of the fading channel. Practical syste
...

A Method for Measurement of Pipe Wall Thickness using Magnetic Flux Leakage Signals

The proposed technique uses magnetostatic Maxwell's equations to model the magnetic fields associated with the magnetizing device and the magnetized pipe. Given certain geometric and magnetic parameters of the magnetizing device and the pipe, the proposed technique yields reference plots of the simu
...

Compressed Sensing Camera

Advantages . Design enables simultaneous sensing and compression of images. . Compression is part of the analog acquisition process, so the need for data compression algorithms is eliminated. . The image or video sequence is automatically encrypted without additional computational expense. . Des
...

Remote Hardware Enabling/Disabling Techniques Using Manufacturing Variability

This invention proposes the first active hardware metering scheme that symmetrically protects the IP designer and the foundry by providing a key-exchange mechanism. The active metering method uniquely locks the IC at the fabrication house by utilizing the unclonable variability-based ID of each sili
...

NOMAD, C++ software for derivative-free optimization

The underlying algorithm in NOMAD is MADS, a direct search algorithm with a very strong theoretical and practical justification. The user provides �blackbox� code that NOMAD can call to evaluate the objective and constraints for the nonlinear programming problem the user wishes to solve. Convergence
...

Bacteriophage Genes as the Basis for New Antibiotics

Discovery of wide-spectrum bacteriocidal proteins creates new opportunities for (a) improving phage therapy and (b) identifying important bacterial drug targets and developing new antibiotics. These bacteriocidal proteins are of interest due to the fact that the bacterial cells do not lyse (burst) u
...

Metabolically-Enhanced Microbial Strain

The key element in this new technology is that metabolic energy which would normally be diverted away from biosynthetic processes is recaptured in the form of NADH. During fermentation with this strain, significant increases in many metabolites have been observed. Also, the strain behaves as if it i
...

Nitric Oxide-Producing Hydrogel Materials for Preventing Arterial Blockage

Endothelial cells, normally present as a monolayer in the arterial wall, are believed to play an important role in the regulation of smooth muscle cell proliferation in vivo. Endothelial cells are seriously disrupted by most forms of vascular injury, including by angioplasty and similar procedures.
...

Abstract Method for Assembling PCR Fragments of DNA

A process for assembling a series of DNA fragments generated by PCR into an ordered circular arrangement for replication and genetic work in cells. The method uses the 3' overhangs created by excision repair enzymes to direct the sequential ligation of PCR fragments on a solid scaffold. The resultin
...

Alternating Recombination Method for Assembling DNA Fragments

A process for recombination assembly of a series of cloned DNA fragments into a large ordered arrangement. Potential uses of this technology include: . Analysis of function of large interrupted coding regions . Construction of gene sets involved in complex metabolic processes . Chromosome engine
...

Development of a Novel Confocal Laser Scanning Microscope for Functional Recording of Fast Neuronal Activity

Dendrites of neurons in the central nervous system are the principal sites for excitatory synaptic input. These neuronal dendrites are known to possess active computational properties also. Currently, these properties are mainly studied using well-known �patch clamp� techniques. However, the small n
...

Non-Invasive Bone and Joint Damage Detection Device

Radiography is an important diagnostic tool in medicine but unfortunately suffers from certain limitations. X-ray detection equipment is not totally portable, cannot detect certain types of injuries and fractures, and requires patients be monitored for and protected from exposure to ionizing radiati
...

Encapsulation of Radioisotopes in Carbon Nanocages for BioMedical Applications

Abstract Encapsulation of Radioisotopes in Carbon Nanocages for BioMedical Applications Technology ID: #23017 Investigator: Prof. Boris Yakobson Delivery of radioactive isotopes to specific targets in the body is important in the diagnosis and treatment of a wide array of diseases. Major probl
...

Prefabricated Tissue Engineering Bone Plug for Bone Defect Repair

Composed of materials for engineering bone tissue, this plug may be inserted into a bone defect and then used to inject and hold in place polymeric materials that enhance bone regeneration. Other applications for this base technology include dental implants, vertebral fusion, and bone anchor implant
...

TGF-Beta Conjugated Growth Scaffolds

TGF-Beta Conjugated Growth Scaffolds can be used to increase the mechanical strength of the cultured tissues by increasing extracellular matrix production. As the growth factor remains on the scaffold, at the site of tissue growth, the resulting tissues demonstrate increased mechanical integrity as
...

Diterpene Production in Recombinant Yeast

Through genetic modification of Saccharomyces cerevisiae and defined culture conditions, the production of diterpenes through fermentation has been achieved. This provides an opportunity to synthesize rare or novel diterpenes in a cost-effective manner. Additional information available upon request
...

Cloning and Expression of Ginkgo biloba Levopimaradiene Synthase

Ginkgo biloba leaf extracts have been used for centuries to treat cerebrovascular and cardiovascular diseases. Recently, the American Medical Association endorsed the Chinese herb as a viable alternative to traditional approaches in the treatment of Alzheimer�s Disease. Recent studies report that th
...

Precision Genetic Regulatory Elements

New versions of the LacI repressor protein with increased DNA binding affinity. The lac repressor protein (LacI) is a genetic regulatory protein widely used to control the expression of cloned genes and is the prototype for negative control of transcription initiation in E. coli. The lac system has
...

Screening Method for Smith-Lemli-Opitz Syndrome

Using this method it is possible to determine, from a small blood sample taken from a newborn, whether there are abnormalities in the sterol content of the blood. The overabundance of certain sterols and the lack of others is a reliable test for Smith-Lemli-Opitz syndrome, a hereditary condition whi
...

The Fluorinated Nanodiamond as a Precursor for Solid Substrate Surface Coating Using Wet Chemistry

A wet chemistry method for coating surfaces with nanocrystalline diamond Advantages . More cost-effective than existing chemical vapor deposition (CVD) methods . Low-temperature process . Adaptable to large scale processes . Compatible with a variety of different substrates Technology T
...

Method for Preparation of New Superhard Boron Carbonitride Material

Method for preparing superhard ternary boron carbonitride compound Advantages . Produces a superhard ternary boron carbonitride compound . Requires temperature and pressure conditions achievable in existing industrial high pressure devices . Produces BC0.5N at >70% yield Technology The method
...

Method for Producing Tetrapodal Nanoparticles with High Selectivity

Large-scale production of tetrapodal CdSe nanoparticles Advantages . Method produces tetrapodal CdSe nanoparticles of uniform size with high selectivity . Production costs (relative to existing methods) reduced approximately 200-fold . Method does not require use of highly toxic alkyl phosphonat
...

Abstract Tungstated Zirconia Nanocatalysts

Preparation of tungstated zirconia solid acid catalyst with enhanced activity Advantages . Enhanced activity relative to solid acid catalysts . Enhanced selectivity, thermal stability, and resistance to deactivation . Environmentally friendly; Low environmental impact relative to liquid catal
...

Variable Duration Camshaft or Helical Camshaft.

This invention (usually referred to as the "Helical Camshaft") allows a conventional four-stroke engine to be able to vary the duration of its valve opening over a very wide and continuous (that is; stepless) range. The system is totally mechanical (that is; not "camless" - solenoid or elec
...

Synchronized Computer Control for Pulsed Quantum Cascade Laser Frequency Scanning

Technology Professor Frank Tittel and Dr. Anatoliy Kosterev, at Rice’s Quantum Institute, have developed a tool for flexible and reproducible control of pulsed quantum cascade (QC) laser frequency scans for laser absorption spectroscopy. A pulsed mode of operation for QC lasers is used to enable th
...

Ultracompact Gas Sensors Incorporating Quartz-Enhanced Photoacoustic Spectroscopy

This invention integrates a quartz oscillator into a photoacoustic device to allow for the detection of resonant acoustic waves, permitting sensitive detection of gases using an extremely small unit. Technology Photoacoustic spectroscopy (PAS) is an established domain of experimental physics bas
...

Selectivity Enhancement in Photoacoustic Gas Analysis via Phase-sensitive Detection at High Modulation Frequency

This invention is a new spectroscopic method of distinguishing molecular species with overlapping absorption spectra. Spectroscopic distinguishing between two species having overlapped optical absorption spectra is difficult and at times impossible. However, photoacoustic spectroscopy (PAS) allows t
...

Piezo activated mode tracking system for widely tunable mode-hop free external cavity mid-IR lasers

Technology Rice researchers have developed a novel architecture of a widely tunable external cavity lasers (primarily in mid-Infrared), which allows performing continuous mode-hop free wavelength scans applicable for high resolution spectroscopy and trace-gas detection. It features a QC laser spect
...

Modulation cancellation method (MOCAM) in modulation spectroscopy

Technology The invention is a new process to acquire analytical spectral data using two optical sources. It is based on balancing the optically excited response of the analyzed media for certain conditions. As a result, small deviations from these conditions (such as a chemical or isotopic composit
...

Plant Scent Enhancement

Highlights Breeding for other qualities has resulted in the loss of scent in many flowers and plants. Genetically enhancing production of scent compounds and changing the plant’s rhythm of volatile scent compound production to a continuous steady state so that daytime scent production is essentia
...

Genetically Controlled Carotenoid Production

Highlights Carotenoid-associated proteins (CHRC and CHRD) were isolated from cucumber flowers From these, new genes, promoters and their nucleotide sequences were derived that can be used to produce, accumulate, and sequester high levels of carotenoids in cells. Enables the production of large qu
...

Resonant optothermoacoustic detection of optical absorption

Technology This technology is an improvement to optothermal spectroscopy and photoacoustic spectroscopy (PAS). The proposed method of resonant optothermoacoustic detection (ROTA) is based upon the following processes: (1) excitation of a fluid region or object under study by a modulated optical r
...

Fast wavelength tuning technique for external cavity lasers

This invention is a novel external cavity – quantum cascade laser (EC-QCL) architecture. The current state of the art uses mechanical translation and rotation stages to synchronously control EC length and diffraction grating angle, which are the two factors that determine tuning speed. This inventio
...

Metal Coated Magnetic Nanoparticles (MCMNP) and their application to chemical/biochemical detection

This technology is a new synthetic method for manufacturing MCMNP. MNMNP are an enabling component of optical spectroscopic techniques, which are currently limited because of their relative susceptibility to spectral interference from chemicals present in the sample matrix and/or from low detection
...

Ultra low loss waveguide for broadband terahertz radiation

This invention is a device which transports terahertz radiation over long distances with much less attenuation than current technology allows. The device incorporates a new concept for guiding THz radiation, which exploits the properties of the lowest-order transverse electric mode of a parallel pla
...

Electromagnetic Levitation for Containerless Processing and Refining of Metals

In response to the growing need to handle high temperature reactive metals and alloys in today�s manufacturing industry, Rice has developed an advanced method for refining pure or precious metals and alloys by a new, more powerful electromagnetic levitation technique. This containerless method for p
...

Combined Membrane, Pressure, and Temperature Swing CO2 Separation

Purpose This invention is a more energy efficient process to separate CO2 from flue gas, natural gas, or process gas (e.g. syngas) stream. Advantages . Combines features of membrane separation, pressure swing, and temperature swing separation into one process that operates continuously . More
...

Adaptive Power System for Extending Device Life

Advantages • Allows the device to maintain full operation while at the same time charging the battery with an alternate energy source that is not large enough to do both at the same time. • Maximizes the energy collected from the alternate energy source. • Because the charging of the battery i
...

Production of Very Fine Powders by Electromagnetic Vaporization

The Electromagnetic Vaporization Process developed at Rice uses an alternating magnetic field to generate molten metal into fine droplets that can be used to produce metal powders or to deposit metal into microscopic, ordered patterns on a substrate. Rice�s EV Process enables a far greater range of
...

Novel Micromechanical Devices for in situ Characterizations of One Dimensional Nanomaterials

The invention is a micro-machined device that can be used, in conjunction with a quantitative nanoindenter, to perform ex situ or in situ nano-mechanical testing experiments within an SEM or TEM chamber. The device, and the technique in general, can perform nano-mechanical characterization of 1-dime
...

Fullerenes for the Treatment of Osteoporosis

In the treatment of osteoporosis and other bone disorders, it is desirable to deliver therapeutic compounds to the bone. However, it is known that certain substances, although therapeutic, are too toxic to be transported in the human body in free form. For example, fluoride anion (F–) is known to be
...

Abstract Fluorescent Security Tag Using Carbon Nanotubes Technology ID

As a result of advanced printing ink technology, invisible inks have found a new venue in business and commerce as a means of protection against fraud, counterfeiting, and theft. The most useful inks are those that are invisible after printing, but which can be made visible through various means to
...

Metal Coated Magnetic Nanoparticles (MCMNP) and their application to chemical/biochemical detection

This technology is a new synthetic method for manufacturing MCMNP. MNMNP are an enabling component of optical spectroscopic techniques, which are currently limited because of their relative susceptibility to spectral interference from chemicals present in the sample matrix and/or from low detection
...

Novel Micromechanical Devices for in situ Characterizations of One Dimensional Nanomaterials

The invention is a micro-machined device that can be used, in conjunction with a quantitative nanoindenter, to perform ex situ or in situ nano-mechanical testing experiments within an SEM or TEM chamber. The device, and the technique in general, can perform nano-mechanical characterization of 1-dime
...

A method for growing high aspect ratio filaments comprising ultra-long vertically aligned carbon nanotube arrays

Advantages Robust method for producing SWNT arrays with high aspect ratios High Yields Filament length and diameter can be controlled by changes in growth conditions Aligned SWNT arrays impart improved properties to composite materials Minimum post-growth processing required The Technology
...

Early Detection of Lung Cancer Treatment

The present invention relates to a method for early detection of lung cancer. The method comprises obtaining samples from the body, especially respiratory tract material including sputum or bronchial fluid or any other pulmonary tissue or thoracic cells or regional lymph nodes, and assaying the samp
...

Using Certification Trails to Achieve Software Fault Tolerance

This novel invention comprises a method and apparatus to achieve fault tolerance in hardware and software systems. The method involves the steps of executing a first algorithm and a second algorithm on input which produces a first output and certification trail, and second output respectively. Compa
...

Vitamin D3 Analogues

The present invention is based on the unexpected finding that the A-ring portion of vitamin D.sub.3 analogues can be modified without negatively affecting the biological activity of the resulting compounds. In its broadest aspects, the invention provides vitamin D.sub.3 analogues which include at le
...

Ceramic Oxide Powders and the Formation Thereof

The invention is concerned with ceramic oxide powders, formed from one or more ceramic oxide precursors, which have utility as ceramic oxides of high strength and low thermal expansion coefficient. The ceramic oxide powders are formed in a counterflow diffusion flame burner using a fuel stream compr
...

1, 2, 4 - Trioxanes Having Antimalarial Activity

Because of the widespread incidence of malaria in certain parts of the world and because of the increasing parasite resistance to standard anti-malarial drugs, there is an urgent need for new and effective anti-malarial drugs. A wide variety of anti-malarial compounds have been proposed for use. One
...

NonBlocking Broadcast Switching Network

This novel invention presents a design for a broadcast network which provides nonblocking connecting capability in a multistage switching network without any disturbance of other broadcast connections already existing in the network. It is notable for its economy of required switching elements and i
...

Formation of Oligonucleotide Triplexes with Selectively Modified Cytosines

The present invention is based on the finding that it is possible to use the bisulfite-catalyzed transamination reaction to selectively introduce aminoalkyl or carboxyalkyl linker arms at a specific deoxycytidine site within oligonucleotides or analogs thereof which also contain one or more 5-methyl
...

Mixing Cell for Microcalorimeters

The present invention relates to a device and method for measuring the heat of reaction resulting from the mixture of a plurality of liquid reagents. The heat of reaction is one of the most important thermochemical characteristics of any reaction and is widely used in fundamental research and appli
...

Monoclonal Antibodies (AE-1) Specific for Cytoskeletal Proteins useful for Tumor Diagnosis

Differential diagnosis of tumors can sometimes be difficult. For example, the histological appareance of thymoma (epithelial-derived) and histicytic lymphoma (mescenchyme-derived) can be similar. Since the mode of treatment and prognosis for these two types of tumors are significantly different, an
...

Polarization Lens

The present invention pertains to a polarization viewer. The polarization viewer comprises a mechanism or means for forming a broadview image having a spectral width preferably greater than 2 angstroms and 0.50.degree. based on polarization information of a scene, although it can be used in that ran
...

Chemoprotective Isothiocyanates

Sulforaphane has been isolated and identified as a major and very potent phase II enzyme inducer in broccoli (Brassica oleracea italica). Sulforaphane is a monofunctional inducer, inducing phase II enzymes selectively without the induction of aryl hydrocarbon receptor-dependent cytochromes P-450 (ph
...

A Completely Polymeric Charge Storage Device and Method for Producing Same

This invention relates to the fabrication of a quasi-solid state charge storage device capable of being repeatedly charged and discharged to yield high capacities. The storage device has one or more electrochemical cells comprised entirely of a layer of ionically conducting polymer gel electrolyte s
...

Apparatus and Method for Exercising and Measuring Strength of a Patient's Limb

An apparatus for measuring the strength of and for performing physical therapy exercises to strengthen a patient's limb. The device includes a pair of pivot clamps each having a end for connecting the pivot clamps to a solid object such as a physical therapy table or hospital bed. A second end of ea
...

Antiproliferative Vitamin D3 Hybrids

The present invention is based on the unexpected finding that certain modifications to the A-ring portion of vitamin D.sub.3 analogues produce compounds of superior biological activity. In its broadest aspects, the invention provides vitamin D.sub.3 analogues which include a 1-hydroxyalkyl group or
...

Polarization Phase-Based Method and Apparatus for Material Classification

This novel invention is an important advance for two distinct environments in which it is necessary to differentiate between electrically conducting and nonconducting materials - - inspection processes such as quality assurance, and high-level object recognition. As an example of the inspection appl
...

Apparatus for the Separation of Cystic Parasite Forms from Water

A continuous flow centrifuge adapted with an insert of glass beads, sand or the like is used to concentrate cysts of microorganisms such as giardia or cryptosporidium from large volumes of water. The apparatus and methods are useful for the detection of contaminating microoorganisms in groundwater a
...

Trioxane Dimer Compounds Having Antiproliferative and Antitumor Activities

Described herein are novel trioxane dimers of structure ##STR1## which possess antiproliferative and antitumor activities. Patent (Set) 6,297,272; 5,840,925; 6,156,790; 6,160,004; 6,004,997; 730722; 2,273,374; RE 38,117; 6,586,464; 739687
...

Carbon/Ceramic Composite Electrodes for Charge Storage Units

The present invention relates to charge storage devices, such as electrochemica supercapacitors and lithium ion intercalation batteries, and the method of preparation thereof. In particular, the invention relates to carbon/ceramic composites produced by sol-gel technology wherein composites pretreat
...

An Electrochemical Storage Cell Containing At Least One Electrode Formulated from a Fluorophenyl Thiophene Polymer

This present invention relates to a battery or a electrochemical storage cell, 'typically a secondary cell, containing as at least one electrode prepared fromat least one electrically conductive polymer. In charge storage, applications such as electrochemical secondary cells, electrode materials sho
...

Water-Soluble Trioxanes as Potent and Safe Antimalarial Agents

Parasitic infections, particularly malaria, are a serious and widespread public health problem. New and better therapeutic agents are needed to fight these parasitic infections. The trioxane drug, artemisinin, is an active anti-malarial constituent of the herb Artemisia annua L., Compositae. Both ar
...

An Epithelial Protein and DNA Thereof for Use in Early Cancer Detection

The present invention is a purified and isolated epithelial protein, peptide and variants thereof whose increased presence in an epithelial cell is at indicative of precancer. One epithelial protein which is an early detection marked for lung cancer was purified from two human lung cancer cell lines
...

Computer Assisted Method for Conducting Library Research from a Remote Locat

This invention is of great potential significance to the library, publishing, archives, and records management communities, among others. It addresses a long-felt need, namely, for improved access to materials (often existent in large quantity) which have not been digitized and, through limitations
...

Arrays of Semimetallic Bismuth Nanowires and Fabrication Techniques Therefor

In the present invention, nanowires are fabricated by electrodeposition using semi-metallic bismuth. In this novel form of nanowire, positive magnetoresistance (MR) as high as 300% at low temperatures and 70% at room temperature, with a quasi-linear field dependence has been achieved. The MR effect
...

Miniature Immuno-Optical Rapid Analyte Sensor Platform

A hand held, self-contained, automatic, low power and rapid sensor platform for detecting and quantifying a plurality of analytes. A sample solution potentially containing an unknown amount of an analyte is passed through an affinity column which contains antibodies to which the analyte binds thereb
...

Method for Electrochemical Conditioning Polymeric Electrodes

The present invention relates to a method of fabrication of polymeric electrodes for use in a battery or electrochemical storage cell, in particular secondary cell. Moreover this invention provides a method of conditioning polymeric electrode materials so as to improve their charge capacities and en
...

Volatile Biomarkers for Analysis of Hepatic Disorders

The present invention features test systems and methods for detecting a hepatic disorder in a mammal and especially a primate. Preferred use of the invention involves staging the hepatic disorder in a human patient. Patent (Set) 6,248,078
...

Multi-Band Image Analysis

Computation of contrast, which includes computation of gradient and zero-crossings, has been used in computer vision as one of the primary methods for extracting grayscale and color features. It seems plausible, therefore, that the correct way to compare versions of the same image in terms of featur
...

Novel Inhibitor of Programmed Cell Death

Apoptosis is the fundamental cellular process for the self-destruction of cells. Modulation of cell survival is essential to tissue development and homeostasis with aberrations of this process accounting for many pathological conditions such as cancer. Apoptosis is a complex, multi-step event involv
...

Copper Metallization Structure and Method of Construction

This novel invention addresses the need for fast, reliable, performance-oriented interconnects and vias in today's and tomorrow's smaller, faster circuit systems. Specifically, it is a process for producing an interconnect layer of continuous copper, with excellent step coverage and superior adhesio
...

Bismuth Thin Films Structure and Method of Construction

The invention is directed to the use of electrochemical deposition to fabricate thin films of a material (e.g., bismuth) exhibiting a superior magnetoresistive effect. The process allows to produce a thin film of Bismuth with reduced polycristallinization and leads to the production of a single crys
...

Bubble-based Micropump

Apparatus used for pumping a small quantity of fluid with a postage stamp-sized bubble-based micropump. The device creates one microscopic bubble at a time by heating the asymmetrical part between two small tubes. The repeated growth and collapse of one bubble forces the fluid through one tube allow
...

C-10 Carbon-Substituted Artemisinin-Like Trioxane Compounds Having Antimalarial, Antiproliferative and Antitumor Activities

Artemisinin is usually administered for the treatment of multi-drug resistant malaria. However, studies have determined that artemisinin not only possesses excellent anti-malarial properties but also considerable anti-cancer activities. Scientists at JHU have described a procedure for the production
...

Inverse Pricing of American Options and Other Financial Derivatives

An apparatus for and method of determining the price of financial derivatives such as options. One preferred embodiment of the invention employs a discretized partial differential linear complementarity problem (PDLCP) based system to determine the forward pricing of financial instruments such as va
...

Compositions and Methods for Prevention of HIV Transmission Across Mucosal Surfaces

(Set) Most newly acquired cases of HIV-1 infection result from sexual, primarily heterosexual, transmission. While mechanical barriers, such as condoms, can be very effective in preventing sexual transmission, this male-dependent method of protection is frequently not accepted or is impractical for
...

�whmd�: Essential Cell Division Gene in Mycobacteria

The slow growth rate of mycobacteria contributes significantly to the pathogenes 'is and treatment of mycobacterial infections such as tuberculosis. To combat infection, patients must undergo extended therapeutic programs that result in poor patient compliance and the emergence of drug-resistant org
...

Method for High Throughput Thermodynamic Screening of Ligands

The optimization of lead compounds as viable drug candidates involves the optimization of their binding affinity towards the selected target, most notably the achievement of high affinity and specificity. JHU scientists have devised a method of rapidly screening ligands on the basis of their binding
...

An Inhibitor of Double Strand Break Repair (Non-Homologous End Joining) in Eukaryotic Cells

DNA damaging agents such as ionizing radiation and chemotherapeutics cause double-strand breaks in cellular DNA. These double-strand breaks interfere with the processes of DNA replication and chromosome segregation and thus are lethal if not repaired. An efficient system to repair double-strand brea
...

Structural Prediction of Allosterism

During the course of biological function, proteins interact with other proteins, ligands, substrates, inhibitors, etc. These interactions occur at precisely defined locations with the protein but their effects are sometimes propagated to distal regions triggering highly specific responses. These eff
...

Intermediated Delivery Scheme for Asymmetric Fair Exchange of Electronic Items

A great deal of valuable data - commercial, medical, educational and scientific - is today stored in electronic format in computer databases. The commercialization of this "electronic" data via Internet is beginning to have a significant economic and technological impact. Outside of cyberspace, at e
...

Electronic Learning Community

The Johns Hopkins Electronic Learning Community (ELC) is a web-based community portal designed to provide groups of professionals with tightly integrated tools for communication and collaboration. The ELC offers a secure environment for schools, organizations, businesses, project teams, etc, to diss
...

Antiviral Compositions and Methods of Use

This invention is related to isolation of two highly potent, non-toxic inhibitors against human immunodeficiency virus type 1 (HIV-1) integrase and viral replication. Two water soluble compounds, M522 and M532, have been discovered by isolating them from Salvia miltiorrhiza roots in purities of > 99
...

Solar Cells Incorporating Light Harvesting Arrays

A solar cell incorporates a light harvesting array that comprises: (a) a first substrate comprising a first electrode; and (b) a layer of light harvesting rods electrically coupled to the first electrode, each of the light harvesting rods comprising a polymer of Formula I: wherein m is at least 1, a
...

High Performance Nanocrystalline Materials and Methods of Making the Same

Under certain conditions, nanostructured materials have been found to exhibit improved mechanical properties over corresponding, coarse-grained materials. However, most methods for creating nanostructured materials typically involve sacrificing one or more desirable properties in favor of another (e
...

Page: 1  -  <10  -  29  30  31  32  33  34  35  -  10>  -  118   Next»