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Hydrophobic Attachment Site for Adhesion Peptides.
Hydrophobic Attachment Site for Adhesion Peptides
5,760,176; 5,120,829; 5,587,456; 5,591,822
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Polypeptides Encoding Transcriptional Activators and Uses Thereof
Polypeptides Encoding Transcriptional Activators and Uses Thereof
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Method for Detection of Fibronectin Receptor Ligands
Method for Detection of Fibronectin Receptor Ligands
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T-Cadherin Adhesion Molecule
T-Cadherin Adhesion Molecule
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Merosin, Nucleic Acids Encoding Fragments and Uses Thereof (Heteromeric Variants of Laminin Like Proteins)
Merosin, Nucleic Acids Encoding Fragments and Uses Thereof (Heteromeric Variants of Laminin Like Proteins)
5,444,158; 5,872,231; 5,837,496; 5,624,905
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Inhibitors of Cell Regulatory Factors
Inhibitors of Cell Regulatory Factors
5,583,103; 6,436,900; 6,509,314; 6,277,812
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Method and Composition for Treating Thrombosis
Method and Composition for Treating Thrombosis
5,672,585; 6,521,594; 6,013,625; 5,648,330; 5,612,311; 6,395,873
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Novel Retinoid X Receptor Heterodimers and Methods of Use
Novel Retinoid X Receptor Heterodimers and Methods of Use
7,098,310; 7,026,125
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Fibronectin Binding Sites and Methods of Modulating Fibronectin Extracellular Matrix Assembly
Fibronectin Binding Sites and Methods of Modulating Fibronectin Extracellular Matrix Assembly
5,658,778; 5,624,832; 5,360,733; 5,684,134
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A Novel beta-1-6 N-Acetylglucosaminyltransferase, Its Acceptor Molecule, Leukosialin, and a Method for cloning Proteins having Enzymatic Activity
A Novel beta-1-6 N-Acetylglucosaminyltransferase, Its Acceptor Molecule, Leukosialin, and a Method for cloning Proteins having Enzymatic Activity
5,629,291; 5,837,813; 5,747,452
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Localized Drug Delivery to Ablate Fat Tissue
Researchers at the University of Michigan we have developed a novel drug delivery application, the ablation of fat tissue by the sustained, localized release of anti-fat drugs. The central premise of this technology is that fat tissue mass can be destroyed by sustained, targeted delivery of drugs af
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Recombinant Calf Intestinal Alkaline Phosphatase
Recombinant Calf Intestinal Alkaline Phosphatase
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Decorin Fragments and Methods of Inhibiting Cell Regulatory Factors
Decorin Fragments and Methods of Inhibiting Cell Regulatory Factors
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A Matrix-Associating DNA-Binding Protein, Nucleic Acids Encoding the same and Methods of Detecting the Nucleic Acids
A Matrix-Associating DNA-Binding Protein, Nucleic Acids Encoding the same and Methods of Detecting the Nucleic Acids
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Method of Inhibiting Replication of Hyperproliferative Cells
Method of Inhibiting Replication of Hyperproliferative Cells
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Soluble TGF-Beta-Binding Endoglin Polypeptides and Homodimers
Soluble TGF-Beta-Binding Endoglin Polypeptides and Homodimers
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Expression of the Developmental I Antigen by a cloned Human cDNA Encoding a Member of a b-1, 6-N- Acetylglucosaminyltransferase Gene Family
Expression of the Developmental I Antigen by a cloned Human cDNA Encoding a Member of a b-1, 6-N- Acetylglucosaminyltransferase Gene Family
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Novel Integrin-Binding Peptides
Novel Integrin-Binding Peptides
5,536,814; 7,067,619; 6,177,542; 5,981,478; 5,627,263
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E-Selectin-Dependent Cell Adhesion Antagonists
E-Selectin-Dependent Cell Adhesion Antagonists
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Trophin and Trophinin-Assisting Proteins
Trophin and Trophinin-Assisting Proteins 5,910,451; 5,880,267; 5,858,360; 5,599,918; 5,654,145
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Methods of Sensitizing Tumor Cells with Adenovirus E1A
Methods of Sensitizing Tumor Cells With Adenovirus E1A
5,776,743; 6,100,243; 6,544,955
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FAS Associated Proteins
FAS Associated Proteins
5,876,939; 5,747,245; 5,632,994
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CD40 Associated Proteins
CD40 Associated Proteins
6,265,556; 6,172,187
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PR Domain Peptides
PR Domain Peptides
6,069,231; 5,811,304; 6,323,335; 6,468,985; 5,831,008
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Structural Mimics of RGD-Binding Sites
Structural Mimics of RGD-Binding Sites
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Isolated Nucleic Acid Molecules which Hybridize to Polysialyl Transferases
Isolated Nucleic Acid Molecules which Hybridize to Polysialyl Transferases
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Cancer-Associated MAR Binding Protein
Cancer-Associated MAR Binding Protein
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Method of Identifying Molecules that Home to a Selected Organ or in Vivo
Method of Identifying Molecules that Home to a Selected Organ or In Vivo 6,068,829; 7,018,615; 5,622,699; 7,341,710; 6,296,832; 6,306,365
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Molecules that Home to a Selected Organ or Tissue in Vivo and Methods of Identifying Same
Molecules that Home to a Selected Organ or Tissue In Vivo and Methods of Identifying Same
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Structural Mimics of RGD-Binding Sites
Structural Mimics of RGD-Binding Sites
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Targeted Therapeutic or Diagnostic Agents and Methods of Making and Using Same
Targeted Therapeutic or Diagnostic Agents and Methods of Making and Using Same
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Tumor Homing Molecules, Conjugates Derived Therefrom and Methods of Using Same
Tumor Homing Molecules, Conjugates Derived Therefrom and Methods of Using Same
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Methods of Modulating Radical Formation by Mutant CuZnSOD Enzymes
Methods of Modulating Radical Formation by Mutant CuZnSOD Enzymes
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Methods of Inhibiting Cancer by Using Superfibronectin-Generating Compounds
Methods of Inhibiting Cancer by Using Superfibronectin-Generating Compounds
6,475,488; 5,922,676
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Thryroid Hormone Receptor
Thryroid Hormone Receptor
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Methods of Inhibiting Angiogenesis and Ameliorating Cancer by Using Superfibronectin
Methods of Inhibiting Angiogenesis and Ameliorating Cancer by Using Superfibronectin
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Antithrombotic Agents and Methods of Use
Antithrombotic Agents and Methods of Use
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Nucleic Acid Encoding a Family of Acetyl-Coenzyme-A Transporter Proteins, and Products Related Thereto
Nucleic Acid Encoding a Family of Acetyl-Coenzyme-A Transporter Proteins, and Products Related Thereto
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Trophinin and Trophinin-Assisting Proteins and Methods to Inhibit Implantation
Trophinin and Trophinin-Assisting Proteins and Methods to Inhibit Implantation
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Anti-Bax Inhibitor Protein Antibodies
Anti-Bax Inhibitor Protein Antibodies
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Integrin Ligand Dissociators
Integrin Ligand Dissociators
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Novel Polypeptides
Novel Polypeptide
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Sulfotransferase for HNK-1 Glycan
Sulfotransferase for HNK-1 Glycan
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Methods of Identifying Lung Homing Molecules Using Membrane Dipeptidase
Methods of Identifying Lung Homing Molecules Using Membrane Dipeptidase
6,174,687; 6,232,287; 6,933,281; 6,784,153; 6,610,651;
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NGR Receptor and Methods of Identifying Tumor Homing Molecules that Home to Angiogenic Vasculature Using Same
NGR Receptor and Methods of Identifying Tumor Homing Molecules that Home to Angiogenic Vasculature Using Same
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Novel Bag Proteins and Nucleic Acid Molecules Encoding Them
Novel Bag Proteins and Nucleic Acid Molecules Encoding Them
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Proapoptotic Peptides, Dependence Polypeptides and Methods of Use
Proapoptotic Peptides, Dependence Polypeptides and Methods of Use
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Methods for using Anti-avb, Integrin Antibody Antagonists
Methods for using Anti-avb, Integrin Antibody Antagonists
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A beta-1-6-N-acetylglucosaminyltransferase that Forms Core 2, Core 4 and I Branches
A beta-1-6-N-acetylglucosaminyltransferase that Forms Core 2, Core 4 and I Branches
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Methods for Inhibiting Tumor Metastasis, and Peptides Useful Therefor
Methods for Inhibiting Tumor Metastasis, and Peptides Useful Therefor
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NG2/HM Proteoglycan-Binding Peptides that Home to Angiogenic Vasculature and Related Methods
NG2/HM Proteoglycan-Binding Peptides that Home to Angiogenic Vasculature and Related Methods
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Highly Active Alkaline Phosphatase
Highly Active Alkaline Phosphatase
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A Method for Determining the Prognosis of Cancer Patients by Measuring Levels of BAG Expression
A Method for Determining the Prognosis of Cancer Patients by Measuring Levels of BAG Expression
10/030,497
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Heart Homing Peptides and Methods of Using Same
Heart Homing Peptides and Methods of Using Same
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Nucleic Acid Encoding Proteins Involved in Protein Degradation, Products and Methods Related Thereto
Nucleic Acid Encoding Proteins Involved in Protein Degradation, Products and Methods Related Thereto
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CARD Proteins Involved in Cell Death Regulation
CARD Proteins Involved in Cell Death Regulation
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Compositions and Methods for Modulating Bone Mineral Deposition
Compositions and Methods for Modulating Bone Mineral Deposition
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Novel TRAF Family Proteins
Novel TRAF Family Proteins
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BCL-G Polypeptides, Encoding Nucleic Acids and Methods of Use
BCL-G Polypeptides, Encoding Nucleic Acids and Methods of Use
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PR-Domain Containing Nucleic Acids, Polypeptides, Antibodies and Methods
PR-Domain Containing Nucleic Acids, Polypeptides, Antibodies and Methods
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Kenaf plants with elevated fiber content
The Invention Transgenic Kenaf plants (Hibiscus cannabinus L.) have been developed by modifying the endogenous concentration of gibberellins using anti-sense technologies. These novel Kenaf plants have elevated fiber content. Furthermore, the fibers in these plants are of higher quality, substant
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Domestication of the Marine Nudibranch Spurilla Neapolitana for Commercial Husbandry: Targeting the Marine Ornamental Industry
The Invention A technology was developed enabling the domestication / commercial husbandry of S neapolitana - The optimal pest control for marine aquaria.The novel technology includes special culture media for propagating the distinct nudibranch life cycle stages, and unique culture apparatus for p
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Inhibitors of Systemic Virus Spread in Plants
The Invention Plant viruses and viroids exploit plasmodesmata nano-channels as conduits for viral spread. Plasmodesmal proteins, endogenous to plants, have been modified such that they permanently block plasmodesmata nano-channels. This blockage inhibits plant virus spread: a major cause of reduced
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Detoxification of Tannins in Transgenic Plants
A novel genetic system for the elimination of tannins in edible plant materials such as canola seeds and sorghum seeds has been developed. This involves genetic engineering of these plants such that they accumulate a tannin-detoxifying agent. The Need Global agricultural production is greatly infl
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Multi-Silencing Algorithm (MSA) for analysis of ´Multi-Knockout´ and perturbation experiments
The Invention The invention describes a new, reliable and efficient method for mapping and quantifying the contribution of elements to the overall performance of the system they compose.
The Need With the genomic revolution a huge amount of data has become available concerning the expression of
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mapping and quantifying the contribution of elements to the overall performance of the system they compose
BACKGROUND Research at the University of Manchester has identified a new tissue marker with potential use in the stratification of breast cancer patient groups and improved targeting of treatment for each patient. THE TECHNOLOGY The human homolog of the suppressor of deltex protein (SDRP) is aberran
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Electroluminescent Yarns
BACKGROUND The concept of electroluminescent (EL) materials is based on the exposure of an electroluminescent substance to a high frequency electrical field, in contrast to photoluminescence in which a light source is needed to provide stimulation. EL polymer sheets are created using micro-encapsula
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Novel Human Gene with Immunoregulatory and Antiproliferative Properties
Abnormal or unregulated control of the body’s immune system can contribute to a variety of disorders, including but not limited to autoimmune disease and cancer. Standard treatments for autoimmune disease involve administration of non-steroidal anti- inflammatory drugs, corticosteroids, and disease
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Embryonic Stem Cell Isolation and Expansion.
Background:
Ageing populations coupled with failings in current drug based therapies are driving the quest for new treatments and methods of disease management. One of the most promising advances towards such goals is in the development of regenerative stem cell based therapies. Embryonic stem cell
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Biodrug Delivery Mechanism Via Yeast Encapsulation
BACKGROUND A research project in in the Faculty of Life Sciences at the University of Manchester has led to the development of a novel yeast-based drug delivery mechanism. THE TECHNOLOGY A genetically engineered yeast strain, able to express recombinant protein drugs / vaccines and incorporating a g
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3-D Self-assembled Peptide Hydrogels
BACKGROUND Pre-designed self-assembling scaffolds are highly advantageous in a number of areas, including tissue regeneration, 3D cell culture, in vitro toxicity testing and understanding of cell/extracellular matrix interactions. Self-assembling peptides, with the various properties of amino acids
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Enzyme Targetted Therapeutics
BACKGROUND Enzymes, especially proteases play essential roles in disease specific processes and are valuable targets for therapeutic intervention. A number of methods of targeting enzymes have been used to date. These include specific enzyme inhibitors and polymeric carriers which disintegrate to re
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Exciplex™ a Highly Sensitive Nucleic Acid Fluorescent Detection System
BACKGROUND Conventional fluorescent dyes used in nucleic acid detection methods suffer from a number of limitations. High backgrounds result in false positives and a reduction in sensitivity. The small Stokes shift (difference between excitation and emission wavelengths) often requires optical filte
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Zebra Fish Models for Drug Discovery
THE TECHNOLOGY Transgenic zebrafish are becoming increasing important as models for human disease. This organism offers the drug discovery industry a number of advantages including rapid reproductive cycle and large numbers of offspring, ethical preference over other animal models, cost effectivenes
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Novel Antimicrobial Peptides
BACKGROUND Ai2 Limited is a University of Manchester spinout company that aims to become a significant player in the global anti-infectives market. The company’s focus is on developing novel anti-microbial products, for out-licensing to healthcare companies across a range of sectors. THE TECHNOLOGY
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Novel Drugs for the Treatment & Prevention of Allergy
BACKGROUND There is a high and increasing incidence of allergic disorders such as asthma and hay fever. It is expected that some 300m people in the western world will suffer from allergic diseases by 2010. Upwards of 60% of asthma cases are triggered by allergic responses and up to 1 in 4 urban chil
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Novel Anti-helminthic
BACKGROUND Gastrointestinal nematode infections are amongst the commonest infections of man and animals worldwide. Collectively 1 in 3 people on the planet are infected by at least one species and approximately 50% of these are school age children In the developing world they affect the well being o
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Collaboration/Licence Opportunity Size and Permeability Selective Encapsulation and Delivery of
BACKGROUND Although there is considerable research being carried out in the area of hollow sub-micron constructs for the purposes of encapsulation of useful therapeutic entities, most of the processes developed to date for the preparation of such constructs are incompatible with maintaining the func
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eLUNSERS: a SOFTWARE TOOL FOR MONITORING THE SIDE-EFFECTS OF NEUROLEPTIC DRUGS
BACKGROUND Neuroleptics are the drugs of choice in the treatment of schizophrenia, bipolar mania and related disorders but suffer from troublesome side-effects such as drug induced parkinsonism, restlessness, facial tics etc. The severity and patient acceptability of these effects varies widely. Res
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A New Controller for Wind Farms Giving Improved Network Stability
BACKGROUND The increasingly wide spread use of wind generation on power networks imposes a greater requirement for wind-farms to contribute to security of network operation in the same way as conventional generating stations based on synchronous generators. DFIG controllers to date have concentrated
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eLUNSERS: a SOFTWARE TOOL FOR MONITORING THE SIDE-EFFECTS OF NEUROLEPTIC DRUGS
BACKGROUND Neuroleptics are the drugs of choice in the treatment of schizophrenia, bipolar mania and related disorders but suffer from troublesome side-effects such as drug induced parkinsonism, restlessness, facial tics etc. The severity and patient acceptability of these effects varies widely. Res
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Enhanced Software for Image Feature Detection and Tracking
BACKGROUND The division of Imaging Science and Biomedical Engineering at Manchester has expertise in the statistical analysis of image data. Image analysis is widely employed in sectors such as life sciences, security, defence, biometrics, forensics and medicine. THE TECHNOLOGY A method for modellin
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New software for high speed inspection of volume printing processes
BACKGROUND:
In a culture of rising print costs, high print run wastage rates, and yet rising demand for printed products, often with a need for precision, high definition printing, there is more than ever a need for accurate inspection of the finished product. Compuweb Online Ltd is a Manchester ba
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Electronically Functional Yarn
BACKGROUND The majority of everyday clothing consists of textile fibres knitted or woven to produce a fabric. Their primary purpose is structural and aesthetic. Fibres can have added functionality by the integration of electronics into the material from which they are formed. Our vision is to enable
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Enzyme-responsive Polymer Hydrogels
BACKGROUND Biomaterials, either natural or synthetic, can be used to replace tissue, organ or body function for a period of time either for permanent implantation (heart valves), long-term application (contact lenses) or short-lived application (wound-dressings, catheters, etc.). They also have othe
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Functional Knitted Gloves
BACKGROUND Knitted gloves are predominantly manufactured using speciality glove-knitting machines, or in certain instances circular-knitting equipment. Seamless gloves are already well-known, but can only be produced with simple plain-knitted structures. In the technical textiles sector, innovation
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Knitted Switches 'K-switch' Technology
BACKGROUND Touch and proximity sensing E-Textiles are being developed by a number of research groups. Several methods have been explored including printing electroconductive materials onto a textile substrate, the use of piezoresistive coatings, embroidering electroconductive fibres and attaching wo
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Production of Novel Human Collagens
BACKGROUND A powerful new platform technology for the production of human collagens is being developed in the Kadler Centre for Cell-Matrix Research within the Department of Life Sciences at the University of Manchester. The collagens most closely mimic human collagen structure, giving a far superio
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Spinal Disc Nucleus Replacement
BACKGROUND In the last 10 years commercial interest in treatment of spinal degeneration in relation to back pain has increased with a large number of devices competing in a market estimated to be worth more than $3.5bn and growing at 15 - 20% pa. This technology being developed at the University of
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Novel Tissue Marker for Stratifying
BACKGROUND Research at the University of Manchester has identified a new tissue marker with potential use in the stratification of breast cancer patient groups and improved targeting of treatment for each patient. THE TECHNOLOGY The human homolog of the suppressor of deltex protein (SDRP) is aberran
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Opticin a Treatment for Cancer and Angiogenesis
BACKGROUND Opticin is a protein present in the eye (in the vitreous humour) and was discovered at University of Manchester by Dr Paul Bishop. Uniquely Opticin has been found to exhibit both cytotoxic AND anti-angiogenic (blood vessel formation) effects on a range of cell lines from different cancers
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Tumour Vascular Targeting Agents
A new pharmacophore for selective targeting of tumour blood-supply BACKGROUND Cancer is a huge killer, responsible for more than 500,000 deaths in the US and 150,000 in the UK each year, thus making new anti-cancer drugs a key driver in the pharmaceutical industry. Most cancer treatments are poorly
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Novel Antimicrobial Peptides
BACKGROUND Ai2 Limited is a University of Manchester spinout company that aims to become a significant player in the global anti-infectives market. The company’s focus is on developing novel anti-microbial products, for out-licensing to healthcare companies across a range of sectors. THE TECHNOLOGY
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A Functional Food with Indications for Peptic Ulcers
BACKGROUND 1 in 10 people are affected by peptic ulcers over the course of their lifetime. Incidence of the condition is set to increase as the population ages. Current treatment relies on combination antibiotic therapy. However, a 20% failure rate and increasing antibiotic resistance highlight the
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Novel Synthesis of Iduronate a Heparan Sulphate Subunit
BACKGROUND Heparan sulphate and heparin play a central role in a large number of processes including anti-coagulation, angiogenesis, cell growth and migration. A new class of medicinal drugs can be envisaged that would either promote or inhibit the function of heparan sulfate/heparin by mimicking or
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Opticin a Treatment for Cancer and Angiogenesis
BACKGROUND Opticin is a protein present in the eye (in the vitreous humour) and was discovered at University of Manchester by Dr Paul Bishop. Uniquely Opticin has been found to exhibit both cytotoxic AND anti-angiogenic (blood vessel formation) effects on a range of cell lines from different cancers
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Corticosteroids with Reduced Side Effects
BACKGROUND Glucocorticoids (GCs) have been used therapeutically for many years to treat a range of inflammatory conditions as immunosuppressants and in the treatment of certain cancers. These compounds are the most potent and effective anti-inflammatory agents known. Their use has been limited howev
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Novel Antimicrobial Peptides
BACKGROUND Ai2 Limited is a University of Manchester spinout company that aims to become a significant player in the global anti-infectives market. The company’s focus is on developing novel anti-microbial products, for out-licensing to healthcare companies across a range of sectors. THE TECHNOLOGY
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A Device for Treating Swallowing Problems (dysphagia) After Stroke
Swallowing problems after stroke are common, with over 40,000 patients annually in the UK suffering from dysphagia and its attendant consequences of aspiration pneumonia and malnutrition. This leads to longer hospital stays, increased demands on feeding resources, higher admissions to nursing homes
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Feiter a New Method of Brain Scanning
BACKGROUND A number of techniques are available for brain scanning and imaging including CT scanners, MRI, fMRI and PET. All require large expensive fixed installations and cannot be made available in all hospitals. Their imaging speed does not allow measuring brain activity or functional responses
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