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Collaboration/Licence Opportunity PAEDIATRIC ANAESTHESIA RE-BREATHING APPARATUS
BACKGROUND In the normal Jackson-Rees system that is used to provide anaesthetic gas to a patient, one part of the apparatus connects to an open tailed reservoir bag. This bag expands and contracts in unison with the patients breathing and allows the anaesthetist to ventilate the patient by partial
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Advanced 3d Flexible Fibre Material for Wound Management, Orthopaedic, Sports & Personal Protective Equipment Applications
BACKGROUND Spacer structures find applications is many areas. These include automotive, sports wear, medical, mattresses and protective clothing such as gloves and body armour. Spacer structures could provide a replacement for foam. These structures can be specifically tailored to meet the needs of
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MUC7 12-mer-D isomer: novel and promising antimicrobial agent
This invention encompasses isomeric peptide derivatives of a naturally occurring protein found within the human body. These isomeric derivatives have been shown to possess potent antifungal activity comparable to that of currently used antifungal ag ents but with far less toxicity. The microbes used
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Novel Measurement of Intermodulation Distortion (IMD) in Ferrite Circulators
BACKGROUND The rapid expansion of wireless communications and the development of mobile phone technology have resulted in a market requirement for large capacity communication systems. Wideband Code Division Multi-Access (WCDMA) is considered to be promising technology to meet this requirement. Idea
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Production of Novel Human Collagens
BACKGROUND A powerful new platform technology for the production of human collagens is being developed in the Kadler Centre for Cell-Matrix Research within the Department of Life Sciences at the University of Manchester. The collagens most closely mimic human collagen structure, giving a far superio
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Ultra High Bulk 3D Spacer Fabric Technology for Orthopaedic, Sports and Personal Protective Equipment Applications
BACKGROUND A new process for the development of a three dimensionally knitted, high bulk, flexible spacer fabric has been developed by the University of Manchester. 3D spacer structures are already being used in many applications including orthopaedic supports, protective clothing, car seats, mattre
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Transparent X-ray Beam Diagnostics
BACKGROUND Today X-ray beams are used in many areas in science and engineering. Their unique properties give a wealth of information in a non-destructive manner. Research with highly collimated beams such as produced by synchrotron and electron laser facilities provide powerful probes for microscopi
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Collagen fibers from a soft coral
A novel source of collagen manifested as fibers derived from certain species of soft corals has been isolated. The New Collagen fibers are strong and flexible compared to commercial collagen. The fibers have a high reversible extensibility compared to mammalian collagen fibers and can be reversibl
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Novel oral formulation of Insulin
The Invention Gagomers are novel particles (neither liposomes nor microspheres/nanospheres) composed of hyaluronan shell which is crossed linked to phospholipids and can be generated either as micro or nano particles. The research team at Tel Aviv University has demonstrated that: (1) Gagomers ef
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Novel baby bottle nipple that mimics breast feeding
The Invention A new nipple for baby bottles has been developed that mimics breast feeding. The structure of the new nipple is based on the functional architecture of the breast nipple anatomy, thus enabling mimicking the physiological suckling pattern of milk from the mother's nipple. The breastfee
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HDACIvir´s- Novel anticancer agents
The Invention The research teams at Tel Aviv and Bar Ilan Universities have developed novel compounds derived from known histone deacetylase inhibitory (HDACI) molecules linked to acyclovir and its analogs. The new compounds (HDACIvir's) demonstrated potent anticancer activity both in vitro and in
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Novel anti cancer drug for the treatment of Brain
The researchers at Tel Aviv University and Perrigo Pharmaceuticals have developed a platform technology (the Rotem Platform) enabling the development of potent anti cancer drugs based on the chemical modifications of known psychotropics.
The leading molecule - Rotem201 – is an NCE derivative of
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A novel system for rapid fluorescence detection of non-amplified nucleic acid sequences
The Invention A new homogeneous technique which utilizes fluorescence resonance energy transfer (FRET) to directly detect and distinguish specific DNA sequences without requiring either an amplification step or a separation step has been developed. The detection system is capable of detecting very
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Targeted filamentous bacteriophages as therapeutic agents
The Invention Targeted drug-carrying filamentous bacteriophages have been developed as a novel therapeutic approach for the treatment of infectious diseases and cancer. The phages are genetically-modified to display an antibody or a targeting peptide as a targeting moiety on their surface and are u
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Over-Expression of Membrane Proteins in Bacterial System
The Invention The invention provides for an increase in the expression of heterogeneous membrane proteins as well as crystallization ability. This is achieved by addition of hydrophilic alpha-helical segments to the desired membrane protein, via a cloning procedure. Two different helices enable con
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Edible Anti-Adhesion Material Derived from Cranberry for the Treatment of Helicobacter Pylori Infection
The Invention An edible, high-molecular-weight, non dialyzable material (NDM) isolated from Cranberry juice inhibits specific adhesion of H. Pylori to immobilized human mucus and to cultured gastric epithelial cells. No relationship was observed between the resistance to antibiotics and the anti-ad
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Edible Anti-Adhesion Material for the Treatment of Oral Bacterial
The Invention A high-molecular-weight, non dialyzable material (NDM) isolated from Cranberry juice, specifically inhibits adhesion and dissociates co-aggregates of oral bacteria. NDM act preferably on co-aggregates that include Gram-negative anaerobes and inhibit, in-vitro, biofilm formation by mut
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Self Assembling Peptide Nanotubes
The Invention Aromatic dipeptides have been demonstrated to self-assemble into discrete nanotubes that are, upon design, either sensitive or resistant to enzymatic degradation. Such nanotubes are homogeneous, with micron-scale persistence length and can serve as molds for conductive nanowires suita
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Self Assembled Peptide Hydrogel
The Invention A breakthrough Self Assembled Peptide Hydrogel (SAPH) has been developed by Professor Ehud Gazit and his team at Tel Aviv University. SAPH is a safe, self assembled, biocompatible, remarkably strong hydrogel with modulated stability that is suitable for various medicinal and cosmeti
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A Potential Target for Discovery and Development of Novel Antiviral Agents Against Porcine Endogenous Retrovirus
The Invention Researchers in Tel Aviv University have cloned and characterized Reverse Transcriptase (RT) of PERV-B - a variant that infects human cells and, hence, might infect human recipients of porcine tissues. The recombinant PERV-RT is expressed in bacteria, giving large amounts of soluble
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Increased Fungal Biomass for Bio Ethanol Production
The Invention Dr. Amir Sharon and his team from Tel Aviv University have developed a transformation-based approach through which fungi can be modified to be less sensitive to external conditions and environmental stresses, have increased sustainability in culture during fermentation, and have both
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A Novel Catalyst Technology for the Polymerization of ?-Olefins
The Invention A novel catalyst technology for the polymerization of alpha -olefins was developed including several families of pre-catalysts based on early transition metal complexes of amine-phenolate ligands. These pre-catalysts, when activated by various co-catalysts under mild reaction conditio
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Three-dimensional (3-D) Thin-Film Microbattery
The Invention Alasan is a novel bioemulsifier produced by the microorganism Acinetobacter radioresistens KA53. It is a high molecular weight complex composed of an anionic polysaccharide containing a significant % of covalently bound alanine and four proteins.
The Need Emulsifiers are used wi
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Algorithm for User Activity Anticipation
The Invention The Algorithm for User Activity Anticipation is capable of anticipating the user’s next “click” with the mouse, therefore increasing the application’s efficiency. This is especially useful in applications that require a great deal of use of the mouse, such as video games, word proc
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Gene Tests for Diagnostics of Psychiatric Disorders
The Invention We suggest two novel gene tests for psychiatric disorders:
1.Diagnostics of susceptibility to schizophrenia, based on single nucleotide polymorphism (SNPs) of the golli myelin basic protein (golli-MBP) gene.
2.A methods for predicting the response to lithium therapy in bipolar
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Novel Simple Assay for Diagnostics
The Invention A novel, simple and cost effective assay for monitoring blood levels of rapamycin (sirolimus), and rapamycin analogues was developed. The conceptual basis of the invention is based on the utilization of the Rapamycin specific target, its binding protein and their complex formation
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Early detection of cancer: Alu sequence exonization
The Invention A method has been developed whereby the generation of new Alu exons in particular genes may be used as diagnostic markers for different cancers. The method associates RNA splicing isoforms with specific cancers which may be readily detected by standard methods.
The Need If detec
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Non-invasive Diagnostics for Liver Diseases
The Invention A new serum marker specific for liver disease has been discovered. The marker is the soluble form of the human asialoglycoprotein receptor (ASGPR). An ELISA assay was developed with specific monoclonal antibodies that confirmed the correlation between reduced soluble ASGPR levels an
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Single photon detector
The Invention The invention is a novel solution to the problem of ultra-low level light imaging. The research team is working on a simple and low-cost method using cost effective imager device technology for implementation of the “Single Photon Imaging” (SPI). This imager is based on an “Electron
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Display of High Dynamic Range Images on Conventional Displays
The Invention Current image acquisition and processing allow construction of images with a very wide range of luminous levels. The invention is a method for intelligently manipulating the luminous levels into a displayed image where a maximum amount of significant viewable detail can be simultaneo
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Miniature Air Vehicle Controlled and Propelled by Active Flow Control
The Invention Miniature Air Vehicles (MAV’s) with Active Flow Control (AFC) is an aviation invention in which the means for thrust generation, flight control and lift augmentation are created by the same fluidic actuators, located within the MAV. This can solve many of the problems that inhibit fu
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Smart Video Retargeting
The Invention We have developed a method that can infer which regions in each frame are of importance – these regions are then used to reconstruct a down-sampled frame. We achieve this using novel image processing computer vision algorithms that determine each region’s importance, map it into an op
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Novel Method for High Quality Thin Film Deposition
The Invention A novel deposition method based on the vacuum arc has been developed to deposit thin films and coating. The method utilizes a homogenous plasma jet which is free of film-degrading macroparticles The Need A vacuum arc discharge is sustained between a water cooled cathode, fabricated
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Generating 3D video from standard 2D compressed video
A new algorithm for generating 3D video from standard compressed 2-D video, using a method for extraction of motion vectors. The method allows the synthesis of dense depth maps for 3D video generation and display.
The Need The method uses inherent motion of the scene to extract enough informati
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Active Aerodynamic Flow Control for Reduced Fuel consumption of Trucks
The Invention The invention improves the flow of air around the aft (rear) section of trucks and other heavy road vehicles (such as UAV's). A small add-on device incorporates a novel air flow control valve which generates suction and high frequency oscillations, forcing the air to conform to the sh
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Highly Efficient Hybrid Bio-Seminconductor Photovoltaic Device
The Invention A novel device for photovoltaic conversion which consists of an oriented photoactive monolayer bound to a bottom metal electrode and a top transparent electrode. The photoactive components are oriented dry layers of a photosynthetic reaction center protein which were isolated from
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Method and Apparatus for Producing Carbon Nano-particles
The Invention Solid particles having micrometer and nanometer dimensions are increasingly needed in technological applications. TAU innovation simply and inexpensively fabricates various micro- and nano-particles in an organic fluid. The particles can be separated from the fluid electrically, magne
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Highly Efficient Fuel Cell
The Invention The new type of fuel cell utilizes a unique nano-porous proton conducting membrane and improved fuel cell components including improved anodic and cathodic catalysts, membrane electrode assembly and bipolar plates with flow fields for both solution and gas. A hydrogen/bromine cell wa
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Three-dimensional (3-D) Thin-Film Microbattery
The Invention The 3-D Thin-film Microbattery is a, lithium or lithium-ion battery conformally formed on all exposed surfaces of a perforated substrate. The extended area provides an increase of 1-2 orders of magnitude in specific energy (per volume and weight) and capacity vs. conventional planar t
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High-Voltage Atomic Force Microscopy
The Invention The High Voltage Atomic Force Microscopy (HV-AFM) is an innovative tool for nano-machining and the MEMS industry. The HV-AFM’s advanced ability to apply high voltage to a very small area enables the production of patterned nano-scaled ferroelectric crystals that increase the current a
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Dynamically Controllable Photonic Crystals (PhCs)
The Invention Dynamically Controllable Photonic Crystals (PhCs) allow for dynamic control of electromagnetic (EM) wave motion through a silicon PhC comprising of arrays of micro-cavities. This is achieved by changing the local refractive index in the vicinity of a micro-cavity. This enables the dyn
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Rapid Fabrication of Carbon Nanotubes
The Invention Carbon nanotubes are a new molecular form in which carbon atoms form a hollow tube with diameters in the nanometer range. The scientific innovation from the University of Tel Aviv provides a simple, inexpensive and rapid method of fabrication of multi-wall carbon nanotubes at selected
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Electroless Deposition of Thin Copper-Molybdenum Layers for ULSI Applications
The Invention Electroless deposition of thin copper-molybdenum layers is a method of producing highly reliable nano-wires for interconnect applications to solve the problems in the use of copper interconnects. By adding small amount of molybdenum the copper resistance to electromigration is increas
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All-optical Imaging System with Extended Depth of Field
The Invention The All-optical imaging system allows for real time, on line imaging in any difficult focal conditions (i.e. movement, changing distances, problematic lighting/contrast ratios) without having to adjust or align the system. The system’s modified lens provides a high depth of field, nam
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Cobalt tungsten phosphorous electroless deposition process and materials
The Invention The new technology of electroless cobalt has lower resistance and enhanced electromigration resistance compared to alternative barriers that are used today. Therefore, for deep submicron technology, the new technology yields better global interconnect delay and improved reliability.
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Approximate Prefix Coding for Program Compression
The Invention Reduction in the size of software on a chip without the reduction of functionality is now possible through the innovation of Approximate Prefix Coding for program compression. This is a PLA (Programming Logic Array) class-based method, which can significantly decrease the amount of me
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Thermodynamically Stable Contacts for Binary Semiconductors
The Invention This invention provides thermodynamically stable electrical contacts for wide band gap binary semiconductors, as well as stable contacts with Ohmic or rectifying properties. This new technology enables the creation of a stable metal contact for semiconductor devices operating at high
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Super Resolving Imaging System
The Invention The Super Resolving Imaging System is capable of increasing the effective diameter of the lens by a magnitude of between 4 and 16, enabling weight and cost reductions in an imaging system with no loss in output quality. The system works on a method of enhancing the spatial frequencie
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Jet Vectoring Through Periodic Excitation
The Invention Jet Vectoring through Periodic Excitation enables the control of the direction of a jet without any moving parts. This method has many advantages, the main ones being the enhanced ability to quickly and effectively control the jet in several axis and the potential weight reduction com
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Harvesting Solar Energy: Hydrogen production by a semi-artificial photo-system
The Invention An artificial ferredoxin-hydrogenase fusion enzyme has been developed for the production of hydrogen gas. This novel fusion enzyme will interfere with the formation of the naturally occurring ferredoxin-sugar production pathway in the photosystem I (PSI) complex and shuttle the donat
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Wastewater treatment using Algae in a Photobioreactor
The Invention The invention uses an efficient, cheap and ecologically safe hybrid photobioreactor for simultaneous industrial wastewater detoxification and microalgal biomass production. It is cheap and self-sustaining and makes use of known technologies. Waste water is treated in a reactor cont
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Developing coral tissue and polyp culture for use in biological and biomedical research
The Invention Model miniature scleractinian coral polyps from single genetic stocks are been produced in a unique and novel way. In this invention numerous miniature coral polyps are created from tissue biopsies from a single adult coral polyp. The process creates tissue biopsies that are initially
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pH modified UV treatment of water pesticidal and pharmaceutical
The Invention The invention consists of introducing a pH influenced polychromatic ultra-violet (UV) photolysis process for disinfection of water contaminated by several organic components (alone or in a mixture of contaminants), where the pH to enhance contaminant breakdown is optimized by correlat
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Increased Fungal Biomass for Bio Ethanol Production
The Invention Dr. Amir Sharon and his team from Tel Aviv University have developed a transformation-based approach through which fungi can be modified to be less sensitive to external conditions and environmental stresses, have increased sustainability in culture during fermentation, and have both
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Passive accurate detection of elderly patient falling events
The Invention A very accurate method utilizing a combination of non-intrusive installed vibration detectors and microphones to detect the fall of humans in the domicile. The Need The elderly desire to remain independent as much as possible. This translates to living alone without constant superv
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Contrast Improvement in CT images
The Invention An improved algorithm for handling CT scan information which enables the display of all relevant anatomical features in a single image.
The Need An important clinical problem in radiology is the inability to see abnormalities in tissues with marked differences between their X-ray
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Drug-Eluting Bioresorbable Composite Fibers for Medical Applications
The Invention A novel class of bioresorbable, composite (core/shell) fibers loaded with bioactive agents (hydrophobic or hydrophilic) has been developed. These fibers have:
excellent tensile mechanical properties (high strength and flexibility)
desired controlled release profile. controllabl
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Improving Speech Intelligibility for the Hearing Impaired
The Invention An improved method for processing audio inputs to hearing impaired, allowing them to better understand speech in a noisy environment The Need Most common speech enhancement techniques were designed and developed on the basis of cochlear psychoacoustical and physiological research. I
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Real-time Diagnosis of Ovarian Malignancy
The Invention Automatic, non-invasive and immediate diagnosis of ovarian malignancy with an accuracy rate of over 90% is made possible through this innovative Real-time Diagnostic ultrasound package. The package includes two components, which together increase the likelihood of a highly accurate
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MRI Sequence for Macromolecule Characterization of Brain Tissue
The Invention Brain macromolecules can now be detected and identified according to contrasting macromolecular characteristics of the tissues, using this new MRI sequence. The dynamics and rigidity of a host of macromolecules can be identified, including proteins and lipid membranes. In the brain
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Slice-Selective DQF-MRI of Connective Tissues
The Invention Reduced signal loss and the achievement of optimal contrast for imaging tendons and ligaments are made possible through the innovation of Slice-Selective Double Quantum Filter MRI (DQF-MRI). This new DQF-MRI is performed on a time scale shorter than any previous imaging sequence, ma
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DQF-MRI Strain Maps of Blood Vessel Walls
The Invention Two images that display a 2D map of a bovine coronary artery, unstressed (Left) and 55% elongated (Right).
Strain maps of blood vessels walls, tissue composition and strain distribution are now possible through the use of DQF-MRI (Double Quantum Filtered-MRI). This innovative m
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An Innovative Implant for Treating Glaucoma
The Invention The Glaucoma Implant is a new shunt that eliminates the complications created by devices currently in use and it may eliminate the need for repeat surgeries. It is small in size, easy to implant and thus causes less discomfort for the patient and results in faster recovery time. For h
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Silencing of Mortalin with siRNA as Adjuvant for Cancer Immunotherapy
The Invention We suggest a novel mode of treatment by inhibition of mortalin or mortalin synthesis as an adjuvant to antibody-based immunotherapy. Novel siRNA was designed as blocker of Mortalin expression. The anti-mortalin siRNA binds specifically to mortalin mRNA and leads to its destruction. Up
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Cell Permeable Peptides for the Treatment of Allergy, Asthma and Inflammatory Related Diseases
The Invention Novel cell permeable peptides that fuse a membrane permeation sequence to a functional sequence were developed. These cell-permeable peptides are capable of blocking signal transduction pathways in mast cells, preventing mediator release and the subsequent inflammatory reactions. The
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Targeting Cancer and Bone Metastases with Novel Anti Angiogenic Polymer Therapeutics
The Invention A new strategy for cancer and bone metastases therapy was developed using combined targeted polymeric drug delivery system with angiogenesis inhibitors. The novel compounds are composed of three elements:
1. Water soluble synthetic copolymer (HPMA) as specific carrier enabling the m
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Novel oral formulation of Insulin
The Invention Gagomers are novel particles (neither liposomes nor microspheres/nanospheres) composed of hyaluronan shell which is crossed linked to phospholipids and can be generated either as micro or nano particles. The research team at Tel Aviv University has demonstrated that: (1) Gagomers ef
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Gagomers - Novel drug delivery system for the delivery of proteins to the brain
The Invention Gagomers are novel particles (neither liposomes nor microspheres/nanospheres) composed of hyaluronan shell which is crossed linked via phospholipids. Gagomers could be generated either as micro or nano particles. The research team at Tel Aviv University has demonstrated the ability
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Novel Hapatatis C Virus NS3 serine protease inhibitor
The Invention Novel single chain and single domain antibodies and peptide aptamers which inhibit NS3 protease, have been isolated The Need Hepatitis C virus (HCV) infection is a major world-wide health problem, causing chronic hepatitis, liver cirrhosis and primary liver cancer (HCC). Currently
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ASSNAC: a novel treatment of oxidative stress induced by reactive oxygen
The Invention ASSNAC, S-allymercapto-N-acetylcysteine, is a small bi-functional molecule that up-regulates cellular glutathione levels, the major cellular anti-oxidant. ASSNAC dissociates in peripheral tissues, slowly releasing s-allylmercaptan and NAC. s-allylmercaptan, the thiol-active component
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Serotonin Reuptake Inhibitors as Novel Anti-Platelet Drugs
The Invention Serotonin-selective reuptake inhibitors (SSRIs) were chemically modified to produce novel quaternary nitrogen derivatives having a peripheral-restricted serotonin reuptake inhibitory activity. The lead compound GR-101 was demonstrated as a novel anti-platelet drug (for reducing plat
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Novel psychotropic agents for the treatment of both negative and positive symptoms of Schizophrenia
The Invention New Chemical Entities (NCE's) psychotropic agents have been developed, possessing anti-dopaminergic activity, along with positive modulatory glutamate NMDA receptor activity. These agents are aimed at the treatment of schizophrenia and bipolar disorder affecting positive symptoms as w
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TAR-1: a human single chain antibody for the treatment of cancer related to mutations in p53
The Invention TAR-1, a human single chain antibody, which recognizes the common epitope exposed in mutant p53, but not in wild type p53, has been isolated. Binding of TAR-1 to the mutant p53 common epitope restores both the wt conformation and function of p53, and thus restores its ability to bind
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Macrolid Induced Correction of Premature Stop Codons: a novel Treatment for Colorectal Cancer
The Invention An antibiotic of the Macrolid family was demonstrated as a new treatment for colorectal cancer and other genetic human diseases that arise from pre-mature stop codons in important coding sequences.
The Need Around one third of all genetic disorders as well as most cases of sporadi
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Adamantyl-OEG-fullerene Hybrids as potential therapeutic agents
The Invention A series of novel soluble adamantyl-oligoethyleneglycol-fullerene hybrids was prepared via Bingel-Hirsch functionalization of C60 fullerene with various adamantyl-oligoethyleneglycol malonates. As NMDA-targeted antioxidants, these compounds have potential as therapeutic agents for the
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Cell THerapy for Diabetes: Expansion and re-differentiation of adult human pancreatic islet cells for transplantation
Invention Conditions have been discovered for efficient expansion of adult human islet cells expressing normal beta-cell function (beta-cell gene expression and insulin content) The Need Type 1 (insulin-dependent) diabetes mellitus, which results from the autoimmune destruction of the insulin-pro
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Cell Replacement Therapy for Diabetes
Invention A novel source of surrogate insulin producing beta cells has been developed. Genetic and epigenetic manipulations are employed to induce differentiation of a number of human progenitor cell types into mature, functional beta cells for treatment of diabetes.
The Need Type 1 (insulin-d
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Genetic Screen for Hepatitis C virus (HCV) Protease Inhibitors
Invention A novel in vivo genetic screen for Hepatitis C virus (HCV) Protease Inhibitors has been developed based on the concerted co-expression of a reporter gene, recombinant Hepatitis C virus (HCV) non-structural 3 (NS3) protease and a potential inhibitor within a bacterial host. Potential inhi
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New Application for Vitamin D
Invention A new application / Use for Calcitriol - It was demonstrated, in vitro, that calcitriol and some of its synthetic analogs have the potential to reduce the damage inflicted to normal tissue by accepted anti-cancer therapy. Vitamin D offers protection from programmed cell death to cells in
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Novel anti-cancer drugs with improved potency and acitivity against drug resistant cells
Invention Antimetabolites and antineoplastic agents have been chemically modified to render them active against resistant as well as sensitive cancer cells The Need The major reason for chemotherapy failure in cancer treatment is the emergence of cells that are resistant to therapeutic agents Po
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Novel Peptides for Therapeutic Angiogenesis and lschemic Cardiovascular Diseases
Invention Novel peptides were identified that bind endothelial cells and induce angiogenesis. The peptides were demonstrated to induce proliferation, migration and vascularization of endothelial cells under hypoxic conditions and completely restored blood perfusion in ischemic tissues in an ischemi
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Immunotherapy for the prevention and treatment of osseous metastasis
Invention A gene encoding a novel cell adhesion protein whose expression is associated with bone metastases has been identified. The gene is termed SEL-OB and codes for a selectin type protein. SEL-OB is expressed in human breast cancer cell lines and invasive pleomorphic lobular carcinoma. The SEL
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Inhibitors of Amyloid Fibril Formation for the Treatment of Type II Diabetes
Invention Novel inhibitors directed against a newly identified sequence, aimed to prevent amyloid plaque formation and beta cell death are currently being developed. These inhibitors present a novel approach to the treatment of Type II Diabetes and prevention of disease progression. They are based
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GSK-3 inhibitors for the Treatment of Insulin Resistance-Related Diseases
Invention Novel inhibitors of GSK-3 were identified. These inhibitors represent substrate competitors that interact specifically with the GSK-3 substrate binding site. GSK-3 modulates insulin action by controlling the activity of two other proteins in the insulin-signaling pathway, and its activit
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Targeted Nanoparticles for Drug Delivery
Invention Novel particulate drug delivery technology comprises of lipidated Glycosaminoglycan, that form micro or nano particles in a controlled manner. The particles (neither a liposome nor a microsphere/nanosphere) can encapsulate DNA, proteins and small molecules with high efficiency and perform
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Single-Trigger Molecular Amplifiers
Invention Dendrimers were synthesized, whereby a single specific cleavage event releases all the functional groups at the tips of the dendrimer, via spontaneous fragmentation of the dendrimer to its building blocks. These dendrimers, with the capacity to self destruct, have been termed Self-Immol
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Collagomers - Widely Applicable Drug Delivery Technology
Invention Collagomers are bioadhesive micro and macro particles generated by linking a phospholipid to collagen. Collagomers entrap a wide range of molecules and release them slowly over long periods of time. They bind with high affinity to cells providing an efficient, widely applicable drug deli
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An inhibitor to the ß-secretase pathway of Aß generation in Alzheimer´s Disease
Invention Antibodies have been raised against the β-secretase cleavage site in Amyloid β precursor protein (AβPP). These antibodies can prevent the processing of AβPP and the subsequent formation of amyloid deposits, a central event in the pathogenesis of Alzheimer’s Disease. This approach will not
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Improved Calcitonin-based Therapeutics
Invention The aggregation site on human calcitonin has been identified, paving the way for development of specific inhibitors of calcitonin amyloid fibril formation. Such inhibitors will enable development of improved calcitonin therapeutics as well as greatly facilitate in vitro calcitonin manipul
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Topical Therapy for Fungal Nail Infections (Onychomycosis)
Invention The invention comprises a two-step topical treatment for fungal nail infections combining (a) enzymatic digestion of dermatophyte hyphae by lysing enzymes to expose the growing tips and (b) application of a new highly effective fungicide (a derivative of the non-specific protease inhibito
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Novel Anti Bacterial Drug
The Invention Two non-toxic short peptides were conjugated to form a novel drug candidate. One of the peptides is a polymyxin-B or polymyxin-E analog (PMBN or PMEN, respectively) while the other is an immune cell chemotactic peptide (fMLF). The resultant new drug candidates (PMBN-fMLF or PMEN-fML
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Modulation of sperm activity in fertility and contraception
Invention Prof. Naor’s team has recently discovered that two Mitogen-Activated Protein Kinases (MAPKs) play a role in human sperm functions. The team discovered that human sperm progressive and hyperactivated motility is maintained by the ratio of these kinases, by either stimulating or inhibiting
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Identification and Isolation of Osteogenic Progenitor Cells
Invention A novel gene, termed chromatin remodeling protein (ChroM1), from osteoblast progenitor cells has been cloned and sequenced. ChroM1 functions as a transcriptional regulator of genes involved in osteoblast differentiation and is differentially expressed on osteogenic progenitor cells. It c
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A novel antibiotic for the control of biofilm formation
Invention TA is a broad spectrum antibiotic differing from known antibiotics by virtue of its adhesiveness to synthetic materials and to biological tissues, whilst retaining its bactericidal activity in the bound form. TA may be topically administered to the implanted device or infected zone withou
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Method for the synthesis of carboxylic acids from aldehydes
Invention An improved method for the preparation of carboxylic acids from aldehydes.The improvements consist of reducing the amount of environment polluting chemicals, higher yields and higher reaction rates than with conventional methods. The Need The known processes for preparing carboxylic aci
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High Power Transistors for Use At High Frequencies
BACKGROUND Prof. Mo Missous at the School of Electrical and Electronic Engineering, the University of Manchester has developed a family of prototype high power high frequency transistors with high breakdown voltage (>20V). They are InP-InGaAs/InAlAs. pseudomorphic High Electron Mobility Transistors
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Implementing Mimo in Mobile Devices By Means of Virtual Receive Antennas
BACKGROUND MIMO (Multiple-Input Multiple-Output) technology is increasingly viewed as a solution to the ever increasing data rates required in mobile devices and its use is taking off, particularly in wireless LAN networks and future cellular communication systems. Among the existing MIMO schemes, s
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Manchester bobber
BACKGROUND Wave energy is a major potential source of renewable energy especially for an island nation. The total power of waves breaking on the world's coastlines is estimated at 2 to 3 million megawatts. In favourable locations, wave energy density can average 65 megawatts per mile of coastline. T
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Removal of Toxic Contaminants from Water
BACKGROUND Industries are under increasing pressure to reduce the pollution being discharged in their effluents. This is due to increasingly stringent legislation in the UK, Europe and elsewhere, such as the ‘Urban Waste Water Treatment Directive’. There is heightened public awareness, concern over
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Leakage Detection Remote Pipeline Inspection
BACKGROUND AcoustekTM is a new, patented pipeline inspection tool, developed in the University of Manchester, which can detect and locate blockage and leakage in pipelines using acoustic techniques. The system is capable of remote application in pipelines and more complicated pipeline networks, with
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