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Novel Adsorbent Systems for Water Purification Using Metal Oxide Bound to Substrate and Heated Metal Oxide Particles

Introduction There is an ever increasing need for potable water. Improvements in conventional purification technologies allow for savings in both time and money and ensure that clean water is available in areas that need it. Technology Description Professor Benjamin at the University of Washington h
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Inductive Salinometer with Data Logging Capabilities and Toroidal Sensor

Introduction Salinity levels in seawater are not constant and can vary dramatically both temporally and spatially due to phenomena such as temperature, precipitation, deep-water upwelling, and tidal action. These variations are especially pronounced in coastal and estuarine waters where seawater int
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Inductive Salinometer with Data Logging Capabilities and Toroidal Sensor

Introduction Salinity levels in seawater are not constant and can vary dramatically both temporally and spatially due to phenomena such as temperature, precipitation, deep-water upwelling, and tidal action. These variations are especially pronounced in coastal and estuarine waters where seawater int
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3-D Tissue Culture Chamber

Introduction Many of the seminal findings in cell and molecular biology have come from cultures of cells grown in two dimensions but the limitations of biology in just 2D are becoming clear. Cells in tissue are not just autonomous masses but consist of many interdependent cell types and their surrou
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Optimum Wireless Communication through Unknown Obscuring Environment Using Time-Reversal Principle

Introduction Wireless communications are often hampered by surrounding environments such as buildings, geographic terrain, trees, and other objects. Conventional techniques analyze the communication characteristics in a complex medium by assuming several models for the environment and calculating th
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A Microfluidic Device and Methodology for Rapid, Quantitative Determination of Analyte Concentration in a Fluid Sample

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, especially for biosensors and environmental monitoring. One recent area of interest is point-of-care diagnostic devices. These devices provide fast, accurate, and inexpensive sample analys
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Extending Tissue Preservation

A method of sustaining cells is provided. The method can include providing a non-perfluorocarbon cell storage medium, providing a pre-oxygenated liquid perfluorocarbon in contact with the storage medium, and placing the cells in contact with the storage medium but not in contact with the perfluoroca
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Transparent Contacts Organic Solar Panel by Spray

A method of fabricating organic solar panels with transparent contacts. The method uses a layer-by-layer spray technique to create the anode layer. The method includes placing the substrate on a flat magnet, aligning a magnetic shadow mask over the substrate, applying photoresist to the substrate us
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Human Immunosuppressive Protein

A composition of an immunosuppressant protein (HISP) which is achieved by the steps of obtaining supernatant from hNT neuronal cells; exposing the supernatant to preparative polyacrylamide gel; placing the active isoelectric fraction on a Blue Sepharose column to bind albumin; and collecting the fre
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Auto-Tuning Amplifier

Introduction In wireless communications and wireless products, architectures can be complex and space-consuming due to the need for circuitry that receives signals from multiple bands. System complexity and increased size leads to higher costs; thus, design improvements that save space and decrease
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TLR2-mediated adjuvant activities of LT-II B subunits

The present invention deals with heat-labile enterotoxins (LT-IIs) in which the toxic A-subunits are absent, leaving only the nontoxic B pentamers. Researchers found that despite the absence of toxic A-subunits, the B-subunits alone are immunostimula tory and that their ability to activate NF-?B and
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Stent Vascular Intervention Device and Method Modification

A team of University at Buffalo researchers has developed novel stent vascular devices for the treatment of cerebral aneurysms. The new stents can be deployed by a conventional balloon-catheter and a single stent could replace the use of multiple emb olic coils resulting in reduced procedure duratio
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Erogorgiaene derivatives and method for making

Marine-derived bioactive compounds hold great promise as therapeutics in the treatment of human disease. One particular family of marine-derived diterpene compounds has demonstrated anti-cancer, anti-tubercular and anti-inflammatory activities. How ever, the complete evaluation of such compounds and
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Near-Infrared Spectroscopic Instrument for Non-Invasive Clinical Chemistry

Introduction The analysis of biological samples is essential during patient care. Many such samples are traditionally measured using lengthy and complicated procedures which require the preconditioning of a blood sample withdrawn from the body. Preconditioning can be a lengthy and expensive process
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Episodic Monitor

Introduction Epilepsy affects over three million Americans and is characterized by recurring seizures, which typically involve problems with motor, sensory, and/or cognitive functions. These seizures may occur with or without loss of consciousness. One of the hazards of having a seizure, especially
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Stabilized Plasma Light Source for EUV Lithography

Introduction Researchers at the UW have developed a novel technique to produce a gas discharge plasma with a lifetime up to 2000 times longer than conventional methods. The plasma can serve as a stable light source for extreme ultraviolet lithography processing of microelectronic devices. Technology
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High-efficiency Light-emitting Diodes Using Neutral Surfactants and Aluminum Cathode

Introduction Light emitting diodes (LED) are desirable for displays due to their high energy efficiency, as compared to more traditional technologies like liquid crystal displays (LCD), which require a backlight. However LEDs are expensive to manufacture. Organic light emitting diodes (OLED), are a
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Shadow Edge Lithography for Fabrication of Nanoscale Structures

Introduction Fabrication of structures at dimensions below 45 nanometers (nm) is a challenge facing commercial semiconductor and emerging nanofluidic devices. The ability to create nanochannels, nanowires, nanodots, and nanogaps will open up a new generation of components for electronic and biotechn
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A Method of Selective Foaming for Porous Polymeric Material

Introduction The ability to create porous polymeric material has a wide diversity of applications ranging from commercial packaging to Lab-on-a-Chip devices due to its ability to create material with reduced weight and tunable pore sizes and its ability to realize utility from different polymers—inc
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Method of Detecting, Characterizing, and Quantifying Bulk, Light-Element Materials Using High-Energy, Penetrating X-Rays

Introduction X-rays have long been used in the characterization of a wide variety of materials. However, conventional techniques for dealing with light-element (or low-Z) materials, such as those containing nitrogen and carbon, are too low in energy to penetrate significant distances into enclosing
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Microcellular Electrical Wire Coatings

Introduction In microcellular plastic foams, inert gas is dissolved in thermoplastic under high pressure. The forced evacuation of this gas during processing creates pores (or cells) within the final hardened plastic. These cells are small enough that clarity of the plastic is unaffected, and becaus
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Air Velocity Sensor System

Introduction Detailed airflow measurements are not always easy or practical to obtain, especially when needing them over multiple points in time and space, when needing high precision, or when needing data from normally inaccessible locations. Technology Description Professor Mamishev at the Univers
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Air-Stable p-Type Semiconducting Polymers

Introduction Conjugated polymers and organic semiconductors promise great advances in electronics because of the benefits they offer over silicon, including being cheaper with less demanding manufacturing requirements and allowing for larger, more flexible, and more robust materials that are more re
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Volume Exclusion Agent to Enhance Formation of Extracellular Matrix

A method of enhancing the formation of extracellular matrix in culture. Cells in culture secrete most of the collagen into the media as unprocessed procollagen, i.e., the cells do not convert procollagen to collagen. In contrast, normal extracellular matrix deposition involves procollagen processing
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Respiratory Detection System (RDS)

Introduction Respiration rates are an important indicator of cellular and metabolic states in cells ranging from mammalian to bacterial, from individuals to large populations. Unfortunately, conventional techniques have significant drawbacks: for instance, electrochemical techniques have low sensiti
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Microporous Micromolding

Introduction In microcellular plastic foams, inert gas is dissolved in thermoplastic under high pressure. The forced evacuation of this gas during processing creates pores (or cells) within the final plastic. These cells are small enough that clarity of the plastic is unaffected, and because of the
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Advanced Biomimetic Surfaces for Surface-Enhanced Raman Biomimetic Surfaces for Surface-Enhanced Raman

Introduction Raman spectroscopy characterizes molecules by their Raman scattering. As incoming light scatters off a molecule, most does so elastically, neither gaining nor losing energy, and this is known as Rayleigh scattering. Some of this light, however, about 1 in 10 million photons, is the subj
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Advanced Biomimetic Surfaces for Surface-Enhanced Raman Biomimetic Surfaces for Surface-Enhanced Raman

Introduction Raman spectroscopy characterizes molecules by their Raman scattering. As incoming light scatters off a molecule, most does so elastically, neither gaining nor losing energy, and this is known as Rayleigh scattering. Some of this light, however, about 1 in 10 million photons, is the subj
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Programmable Generation and Transport of Droplets on Microscale Generation and Transport of Droplets on Microscale

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications. Currently, many laboratory processes can be combined on a single chip commonly only millimeters in size while manipulating liquid volumes of picoliter size or less. In order to effectively
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Solution Processable n-Type polymers

Introduction Conjugated polymers and organic semiconductors promise great advances in electronics because of the benefits they offer over silicon, including being cheaper with less demanding manufacturing requirements and allowing for larger, more flexible, and more robust materials that are more re
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Tissue-Engineered Urinary Bladder Using Autologous Cells

Introduction There is a variety of reasons that a person’s bladder may fail or require removal, including bladder acontractility, cancer, and cystitis. Unfortunately, conventional artificial bladders tend to suffer from critical complications, such as inadequate performance, infection, and adverse h
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Novel Adsorbent Systems for Water Purification Using Metal Oxide Novel Adsorbent Systems for Water Purification Using Metal Oxide

Introduction There is an ever increasing need for potable water. Improvements in conventional purification technologies allow for savings in both time and money and ensure that clean water is available in areas that need it. Technology Description Professor Benjamin at the University of Washington h
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Novel Adsorbent Systems for Water Purification Using Metal Oxide Novel Adsorbent Systems for Water Purification Using Metal Oxide

Introduction There is an ever increasing need for potable water. Improvements in conventional purification technologies allow for savings in both time and money and ensure that clean water is available in areas that need it. Technology Description Professor Benjamin at the University of Washington h
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Sample and hold circuit and method for maintaining unity power factor

An AC electrical system has a source voltage and current interconnected through an energy storage device with a load. A unity power factor control circuit maintains unity power factor incorporating the steps of producing a sample and hold voltage related to the input voltage and an output voltage wh
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Monopolar fuel cell stack coupled together without use of top or bottom cover plates or tie rods

BRIEF SUMMARY OF THE INVENTION A novel stack design is disclosed below that overcomes the limitations of the conventional bipolar fuel stacks bipolar fuel stacks is proposed. This new stack design offers a two-to-three fold improvement in power densities, suitable for manufacturing, uses inexpen
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Contact Lens as Computing Interface

Introduction The study of human-computer interaction (HCI) strives to understand and evolve how people interact with computers in order to develop systems that are more usable and more responsive to a user’s actual needs. One important aspect of this field is the design of interfaces, best exemplifi
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Multilevel Modulation for Free Space Optical (FSO) Communications and Error Correction Methodology

Introduction Wireless optical links, or free space optics (FSO), enable point-to-point, high-speed communication with low installation costs and high levels of security, and they are especially useful in situations where fiberoptics are impractical. Unfortunately, this technique suffers from signal
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Carbon Nanotubes by Electrospinning with a Polyelectrolyte and Vapor Deposition Polymerization

Introduction Ever since the discovery of carbon nanotubes they attracted a great deal of attention due to the myriad of possible applications, such as in fuel cells, lithium-ion batteries, and supercapacitors. Nevertheless, the synthesis of well-defined carbon nanotubes of 50 to 100-nm diameter has
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Carbon Nanotubes by Electrospinning with a Polyelectrolyte and Vapor Deposition Polymerization

Introduction Ever since the discovery of carbon nanotubes they attracted a great deal of attention due to the myriad of possible applications, such as in fuel cells, lithium-ion batteries, and supercapacitors. Nevertheless, the synthesis of well-defined carbon nanotubes of 50 to 100-nm diameter has
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Method for Fast Crosslinking of Silicone Compounds at Low Temperature By in Situ Water Generation

Introduction Deposition of small amounts of functional materials has recently become a matter of intensive research. Inkjet printing technology is a promising and widely used technique for the fabrication of small parts with specific functionalities into welldefined locations. The limits of this tec
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A method for quantitative, proteome-wide analysis of protein phosphorylation

Introduction Protein phosphorylation is one of the most important regulatory events in cells. The state of activity of numerous enzymes and processes and the association of specific proteins into functional complexes are frequently controlled by reversible protein phosphorylation. Because cellular p
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Method for Deconvolving Single-Molecule Intensity Distributions for Quantitative Biological Measurements

Introduction Fluorescence microscopy images of cells often contain puncta, or clusters of fluorescence signal. To measure the concentration of labeled proteins in a puncta, calibration typically needs to be performed for each fluorescence species. Traditional calibration techniques only provide aver
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A Method and Design for Performing Rapid Parallel Microfluidic Molecular Affinity Assays

Introduction Point-of-care diagnostic testing, or testing performed at the patient bedside, allows physicians to diagnose patients more rapidly than traditional laboratory-based testing. Rapid results can enable better patient management decisions, improved patient outcomes, and a reduction in the o
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Signal Amplification Method for SPR-based Chemical Detection

Introduction Surface plasma resonance (SPR) is a general spectroscopic method for sensing refractive index changes near the surface of a metal film. Its sensitivity to these changes provides a versatile platform for the observation and quantitation of chemical reactions and intermolecular binding at
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Catch and Release Method for Charged Particle Concentration

Introduction Cell separation in a microfluidic device can be difficult at times. One difficulty researchers face is the ability to capture and separate charged particles when carried in an aqueous solution. Technology description Our researchers have developed a microfluidic method and device to cap
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Novel Optical Micro-manipulator and Micro-rotator

Introduction Non-invasive manipulation of micro- and nano-scale objects with rotational capability is attractive for various biomedical applications such as constructing biofims, human tissue engineering, and in vitro fertilization. The technology is also uselful for nano-fabrication such as alignin
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Fast Calibration for 3D Ultrasound Imaging and Multimodality Image Registration

Introduction Three-dimensional (3D) localization of two-dimensional (2D) ultrasound (US) images involves the determination of the position and orientation of a set of acquired 2D US images with respect to a given coordinate system. Accurate image localization is critical when US is used for the mea
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Direct Reading, Quantitative Biosensors for Measuring Chemical Concentrations

Bioluminescence and chemiluminescence are chemical oxidation processes that result in photon emission. Adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide (NADH) are two molecules that play unique and central roles in biology and are the basic coupling agents of cellular metabolism. M
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Colorimetric imaging for abdominal organs

Introduction Color, a significant aspect of visual input, can provide medically relevant information. Visual input is critically important to surgeons as it provides 70% of the sensory input. Accurate representation of the color of organs and tissues is important to better understand the impact of m
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Ribozymes for Treating Hepatitis C

Introduction Hepatitis C virus (HCV) is one of the main causes of liver-associated morbidity and mortality, and is the leading indication for liver transplantation in the western world. It is estimated that HCV infects more than 170 million people worldwide, including 2-4% of Americans. In about 70%
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Targeted Gene Modification by Parvoviral Vectors

Introduction Though the development of integrating vectors based on eukaryotic viruses has made possible the efficient introduction of genes into mammalian chromosomes, there are many situations where it would be preferable to modify specific chromosomal sequences. This ability could eliminate unwan
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Copper Chloride-mediated Synthesis of Silver Nanowires

Introduction Owing to the high electrical and thermal conductivity of bulk silver, the synthesis of Ag nanowires has been and continues to be an area of active research. The properties and applications of the nanostructures are determined by the shape, size, structure, and composition of the nanostr
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Safe last step

Introduction A common cause of injury among orchard workers in Washington state occurs when the user dismounts the ladder. The user often cannot accurately gauge the last step of the ladder because the line of sight is obscured by the apple bag when descending the ladder, with their back facing the
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Use of Liquid Junction Potentials for Electrophoresis without Applied Voltage

Introduction One of the problems with producing a small field usable microfluidic device is the requirement to have some form of power to make it work. More and more devices currently being developed will either require the system to work with a minimal power supply or none at all. Technology descri
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Laser Treatment of Acne Using Scanning Fiber Delivery

Introduction Acne is a problem that affects approximately 85% of all teenagers. The typical drug treatments, such as isotretinoin, are known to have many risks and side effects. Many other over the counter treatments have little or no effect. Technology description Researchers at the UW have develop
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Removal of Toxic Metal from Wastewater

Highlights New method for removing metals, including toxic metals, from industrial or domestic wastewater and seawater Simple flow system may be integrated into conventional industrial or municipal treatment facilities Enables purification of water to environmental standards for sewage system or
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Extrusion of Solid State Polymer Foams and Foam Composites

Introduction Microcellular polymers are plastic foams with cell size on the order of 10 um in diameter. Technology description Researchers at the University of Washington have developed methods for continuous production of solid-state foamed plastics and composites. These methods are based on proces
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Improved use of Recombinant Viruses for Liver Regeneration

Introduction Diseases of the liver, both genetic and acquired, are especially detrimental due to the fact that the liver is a key organ for most metabolic pathways. Currently, the only method of curing liver diseases is via a liver transplant. Unfortunately, many transplants succumb to rejection, le
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Thermo-reversibly Crosslinked Cladding Materials with Highly Tunable Conductivity for Nonlinear Optical Polymer-based Devices

Introduction A typical electro-optic waveguide device includes a lower electrode layer, a lower cladding layer, an active guiding layer, an upper cladding layer, and an upper electrode layer. The purpose of the cladding layers in an electro-optic device is to confine light in the active guiding laye
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Concentration and Selectivity of Nucleic Acids using a Nano needle

Introduction There is a need in the medical industry for cost-effective, non-invasive methods of sampling biological fluids that often contain bio-markers such as nucleic acids, which can be indicative of disease states; thus, sensitive and specific diagnostic tests to locate bio-markers are needed.
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Solubility Enhancing Fusion Proteins

Introduction Recombinant proteins having therapeutic, diagnostic or any other commercial or research applications are produced by expression in a host cell. However these proteins of interest are often misfolded and form insoluble aggregates known as inclusion bodies. Inclusion bodies are difficult
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Acousto-optic Modulators with a Broadband Spectrum Throughput and a Tunable Peak Wavelength

Introduction Optical coherence tomography (OCT) is an emerging technology that can image tissue microanatomy at depths of up to 2mm in real time. Technology description Researchers at the UW have developed a method to optimize the optical spectral throughput of a pair of acousto-optic modulators (AO
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Redoxint project

Here are some key phrases that describe the Redoxint project: 1. Completely ecological industrial platform without any gas emittion or other polluting materials. 2. Burning thousands of tonnes of household waste annually per furnace (without needing selection). 3. Alternative fuel production at c
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Microcellular and Nanocellular Thermoplastic Thin Films as Printing Media

Introduction Common overhead transparencies and movie film is made from PET. UW researchers are using PET foaming to increase brightness, decrease mass, and make tear-resistant print media. Technology description Researchers at the UW have developed a method to substitute printing papers used in bus
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Efficient Loading of Hollow Polymeric Particles

Introduction The encapsulation of active materials in colloidal particles has enabled a variety of new, high value products to be developed; such as controlled release drugs, cosmetics, pigments, and chemical reagents. Introducing functional material into hollow polymeric particles is typically limi
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Magnetostrictive Composites and Process for Manufacture by Dynamic compaction

Magnetostrictive alloys change in dimension in response to an applied magnetic field, and have been used in sonar transducers, actuators, vibration control and sensors. Of particular interest are alloys of iron and rare earth elements that have large magnetostriction constants. These include alloys
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Rapid synthesis of small silver nanocubes by mediating polyol reduction with a trace amount of sodium sulfide or sodium hydrosulfide

Introduction The impact of metal nanostructures is continually increasing as we become more capable of producing them with well-controlled sizes and shapes for fine-tuning their properties and further development of emerging applications. Silver has been one of the most studied materials for nanostr
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Fiberglass Siding

RBG SuperSiding (TM) is a patented fiberglass siding product with a "SEAT" design that creates an Air & Water tight seal when applied to any exterior wall. The advantage of this design allows for much faster install; reducing labor costs by as much as 50%. RBG SuperSiding is manufactured using a
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Methods and Apparatus for Force Reduction in the Self-Piercing Riveting Process with Resistance Heating and Multi-Step Punching

Introduction Self-piercing riveting (SPR) requires a very high processing force to finish its piercing and riveting actions. U.S. auto manufacturers are hesitant to adopt SPR because of this particular disadvantage. Reducing the processing force is therefore a key factor in eventually adopting SPR f
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Method of High-Performance CMOS Design

Introduction Dynamic circuit families such as domino are commonly used in today’s highperformance microprocessors for obtaining timing goals that are not possible using static complimentary metal oxide semiconductor (CMOS) circuit. Their increased performance is due to reduced input capacitance, low
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Method to inhibit ectopic calcification by blocking phosphate uptake

Introduction Vascular calcification is associated with cardiovascular morbidity and mortality. A number of diseases are associated with ectopic calcification including calcific aortic stenosis, idiopathic arterial calcification, fibrodysplasia ossificans progressiva, calcific uremic arteriolopathy,
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Fluid flow assisted dielectrophoretic alignment and sorting of Nano/bio materials

Introduction The accurate and precise sorting and deposition of nano/bio materials within a nano- or micro-environment is critical for the functionality of devices such as biochips. Fluid flow in a microchannel is one method of controlling long-range transport and electric fields may be employed to
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Direct Phase-based Strain Estimator for Ultrasound Tissue Elasticity Imaging

Introduction Strain estimation is used when studying and diagnosing tissues that have hardened from disease. Tumors are typical examples of such tissues. Information about stiffness and elasticity obtained from strain estimation help doctors and researchers determine stage and type of disease. Techn
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Membrane for the separation of CO2 in medical systems

In the field of medical systems, removing CO2 contributes to a more effective recycling of anaesthesia gas, thereby reducing costs and improving the working environment in the operating room. Gas separation membranes offer a more cost-efficient and less complex alternative to traditional gas separat
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Cold Extrusion of Aluminium

Recycling of aluminium is highly energy efficient compared to making virgin metal, but still the recycling process can be improved upon. By avoiding the problems related to melting of scrap aluminium, even more energy can be saved and more material can be recycled (less loss to oxidation). DESCRI
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Fixed Site Carrier Polymer Membrane for high pressures

Research into CO2 technology is receiving increased attention due to the rapid increase in concentration the last 100 years, and the problems that it may cause for our environment. This technology is developed to clean combustion gases of CO2 so that it can be stored or used for enhanced oil recover
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Sorption material using Li/Na Zr

Production of hydrogen from natural gas sources (methane) is energy consuming and this technology enables the manufacturing of a sorbent material that has the potential to reduce this energy cost by 10 – 30% depending on process (PSA, SESMR). The material has applications for other areas as long
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Carbon Membrane

Research into CO2 technology is receiving increased attention due to the rapid increase in concentration the last 100 years, and the problems that it may cause for our environment. This technology is developed to clean biogas to reach fuel quality, but can be used for virtually any CO2 separation pr
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The coanda gripper

Automatic handling of porous and soft materials The Norwegian University of Science and Technology (NTNU) is actively seeking companies to license an exciting novel gripping technology for robotic applications. The Coanda gripper opens new opportunities and enables increased quality and cost reducti
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Contra-Rotating Propeller for Hydropower

Mini- and micro power plants have become more important in recent years, and small-scale water turbines are in demand. The contra-rotating propeller is easily manufactured, easy to move and adapt from one water- course to another. It can serve as a power generator, pressure reducer or as an element
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Tensegrity structure for offshore use

In the aquaculture and fish farming industry, flexible and reliable net cage structures are vital. Large installations which are easily transported/moved without being compromised are a pain in the market. The repeating cell system of the tensegrity structure is of great flexibility and low weight,
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Burner for combustion of gaseous fuels

During the production of heavy oils from, for example oil-sand, it is necessary to burn gaseous fuels produced in the process of cracking the heavy molecules of the heavy oils. DESCRIPTION The inventors of the technology are researchers at NTNU and SINTEF. The invention consists of a burner geom
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Metal-composite interface for tubular structures

The technology has its main application as a solution for end-termination of tubular structures of composite materials. Carbon-composite risers for oil and gas production are one important arena where the technology can be used. This interface offers a stronger, more secure and less costly soluti
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High capacity drill pipe for oil recovery

In the field of oil extraction, drilling new wells is crucial for increased oil recovery. A wide range of measurement and steering tools is needed to improve well placement and identify a reservoir’s “sweet” spot. High-speed, real-time data transmission in wired drill pipe is essential to obtain max
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Recuperative heat exchanger for aluminium production

The production of aluminium results in huge amounts of waste gas which consume a lot of power in disposal because the gas holds a high temperature. It is essential to recuperate as much heat as possible from the waste gas, a procedure that is limited by current technology. If a solution can be fo
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Liquefied Natural Gas Chain

The technology has its main application in the area of LNG handling. An improved transport chain involving CO2, nitrogen and LNG is incorporated to obtain enhanced oil recovery while optimizing ship utilization and saving power by preservation of cooling properties in both ends of the new LNG chain.
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Methods of Inhibition of Stenosis and/or Sclerosis of the Aortic Valve

Introduction Calcific aortic valve disease (CAVD), ranging in severity from sclerosis to stenosis, is characterized by irregular areas of increased thickening on the aortic side of the valve. Until recently, CAVD was thought to be a degenerative and therefore unmodifiable disease. No pharmacological
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Methods and compositions for prevention or treatment of inflammatory-related diseases and disorders

Introduction Leukocyte adhesion and migration plays a key role in response to inflammation and infection. This process is a well-orchestrated series of adhesion, de-adhesion, signaling and cytoskeletal changes that is tightly regulated. Upon activation, i.e., by cytokines or chemokines, leukocytes r
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Method for Generating Human Retinal Neurons and Phoreceptors from Embryonic Stem Cells

Introduction There are a number of degenerative conditions, both inherited and acquired, that affect the retina and lead to blindness. Retinal photoreceptors degenerate from inherited conditions, such as retinitis pigmentosa or as a result of light damage or normal ageing; retinal ganglion cells deg
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Quotation Highlighting in a Hypertext System

A hypertext system is for the display of text information grouped as documents. Within documents there are references, called links, to other documents or portions of the same document. Text associated with a link may be highlighted or displayed in a way that indicates that there is a link. The docu
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Ring Resonator on a Side Polished Optical Fiber

Introduction As telecommunication and computing devices increasingly move towards optical transmission, the ability to filter optical signals with devices such as ring-resonators, without incurring signal loss becomes more important. Additionally, ring-resonators can be used as sensors in a number o
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Microfluidic Device and Surface Decoration Process for Surface Capture-Based Bioassays

Introduction Immunoassays remain the most versatile and rapid method for the detection of chemical and biological warfare (CBW) threat agents. Current requirements from our military and government is to be able to deploy a field hardened and easily mobile device. Historically this has led to serious
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Droplet Compartmentalization for Chemical Separations and On-Line Sampling

Introduction The ability to separate complex mixtures of chemicals and biomolecules is an important component of any chemical synthesis or biological processing. To date, there is no technology available to combine the high resolution of analytical separations with monodisperse droplet generation. I
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Microfluidic Device and Method for Detection and Separation of Particles by Isoelectric Focusing

Introduction Electrophoresis and isoelectric focusing techniques are well suited to rapid isolation and detection of biological particles. Microfluidic devices are particularly amenable to electrophoresis-based applications, offering advantages such as low reagent and sample consumption, reduced ene
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Electrospinning of Polymeric and Ceramic Nanofibers as Uniaxially-Aligned Arrays

Introduction Nanotechnology is the use of nanoparticles, which are particles made to a scale measured as one millionth of a millimeter. One difficulty associated with manufacturing to this scale is manufacturing nanofibers out of polymeric and ceramic materials. Another problem is finding a method t
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Inducible Mutagenesis of Target Genes

Introduction The B cell alters its genome during differentiation, and under environmental signals. The plasma cell DNA is rearranged during the cell’s development from a B cell to create the antibody-encoding genes. The genetic mechanisms contributing to variability are 1/ somatic hypermutation that
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Intraoperative Dosimetry for Prostate Brachytherapy using Transrectal Ultrasound and X-Ray Fluoroscopy

Introduction Prostate Brachytherapy is a method of treating prostate cancer by strategically placing small, radioactive “seeds” into the prostate. During a typical treatment, about one hundred seeds are implanted creating a radioactive field within the prostate. Intraoperative Dosimetry is the techn
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A Chemical Enhancer of Net Photosynthesis

A University of California researcher has isolated genes (described in PCT application #WO00029607A1) from the soil bacterium Sinorhizobium meliloti (a symbiont naturally found with alfalfa) that produce a molecule that increases net photosynthesis by 25% to 30% within 20 hours after being applied t
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Protein Microarray Fabrication with Novel Functionalization

Introduction Protein microarrays are enjoying increasing use in both research and diagnostic applications. One of the key challenges in protein microarray manufacture is the fixation of the protein or the protein ligands of interest on the microarray surface with a robust linkage that doesn’t alter
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Sports Training Device - Optimal Point of Impact: Perfection Sleeves.

OPOI’s Perfection Sleeves are designed to isolate the optimal point for hitting a golf ball during driving or iron play. This point is surrounded by a dense silicon, which, when contacted, absorbs the energy from the hit and reinforces the ball’s dead spot. When incorrect technique is used the club
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