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Inhibiting Binding of Inducible Nitric Oxide Synthase to Cyclooxygenase-2 to Treat Inflammation
Cyclooxygenase (C0X2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. Inducible NOS specifically binds to C0X2 and S-nitrosylates it, enhancing C0X2 catalytic activity. Selectively disrupting iN0S-C0X2 binding prevents NO-mediated activation of C0X2. The synergistic
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A Compression Device for Enhancing Normal/Abnormal Tissue Contrast in MRI
This invention is a pneumatic device for detecting breast cancer with MRI. The device enables imaging of the elasticity (stiffness) of the tumor and mechanical properties of the surrounding tissue through the use of the SENC (Strain Encoding Imaging) spectrum. The SENC technique also allows for real
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Reactive Oxygen Generating Enzyme Inhibitor with Nitric Oxide Bioactivity and Uses Thereof
In the US, CHF is the number one cause of hospitalization in people over age 65, and it affected approximately 5 million people in 2004. This translates into a potential cost of $29 billion for the healthcare system. In the US over half a million new cases are diagnosed with, and over 50,000 individ
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Neuropilin-1 Sema Mice
Neuropilin-1 (Npn-1) is a receptor that binds ligands from structurally distinct families like semaphorins (Sema) and vascular endothelial growth factors (VEGF). Npn-1 is a type I transmembrane protein with a small cytoplasmic domain and multiple extracellular domains capable of mediating a variety
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IB3-1
Cystic Fibrosis bronchial epithelial cell line isolated from a patient with genotype ?F508 /W1282X. Cells were immortalized with adeno12SV0. Description (Set) Proposed Use (Set) This cell line will be useful for the identification of drugs that treat cystic fibrosis.
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Immortalization of Nociceptive Dorsal Root Ganglion Sensory Neurons
This invention involves a novel method to immortalize nociceptive dorsal root ganglion (DRG) neurons. DRG neurons are terminally differentiated cells that extend long axons to their target tissues. More than half of all DRG neurons are unmyelinated axons that extend to the skin and have nociceptive
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Gowth of Mesenchymal Stem Cells Under Non Adherent Conditions for Clinical Applications
The use of bone marrow derived mesenchymal stem cells (MSC) has been proposed for a number of regenerative therapies including repair of myocardial tissue. The data to date has suggested improved functional outcomes but have failed to demonstrate incorporation of MSC into the tissue. These studies
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Method for identifying mutations in coding and non-coding DNA
Annotation of the completed human genome has demonstrated that about 1.5 % encodes protein. About twice (roughly 3.5%) falls within non-coding sequence and is suggested to be functional based on extensive (>50nt) sequence conservation. The remainder of the genome consists of non-coding DNA with less
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Novel Drugs for the Treatment of Optic Nerve Disease
A small molecule library was screened using an RGC cell culture system for novel factors that promote RGC survival and outgrowth. Five novel compounds have been identified that promote the development of neuritis and/or survival of cultures of retinal ganglion cells. These compounds are beneficial i
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Inhibition of Ischemia-induced Arrhythmias by Blocking Mitochondrial Inner Membrane Ion Channels
This invention describes a method for preventing and/or terminating ischemia-related arrhythmias by targeting the mechanism responsible for the electrical instability occurring during an ischemic episode or upon reperfusion of the heart. Inhibition of a mitochondrial inner membrane anion channel, ei
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Large-scale Survival, Differentiation and Structural Integration of Human Neural Stem Cells Grafted into the Adult
The present invention provides methods and compositions for treating spinal cord diseases and injuries. The methods involve transplanting neural stem cells which have been previously expanded in vitro into a patient such that the cells can ameliorate the disease or injury. The stem cells to be trans
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Total Human Serum Free IgE Immunoenzymetric Assay (IEMA)
Xolair (generic name, omalizumab) is currently approved by the FDA for the treatment of extrinsic asthma. Presently, there are no serological markers or assays for monitoring the efficacy of prolonged Xolair therapy in patients with extrinsic asthma. Monitoring the free IgE level in the blood is on
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Hi-Throughput Assay for Screening Small Molecule Inhibitors of Uracil DNA Glycosylase
Uracil DNA glycosylase (UDG) is one of the primary enzymes that prevents the incorporation and accumulation of deoxyuridine in genomic DNA. The identification of pharmacologic agents that inhibit UDG is desirable for both investigational and therapeutic purposes. JHU scientists have developed a nove
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Short Chain Fatty Acid (SCFA) - Carbohydrate Bifunctional Hybrid Molecules with Novel Anti-cancer Properties
Butyrate, a natural short chain fatty acid (SCFA), is well-established to have anti-cancer properties via its ability to induce cell cycle arrest and apoptosis in cancer cells. Currently, several clinical trials are underway for treatment of cancer (leukemia, prostate, sickle cell ulcers and liver d
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Instrument System for Managing and Cherry Picking Microorganism Collections
Large biomaterial collections require precise and selective access to a subset of material under sterile conditions. JHU researchers have invented a novel integrated instrument system built from existing standard components that allows efficient management of large, complex libraries of biomaterials
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A Multifunctional Intermediate for Imaging PSMA
The present invention includes a novel Prostate Specific Membrane Antigen (PSMA) intermediate. This molecule can be functionalized to become either a nuclear, optical, or magnetic resonance based imaging agent as well as radiohalogen or radiometal therapeutic agents. The PSMA imaging agent can be ad
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Transcaval Mesenteric Venous Anastomosis and Access System
This device is used to create a percutaneous anastomosis between the Inferior Vena Cava (IVC) and the mesenteric/portal system. The subsequent anastomosis can be used to divert blood flow for the reduction of portal hypertension; and provide access into the mesenteric, portal, and splenic system for
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Modulation of Regulatory T cell (Treg) Function
Abstract (Set) Regulatory T cells (Treg) are a subset of the CD4 T cell population that down-modulate an immune response. In some diseases, i.e. autoimmunity, Treg activity can prove beneficial by inhibiting a pathological response. However, under other conditions, including but not limited to
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Olfactory Receptor I7 Targeted O/E3 Knockout Mice
The mammalian Olf1/EBF (O/E) family of repeated helix-loop-helix (rHLH) transcription factors has been implicated in olfactory system gene regulation, nervous system development and B-cell differentiation. Researchers at Johns Hopkins have generated a genetic knockout transgenic mouse in which the O
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Mouse Monoclonal Antibody 8A2
Abstract (Set) This technology is a mouse monoclonal antibody, which specifically recognizes vertebra SUMO-2 and SUMO-3. SUMOylation is essential for cell-cycle regulation in invertebrates; however, its functions during the mammalian cell cycle are largely uncharacterized. Mammals express three SUM
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Emission Ratiometric Indicators of Phosphoinositides
cellular processes via activation of the serine/threonine kinase, Akt. JHU inventors have developed an emission ratiometric reporter, InPAkt, as research tool for monitoring the production and degradation of PIP(3,4)2 and PIP3 in living cells after transfection with plasmid constructs encoding the r
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Mutational Analysis of the Serine-threonine Kinome in Colorectal Cancers
The invention describes novel mutations in serine-threonine kinase genes within the Phosphatidylinositol-3-OH Kinase (PI(3)K) pathway in patients with colorectal cancer. Details are described in the paper by Parsons et al., 2005 (see below). Description (Set) Proposed Use (Set) The discovery of
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Carcinoembryonic Antigen as a Potential Biomarker for use in Targeted Drug Delivery Applications as well as Other Therapeutic Strategies
Abstract (Set) Blood-borne metastasis is a highly regulated and dynamic process, whereby cancerous cells separate from a primary tumor, migrate across blood vessel walls into the bloodstream, evade host defenses, adhere to the vascular endothelium of distant organs, extravasate and colonize these s
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A Predictive Test for Determining Chemotherapy Regimens in Patients with Cancer
Abstract (Set) The ability to predict sensitivity to individual cytotoxic chemotherapies could improve treatment response and survival of cancer patients. There is currently no method in routine use to determine sensitivity to agents directed at the microtubule, and particularly the taxanes. JHU sc
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Novel Peptide and Delivery Method for the Treatment of Human Cancers
Description (Set) The PIK3 signaling pathway has recently been recognized a major player in the regulation of cell survival and cell proliferation as it relates to cancer. Scientists at JHU have utilized a small peptide based upon a component in this pathway to block cell proliferation and cell cyc
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Monoamine oxidase (MAO) inhibitors reduce cardiac hypertrophy and prevent heart failure
Description (Set) JHU scientists have developed a method to reduce heart muscle cell changes that lead to heart enlargement and congestive heart failure, using agents that inhibit monoamine oxidase (MAO) activity. MAO functions in normal metabolism as an oxidizing enzyme and is present in cardiac m
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High Affinity Small Molecule Inhibitors of Hepatitis C NS3/4A Protease
Description (Set) Hepatitis C virus (HCV) infection is a growing global health problem with over 3 million new cases of HCV infection each year. Johns Hopkins University scientists have discovered a new class of small molecule non-peptidic inhibitors of the HCV NS3/4A protease. The HCV NS3/4A prote
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Novel Cell Surface Receptor Variants as Biomarkers for Hormone-Refractory Human Prostate Cancer
Abstract (Set) Prostate cancer cells depend on hormones and hormone receptor activity for growth and survival. Some prostate cancer cells progress to a phenotype that is aggressive and no longer susceptible to hormone therapies that are standard treatments for prostate tumors. JHU scientists have i
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Cancer Immunotherapy Using Irradiated Tumor Cells Secreting Hsp 70
Abstract (Set) Ovarian cancer is responsible for the highest mortality rate among patients with gynecologic malignancies. Therefore, there is an emerging need for innovative therapies for the control of advanced ovarian cancer. Immunotherapy has emerged as a potentially plausible approach for the c
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Beta-3 Adrenergic Receptor Agonists Reduce Cardiac Hypertrophy and Heart Failure
Abstract (Set) This invention is based on the discovery of a novel role for beta-3 adrenergic receptors (B3AR) in the control of cardiac hypertrophy when the heart is under physical stress. The precise role of B3AR in the heart has not been previously elucidated. In general, beta-1 and -2 adrenergi
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Salivary Rinse and Serum Detection Test for Head and Neck Cancer
Description (Set) A Johns Hopkins University investigator has identified unique profiles of hypermethylated gene promoters that are effective markers of risk for head and neck cancer. Head and neck squamous cell carcinoma (HNSCC) is a disease that is often diagnosed at an advanced stage. The result
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Detection of Virus Exposure as an Etiological Agent in Patients with Sudden Onset of Psychosis
Description (Set) JHU scientists have developed an assay based on detection of certain viral antigens in patients with a sudden and unexplained onset of psychiatric symptoms. This discovery is rooted in the premise that some viruses are implicated as etiological agents in neurological conditions. J
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Dually Targeting the PI3K/Akt and MAP Kinase Pathways in Poorly Differentiated and Undifferentiated Thyroid Cancer Cells has High Therapeutic Promise
Abstract (Set) JHU scientists have discovered an innovative method of targeting aggressive thyroid cancers that are resistant to conventional treatment. Poorly differentiated anaplastic thyroid cancer cells do not respond to radioiodine treatment due to abnormal silencing of iodide-metabolizing gen
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Rapid Induction of Cancer Cell Death by Synergistic Treatment of Tetra-O-methyl Nordihydroguaiaretic Acid (M4N) with either Two Specific Kinase Inhibitors
Abstract (Set) M4N is an anti-cancer drug candidate, which is currently under the first phase of clinical trials. Although M4N can reduce tumor cell growth; it fails to induce quick tumor cell death. JHU scientists showed that the combination treatment of M4N with either two specific kinase inhibit
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Molecular Insights into Breast Cancer Prevention and Therapeutics Involving Novel Genistein Analogs
Abstract (Set) Cancer is the second leading cause of death in the U.S. and claims the lives of around 555,000 Americans each year. An estimated 1.3 million new cases of cancer are reported in the U.S. each year, of which breast cancer accounts for 15.3 percent. In Asia, an area with high soya isofl
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Efficient Hybrid Transistor for Low-Cost Organic Circuitry
Abstract (Set) The Johns Hopkins University seeks a partner to commercialize a novel low-voltage, electron-carrying hybrid transistor. The organic field effect transistor (OFET) operates in a voltage range between 0.1and 10 volts, making it useful for constructing complex organic electronic circuit
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Immunoliposomal Delivery of Vaccine to the Spleen
Abstract (Set) A fundamental problem in all vaccination methods is to present the target antigen to the appropriate population of cells so that the immune system will be sufficiently activated to mount an immune response against cells that exhibit the target antigen. The problem in many cases is th
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Radiolabeled Analogs of Cyclopamine for Imaging Hedgehog Signaling
Description (Set) The hedgehog (Hh) signaling pathway is increasingly recognized as an important therapeutic target in cancer. When Hh signaling goes awry patients may develop a wide variety of tumors including medulloblastoma, glioblastoma, pancreatic cancer, prostate cancer, among others. In addi
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The Method to Enhance Death of Cancer Cells
Abstract (Set) B7-H1 is an immunoglobulin-like immune suppressive molecule broadly detectable on the majority of human and rodent cancers and its functions have been attributed to delivering an inhibitory signal to its counter-receptor programmed death-1 (PD-1) on T cells. JHU scientists have disco
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A New Method for Co-registering PET and CT Images Acquired in Separate Dedicated Small Animal Scanners
Abstract (Set) Background - Positron Emission Tomography in dedicated small animal scanners is a very attractive imaging modality for many research applications due to the high sensitivity and potential for absolute quantification. However, PET images, although revealing valuable functional informa
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Methods to Reduce Mesh Spacing of the Protective Mucus Barrier
Description (Set) Human mucus forms a protective barrier to toxins and infectious pathogens on all the most susceptible surfaces of the body such as the lung airways, gastrointestinal tract, nose, eye, and female reproductive tract. Mucus possesses a mesh-like structure which evolved viruses can by
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LRRK2 Fly Model for Parkinson's Disease
Abstract (Set) Mutations in the leucine rich repeat kinase (LRRK2) gene causes late onset autosomal dominant Parkinson's disease (PD). The LRR protein has two enzyme activities (kinase and GTPase) which play important roles in regulating neuronal death and other cellular functions. We have created
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Novel Antibiotic Treatment of Gliosarcoma Reduces Tumor Size and Increases Survival
Abstract (Set) The present invention is directed to methods of using a bacteriostatic antibiotic to treat glioma and other brain tumors including astrocytoma, oligodendroglioma, glioblastoma multiform but also other cancer types including breast cancer, cervical cancer, AIDS related cancer, gastric
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http://www.jhttportal.jhu.edu/TechTransfer/TechnologyLocator.asp
Description (Set) JHU inventors have identified a population of microRNA (miRNA) associated with a critical neurotransmitter transporter gene regulatory region. miRNA has roles in modulating gene expression levels. Transporter activity is essential to maintain proper neurotransmitter levels in the
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Cost-Effective Method for High-Throughput and Quantitative Analysis of DNA Methylation
Abstract (Set) Investigators at Johns Hopkins University developed a simple and cost-effective approach to detect and quantify the status of DNA methylation, termed MSqFRET. This method couples the well established methylation-specific PCR (MSP) technology with quantum dot-mediated fluorescence res
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Method for Investigating Long-Range Chromatin Interactions in Vivo
Abstract (Set) The packaging of DNA into chromatin, the complex of DNA and protein that makes up chromosomes, is an important mechanism for regulating gene expression. Recent studies demonstrate that long-range chromatin interactions play an important role in transcriptional regulation of genes. Cu
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Tumor Suppressor MicroRNAs Controlling Cancer Cell Growth
Description (Set) Johns Hopkins scientists have discovered two microRNAs that are expressed in normal blood cells, but are not expressed in virtually any of the leukemia-lymphoma cell lines and primary patient samples which have been tested to date. The miRNAs are not expressed in other types of so
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Mosquito-based Malaria Transmission-blocking Antibodies
Abstract (Set) A single effective vaccine against malaria is lacking. As such, the global research effort has focused on developing a "cocktail" vaccine, wherein different life stages of the parasite can be targeted specifically by separate vaccine components. Therefore, one vaccine component of in
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Technique for Identifying and Measuring Narp in Plasma
Abstract (Set) JHU scientists have developed a method of concentrating Neuronal activity regulated pentraxin (Narp) in plasma using taipoxin bound affinity beads. The concentrated Narp is detected using western blot methodology. The method can be used as a diagnostic tool for evaluating the physiol
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CisGenome Software
Abstract (Set) Chromatin immunoprecipitation followed by genome tiling array analysis (ChIP-chip) or by massively parallel sequencing (ChIP-seq) is an extremely powerful tool to understand gene regulatory programs in development and disease. CisGenome is a software system for analyzing genome-wide
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Ras-regulated microRNAs as a novel anti-cancer therapeutic strategy
Abstract (Set) MicroRNAs (miRNAs) are 18-24 nucleotide RNA molecules that regulate the stability or translational efficiency of target mRNAs. miRNAs are frequently dysregulated in cancer cells and can act as both oncogenes and tumor-suppressors. It is estimated that there are approximately 37,170 n
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Modified Pipette Tips for Plasma Collection
Description (Set) Blood collection is a common technique used in a variety of capacities ranging from human to mouse. In all cases, blood coagulation during and after collection can be fairly problematic. Scientists at Johns Hopkins University have invented a modified pipette tip designed to inhibi
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Imaging Methods for Assessment and Quantification of in vivo Antigen Capture and Vaccination
Abstract (Set) Immunization has eradicated many harmful infectious diseases in the Western world. This is commonly achieved by injecting individuals with attenuated pathogens such as viruses and bacteria. By using cancer vaccines, similar success will be achieved for eradicating the most common for
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Cardiac Stem Cell and Myocyte Secreted Paracrine Factors
Abstract (Set) Stem cells hold the promise to revolutionize future reparative medicine through the development of stem cell-based therapies. Transplanting stem cells (either embryonic or adult derived) into damaged myocardium is emerging as a novel means for acute repair and as an alternative to or
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L2 Lipopeptide Vaccine for Prevention of Human Papillomavirus Infection
Abstract (Set) Human papillomavirus (HPV) infections are the most common sexually transmitted infection in the United States. Infection by over 15 different oncogenic HPV genotypes is a cause of cervical cancer. Therefore, a low-cost, broadly protective vaccine that can be delivered without needles
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Removing Insult from Injury: Disclosing Adverse Events
Abstract (Set) Researchers at Johns Hopkins developed 25-minute training video, Removing Insult from Injury: Disclosing Adverse Events that helps to educate physicians and hospitals in how to disclose adverse events to their patients and their families. The video features short vignettes of doctors
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Tandem L2 Fusion Vaccines for Prevention of Human Papillomavirus Infection
Abstract (Set) HPV infection causes 5% of human cancers worldwide. Prevention of HPV infection will eliminate HPV associated cancers and their precursors. However, current licensed vaccines are derived from Ll capsid protein and only target a subset of the oncogenic HPV types (and therefore Pap scr
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Genome-wide Direct Transcription Measurement using Array-based Assay of Labeled Nascent RNA
Description (Set) JHU scientists have developed, optimized and validated an innovative approach for study of nascent RNA transcription. Post-transcriptional regulation of gene expression constitutes critical and wide-spread mechanisms. However, only ongoing transcription accurately reflects momenta
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Revolving Robotic Needle Driver
Abstract (Set) Image-guided robots are manipulators that operate based on medical images. These are modern medical tools with applications in most medical fields, allowing the physicians to perform interventions not only under direct vision, but with the additional help of the transcutaneous data.
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Dual Vector Information via Audible Pulse Oximeter Signals
This invention allows anesthesia providers to audibly detect both a patient�s oxygen saturation and blood pressure. Currently, the pulse oximeter signal carries information about oxygen saturation (via frequency) and heart rate (via time between pules). Modifying the timbre of the audible signal pro
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Arginase, a Target Enzyme for the Treatment of Myocardial Dysfunction in Aging and Heart Failure
We have identified a novel method to treat heart failure and age related myocardial dysfunction by inhibiting the enzyme Arginase. The seminal observations underlying this claim involve the following: We have demonstrated The expression of arginase I and II in rat heart and isolated cardiac myocyte
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A New Method for High-efficiency Integration of Transgenes into Bacterial Chromosomes without a Drug Marker
This invention allows the insertion of foreign DNA into an innocuous site in the bacterial chromosome using the site-specific recombination system of Tn7. Drug selection is not required since this integration event occurs in up to 97% of cells treated. The plasmid that carries this system is curable
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Neuroprotection Actions of EP1 Receptor Drugs
Prostaglandin E2 is the primary product of arachidonic metabolism and is synthesized via the prostaglandin and cycloxygenase pathways. The hormone-like chemical has been shown to affect the central nervous system and can modulate synaptic transmission and neurotransmitter release, the sleep/wake cy
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RAS KO Lines for Drug Discovery
RAS gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are described in the paper by Parsons et al., 2005 Description (Set) Proposed Use (Set) The cell lines described in this invention can be used in screens for novel molecules that target the RAS pathway in human canc
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Fluorescent 6-O-glucosamine compounds to label lysosomes in tumors in vivo and in cell culture systems for detection with optical imaging or fluorescence microscopy
Lysosomes contain numerous proteases, the release of which may play a vital role in breast cancer invasion and metastasis. Lysosomal trafficking may be an important factor affecting lysosomal enzyme release and effective techniques are needed to fluorescently label lysosomes and study the role of l
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Interference of the mir-17 miRNA Cluster as a Novel Cancer Therapeutic Strategy
The MYC cancer gene increases the expression of a cluster of microRNAs that are implicated in the development of human cancers. Researchers at JHU have discovered that MYC regulates a growth regulator, E2F1, through several miRNAs. This novel discovery suggests that interference of E2F1 or other tar
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C38
JHU scientists have created a Cystic Fibrosis bronchial epithelial cell line that was isolated from a patient with genotype ?508/W1282X. Cells were immortalized with adeno12SV0 and later transfected with a cDNA from AAV carrying CFTR truncated for the first 119 amino acids. Description (Set) Pr
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Image Guided Device for Rodent Brains
Stereotaxic device for rodent brains is widely used for various types of brain surgeries, injections, and other types of manipulations. The device is essential for many research labs in Universities and Chemical and Pharaceutical companies. For stereotaxic operations, precision is the key element.
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A Novel Statistical Method to Identify Robust Prostate Cancer Marker Genes
The most commonly used diagnostic screen for prostate cancer (measurement of levels of prostate specific antigen) is now known to function very poorly as a disease biomarker. The test developed in this work exhibits performance that dramatically exceeds that of PSA. The invention is the TSP (Top Sco
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An Algorithm for the Discovery of Robust Protein Biomarkers with Application to the Design of Classification Protein Arrays
The application of high throughput proteomics to the discovery of protein expression patterns enabling accurate, sensitive and specific prediction of disease class and progression holds great promise. Typically, tissue samples are obtained from populations of patients sharing a specific disease diag
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Nrf2 as a Target for Intervening Pulmonary and Systemic Inflammation
Sustained inflammation is critical in the development of several pathophysiological diseases such as Chronic Obstructive Pulmonary Disease (COPD), asthma, sepsis, acute lung injury, cardiovascular disease, in addition to cancer. Research suggests that controlling inflammation is an effective mechan
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S9
Cystic Fibrosis bronchial epithelial cell line isolated from a patient with genotype ?508 /W1282X. IB3-1 Cells were immortalized with adeno12SV0 and later infected with a viral vector AAV carrying CFTR full length. Description (Set) Proposed Use (Set) This cell line may be useful in the discov
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Molecular Targets for the Anti-cancer Natural Product Pateamine A
v The natural marine product Pateamine A (PatA) is a potent anti-tumor and pro-apoptotic agent. Until recently, PatA?s mechanism of action was unknown until scientists at JHU determined that the protein inhibits cell proliferation through blockade of eukaryotic translation initiation. Specifically,
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Site-specific Modification of the Human Genome Using Custom-designed ZFNs
Scientists at JHU have designed sets of Zinc Finger Nucleases (ZFN) to target mouse genes, namely the tyrosinase (mTYR) and CFTR (mCFTR) and human genes, namely the CCR5 co-receptor (hCCR5) through which HN gains entry into cells early in the infection; the DMPK gene, which is involved in myotonic
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Novel Imaging Agent to Detect Multidrug Resistance in Tumors Using Multimodality Imaging
Multidrug resistance (MDR) can develop during chemotherapy to desensitize tumors to a variety of structurally and functionally different chemotherapeutic agents and is linked to the expression of ATP drug efflux transporters such as MDR1 P-glycoporin and MRP. MDR can be detected in vitro with molecu
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Genomic and Proteomic Biomarkers for Cystic Fibrosis
Cystic fibrosis is a common lethal genetic disease which is manifest by intrinsic hyperactivation of proinflammatory signaling pathways in the lung. However, the mechanism linking the CFTR mutation to inflammatory disease is still not known. Researchers from Johns Hopkins and The Uniformed Services
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Pneumatic Stepper Motor
The present technology is a new pneumatic motor, a pneumatic stepper motor that can be easily controlled for precise motion. Directional rotary motion of discrete displacement is achieved by sequentially pressurizing three ports of the motor. This is the first pneumatic stepper motor. The motor asse
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Device for High-throughput Stimulation, Immunostaining, and Visualization of Single Cells
This invention exploits the high efficiency and exquisite control afforded by microfluidic devices by allowing a group of cells to be stimulated in a precise and dynamically regulated fashion and stained in parallel. The device is composed of a series of chambers in which cells are seeded and susta
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Microfluidic Device for High-throughput Cellular Gradient and Dose Response Studies
This invention is a microfluidic device made of a silicone elastomer (PDMS) that can be used for dose response, gradient detection, and chemostatic growth studies of most cell types, particularly non-adherent cells. The gradient is generated by the diffusion of molecules between two reservoirs of c
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pT2cfosGW
A current hypothesis is that sequences conserved over greater evolutionary distances are more likely to be functional than sequences that are less well conserved. In order to identify non-coding regulatory sequences, scientists at JHU developed a novel reporter vector based on the Tol2 transposon, a
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A Method for the Efficient Functional Examination of Mammalian Noncoding Sequences in Transgenic Zebrafish
sequence conservation is recognized as a reliable indicator of both coding and non-coding functional sequences. Consistent with this hypothesis, coding sequences may be readily identified based on evolutionary conservation. However, of the 5% of the human genome that is predicted to be functional ba
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A New Method to Increase Memory T Lymphocytes and Enhance their Functions for Resistance of Cancer and Infections
CD137 has long been recognized as a co-stimulatory receptor for growth and functional maturation of recently activated T cells in the presence of T cell receptor signal. Now, researchers at JHU have discovered a new method to grow memory T lymphocytes and to stimulate their function. In addition, th
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New uses for old drugs: Identification of Hedgehog pathway antagonists previously tested in humans
Hedgehog (Hh) pathway activity is responsible for the growth of lethal cancers such as small cell lung cancer, and carcinomas of the esophagus, stomach, pancreas, biliary tract, and prostate, and account for as many as 25% of cancer deaths. Evidence for the critical role of continuous Hh pathway ac
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Johns Hopkins Diabetes Management Program
The invention encompasses a team of health care professionals who directly manage the pharacologic, nutritional and educational components of the medical care plan for hospitalized patients with diabetes mellitus. The director of the team wil be a board certified endocrinologist, who wil be responsi
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Highly Efficient Transistors for Low-Cost Organic Circuitry
The Johns Hopkins University seeks a partner to commercialize a highly efficient and novel method for fabricating multiple types of organic field effect transistors (OFETs) from one organic semiconductor (OSC) thin film. OFETs show promise as building blocks for low-cost, large-area, and flexible e
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Valosin Containing Protein (VCP)/p97 Gene Inhibition Rescues cystic Fibrosis Transmembrane Regulator (CFTR) from Endoplasmic Reticulum Mediated Degradation
Endoplasmic reticulum (ER)-associated protein degradation (ERAD) eliminates misfolded, damaged, or mutant proteins with abnormal conformation from the cell. The most common disease-causing protein folding mutation is deletion of phenylalanine at position 508 of the cystic fibrosis transmembrane regu
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PS-341 Rescues Cystic Fibrosis Transmembrane Regulator (CFTR) from Endoplasmic Reticulum Mediated Degradation
Endoplasmic reticulum (ER)-associated protein degradation (ERAD) eliminates misfolded, damaged, or mutant proteins with abnormal conformation from the cell. The most common disease-causing protein folding mutation is deletion of phenylalanine at position 508 of the cystic fibrosis transmembrane regu
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Improved Production of Clavulanic Acid by Genetic Engineering of Streptomyces Clavuligerus
Clavulanic acid is a potent beta-lactamase inhibitor used to combat resistance to penicillin and cephalosporin antibiotics. There is a demand for high-yielding fermentation strains for industrial production of this valuable product. This invention describes genetic engineering of the glycolytic path
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Web-Based Diabetes Data Management Application
Intensive control of blood glucose levels may delay the onset and progression of microvascular complications that contribute to the morbidity and mortality of patients with type 1 and type 2 diabetes melltus. Treatment regimens targeting intensive control rely on the administration of multiple dose
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Identification of Novel Putative Endogeneous Angiogenic Protein Inhibitors
The present invention identified over 70 novel putative endogenous angiogenesis inhibitors using methods of bioinformatics. Classification of these inhibitors is based on conserved domains of known anti-angiogenic fragments. Utilizing bioinformatics algorithms and searching the human protein databa
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Tetrahydrobiopterin for Treatment of Cardiac Failure and Remodeling
Tetrahyrdobiopterin (BH4) is an obligate cofactor for the aromatic amino acid hydroxylases (tyrosine, tryptophan, and phenylalanine), as well as for the nitric oxide synthases. It is currently used clinically in a subset of patients born with an inborn error of metabolism known as phenylketonuria (P
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Chemical Control of Trk Signaling in Mice
Neurotrophins are a family of molecules that encourage survival of nervous tissue by secreting factors in a neuron's target field, and act by prohibiting the neuron from apoptosis. The neurotrophin family include nerve growth factors nerve growth factor (NGF), Brain-derived neurotrophic factor (BDNF
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Emission Ratiometric Kinase Activity Reports in High Throughput Drug Screening and Analysis
Protein phosphorylation is one of the major regulatory mechanisms controlling cellular functions and aberrant kinase activities are found to form the molecular basis for many disease phenotyes. As a result, protein kinases are well recognized as important drug targets and are a focus of small molecu
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Johns Hopkins University PROTEIN-DB2 Database System
Genomic data collection follows the workflow of amplification of DNA expression, amplified DNA extraction, high-throughput sequencing, and subsequent processing/analysis of the sequence data. DNA itself is a structurally stable molecule that can withstand cell lysis and remain relatively intact. Pro
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Antibody Based Anti-HIV-1 Microbicide Targeting a Host Protein
Development of microbicides to prevent HIV-1 transmission to women plays a valuable role in stemming the worldwide epidemic of the disease. In order to address some of the shortcomings of microbicides currently in advanced stages of clinical testing, scientists at JHU explored the development of an
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Peptide Substrates for Fibroblast Activation Protein (FAP) that can be Used to Generate FAP-activated Prodrugs and Protoxins
Fibroblast activation protein alpha (FAP-alpha) is a membrane bound serine protease that is only produced by reactive stromal cells present within sites of epithelial cancers. FAP-alpha is not expressed within normal stroma of any other adult tissues and therefore represents a potential target for e
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Prostate Specific Membrane (PSMA)-binding Peptides Useful for Targeted Therapy for Cancer
Prostate-Specific Membrane Antigen (PSMA) is a glutamate carboxypeptidase II that is expressed by normal prostate epithelium and is even more highly expressed by a large proportion of prostate cancers and other tumor types. As PSMA is not expressed in the normal endothelium of non-prostate tissues,
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HIMF and related proteins in pulmonary, cardiac and inflammatory disorders
Hypoxia-Induced Mitogenic Factor (HIMF; also known as FIZZ1/RELM? a member of the resistin protein family, is a secreted protein that was found to be highly up regulated in the lungs as a result of hypoxia-induced pulmonary hypertension. HIMF has pro-mitogenic, antiogenic and inflammatory propertie
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TGFbeta Antagonists, Including AT1 Receptor Blockers, Rescue the Multisystem Pathogenesis of Marfan Syndrome
This invention is based on the discovery that excessive activity of an important signaling protein, TGF?likely underlies a variety of problems in Marfan syndrome, including the tendency to develop emphysema. The many problems associated with increased TGF?ignaling can be rescued by TGF?ntagonism. Th
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Novel methods for genetic calcium channel blockade
The development of left ventricular hypertrophy (LVH), irrespective of etiology, confers an incremental risk of adverse outcomes in the general population and in patients with different forms of cardiovascular disease. Importantly, LVH is also an early event in patients destined to develop congesti
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