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Design of Thermal Interface Material Based on High Temperature Shape Memory Alloy for Connecting Two Thermoelectric Legs

Introduction Efficient heat management is crucial for electronics to optimize performance and to avoid premature component deterioration. An area of primary concern is at the interface of adjoining thermal components, such as with heatsink interfaces and with connections between thermoelectric legs.
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Crosslinkable Hole Transporting Materials for Organic Lightemitting Diodes

Introduction High-performance organic or polymer light-emitting diodes comprise multilayer configurations having hole-transporting, emissive and electron-transporting layers to balance the injection and transport of both holes and electrons. In general, holetransporting material is the first applied
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Method of Detecting, Characterizing, and Quantifying Bulk, Light-Element Materials Using High-Energy, Penetrating X-Rays

Introduction X-rays have long been used in the characterization of a wide variety of materials. However, conventional techniques for dealing with light-element (or low-Z) materials, such as those containing nitrogen and carbon, are too low in energy to penetrate significant distances into enclosing
...

Application of Grating Light Reflection Spectroscopy in Analytical Sensors

Introduction There are a number of methods for measuring bulk fluid compositions in statics and flow by visible light reflection characteristics from the optically inhomogeneous wall of a vessel. Surface Plasmon Spectroscopy (SPS) on gratings and randomly rough surfaces has proven to be especially s
...

Suspended Carbon Nanotubes as Mulecular Sensors

BACKGROUND: Relatively large surfaces areas and great sensitivity to environmental conditions make carbon nanotubes (CNTs) very promising candidates for sensing elements. However, all existing CNT sensing methods based on electronic or acoustic techniques require complicated nanotube architectures i
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High-Speed, High-Resolution Impedance Sensor

BACKGROUND: While there has been extensive work in developing radio-frequency probes for measuring proximal impedances in air, these probes have been limited to applications using good conductors as their proximal impedance source. For electrolytic and biological samples, lower frequency probes have
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Tissue-Specific Gene Inactivation of Beta-1 Integrin

BACKGROUND: Beta-1 integrin is a critical member of the large family of integrin proteins necessary for cell-extracellular matrix adhesion and bi-directional signaling across the cell membrane. Conventional deletion of beta-1 integrin from the mouse genome results in embryonic death soon after impla
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3-D Tissue Culture Chamber

Introduction Many of the seminal findings in cell and molecular biology have come from cultures of cells grown in two dimensions but the limitations of biology in just 2D are becoming clear. Cells in tissue are not just autonomous masses but consist of many interdependent cell types and their surrou
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A New Protocol of Diels-Alder Lattice Hardening for Highly Efficient Electro-optic Materials Showing Outstanding Temporal Stability over

Introduction Organic electro-optic (EO) materials have attracted much interest in the past two decades because of their extensive potential applications in various fields, ranging from waveguides, switches, emitters, and detectors. Though EO materials have a huge potential in Photonics and Electroni
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Microcellular Foaming of Cyclic Olefin Copolymer (COC)

Introduction Cyclic olefin copolymer (COC) is a commercially available thermoplastic. It possesses exceptional clarity in its natural form, similar to that of glass, and it has high moisture resistance and low absorption rates. This thermoplastic’s many qualities make it an exceptional candidate for
...

Continuous Production of Microcellular Fibers

Introduction In microcellular plastic foams, inert gas is dissolved in thermoplastic under high pressure. The forced evacuation of this gas during processing creates pores (or cells) within the final plastic. The pores are small enough that clarity of the plastic is unaffected, and because of the po
...

Advanced Biomimetic Surfaces for Surface-Enhanced Raman Spectroscopy (SERS)

Introduction Raman spectroscopy characterizes molecules by their Raman scattering. As incoming light scatters off a molecule, most does so elastically, neither gaining nor losing energy, and this is known as Rayleigh scattering. Some of this light, however, about 1 in 10 million photons, is the subj
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Solution Processable n-Type polymers

Introduction Conjugated polymers and organic semiconductors promise great advances in electronics because of the benefits they offer over silicon, including being cheaper with less demanding manufacturing requirements and allowing for larger, more flexible, and more robust materials that are more re
...

Nanocellular Foaming of Ultra High Molecular Weight Polyethylene using Ultrasound

Introduction Ultra high molecular weight polyethylene (UHMWPE) is a thermoplastic consisting of molecules of incredibly long chains with molecular weights of several million. It has the highest impact strength of any thermoplastic, has a high resistance to corrosion, moisture, and abrasion, and has
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Tissue-Engineered Urinary Bladder Using Autologous Cells

Introduction There is a variety of reasons that a person’s bladder may fail or require removal, including bladder acontractility, cancer, and cystitis. Unfortunately, conventional artificial bladders tend to suffer from critical complications, such as inadequate performance, infection, and adverse h
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Novel Adsorbent Systems for Water Purification Using Metal Oxide Bound to Substrate and Heated Metal Oxide Particles

Introduction There is an ever increasing need for potable water. Improvements in conventional purification technologies allow for savings in both time and money and ensure that clean water is available in areas that need it. Technology Description Professor Benjamin at the University of Washington h
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Method and system for background estimation in localization and tracking of objects in a smart video camera

Aspects of a method and system for change detection in localization and tracking of objects in a smart video camera are provided. A programmable surveillance video camera comprises processors for detecting objects in a video signal based on an object mask. The processors may generate a textual repre
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Smart Network Camera System-on-a-Chip

Aspects of a method and system for processing video data are disclosed and may include detecting, within a single chip in a programmable surveillance video camera, one or more moving objects in a raw video signal generated by the programmable surveillance video camera. One or more characteristics of
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Improvements to the Quasi-1D SCM AC to Dopant Density Conversion Algorithm and a New Quasi-3D SCM AC Bias to Dopant Density Conversion Algorithm

State of the art integrated circuit technology demonstrates that it is possible to create active and passive electrical and electronic components on a semi-conductive substrate at the sub-micron level. This ability requires accurate knowledge of the spatial extent of dopant impurities that are inco
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SV2A Knockout Mouse

Introduction Synaptic vesicle protein 2 (SV2) is a membrane glycoprotein found only in the secretory vesicles of neural and endocrine cells. It appears to be unique to vertebrates, suggesting that it evolved as a part of complex signaling systems. SV2A was shown to be the binding site for the antiep
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HIV antisense ORF(s) and putative protein(s)

The current invention is a gene comprising an open reading frame on the plus strand of the pro-viral DNA, and located in the region of HIV-1 long terminal repeat. The gene encodes a protein that is related to, and has a structural motif resembling t hat of chemokine proteins. Depending upon the ribo
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Type 1 X Type 8 Adenylyl Cyclase double Knockout Mice (DKO strain)

Introduction Production of cAMP by adenylyl cyclase (AC) provides an important mechanism for the regulation of neuronal physiology. The calcium-stimulated AC isoforms have been strongly implicated in the alteration of neuronal function. Targeted inactivation of the calciumstimulated AC type I (AC1)
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Genetically Encoded Cell Death Reporter

Introduction Determining cell viability is critical to a wide variety of scientific disciplines. Currently, cell viability is assessed by incubating the cells of interest with a chemical dye or stain that reacts differently with living cells compared to dead cells. The stained cells are then analyze
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3-D Tissue Culture Chamber

Introduction Many of the seminal findings in cell and molecular biology have come from cultures of cells grown in two dimensions but the limitations of biology in just 2D are becoming clear. Cells in tissue are not just autonomous masses but consist of many interdependent cell types and their surrou
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Higher Order Construction Algorithm for Rapid Prototyping

To remain competitive in a global market, manufacturers are called upon to bring a variety of products to market with continually decreasing lead times and development costs. These commercial realities are a driving force demanding the development of improved rapid prototyping techniques. A rapid pr
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Cell line expressing functional alpha1D-adrenergic receptors

Introduction The alpha1D-adrenergic receptor (AR) is a major regulator of cardiovascular and central nervous system function. Targeting AR is thus of major interest to the pharmaceutical industry for developing new medicines to treat hypertension and neurological disease. However, it has been imposs
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Methods for Detecting and Extracting Gold

Introduction Gold is found in various forms on earth. It can be found in rocks, ore deposits, eluvial deposits, alluvial deposits, placer deposits etc. Gold is also recovered from secondary sources such as electronic scrap and waste electroplating solutions. Most methods of extracting gold are extre
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Method for disabling the audible and visual notifications that are played and displayed upon receiving an incoming message

In a nutshell, what is this patent about ? It gives a sender of a message, the power to disable the ringtone that usually plays, when the message reaches the receiver. In addition, it gives another option – preventing the screen of the receiver from turning on, when the message reaches the rec
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Method and System for Programmable Camera for Configurable Security and Surveillance Systems

A method and system for a programmable camera for a configurable security and surveillance system are provided. A programmable sensor agent for video surveillance may comprise a network interface, a processor, an image processor, and an image sensor. The image processor may comprise at least one con
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Identification of Genes Involved in Aging

Introduction Genes involved in aging are targets for diagnostic, prognostic, and therapeutic products related to aging. This technology encompasses methods, reagents, and compounds that can be used either for the treatment of a life span disease or disorder or a disease or disorder associated with a
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Cell line stably expressing rat cardiac sodium channel α subunits (Nav1.5)

Introduction The Nav1.5 sodium ion channel protein is an integral membrane protein and tetrodotoxinresistant voltage-gated sodium channel subunit. The encoded protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Def
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cDNA for B1 subunits of human sodium channels

Introduction Voltage-gated sodium channels in the brain are composed of a central, pore-forming α subunit and one or two β subunits. Sodium channel β1 subunits modulate α subunit gating and cell surface expression and participate in cell adhesive interactions in vitro. β1 subunits play important rol
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A novel mouse model to screen compounds for the treatment of neurodegenerative disorders

Introduction Protein misfolding and aggregation are thought to play a central role in the pathogenesis of many, if not most, neurodegenerative disorders. The pharmaceutical industry has recently invested significant effort to identify small molecule inhibitors of protein misfolding and aggregation,
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Monoclonal antibody to RGS9

Introduction RGS9 is a member of the RGS family of GTPase accelerating proteins (GAPs) and is the predominant source of GAP activity in rod outer segments. Because of its pivotal position in the inactivation phase of the light response, RGS9, found predominately in vertebrate cone and rod photorecep
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Clonal Cell Lines Expressing Sodium Channel RIIA (Nav1.2) and Subunits

Introduction Voltage-gated sodium channels are responsible for action potential initiation and propagation, placing them in ideal position to regulate firing and conduction in neurons. Nav1.2 (rat brain type IIa) represents a highly tetrodotoxin (TTX)–sensitive sodium channel that is broadly express
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The Gene Encoding the Drosophila Muscarinic Acetylcholine Receptor & Its Expression in Mammalian Cells

Introduction Muscarinic acetylcholine receptors are involved in the activation of various signal transduction pathways through their interaction with G protein. They play a major role in regulating the functions of the target organs of the parasympathetic nervous system of mammals. Acethylcholine is
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Droplet Compartmentalization for Chemical Separations and On-Line Sampling

Introduction The ability to separate complex mixtures of chemicals and biomolecules is an important component of any chemical synthesis or biological processing. To date, there is no technology available to combine the high resolution of analytical separations with monodisperse droplet generation. I
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Dice1.1 and Dice1.2 congenic mice

Technology description Dice1.1 and Dice1.2 inbred congenic mouse strains were produced on a BALB/c background and contain discrete non-overlapping chromosome 16 congenic intervals inherited from B10.D2. These congenic intervals contain genetic loci that control the propensity of CD4+ helper T cells
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Soluble Tetrahedral Compounds for use in Electroluminescent Devices

BACKGROUND: Recent research efforts have produced stable amorphous materials that can be cast into films directly from solution. However, a tendency towards crystallization minimizes the utility of these materials as the electroluminescent layer in light emitting diodes (LEDs). Attempts to use these
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Nanoparticle Assembled Hollow Spheres

BACKGROUND: Nanoparticles with very small diameters (
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A Novel Class of Pre-Emergent Herbicides

The University of California is seeking industrial partners to commercialize a novel class of herbicidal compounds, the DHC’s. The DHC’s were developed by a major producer of ag chemicals. This company decided to follow different leads and recently donated patents applications claiming the DHC’s as
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Novel Conductive Polymers

POLYISOTHIANAPHTENE, A NEW CONDUCTING POLYMER UC Case No. 1984-044-2 U.S. Patent 4,640,748 Patent Abstract: A polymer having an isothianaphthene structure represented by the formula (Ia) and/or Ib): wherein R.sup.1 and R.sup.2 each represents a hydrogen atom or a hydrocarbon residue having
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Novel Self-Doped Polymers

PATENT ABSTRACT: A self-doped conducting polymer having along its backbone a .pi.- electron conjugated system which comprises a plurality of monomer units, between about 0.01 and 100 mole % of the units having covalently linked thereto at least one Bronsted acid group. The conductive zwitterionic po
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Novel Chromogenic Ionophores

Ionophores selectively complex with specific ions in sample solutions, and are widely used for measuring ion concentrations in such solutions in conjunction with ion-selective electrodes. University of California researchers have developed new classes of ionophores, called chromogenic hemispherands
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Recombinant Baculovirus that Produces Human Topoisomerase I

Introduction Eukaryotic topoisomerase I (Topo I) is capable of relaxing both negatively and positively supercoiled DNA. The enzyme catalyzes changes in the superhelical state of duplex DNA by transiently breaking a single strand. Technology description Dr James Champoux’s laboratory has generated re
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Electrospray Evaporative Spray Cooling (EESC)

Introduction As electronic devices get increasingly more powerful and more compact, there are an increasing number of semiconductor components that emit an increasing amount of heat. In order to ensure that these devices remain long-lived and reliable, more efficient methods of dissipating heat buil
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A New and More Accurate Mouse Model for Alzheimer’s disease

Introduction Alzheimer’s Disease (AD) is a neurogenerative disease with two cardinal features: the senile plaque consisting of an amyloid core surrounded by dystrophic neuritic and glial processes; and the neurofibrillary tangle (NFT) composed largely of filamentous hyperphosphorylated tau. A diseas
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Application of Grating Light Reflection Spectroscopy in Analytical Sensors

Introduction There are a number of methods for measuring bulk fluid compositions in statics and flow by visible light reflection characteristics from the optically inhomogeneous wall of a vessel. Surface Plasmon Spectroscopy (SPS) on gratings and randomly rough surfaces has proven to be especially s
...

Scanning Probe Microscopy Based Diffusion of Dopant and Impurities

It is common to see devices shrink in size with time, especially electronic devices such as computers, cell phones, mobile music players, pagers, calculators etc. There are, however, some important working components in these devices that cannot be replaced by an alternate component but have to be d
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BCRP expressing cell lines

Introduction The breast cancer resistance protein (BCRP) is an ATP-binding cassette efflux transporter originally identified by its ability to confer multidrug resistance in cancer cells. BCRP mediates the efflux transport of a broad spectrum of substrates, including many drugs routinely administere
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Microcellular Foaming of Cyclic Olefin Copolymer (COC)

Introduction Cyclic olefin copolymer (COC) is a commercially available thermoplastic. It possesses exceptional clarity in its natural form, similar to that of glass, and it has high moisture resistance and low absorption rates. This thermoplastic’s many qualities make it an exceptional candidate for
...

Continuous Production of Microcellular Fibers

Introduction In microcellular plastic foams, inert gas is dissolved in thermoplastic under high pressure. The forced evacuation of this gas during processing creates pores (or cells) within the final plastic. The pores are small enough that clarity of the plastic is unaffected, and because of the po
...

Cell and Microparticle Separator Employing Patterned Grooves

Introduction Microscale enrichment and separation are important for various research, biomedical, and industrial uses. Conventional means for these processes typically require specific labels— either inherent to the structure or appended to it. Unfortunately, not every important substrate has a con
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Phospholipase C-γ1 Fusion Protein Constructs

Introduction Phosphoinositide phospholipase C (PLC) is a family of eukaryotic intracellular enzymes that play an important role in signal transduction processes. PLCs participate in phosphatidylinositol bisphosphate (PIP2) metabolism and lipid signaling pathways in a calcium-dependent manner. Phosph
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Surgical Electric Blade Coated with Quasicrystalline Twin Films

Medical surgery is performed in all countries of the world ranging from very simple procedures involving flesh and bones in hands to very complex procedures on the brain. It is desirable to use surgical tools that are of high quality that do not cause unnecessary damage to the organ or tissue. Elect
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Novel Continuous Solvent Extraction Without Moving Parts

Solvent extraction is an efficient method for selectively removing, purifying and concentrating certain elements or compounds from a solution because the solutes can be selectively removed and they can be concentrated from a very dilute stream. Two types of solvent extraction systems are commonly
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Parametric Cost Model

The Parametric Cost Model can be used to work out unit, sub-system, system and total project costs for a variety of projects. The model has been used by BA Systems, ESTEC, Airospatial plus many other major companys. The full source code and intellectual propert rights are for sale.
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Cryopreservation of Human Embryonic Stem Cells

Introduction Embryonic stem cells (ESC) have unique capacities both for self-renewal and pluripotency. Human ESCs (hESCs) are therefore a potential source for regenerative medicine and tissue replacement after injury or disease. Significant obstacles to using hESCs arise from extremely poor survival
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Retinoic Acid Activated Reporter

Introduction Retinoic Acid Receptors (RARs) are transcription factors that are involved in many cellular processes. Upon binding of activators such as Retinoic Acid, a derivative of Vitamin A, RARs bind a consensus DNA sequence, termed the Retinoic Acid Response Element (RARE), and initiate transcri
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Design of Active Materials and Structures based on Composites of Shape Memory Alloy and Shape Memory Polymer

Introduction Shape memory alloys (SMA) and shape memory polymers (SMP) have shown tremendous promise for a wide variety of applications because of their ability to “remember” a previous state when heated. However, they can only remember a single shape. The ability to remember two shapes would make t
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Respiratory Detection System (RDS)

Introduction Respiration rates are an important indicator of cellular and metabolic states in cells ranging from mammalian to bacterial, from individuals to large populations. Unfortunately, conventional techniques have significant drawbacks: for instance, electrochemical techniques have low sensiti
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Nav1.2/β1/contactin cell line

Introduction Mammalian Na+ channels are heteromultimeric structures that include the poreforming α subunit in association with auxiliary β subunits. Contactin is a neuronal cell adhesion molecule of the immunoglobulin superfamily. Numerous lines of evidence indicate a role for contactin in regulati
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Inexpensive, Sensitive, Rapid and Selective Detection of GHB (Gamma-Hydroxybutyrate)

Researchers at the University of California have invented a rapid, selective, sensitive, and inexpensive enzyme-based colorimetric assay for GHB that will provide means by which: * People can protect themselves from unknowingly ingesting GHB; * Law enforcement can obtain probable cause to detain
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Device to Monitor Cardiac Tissue Viability

DESCRIPTION: The last decade of cardiac surgery has witnessed significant strides towards better understanding and management of previously lethal cardiac pathologies. It is now recognized that conditions of myocardial stunning and hibernation exist, in which the injured myocardium is only temporari
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Solution Processable n-Type polymers

Introduction Conjugated polymers and organic semiconductors promise great advances in electronics because of the benefits they offer over silicon, including being cheaper with less demanding manufacturing requirements and allowing for larger, more flexible, and more robust materials that are more re
...

Nanocellular Foaming of Ultra High Molecular Weight Polyethylene using Ultrasound

Introduction Ultra high molecular weight polyethylene (UHMWPE) is a thermoplastic consisting of molecules of incredibly long chains with molecular weights of several million. It has the highest impact strength of any thermoplastic, has a high resistance to corrosion, moisture, and abrasion, and has
...

Digital paint projection method and apparatus

According to an embodiment, a color is projected onto a surface. An estimate of the surface color is processed and a projection color is selected as a function of the surface color estimate and a chosen color so that the projection color yields the chosen color or a color substantially similar to th
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Method of synthesis of CMK-3 carbon replica

The subject of the offer is an innovative, environmentally friendly method for obtaining of CMK-3 carbon replica, which may be a material useful in various catalytic and sorption processes as well as electrochemical applications. The method has a high potential for industrial application, and its us
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Method of Detecting, Characterizing, and Quantifying Bulk, Light-Element Materials Using High-Energy, Penetrating X-Rays

Introduction X-rays have long been used in the characterization of a wide variety of materials. However, conventional techniques for dealing with light-element (or low-Z) materials, such as those containing nitrogen and carbon, are too low in energy to penetrate significant distances into enclosing
...

Inductive Salinometer with Data Logging Capabilities and Toroidal Sensor

Introduction Salinity levels in seawater are not constant and can vary dramatically both temporally and spatially due to phenomena such as temperature, precipitation, deep-water upwelling, and tidal action. These variations are especially pronounced in coastal and estuarine waters where seawater int
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Design of Thermal Interface Material Based on High Temperature Shape Memory Alloy for Connecting Two Thermoelectric Legs

Introduction Efficient heat management is crucial for electronics to optimize performance and to avoid premature component deterioration. An area of primary concern is at the interface of adjoining thermal components, such as with heatsink interfaces and with connections between thermoelectric legs.
...

A Microfluidic Device and Methodology for Rapid, Quantitative Determination of Analyte Concentration in a Fluid Sample

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, especially for biosensors and environmental monitoring. One recent area of interest is point-of-care diagnostic devices. These devices provide fast, accurate, and inexpensive sample analys
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Polymer Solar Cells using Self-Assembled Monolayer modified Zinc Oxide/Metal as Cathodes

Introduction Conjugated polymer-based organic solar cells are considered an essential source of inexpensive renewable energy due to their advantages of being fabricated by low-cost and large-area printing and coating techniques on light-weight flexible substrates. Bulk heterojunction (BHJ) solar cel
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Nanocomposite Photovoltaic Cell

Introduction Photovoltaic cells based on polymer semiconductors are of great interest as a low cost approach to solar energy conversion into electricity. The most efficient polymer solar cells are based on binary blends, in which polymers function as electrondonors and fullerenes as electron-accepto
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Thermoelectric power generation method and apparatus

Power is generated using a thermoelectric power generation unit. The thermoelectric power generation unit has at least one thermoelectric module disposed between a first heat sink arranged inside the thermoelectric power generation unit and a second heat sink arranged outside the thermoelectric powe
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Microcellular Foaming of Cyclic Olefin Copolymer (COC)

Introduction Cyclic olefin copolymer (COC) is a commercially available thermoplastic. It possesses exceptional clarity in its natural form, similar to that of glass, and it has high moisture resistance and low absorption rates. This thermoplastic’s many qualities make it an exceptional candidate for
...

Continuous Production of Microcellular Fibers

Introduction In microcellular plastic foams, inert gas is dissolved in thermoplastic under high pressure. The forced evacuation of this gas during processing creates pores (or cells) within the final plastic. The pores are small enough that clarity of the plastic is unaffected, and because of the po
...

Solution Processable n-Type polymers

Introduction Conjugated polymers and organic semiconductors promise great advances in electronics because of the benefits they offer over silicon, including being cheaper with less demanding manufacturing requirements and allowing for larger, more flexible, and more robust materials that are more re
...

Hexon-Modified Adenovirus Vectors that are Unable to Bind Human Blood Factors and their Use

Introduction Human species C adenovirus serotype 5 (Ad5) is the most common viral vector used in clinical studies worldwide. Ad5 vectors infect liver cells in vivo with high efficiency via a poorly defined mechanism, which involves virus binding to vitamin K-dependent blood coagulation factors. The
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Improved use of Recombinant Viruses for Liver Regeneration

Introduction Diseases of the liver, both genetic and acquired, are especially detrimental due to the fact that the liver is a key organ for most metabolic pathways. Currently, the only method of curing liver diseases is via a liver transplant. Unfortunately, many transplants succumb to rejection, le
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Chlamydia Oligosaccharides

Introduction Chlamydia trachomatis is an obligate intracellular bacterium which parasites eukaryotic cells and is one of the most common causes of blindness and sexually transmitted diseases in humans. Different chlamydia species are also responsible for a broad array of diseases, including, but not
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Safe, effective and selective oral androgen therapy with the combination of high-dose oral testosterone or testosterone esters and a dual 5-alpha reductase inhibitor

Introduction Men with a testosterone deficiency may have symptoms of depression, reduced libido, and low energy. They may suffer from anemia, osteoporosis and debilitating muscle weakness. Testosterone replacement therapy can improve well-being, maintain bone and muscle mass, and retain healthy sexu
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Sun Care Patent

Sunscreen Protectant – Dermal Science UV ProtectantTM protects you and your clothing from harmful UV radiation. Available in tablet form, this protectant is added to a normal load of laundry and provides long lasting UPF protection to cotton clothes. Laundry care is an $8B category in the US and s
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Subterranean Material Dispensing Apparatus and Method

A material dispensing device delivers material directly into the ground. According to one embodiment of the material dispensing device, the device comprises an elongated hollow shaft, a receptacle, a helical flange and on or more openings formed in the shaft or helical flanges. The receptacle is
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Innovative and Targeted Treatment of Kidney Disease

Introduction Twenty million Americans are currently afflicted with kidney disease, and this number is expected to more than double in the next decade. UW scientists have identified that treatment with ATRA/retinoic acid is able to reverse damage and significantly improve kidney function. Technology
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Botanicals as Antiviral and Hepatoprotective Compounds for Hepatitis C Virus Infection

Introduction Hepatitis C virus (HCV) is one of the several viruses that cause hepatitis, i.e., inflammation of the liver. The infection is usually chronic, and results in fibrosis, cirrhosis (scarring of the liver) and sometimes liver cancer. Interferon-alpha (IFN-α) based treatments, the only FDA
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Methods and Compositions for enhanced stability of non-adenoviral DNA

Introduction A central challenge in gene therapy is delivering the therapeutic gene to the tissue site where it can be of benefit. Many pathological conditions have been identified that should be amenable to genetic therapy. Although therapeutically relevant genes have been cloned and sequenced, and
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Recombinant adenoviral vectors expressing chimeric fiber proteins for cell specific infection and genome integration

Introduction Gene transfer vectors require the efficient transduction of target cells, stable association with the host genome, and adequate transgene expression in the appropriate target cell, without associated toxic or immunological side effects. Currently available viral vector systems, includin
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Method for producing Beta-Carotene on a Large Scale for use in the Medical, Food and Cosmetics Industry

Carotenoids are antioxidant micronutrients reported to protect against the adverse activity of free redicals. Among the carotenoids, Beta-carotene is the most recognized and widely known carotenoid. Flavobacterium multivorum ATCC 55238 is best known for zeaxanthin production, but it was culturally m
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One-Step Manufacture of Nanowire Biosensors

Electrochemical biosensors based on nanotubes or nanowires could be widely used in diagnostic, research, and security applications. However, the problems associated with functionalizing and placing these nano-elements on a device have prevented the practical application of this technology. Univer
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Hybrid Energy Transfer for Nucleic Acid Detection

BACKGROUND: The need for efficient assays to detect DNA sequences is enormous and constantly growing. The recent increases in the number of sequenced genomes for bacterial and viral pathogens as well as humans provide the potential for improved medicine and diagnostics. Molecular beacon-based nuclei
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Platform for Chemical and Biological Sensing by Surface Enhanced Raman Spectroscopy

BACKGROUND: Surface-Enhanced Raman Spectroscopy (SERS) is an optical analysis technique that can provide molecular identification and quantification by recording a spectrum that displays characteristic vibrational fingerprints of molecules or parts of molecules. SERS is potentially among the most s
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Remediation of Sediments Containing Organic Contaminants

Polychlorinated biphenyls (PCBs) are environmentally hazardous compounds that occur in soil and sediments due to past industrial activity. There have been several efforts to remediate PCB-contained sediments and most methods face a multitude of problems that includes logistics, costs, and disposal o
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Methods and Compositions for the Treatment of Neurological Diseases

Introduction Amyloid β (Aβ) peptides are thought to be the key pathogenic element in the initiation and progression of Alzheimer’s disease (AD) and alpha-synuclein (αS) is thought to play a similar role in Parkinson’s disease (PD). Microglia can be neuroprotective by phagocytosing Aβ; however, this
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Poly(2-Methoxy,g-(2'Ethyl-Hexyloxy)-P-Phenylene Vinylene), MEH-PPV, and Methods for Use

BACKGROUND: The possibility of combining the important electronic and optical properties of semiconductors and metals with the attractive mechanical properties and processing advantages of polymers has existed since the discovery of conducting polymers in the late 1970's. However, early attempts res
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Synthesis of Beta-Amino Alcohols

Enantiomerically pure .-amino alcohols play an increasingly important role in both the treatment of a wide variety of human disorders and as chiral auxiliaries in organic synthesis. The importance of enantiomeric purity in pharmaceuticals has been amply demonstrated by the debilitating and sometime
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Safe and Powerful Reductant

Researchers at the University of California have synthesized a family of compounds which have very strong reduction properties and are also inexpensive and exceptionally safe. Since 1947 the standard high-powered reductant available has been lithium aluminum hydride, but its violent reaction wit
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Rollfast

Rollfast is an all new security toilet tissue dispenser for public washrooms that finally beats the vandals. Vandalism of dispensers in toilet cubicles is a major world wide problem that has never been fully resolved - until now. Costs of $100 to $200 per cubicle per year are quite normal and is
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Synchronous Ripening of Tomatoes

A method of cultivation of tomatoes resulting in the essentially simultaneous ripening of the entire crop, enabling "one time over" harvesting, saving time and manpower. Sterile tomato plants are cultivated, parthenocarpy is induced by application of a growth regulator. Suitable substances resulting
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Method for Large Scale Mutagenesis and Gene Knockout in Crop Plants

The present invention relates to a rapid and large-scale production of tomato mutants by utilizing miniature tomato plants which can be crossed with tomato commercial plants. Mutations are induced in the miniature tomato cultivars and desired mutants are subsequently identified in the resulting muta
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