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A Fast, Cell-based, High-throughput Assay for the Identification of Compounds with DNA-interstrand Crosslinking Capability

Using somatic cell gene targeting, isogenic cell clones were created from the colorectal cancer cell line RKO. Each KO cell line differed only in the allelic status of one Fanconi Anemia (FA) gene, either FANCC or FANCG. For details, see publication by Gallmeier, E et al., 2006. Description (Set)
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Multi-Imager Compatible Robot for Image-Guided Interventions and Fully Automated Brachytherapy Seed Injector

The present technology is a robot designed for image based percutaneous needle intervention of the prostate gland. The robot is constructed of nonmagnetic and dielectric materials for complete MR compatibility. The system utilizes a pneumatic stepper motor (PneuStep) providing the precision required
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COMPARE-MS: a Novel Technique for Rapid, Sensitive, and Accurate Detection of DNA Methylation

Hypermethylation of CpG island (CGI) sequences is a nearly universal somatic genome alteration in cancer. The rapid and sensitive detection of DNA hypermethylation can aid in cancer diagnosis and risk stratification but its detection has remained labor-intensive and time-consuming. To address these
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Developing a High-throughput Screening Method for Identification and Validation of T Cell Epitopes Based Upon the Mass Spectral Analysis of Antigens Bound to Class II HLA-DR Constructs

All currently established methods for the identification of immunogenic epitopes are extremely tedious, time consuming and frequently unsuccessful. The identification of high throughput methods to isolate most likely candidates derived from natural processing of protein antigens is a most desirable
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Co-assembling Peptide Hydrogels

Peptide-based hydrogels have become popular for biomedical applications such as tissue engineering and drug delivery due to their biodegradable and bioresorbable properties. For use in vivo, hydrogels should assemble easily in a controlled fashion and be compatible with native entrapped biomolecules
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Unidirectional Proxy Re-encryption with Applications to Secure Distributed Storage

The invention consists of three public-key encryption schemes that support �proxy re-encryption�. In a typical public-key encryption scheme, a sender (Alice) may encrypt messages to a recipient Bob under Bob�s public key, such that only Bob may decrypt (and learn the message contents) using his secr
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Trioxane Dimers Having Surprisingly High Anticancer Activities and Surprisingly Long-lasting Antimalarial Activities

Artemisinin (1), a monomeric 1, 2, 4 trioxane, is usually administered for the treatment of multi-drug resistant malaria. However, studies have determined that artemisinin not only possesses excellent anti-malarial properties but also considerable anti-cancer activities. Dimeric trioxanes also posse
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Increasing the Depth and Breadth of Coverage of Sequences on a Microarray

Microarrays are used as an investigative tool for answering questions concerning DNA sequence and structure, gene expression, and the location of protein binding targets. Although microarray systems are considered high-throughput compared to pre-existing technologies, they are currently limited by f
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Novel Compounds that Target Estrogen Receptor (ER) Positive. Tamoxifen-resistant Breast Cancers

The drug tamoxifen is widely used to treat estrogen receptor (ER) positive breast cancer and to prevent relapse. However, half of all recurrences in breast cancer patients are resistant to tamoxifen and often, more aggressive tumors result. Recently, researchers at The Johns Hopkins University, in
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Identification of the Most Common Gene for Bardet-Biedl Syndrome

Bardet-Biedl syndrome (BBS) is characterized by multiple clinical phenotypes including retinal dystrophy, polydactyly, cognitive defects and retinal dysplasia. To date, nine BBS genes have been cloned and determined to contain 40-50% of the total mutational load of the disease. Scientists at Johns H
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A. phagocytophilum Monoclonal ab hybridomas

Researchers at JHU have created hybridomas producing monoclonal antibodies reactive with the obligate intracellular bacterium Anaplasma phagocytophilium 44kDa antigens (Msp2), AnkA and unidentified labile antigens. Description (Set) Proposed Use (Set) Useful tool for immunohistochemistry, immun
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A Novel Approach to Peptide/Protein Chip Fabrication

This technology describes improved methods for stalling ribosomes during protein translation and capturing the nascent polypeptides through puromycin which is grafted at the end of an oligo immobilized on a solid phase. Existing technologies include an inefficient ligation step to incorporate puromy
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MR-visible and radiopaque microcapsules for use as embolic agents and for immunoisolation of cellular therapeutics

Immunoisolation of cells through microencapsulation is a means to prevent their immune destruction following transplantation. To date, microencapsulation has shown great clinical potential for a wide range of diseases requiring enzyme or hormone replacement therapy, particularly diabetes. This inven
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Protein-Encapsulated Aligned Fibers by Electrospinning for Enhanced Peripheral Nerve Regeneration

We have developed novel protein-encapsulated fibrous meshes that are composed of micro-/nano-sized aligned fibers. The encapsulated protein in the fibers can be released in a sustained manner for up to several months while maintaining partial bioactivity. Direct application of these aligned electros
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The MR-eye: Methods and Devices for Local MRI

The present invention is a novel method to lock the MRI frame-of-reference to an internal device, where the RF excitation is confined to the immediate region surrounding the probe. Two dimensions are encoded using cylindrical encoding or conventional read/phase encoding. The third dimension is resol
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Inducing and Inhibiting T Cell Tolerance with A2a Receptor Agonists and Antagonists

T cells play a critical role in fighting disease and infection. However, when T cells recognize and attack normal or non-infected cells, autoimmunity ensues. A contrasting, but similarly detrimental situation is T cell tolerance, the state of antigen-specific unresponsiveness in the absence of immun
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Compounds with Effects on Potassium Channels

KCNQ channels play a role in cardiac and neuronal membrane excitability. Scientists at JHU have identified a series of novel compound that potently activates KCNQ channels. Initial studies of electrophysiology using whole cell recording and animal models revealed that the compound potentiates KCNQ c
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Chest Pain Differentiation Serum Diagnostic Panel (CPDP)

Abstract (Set) Patients presenting at an emergency room with acute chest pain are likely to be evaluated for acute coronary syndrome (ACS), pulmonary embolism (PE), aortic dissection (AD) and other less fatal conditions, all of which have indistinguishable symptoms. Although rapid diagnosis and app
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Promoters for Neural Regeneration

Background Injury to the human central nervous system (CNS) is usually difficult to treat because of the limited regeneration capabilities of the neurons. Evidence suggests that the lack of CNS regeneration is due to the presence of inhibitory factors in the CNS environment. Myelin-associated Glycop
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Estrogen Receptor in Normal (ERIN) Cells

There is no ideal system for studying pre-neoplastic cells that are ERpositive due to the inability to establish an estrogen growth stimulated but non-tumorigenic breast epithelial cell line. Scientists at JHU have developed independently derived clones from the non-cancerous MCF-10A human breast ce
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NAC-1 Monoclonal Antibody

Scientists have developed a human NAC-1 monoclonal antibody. The antibody can be applied by immunohistochemistry, Western blot and immunoprecipitation to detect NAC-1 protein expression. Description (Set) Proposed Use (Set) This antibody has the potential to be used as a diagnostic reagent for
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Neuroprotective Actions of Polyphenols, Flavonoid Derivatives and their Respective Extracts

Polyphenols, such as resveratrol, have been linked to many health benefits. This widespread belief stems from its intrinsic antioxidant properties that protect against oxidative damage. Recently, other data has suggested that polyphenols act as signaling molecules to regulate gene expression, the h
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Mycobacterial Catalase-peroxidase in the Diagnosis and Treatment of Sarcoidosis

Sarcoidosis is an organ-wide inflammatory disease of unknown etiology that is characterized by the presence of granulomas, and frequently, pulmonary dysfunction. Currently there are no definitive diagnostic tests, and treatment regimes consist of drugs with significant side-effects. Johns Hopkins sc
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Line 1: Pkhd1flox3-4 mouse line, formal name Pkhd1tm1Ggg.; Pkhd1del3-4 mouse line, formal name Pkhd1tm1Ggg.1

Pkhd1flox3-4, when mutated, causes human autosomal recessive polycystic kidney disease (ARPKD). The Pkhdlde13-4 allele results after Cre-mediated deletion of exons 3 and 4. Homozygosity for this allele results in a wide range of abnormal phenotypes including ductal plate malformations of the liver,
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MEK KO Lines for Drug Discovery

MEK knockout in human colorectal cancer cell line HCT116. Description (Set) Proposed Use (Set) MAP kinase/ERK kinase (MEK) is the specific activator of extracellular signal-regulated kinase (ERK) and is part of a signaling pathway with a pivotal role in the control of cellular proliferation. Th
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HOXB7 as a Potential Prognostic Marker and Therapeutic Target in Cancer

Scientists at The Johns Hopkins University have determined that HOXB7, a member of homeobox superfamily of transcription factors, regulates the expression of EGFR/ER2 and ER?and functionally orchestrates their function in breast cancer cells. In addition, the amelioration of HOXB7 expression using s
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Cell Lines that Express SIV/HIV Receptors and Co-Receptors in the K562 Human Cell Line

Both simian and human immunodeficiency viruses (SIV and HIV) utilize chemokine receptors, with or without CD4, as portals for entry into susceptible cells. JHU researchers constructed a reporter cell line derived from non-susceptible human K562 cells, xKLuSIV, that can be used to readily identify c
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Augmentation of Endocardial Thromboresistance

A critical function of the endocardium is to maintain local thromboresistance by providing an anticoagulant surface. Thrombomodulin, is expressed on the surface of the endocardium endothelial cells and is the key component of the anticoagulant protein C pathway, and thus is critical to maintaining v
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A Bench-top Image Guided Conformal Irradiation System for Laboratory Animals

The present technology is a bench top small animal research platform designed for focused delivery of radiation to laboratory animals. The system is equipped with CT image guidance and a robotic stage for positioning of the animal. High quality CT reconstructions are possible with the prototype. The
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Flexible, Highly Sensitive Piezoelectric Polymer Composite

Johns Hopkins University seeks a partner to commercialize a fundamentally new approach for fabricating flexible piezoelectric materials. The invention is a breakthrough in piezoelectric materials, allowing for thermally stable flexible piezoelectric film to be manufactured for the first time. Cl
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A Novel Method for Programmed Release of Biomolecules

Johns Hopkins University seeks a partner to commercialize a novel method for programmed release of biomolecules and nanoparticles. This is a useful tool for the controlled delivery of drugs, DNA, proteins, viruses, and nanoparticles. This invention provides a method to release small quantities of th
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Multifunctional Neck Brace

strengthening of cervical muscles and the prevention of atrophy of cervical muscles; and graduated mobility and improved comfort in patients with a disease attributable to the cervical region of the spinal column. All braces distribute the weight of the head more evenly to the base of the brace surf
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HEYL, a Novel Oncogene

TGF-beta signal transduction is a primary tumor suppression pathway in breast cancer. Many breast cancer cells gain mechanisms to counteract the TGF-beta inhibitory effect but the mechanisms have remained elusive. Recently, scientists at Johns Hopkins University have identified a new oncogene that a
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EXIGO-MS: a new MS solution platform for the robust identification and characterization of proteins

The major bottleneck of proteomics is no longer the ability to generate data, but the analysis of proteomics data, and mining as much information from it as possible. This new software allows one to rapidly analyze data generated by mass spectrometry in an iterative manner to solve this problem. ?
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Identification of E. Coli Determinants Contributing to Bacteremia that Form the Foundation for Development of Vaccines Against E. Coli Bacteremia Andsepsis

E. coli is the most common gram-negative organism causing nosocomial bacteremia and bacteremia in VA and elderly patients. The mortality and morbidity associated with E. coli bacteremia is substantial. For example, E. coli sepsis is associated with an estimated 40,000 deaths each year at a cost of t
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SIV Clonal Isolates: SIV/17E-Fr, SIV/17E-C1, SIV/3-11RG, and SIV/3-7

Abstract (Set) JHU researchers have constructed infectious simian immunodeficiency virus (SIV) molecular clones that differ in their Env and Nef proteins. These clones display differences in neurovirulence and cellular tropism. Description (Set) Proposed Use (Set) SIV clones for studying cell
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Multiple Inversion Flip Flop (MIFF) Vectors

JHU researchers have developed novel Multiple Inversion Flip Flop (MIFF) plasmid vectors for controlling the expression of transgenes that are either stably-integrated or transient. These vectors comprise a cytomegalovirus (CMV) promoter flanked by LoxP sites in opposing orientations, which allow fo
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The Use of Lumican as an Inflammation Modulator

This technology identifies an extra-cellular matrix protein, lumican, that plays a role in the inflammation pathway. This protein is present in the skin, cornea, intestines and blood vessels, and modulates its action through cell surface signaling molecules. Mice deficient in lumican have are resist
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A Rapid Assay Using Fine Needle Aspiration (FNA) to Test for 5-fluorouracil Dosing and Efficacy

Scientists at JHU have developed a functional assay for a class of widely used anti-cancer drugs, 5-fluorouracil and related compounds (5FU). The assay is based on Fine Needle Aspiration (FNA) of any neoplastic lesion from a patient being treated with 5FU, and processing of the material for thymidyl
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Fabrication and Application of a Prokaryotic Proteome Chip

from E. coli, and the use of the purified proteins in the fabrication of a proteomic chip. This invention also relates to various methods of using the proteomic chip to identify protein factors which mediate pathogen-host interactions, and to identify novel enzymatic activities associated with such
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TC-1/A2

Scientists at JHU have developed an HLA-A2 expressing tumor mouse model that can naturally process and present E7 antigen via HLA-A2 molecules. Description (Set) Proposed Use (Set) This mouse model should be useful for assays of HLA-A2-restricted E7-specific antitumor responses and antitumor ef
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Optimized MRI Strip Detectors

Strip MRI detectors offer the advantages over conventional detectors of minimal coupling and high-frequency operation as phased arrays. This invention is a method to optimize the SNR for MRI strip detector designs. The rules were determined by numerical electromagnetic Method of Moment (Mom) analysi
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Phase 2 Inducers and Related Signaling Pathways Protect Cartilage Against Inflammation/Infection, Apoptosis and Stress

The molecular pathogenesis of arthritis associated with increased chondrocyte apoptosis is earmarked by over-expression of cyclooxygenase-2 (COX-2) in articular tissues. COX-2 inhibitors are efficacious in the treatment of osteoarthritis and rheumatoid arthritis but clinical findings of serious gast
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Platform for High-Quality 3D Elasticity Ultrasound

The Johns Hopkins University seeks a partner to commercialize a new platform for generating high-quality elasticity ultrasound images. The system uses a novel set of algorithms that integrate with traditional ultrasound machines to produce highly accurate and stable segmentation of areas with high o
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Diagnostic Screening for Disorders of the ER-to-Golgi Trafficking

This technology describes Cranio-lenticulo-sutural dysplasia (CLSD) as a novel autosomal recessive syndrome, and identifies a missense mutation in SEC23A segregating with this syndrome. SEC23A is an essential component of the COPII-coated vesicles that transport secretory proteins from the endoplas
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Processes for Regulating Blood Glucose in a Mammal and Novel Polypeptides Useful in Nad Biosynthesis

Scientists at JHU have discovered of a novel blood-circulating form of Nampt. This novel isoform a slightly higher molecular mass compared to the intracellular form of Nampt and is mainly secreted by brown adipose tissue or cells in mice. Scientists at JHU also have created a novel use for the HIB-
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A System and Method for Image Based MR Interventional Device Tracking and Scan Plane Guidance

The present invention is a method of using projection images for interventional device tracking. Specifically, the new tracking method involves acquisition, device detection on 2D projection images, reconstruction of the 3D device from its 2D projection, and selecting the plane of the device without
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Embryonic Stem Cells from Animal Models of Motor Neuron Diseases Including Spinal Muscular Atrophy (SMA) and Amyotrophic Lateral Sclerosis (ALS)

Progress in the development of therapies for motor neuron diseases has been hampered by the lack of effective cell culture models. Since spinal motor neurons selectively die in ALS and SMA, an effective cell culture model must have mature motor neurons that have the genetic defect found in humans wi
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Development of Peptide Antibody Depletion (PAD) and its Application to Mass Spectrometry Sample Preparation

One of the major limitations of mass spectrometry is obtaining mass information on proteins in the presence of contaminating materials or other high abundant proteins that, when present in the sample, suppress the observation of proteins of interest. JHU scientists have developed a novel application
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Enhanced Novel Diagnostic and Prognostic Markers and Therapeutic Targets for Melanoma

Presently there are few effective systemic therapies to treat advanced stages of melanoma and the key to improved survival in all affected individuals remains early diagnosis and treatment. Scientists at JHU have identified melanoma progression and invasion-associated markers that are likely to pred
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Vaccine to Prevent/Treat Esophageal Cancer in Individuals with Barrett's Esophageal Metaplasia

Esophageal cancer affects approximately 14,000 individuals per year in the United States, is increasing in incidence, and is associated with an exceptionally high mortality rate. The poor outcome in patients with esophageal cancer is reflective of both deficiencies in early detection - the disease i
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Role of Kv Channels in Neuroregeneration and Protection

Injury to the human central nervous system (CNS) is usually difficult to treat because of the limited regeneration capabilities of the neurons. Evidence suggests that the lack of CNS regeneration is due to the presence of inhibitory factors in the CNS environment. While there is clearly a great need
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Sequence Motifs that Direct Nuclear Import of Small RNAs

Small RNA species, such as small-interfering RNAs (siRNAs) and microRNAs (miRNAs), have important roles in gene silencing and possess great potential for the development of novel therapeutics. Researchers at Johns Hopkins University have discovered the first known sequence element that regulates the
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Tumor Repressor Genes in the Prevention of Cancer

Some epidemiological studies suggest that many solid tumor types occur less often than predicted in individuals with Down syndrome. Using mouse models of trisomy 21 and cancer, scientists at JHU have provided biological proof of this phenomenon. In doing so, they propose to have identified a novel
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ATR-Seckel Cancer Cells for Drug Discovery

Advanced gene targeting methods were used to generate biallelic knock-in point mutations in human colorectal cancer cells that cause a loss of ATR function, but retain enough activity to permit viability. JHU researchers determined that progression of the cancer cell cycle after radiation treatment
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Formation of Functional Motor units and Recovery from Paralysis Using Embryonic Stem Cell Transplantation

The technology describes the potential of embryonic stem cell-derived motor neurons to functionally replace those destroyed in a paralyzed rat model. JHU researchers have successfully demonstrated the ability to increase the success of transplanted axons extending out of the spinal cord into ventral
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Alteration of the Albumin-bound Protein/peptide Complex (ABPPC) is Biomarker for Disease

JHU scientists have invented a cost-effective, rapid, and sensitive assay that characterizes proteins differentially bound to albumin in diseased and healthy patients and is compatible with current blood collection protocols. The current hypothesis states that albumin changes with disease, and there
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Pull-Out Resistant Pedicle Screw for Osteoporotic Patients

This novel device is a pullout resistant pedicle screw that will provide enhanced stability and fixation in osteoporotic spine surgery patients. The use of the new pedicle screw may also be indicated in patients necessitating revision surgery due to the fact that it increases osseous fixation and pu
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Epigallocatechin-3-Gallate (EGCG) Enhances CD8+ T Cell Mediated Anti-Tumor Immunity Induced by DNA Vaccination

Immunotherapy and chemotherapy are generally effective against small tumors in animal models of cancer, but many tumors can grow rapidly and become resistant to both therapies. JHU researchers have now shown that this resistance can be overcome by combining immunotherapy using DNA vaccination with
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Discovery of Novel HTLV-3 and HTLV-4 Retroviruses

Scientists at JHU have recently discovered the existence of two new types of Human T Lymphotropic Viruses (HTL-V), HTLV-3 and HTLV-4, which may be transmitted within humans. The HTLV-4 and HTLV-3 are serologically indistinguishable from existing HTLV-1 and HTL V-2 using current assays and this may
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Functional Cardiac Tissue Engineering Using Nanostructured Scaffolds for Cardiac Cell Therapy & High-Throughput Drug Screening

This technology incorporates a method to guide the three-dimensional growth and generation of functional cardiac tissues with controlled and enhanced electrophysiological properties using a nanostructured tissue scaffold. Ultraviolet (UV)-assisted capillary lithography or nano-imprinting technique i
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EmboGel / EmboClear Therapeutic Solution � Dissolvable radio-opaque alginate-based biomaterial for endovascular delivery and controlled therapeutic agent release

Johns Hopkins University is seeking licensees for EmboCaps and Emboclear. EmboCaps are an alginate matrix with controllable porosity that provides diffusion-controlled release of therapeutic agents. EmboClear is an alginate dissolving solution with minimal toxicity in vivo and enables erosion-contro
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Novel Class and Clinical Application of Antithrombotic Agents that Specifically Inhibit Inflammation-related Vascular Occlusion

Inflammation is known to be an integral part of the vascular occlusive events that occur during heart attack and stroke, although the specific pathway that links inflammation to clot formation has not previously been determined. Using both in vitro and in vivo studies, JHU researchers have identifi
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Mouse Adult Kidney Stems Cells Modulate Function of Dendritic Cells

Abstract (Set) Recent data has suggested that stem cells, such as mesenchymal cells derived from bone marrow, demonstrate an immunosuppressive ability and could represent a new approach for the treatment of immune-related disorders and the regeneration of damaged tissue. Organ resident cells, on th
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High throughput generation of water-in-oil emulsions for molecular genetic analyses

Researchers have developed a technology called BEAMing (Beads, Emulsion, Amplification and Magnetics), which can assess millions of molecules simultaneously for the study of human genetic variation (see invention number 4273 for more details). Following the development of BEAMing, JHU researchers m
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Method of Synthesis of Chemospheres and Chemogel, Hydrogel Embolic Particles and Gel for Locoregional Delivery of Therapeutic Agents and Immunoisolation of Cellular Therapeutics

Description (Set) JHU scientists have developed a method of producing innovative biocompatible compositions useful for variety of therapeutic applications. The biocompatible polymer gel compositions are innovative in the way that they incorporate trackable contrast agents and bioactive agents for s
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Liposomase for the Tumor-specific Delivery of Chemotherapeutic Drugs

The challenge in developing effective cancer treatments is in achieving specificity so that only cancer cells are destroyed. JHU scientists have developed a novel drug delivery system that overcomes the problems caused by the low specificity of chemotherapeutic drugs. The technology utilizes a uniq
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The Direction of Controlled Heat Specifically to Cancer Cells to Enhance Therapeutic Responses to Combination Therapy

The novel featues outlined in ths invention are: 1. The use of localized limited heat that is specifically directed to the cancer cells and their environment to sensitize the cell to combination therapeutic approaches including cytotoxic, immunologic and radiation therapy. 2. To enhance this effect
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Small molecule as Novel Anti-tumor and Anti-angiogenic Agent

Abstract (Set) JHU scientists found that a known antibiotic that inhibits the type 2 methionine aminopeptidase and possesses anti-angiogenic activity both in vitro and in vivo. It causes both primary human endothelial cells and cancer cells to undergo senescence. It was demonstrated that this antib
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Method to Predict Severity of Inflammatory Central Nervous System Attacks by Detection of Interleukin-6 Levels

The present invention relates to soluble immune derangements in the cerebrospinal fluid of patients with autoimmune, inflammatory disorders of the central nervous system (CNS). Specifically, IL-6 is selectively and dramatically elevated in the CSF of these patients. IL-6 levels are directly correla
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Multitypic Recombinant Adenovirus Vaccines Against HPV

This invention is a vaccine against human papillomavirus infection consisting of recombinant adenoviruses that are engineered to include peptides of the human papillomavirus 16 minor capsid protein (L2). The L2 sequences are displayed on the outside of the adenovirus particles, where they induce imm
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Mutant DISC1 Inducible Transgenic Mouse Model of Schizophrenia

Description (Set) Transgenic mice with inducible expression of mutant human DISC1 (hDISC1) limited to forebrain regions were generated. Proposed Use (Set) The mouse model could be used to study of aspects of the pathogenesis and preclinical experimental therapeutics of schizophrenia.
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Alternative Splice Variant Patterns of Human Telomerase Reverse Transcriptase (hTERT) in Thyroid Tumors Distinguish Benign from Malignant

Human telomerase reverse transcriptase (hTERT) is activated in thyroid cancer. Despite this, its usefulness as a marker in the distinction of benign from malignant neoplasm has not been proven. hTERT is known to have several deletion isoforms or alternative splice variants in addition to its full le
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A "Molecular Switch" in Group 1 mGluR Signaling Relevant to Neurological and Psychiatric Diseases

Abstract (Set) Reported here is the mechanism by which group 1 metabotropic glutamate receptors (mGluR) are co-functional with dopamine receptors or growth factor receptors. This convergent signaling is central to understanding several diseases including drug addiction, inflammatory pain, schizophr
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Near-infrared Fluorescent 6-0-glucosamine Compounds with Targeting Specificity to Lysosomes in Tumors

Optical imaging is a non-invasive, diagnostic imaging technology which can be used to inexpensively image pathological conditions with high sensitivity and low tissue irradiation. Technologies using near infrared (NIR) light are preferred in molecular imaging studies because its long wavelength cau
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Ligands for Nicotinice Acetylcholine Receptors, and Methods of Making and Using Them

One aspect of the present invention relates to heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. A second aspect of the invention relates to the use of a compound of the invention for modulation of a mammalian nicotinic acetylcholine receptor. The present invention also
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The Immediate Early Gene Arc Interacts with Endocytic Machinery and Regulates the Trafficking and Function of Presenilin

Abstract (Set) These discoveries promise a novel approach to develop agents to regulate presenilin 1 (PS 1) and treat Alzheimer's Disease and age-dependent memory decline. PS 1 functions as part of the gamma secretase (protease) complex that acts on amyloid precursor protein (APP), Notch and severa
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Biocompatible "smart" nanogels as carriers for hydrophobic drugs

The present invention involves a biocompatible nanogel composition for the delivery of hydrophobic substances that are not readily soluble in organic solvents. These nanogels have been designed to contain hydrophobic cores which encapsulate the insoluble molecules, and a hydrophilic shell which allo
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N171-82Q Huntington's Disease (HD) Mouse Model

This transgenic line expresses an N-terminally truncated human huntingtin cDNA that encodes 82 glutamines and encompasses the first 171 amino acids. The altered huntingtin cDNA is under the control of a mouse prion protein promoter. Expression is observed in neurons of the central nervous system.
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Topical Administration of Peripherally Acting Drugs for the Treatment of Chronic Pain

Abstract (Set) Clinicians currently have few therapeutic options when it comes to treating chronic neuropathic pain. Drugs available on the market today are not effective in all patients, and often result in partial alleviation of pain. Multiple studies have shown that opioids are effective in trea
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Drugs Targeting Cancer Stem Cells

The study of cancer stem cells is important for the development of new cancer treatments. Existing chemotherapeutics may eradicate the bulk of a tumor but residual stem cells may remain to initiate new tumor growth. Novel treatments that target cancer stem cell will help to eliminate the source of
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MicroRNAs As Targets for Anti-Angiogenic Therapies

MicroRNAs (miRNAs) are 18-24 nucleotide RNA molecules that regulate the stability or translational efficiency of target mRNAs. miRNAs are frequently dysregulated in cancer cells and can act as oncogenes and tumor-suppressors. The proto-oncogene c-MYC encodes a transcription factor that regulates ce
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PSMA-targeted Nanoparticles for Therapy of Prostate Cancer

Description (Set) Targeted therapy for cancer has gained considerable importance recently with various improvements not only in target identification, but also in small molecule or antibody development. It has also been demonstrated that polymeric nanoparticles can passively target tumors via the e
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Mouse Model of Human Head and Neck Squamous Cell Carcinoma

Abstract (Set) Cancers of the head and neck, the majority of which arise in the squamous cells that line the mucosal surfaces in the head and neck, account for 3% of all malignancies in the United States. Human head and neck squamous cell carcinoma is a clinically aggressive tumor, and fewer than 5
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Novel Immunotherapy for Contact Dermatitis

Abstract (Set) Allergic contact dermatitis, the third most common reason for outpatient dermatology visits, is an immunological disease that gives significant influences on patient's quality of life and makes enormous economical impacts. Current therapies for contact dermatitis are largely dependen
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New Angiogenesis Inhibitors Derived from Fumagillin

Angiogenesis, the formation of new blood vessels, is involved in the pathogenesis of a number of common human diseases, including cancer, diabetic retinopathy, rheumatoid arthritis, and macular degeneration. Inhibitors of angiogenesis can be used for the treatment of all aforementioned disease condi
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ER alpha M4, ER alpha U4, p16 M4, p16 U5, Hin1 M1, Hin1 U2, RASSF1a M1, RASSF1a U1, RAR beta M1, RAR beta U1, Twist BM2, Twist BU5, APC M3, APC U3, Cylin D2 M1, Cyclin D2 U4, 14-3-3 M2, 14-3-3 U3, HIC

Abstract (Set) Plasmid DNAs incorporating human gene-specific promoter sequences altered by sodium bisulfite treatment. Description (Set) Proposed Use (Set) Their use includes serving as reagents, standards, or controls for assays of gene methylation (e.g. for determining Methylated or unmethy
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Selective Fluorescent Labeling of S-Nitrosothiols: S-FLOS

Johns Hopkins University is seeking licensees for a powerful analytical and quantitative technique for S-nitrosylation of proteins. S-nitrosylation is a post-translational protein modification that can alter protein structure and activity. Emerging evidence suggests that dysregulation of S-nitrosyla
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Candidate Proteasome Inhibitors that Prevent E6 Mediated p53 Degradation and Selectively Kill HPV+ Cervical Cancer

Abstract (Set) High-risk strains of Human papillomavirus (HPV) cause over 90% of cervical cancers. About 20 million people (men and women) are thought to have an active HPV infection at any given time. Yearly, 14,000 cases are diagnosed and 5,000 women each year die of cervical cancer in the United
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Monoclonal Antibodies (mAb) Specifically Against Mouse and Human LIGHT and B7-H4

Scientists at JHU have made antibodies against mouse and human LIGHT and B7-H4 molecules. Description (Set) Proposed Use (Set) These mAb could be used specifically to detect the expression of LIGHT and B7-H4 and to block interactions of these molecules with their counter-receptors.
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Transplantable Membrane Systems for Use in Ocular Tissue Repair

The present invention is a novel non-immunogenic collagen vitrigel membrane for use in ocular tissue repair. The unique properties of the collagen vitrigel permit it to be transplanted alone or as a supporting film for corneal epithelial, stromal, endothelial, or other ocular surface tissue. The mem
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Genomewide Analysis of Chromosomal Translocation

Abstract (Set) The cancer genome is quite unstable with many aberrant genetic translocations dispersed across its sequence. Many chromosomal translocations result in chimeric transcripts resulting in elevated expression levels, believed to be responsible for tumorigenesis. Therefore, it is importan
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Melanoma Metastasis-associated Genes As Novel Diagnostic and Prognostic Markers and Therapeutic Targets for Melanoma

The incidence of melanoma is increasing at the highest rate for any form of cancer in the United States and the current lifetime risk in the US is 1 in 68. Presently there are few effective systemic therapies to treat advanced stages of melanoma and the key to improved survival in all affected indiv
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The Consensus Coding Sequences of Breast and Colorectal Cancers

Human cancer is a disease caused by an accumulation of mutations in genes involved in cell cycle regulation. To date only a small fraction of the genes underlying tumorigenesis have been identified, and the number and type of genes responsible are unknown. With the sequencing of the human genome res
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A Novel Cystic Fibrosis Therapeutic Agent

Abstract (Set) JHU scientists found that a known drug has a novel function as a stimulator of calcium-activated Cl- channels (CaCCs) and, thus, is a potential therapeutic drug in the treatment of cystic fibrosis. Cystic fibrosis is the number one genetic killer of children and young adults in the U
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Antipsychotic Drugs that do not elicit Weight Gain by Screening for Influences on Hypothalamic AMP-Kinase and Histamine H1 Receptors

Atypical antipsychotic drugs (AAPDs) have markedly enhanced the treatment of schizophrenias but their use has been hindered by the major side effect of weight gain. Ignorance of the mechanism of these orexigenic actions has delayed efforts to develop alternative therapeutic agents. JHU scientists h
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A Novel Method for Generating and Screening Peptides and Libraries Displayed on Adenovirus Fiber

Abstract (Set) Capsid-displayed adenoviral peptide libraries have been a significant yet unfeasible goal in biotechnology. Three barriers have made this difficult: the large size of the viral genome, the low efficiency of converting plasmid-based genomes into packaged adenovirus, and the fact that
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Novel Inhibitors of CRAC Channel As Immunosuppressants

T cell activation is essential for immune response. It is primarily responsible for graft rejection upon organ transplantation. Moreover, dysregulation of T cells has been implicated in several autoimmune disorders, including MS and rheumatoid arthritis. Existing immunosuppressive drugs have signifi
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Tamoxifen-resistant MCF-7 Breast Cancer Cell Line

MCF-7 cells serve as a prototypic model system for human breast cancer and their response to secretive endocrine response modifiers (SERM) therapy. MCF-7 cells, upon long term exposure to tamoxifen, acquire tam-resistance and continue to grow in the presence of tamoxifen. Description (Set) Prop
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Methods to Block or Reduce Damage from Stroke and Other Neurological Disorders

Description (Set) An acute neurological condition caused by blood clots that block blood vessels in the brain is cerebral ischemia (stroke) similarly; blood vessel breakage in the brain is cerebral hemorrhage (stroke). These blood vessel miscues result in the initiation of an ischemic cascade that
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