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An Expression Silencing System and Different Uses Thereof

Highlights Provides a process for hybridizing plants with selectively altered genomes Transforms a plant cell with a T7 RNA polymerase gene (T7-pol), a NLS sequence, and at least one promoter and at least one terminator sequence Plants are capable of regeneration Suppresses expression of targeted
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A Current Steering Folding Amplifier

The analog-to-digital converter (ADC) is a key functional building block in most analog/digital VLSI systems. Most applications require high-speed ADC�s with low power consumption. Our technology provides a novel current steering folding amplifier that significantly reduces the power dissipation of
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Use of Magnetic Fields to Control Diffusion and Hydrogen Embrittlement in Iron and its Alloys Containing Hydrogen and its Isotopes

The application of magnetic field will cause different magnetostrictive stains in iron (and its alloys including steels) when hydrogen (H) or deuterium (D) or tritium (T) is dissolved in iron lattice compared when no dissolved H, D, or T is present in iron. The resulting differences in the dimension
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A Chewing Gum for Preventing Tooth Decay

Highlights Bacteria immobilized in biofilms coating teeth (dental plaque) cause dental diseases and disorders. Special additives in chewing gum cause active absorption of bacterial biofilm from teeth Significantly successful results in 130 humans: between 10x-100x improved reduction in cariogenic
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Polynucleotide Molecule from Haematococcus Pluvialis for Biotechnological Production of Astaxanthin

Highlights Astaxanthin is a powerful antioxidant, 10 times more capable than other carotenoids Astaxanthin does not convert to vitamin A, circumventing fat solubility and toxicity Results in a safe food colorant, protecting against photooxidative damage Method enables the production of natural a
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Novel Glossmeter

Highlights Instrument measures properties of glossiness, suitable for flat and curved surfaces Computer gives a single number representing the gloss of flat or curved surface by using appropriate software and hardware analysis techniques Grades perishable foods, textiles, paper, metals, and more wit
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Attenuating Mutations for Tularemia Live Vaccine

Introduction Francisella tularensis is a bacterial pathogen that causes the zoonotic disease tularemia and that is often transmitted to humans through the bite of ticks or mosquitoes, inhalation of hay dust, ingestion of infected food or water or physical contact with infected animals. The severity
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Sports Training Device - Optimal Point of Impact: Perfection Sleeves.

Please see patent link and also description below. OPOI’s Perfection Sleeves are designed to isolate the optimal point for hitting a golf ball during driving or iron play. This point is surrounded by a dense silicon, which, when contacted, absorbs the energy from the hit and reinforces the ball’
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A Methyl Bromide Substitute for Agricultural Use

Methyl bromide is extremely important to United States and World agriculture (64,000,000 lbs. used in the U.S. in 1990), and is the most widely used and efficacious general-purpose fumigant in the world. It has extensive applications in soil fumigation, quarantine treatment of exports and imports,
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Novel Food Product (Packaging)

Unique hand-held cup with two compartments that keeps pasta and sauce separated until just before microwave heating, resulting in the freshest possible taste and perfect al dente texture. Sauce is in the lid and pasta/rice/noodles is in the cup. The consumer pulls tab to break seal of lid to
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Method and System for Detecting an Individual by means of Passive Infrared Sensors

Geo-location and tracking by sensing the body’s heath. The videosurveillance market is rising drastically and needs new smart sensors at a low price. This geo-location systems qives the real-time location of individuals to Video Management Systems an to video-cameras. The present invention relate
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A Novel Tumor Suppressor Gene

BACKGROUND: Tumor suppressor genes are genes that, when damaged, fail to suppress tumorigenesis. Typically, tumor suppressor genes are genes that, in their wild-type alleles, express proteins that suppress abnormal cellular proliferation. When the gene coding for a tumor suppressor protein is mutat
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Seed Size Regulation using Parent-Specific Hypomethylation

BACKGROUND: In plants, hypomethlyation of genomic DNA helps regulate seed size. At present, antisense MET1 transgenic plants can be used for creating seeds with increased size and weight. However, the dominant nature of MET1 means that a parent's genome, the genome of its gametophytes, and both sets
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Identification of Sortase

BACKGROUND: Hospital-borne bacterial infections present a major challenge in patient care due to the rising number of strains resistant to multiple antibiotics in recent years. Gram-positive bacteria, such as Staphylococci, Streptococci and Pneumococci, are the most common cause of these often fatal
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Identification of Sortase

BACKGROUND: Hospital-borne bacterial infections present a major challenge in patient care due to the rising number of strains resistant to multiple antibiotics in recent years. Gram-positive bacteria, such as Staphylococci, Streptococci and Pneumococci, are the most common cause of these often fatal
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EPLIN, a marker for human Cancer

BACKGROUND: EPLIN, a novel gene not previously described encodes a protein expressed in human epithelial cells. EPLIN is of significant importance because its expression is diminished in many forms of human cancers including breast and prostate cancer. Restoring the expression of EPLIN in cancer cel
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Biological Vaccine Delivery System

This invention relates to methods and compositions for producing a fusion protein comprised of Haemophilus influenae P2 amino acid sequences, wherein in place of loop 5, or a portion thereof, is displayed a heterologous or homologous peptide sequence having biological activity. The protrusion of loo
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A Computer Aided Tomography to Ruled Edge Prototyping Translator

To remain competitive in a global market, manufacturers are called upon to bring a variety of products to market with continually decreasing lead times and development costs. These commercial realities are a driving force demanding the development of improved rapid prototyping techniques. A rapid pr
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Nanocellular Foaming of Ultra High Molecular Weight Polyethylene using Ultrasound

Introduction Ultra high molecular weight polyethylene (UHMWPE) is a thermoplastic consisting of molecules of incredibly long chains with molecular weights of several million. It has the highest impact strength of any thermoplastic, has a high resistance to corrosion, moisture, and abrasion, and has
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A container for separately storing two different contents, and mix right prior to usage

wo separately stored drinks in a single container/ can/ bottle. On can's opening it is only one drink. Pressing the can's side will release the second drink to create a fresh and authentic cocktail in less than 3 seconds anywhere and anytime, at home or outdoors. The product is fully functional.
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Dielectric Elastomer Fiber Transducers

Artificial muscle fibers. Disclosed are electroactive polymer fibers, processes of preparing electroactive polymer fibers, and devices containing electroactive polymer fibers. Devices can be used as actuators and sensors, generators and transducers. Applications include inter alia artificial muscle
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Signal Amplification Method for SPR-based Chemical Detection

Introduction Surface plasma resonance (SPR) is a general spectroscopic method for sensing refractive index changes near the surface of a metal film. Its sensitivity to these changes provides a versatile platform for the observation and quantitation of chemical reactions and intermolecular binding at
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A New Protocol of Diels-Alder Lattice Hardening for Highly Efficient Electro-optic Materials Showing Outstanding Temporal Stability over 200 Degrees C

Introduction Organic electro-optic (EO) materials have attracted much interest in the past two decades because of their extensive potential applications in various fields, ranging from waveguides, switches, emitters, and detectors. Though EO materials have a huge potential in Photonics and Electroni
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Design of Spring Actuators Based on Ferromagnetic Shape Memory

Introduction Shape memory alloys (SMA) and ferromagnetic shape memory alloys (FSMA) have shown tremendous promise for a wide variety of applications because of their ability to “remember” a previous state when either heat or a magnetic field is applied, respectively. This is especially important fo
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Topical Pediculicidal Compositions

Topical arthropod ectoparasite treatment - containing a synergistic combination of a pyrethrin and piperonyl butoxide, and cationic polymer to increase uptake of active agents
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Compositions and Methods for in Vitro Molecular Sorting Compartmentalization in Double (W/O/W) Emulsions

The present invention provides an in vitro system for compartmentalization of molecular or cellular libraries and provides methods for selection and isolation of desired molecules or cells from the libraries. The library includes a plurality of distinct molecules or cells encapsulated within a water
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A Process for Preparing a Solid State Dye Laser

The invention provides a process for preparing a solid state dye laser in a composite glass matrix, without the use of polymerization initiators, comprising preparing a porous silica gel, effecting thermal treatment thereof at a temperature of at least 500.degree. C. to produce a glass with improved
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A Unique Approach to the Design and Production of Photochemical Sensors

Highlights Enables the preparation of stable, multi-use remote sensors for detection systems for environmental impurities Based on the introduction of indicator dyes into a novel composite glass film from which sensitive waveguides are fabricated Uses a plurality of nanopores sized between 20 and
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A Process for the Epoxidation of Alkenes and Polyoxofluorometalates for Use therein

The invention provides a process for the catalytic epoxidation of an alkene comprising contacting a transition metal substituted polyoxofluorometalate and molecular oxygen with said alkene.
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Fabrication of Robust Electro-Optical Switching Devices

Highlights Method for producing robust, long-lasting electro-optical light-controlling devices May be used for beam steering or switching or electro-optically tuneable filter devices Concept for beam switching device demonstrated in laboratory Applications in telecommunications or wherever there
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Nanoemulsion that Improves Light Fastness of Ink

Highlights Hinders the photodegradation of colorant in ink and inkjet ink in sunlight or artificial light Submicron particles do not cause nozzle clogging on the orifice plate of inkjet cartridges Preparation also suitable for water-based industrial inks, pad inks, paints and coatings Our Innovat
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A polysaccharide-based bioadhesive hydrogel

Highlights Proprietary adhesive patches for novel drug delivery with improved patch-skin adhesion and biocompatibility. Work in a range of pHs, provide better adhesion and higher permeation than commercial patches. Proof of concept was shown in several in-vivo and in-vitro models. These novel pa
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Copolymer self-assemblies for synthesis of inorganic-organic nanoparticulate compositions

The present invention relates to a method for the production of particles of nano-materials being transition metals and alloys; metal oxides; and ceramic compositions having a small nanosize, i.e. about 1-6 nm. The method comprises a synthesis in the solutions of complex liquids from suitable precur
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Biofuel Cell with Switchable and Tunable Electrodes

Highlights Biofuel cell that uses blood glucose as fuel source The food consumed by a human being each day contains as much energy as a thousand AA batteries Enzymes are used as catalysts that lead to oxidation of fuel and production of electricity To prevent all glucose in blood being turned int
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Electronic Detection of Molecular Targets, Including Proteins, Oligonucleotides and other small Molecules

BACKGROUND: While many assays exist for the detection of DNA, RNA, proteins and other molecular targets, most sensors require sample purity and rigorous controls available only under ideal laboratory settings. These constraints significantly dampen the effectiveness of most reported sensing technol
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Enhancing Biomass Pretreatment Using Ionic Liquids EIO-2587

APPLICATIONS OF TECHNOLOGY: - Pretreating biomass to extract sugars for conversion to liquid biofuels ADVANTAGES: - Increased yield. Cellulose recovery of 95% by mass. Current techniques recover 50-90%. - Reduced time to recover sugars from plant material from 3-4 days for acid-based techniqu
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Lignin from Biomass to Co-Products

APPLICATION OF TECHNOLOGY: * Convert lignin from sustainable biomass to high value products ADVANTAGES: * Produce high value products without the need for petroleum * Improve biofuels cost effectiveness by utilizing lignin to produce high value co-products * Produce products thr
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Techno-Economic Cellulosic Biorefinery Simulation Model

Project Goal: JBEI proposes to develop a comprehensive Techno-Economic model of a cellulosic biorefinery to better understand the biorefinery process and estimate the operating costs, research needs, environmental impacts, and the overall viability of these biorefineries. The first stage of the p
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Genetically Encoded Cell Death Reporter

Introduction Determining cell viability is critical to a wide variety of scientific disciplines. Currently, cell viability is assessed by incubating the cells of interest with a chemical dye or stain that reacts differently with living cells compared to dead cells. The stained cells are then analyze
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Protein Components of Streptococcus Pneumonae That Bind to Mucin Glycoproteins of Human Nasal and Middle Ear Secretions

Currently, there is no effective vaccine to prevent infections by Streptococcus pneumoniae, a leading cause of otitis media (OM) as well as a number of other upper respiratory tract infections that affect both pediatric and adult populations. A prer equisite for infection is bacterial colonization o
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Adjuvant activities of a mutant LT-IIb enterotoxin lacking binding to ganglioside GD1a

UB microbiologists have developed a mutant heat-labile enterotoxin (LT-IIb) that demonstrates promising adjuvant activity and appears to overcome the limitations and concerns related to various mucosal adjuvants currently under investigation. The abi lity of the mutant LT-IIb to stimulate mucosal an
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Novel Chalcogenoxanthylium Dyes for Purging Blood Pathogens

Researchers at the University at Buffalo and the American Red Cross have developed a suite of chemical compounds to be used to purge pathogens found in the blood supply. There is a dire need to increase the blood supply. At current rates of donat ion, there is barely a three-day supply in many a
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Gene silencing of human c-myc oncogene by poly-DNP-RNA

Overexpression of the c-myc proto-oncogene has been implicated in the onset and progression of a wide range of cancers; in restenosis following arterial injury or intervention; and in the loss and dysfunction of insulin-producing ??cells in diabetes. UB researchers have synthesized a new compound, D
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Application of Grating Light Reflection Spectroscopy in Analytical Sensors

Introduction There are a number of methods for measuring bulk fluid compositions in statics and flow by visible light reflection characteristics from the optically inhomogeneous wall of a vessel. Surface Plasmon Spectroscopy (SPS) on gratings and randomly rough surfaces has proven to be especially s
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Control of Engineering Processes Using New Magnetostrictive Alloy Compositions

Nickel-Palladium (Ni-Pd) alloy based catalysts play an important role in chemical and petroleum industries. So do other ferromagnetic alloy based catalysts. Some of these metals, that form the catalysts, have magnetic characteristics, which when favorably used, could have a huge impact in their cata
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BCRP expressing cell lines

Introduction The breast cancer resistance protein (BCRP) is an ATP-binding cassette efflux transporter originally identified by its ability to confer multidrug resistance in cancer cells. BCRP mediates the efflux transport of a broad spectrum of substrates, including many drugs routinely administere
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Cell and Microparticle Separator Employing Patterned Grooves

Introduction Microscale enrichment and separation are important for various research, biomedical, and industrial uses. Conventional means for these processes typically require specific labels— either inherent to the structure or appended to it. Unfortunately, not every important substrate has a con
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Chimeric LT-II toxins as adjuvant-carrier molecules

One of the factors limiting the commercial development of mucosal vaccines is the availability of appropriate, safe and effective adjuvants, or delivery systems that promote the desired kinds of immune responses. The present invention provides m ethods of inducing immune responses by recombinant
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Respiratory Detection System (RDS)

Introduction Respiration rates are an important indicator of cellular and metabolic states in cells ranging from mammalian to bacterial, from individuals to large populations. Unfortunately, conventional techniques have significant drawbacks: for instance, electrochemical techniques have low sensiti
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Initiators for Block-Copolypeptide Synthesis

BACKGROUND: Amino acid-N-carboxyanhydride (NCA) polymerizations employing conventional initiators (e.g. hexylamine or sodium methoxide) are plagued by chain-breaking transfer and termination reactions which prevent the formation of block copolymers. The mechanisms of NCA polymerization have been und
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Tough, Self-Healing Silicone Materials

Siloxane- and organosiloxane-based materials (collectively termed "silicones") are ubiquitous in commercially available goods and high technology applications, often in the form of oils, rubbers, resins, and hard solids. Their general usefulness is due to their broad and tunable range of beneficial
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Use of Vanadium Bromoperoxidase as a Signal-Generating Enzyme for Chemiluminescent Systems: Test Kits and Analytical Methods

PATENT ABSTRACT: Aqueous compositions, test kits and methods can be used to detect hydrogen peroxide or vanadium bromoperoxidase by generating a chemiluminescent signal in the presence of the analyte. Signal generation as well as reaction kinetics are improved by using a composition which compris
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Design of Thermal Interface Material Based on High Temperature Shape Memory Alloy for Connecting Two Thermoelectric Legs

Introduction Efficient heat management is crucial for electronics to optimize performance and to avoid premature component deterioration. An area of primary concern is at the interface of adjoining thermal components, such as with heatsink interfaces and with connections between thermoelectric legs.
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Multilevel Modulation for Free Space Optical (FSO) Communications and Error Correction Methodology

Introduction Wireless optical links, or free space optics (FSO), enable point-to-point, high-speed communication with low installation costs and high levels of security, and they are especially useful in situations where fiberoptics are impractical. Unfortunately, this technique suffers from signal
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Auto-Tuning Amplifier

Introduction In wireless communications and wireless products, architectures can be complex and space-consuming due to the need for circuitry that receives signals from multiple bands. System complexity and increased size leads to higher costs; thus, design improvements that save space and decrease
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Frequency and phase measurements using the Morlet transform

Introduction Telecommunication systems designed for Bluetooth or other standards deal with transmitted and received signals in the radio frequency (RF) range. Modulation methods and frequency-hopping techniques are employed to optimize access for multiple users. These communication architectures cre
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Calibrated Low-Loss Phase Shifter with Negative Resistance Circuit and Sigma-Delta PLL for Multiple-Antenna Receivers

Introduction Variable Phase Shifters are used in many applications such as adaptive smart-antenna receivers. In adaptive antenna receivers, antenna paths are linearly combined in an RF stage after being adjusted in both amplitude and phase. Variable-gain low-noise amplifiers and variable phase shift
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A Common-Gate Low Noise RF Amplifier for Ultra High Frequencies

Introduction Typically the first stage of an integrated receiver is a low-noise amplifier (LNA); hence, it is one of the most critical RF building blocks. An LNA is required to provide enough gain to suppress the noise contributions of subsequent blocks such as mixers. Noise figure is the most impor
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Influencing the orientation of chromophores to increase the opticelectric effect

Introduction The electro-optic effect, important for optical communications and quantum optics, occurs in materials that alter their refractive index in the presence of an electrical field. One of the more important specific electro-optic effects is known as the Pockels effect. Materials exhibiting
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Scalable, Rapidly Tunable Wavelength Selective Ring Resonator

Introduction Wavelength-division multiplexing (WDM) is a capacity increasing technology used in fiber-optic communications to carry different optical signals in a single optical fiber. Optical add-drop multiplexers are required at either end of a fiber for WDM. Current technologies switch too slowly
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Specific glycan-modified HIV envelope proteins as vaccine immunogens against

Introduction A major obstacle in current AIDS/HIV vaccine development is the failure to induce broadly neutralizing antibodies against primary isolates of human immunodeficiency virus. Standard vaccination approaches prime the adaptive immune system to recognize viral envelope proteins. However, the
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Vaccinia Antigens for Development of a Smallpox Vaccine

Introduction Smallpox is a disease of increasing biodefense importance. The current smallpox vaccine is too virulent, and therefore unsafe, for up to 5% to 10% of the American public. Vaccinia are viruses that are genetically related to smallpox and inoculation with live, replicationcompetent vaccin
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Improved use of Recombinant Viruses for Liver Regeneration

Introduction Diseases of the liver, both genetic and acquired, are especially detrimental due to the fact that the liver is a key organ for most metabolic pathways. Currently, the only method of curing liver diseases is via a liver transplant. Unfortunately, many transplants succumb to rejection, le
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Prevention of Browning in Fruits and Vegetables

Bruising or other mechanical wounding of fruits and vegetables cause many post-harvest problems; including the browning of injured and adjacent tissue. Currently, the only way to control browning induced by mechanical wounding is with refrigeration or chemical treatment. While these treatments slow
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Conductive and Magnetic Phases in an Electron Trapping Semiconductor Array

Nanotechnology is a rapidly evolving field where the race is on to develop self-organizing structures that can be used as active circuit elements. This technology describes a semiconductor array that can be configured so as to exhibit a number of distinct physical phases, each of which has its own d
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Formation of AIFeCu Quasicrystalline Thin Films by Solid State Diffusion

This technology describes the fabrication and coating of quasicrystalline films (less than about 3000 A� thick) of AlCuFe on different substrate materials such as strontium titanate, and sapphire by radio-frequency sputtering and subsequent anneal. The applications of this technology are quite broad
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Novel 4-Substituted Indole compounds and methods for making same

The basic indole structure has been a structure of great interest to synthetic and medicinal chemists because of its presence in a large number of biologically active agents. For the most part, the current methods for producing substituted indole mo lecules rely upon cyclization of a suitably substi
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Composition and method of preparation of lipid nano particulates containing antigens as cancer vaccine

Using a rational design strategy, compositions (LINAP) have been developed for the targeted delivery of cancer vaccine antigens. Designed to target Dendritic cells (DC), LINAP is able to facilitate more potent T-cell immune responses than immunizing with antigens alone. In addition, LINAP confers st
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Composition and method of preparation of liposomal microparticulate IL-12 for immunotherapy

Pharmaceutical and immunological scientists at the University at Buffalo have developed novel formulations for cytokine and growth factor drugs, including recombinant interleukin-12 (rhIL-12), GM-CSF and VEGF-C. Depending on the preferred method of a dministration, these formulations can be customiz
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Method and composition of Pegylated protein (FVIII)-Phosphoserine complex

These novel compositions provide for enhanced delivery of protein therapeutics. Proteins (e.g. recombinant Factor VIII) associated with LIPRO-FORM exhibited improved pharmacokinetic profiles and higher efficacies in animal models. With characterist ics such as lowered immunogenicity and increased ci
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Isolation of Functional Smooth Muscle Cells using Tissue Specific Promoters

Chemical engineers at the University at Buffalo have developed a method for isolating a patient’s own functional smooth muscle cells from hair follicles, bone marrow, cord blood or peripheral blood cells. The cells isolated via this method have shown utility in at least one tissue engineering applic
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Method and Composition of Less Immunogenic, Long- Circulating Protein- Lipid Complexes

These novel compositions provide for enhanced delivery of protein therapeutics. Proteins (e.g. recombinant or full-length Factor VIII) associated with LIPRO-FORM (see R-6031 as well) exhibited markedly improved pharmacokinetic profiles and higher e fficacies in animal models. With characteristics su
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Chimeric TBP-Toxin Proteins as Mucosal Antigens for Vaccination against Neisseriae

Neisseria gonorrhoeae, the causative agent of the sexually transmitted disease gonorrhea, has been a burden to mankind from antiquity. Central to this bacteria's prolific nature, is its antigenic avariability of surface structures, as well as abilit y to avoid initiating host immune responses. Its c
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Method for Inhibiting Proteases in the Oral Cavity

Sensitive teeth, a condition which affects more than 45 million Americans each year, likely results from exposed dentinal tubules. A number of products have been developed that either occlude the exposed dentinal tubules or desensitize the nerves r esponsible for transmitting signals that the brain
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Organically Modified Silica Nanoparticles Coencapsulating Photosensitizing Drug and Two-Photon Absorber for Two-photon Activated Photodynamic Therapy

Photodynamic therapy (PDT), following health agency approvals throughout the world for various cancers and other diseases, is slowly being accepted as a standard treatment for the treatment of obstructive esophageal and lung cancers as well as e arly stage lung cancer, and actinic keratoses. However
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Method for Delivering Hydrophobic Drugs Via Nanocrystal Formulations

This technology explains the formulation of a nanosized drug delivery carrier and the method of delivering photodynamic drugs, which are free from the external agents. From the results obtained for significant photosensitizing efficacy in vitro and in vivo conditions, it is believed that upon admin
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Calcium Sulfate (sulphate)-Based Nanoparticles: Synthesis and Modification Methods and Application in Bone Regenerative Therapy

Bone regeneration within critical size defects, both in the oral cavity and throughout the rest of the body, occurs very slowly in the absence of bone stabilizing agents to act as scaffolds. Though autogenous and allogenic bone grafts have been used to address this limitation, each faces its own set
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Using Selection to Define Rules for Small Molecule Targeting of RNA

Information needed to design nucleic acid-based compounds which target RNA can be as limited as knowing the Watson-Crick base pairing “code”. However, to date, the clinical success of such compounds (e.g. antisense and RNAi) has been elusive. Unlike nucleic acid-based drug candidates, delivery and s
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Use of RNA inhibitors based on IL-14 and antibodies to IL-14 for the treatment of autoimmune diseases and lymphomas

Autoimmune disorders and B cell derived lymphomas cause life-long suffering or premature death. Often the treatment for these diseases is symptomatic at best with severe side effects. An effective new treatment would be life saving for those patie nts. The cytokine interleukin-14 (IL-14) also known
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Method and Composition of Less Immunogenic, Long Circulating EPO

Over one million patients in the U.S. are prescribed a therapeutic erythropoietin to treat anemia caused by kidney failure or cancer chemotherapy. It is estimated that over 80% of cancer patients and 87% of patients with severe kidney disease devel op this condition. Treatment is critical considerin
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Anti-tumor compounds

Members of the inhibitor of apoptosis protein (IAP) protein family are often expressed at high levels in cancer cells. It is thought that high expression of IAP proteins leads to a disruption in the apoptotic pathway (programmed cell death). This d isruption allows for continuation of the cell cycle
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Methods for Preparing Multivalent RNA-Targeting Ligands with Specific Application Towards Targeting the (CUG)n Oligomers that Cause Myotonic Dystrophy

Trinucleotide repeat disorders are genetic disorders caused by extended stretches of DNA encoded with the same trinucleotide sequence repeated many times. Some of the most notable trinucleotide repeat disorders include Myotonic Dystrophy, Fragile X, Huntington’s, and Friedreich’s ataxia. Myotoni
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Composition of Liposomal GM-CSF

Pharmaceutical and immunological scientists at the University at Buffalo have developed novel formulations for cytokine and growth factor drugs, including recombinant interleukin-12 (rhIL-12), GM-CSF and VEGF-C. Depending on the preferred method of a dministration, these formulations can be customiz
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Method of treating bacterial infection in humans using antimicrobial nanoparticles applied in vivo and ex vivo

Method of treating bacterial infection in humans using antimicrobial nanoparticles applied in vivo and ex vivo Categories: Environment, Therapeutic and Vaccines
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Identification of a new Type II Heat-labile Enterotoxin

One of the factors limiting the commercial development of mucosal vaccines is the availability of appropriate, safe and effective adjuvants and antigen delivery systems that promote the desired kinds of immune responses. In addition, many of the new subunit vaccine candidates lack sufficient immunog
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Composition and Method of preparation of Lipidic particles containing VEGF for lymphadema

Pharmaceutical and immunological scientists at the University at Buffalo have developed novel formulations for cytokine and growth factor drugs, including recombinant interleukin-12 (rhIL-12), GM-CSF and VEGF-C. Depending on the preferred method of a dministration, these formulations can be customiz
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Use of hair follicle cells for tissue engineering of artificial organs or cell therapy

Many different tissues have been identified as stem cell sources for cell-based tissue engineering and cell therapies. However, the procurement of such cells is limited by ethical issues or the accessibility of donor sites. A definite need exists for an alternative, easily accessible stem cell sourc
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Rapid Colored Prototypes (RCP)

A rapid colored prototype (RCP) process is a rapid process of producing colored three-dimensional objects. This method is a marked improvement over the colorless traditional rapid prototyping techniques. Adding functional color into rapid prototype s benefits the user by increasing visualization, un
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Biometric Convolution: a system and method for securing biometric data using multiple biometrics

Biometrics (signature, finger print, facial recognition, etc) are used in a growing number of security applications. There is major public concern/unease with using biometric data, particularly concerning the level of security and robustness of encr yption of personal information. This invention
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Hyperspace Diagonal Counting (HSDC) for Multiobjective Pareto Frontier Visualization

This technology describes a new mathematical technique to graphically visualize and present objects and shapes in hyperspaces, i.e., in extensions of space beyond the third dimension. Currently, these are visualized only as mathematical abstractions, although there have been attempts to capture and
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Hyperspace Diagonal Counting (HSDC) for Multidimensional Visualization

This technology describes a new mathematical technique to graphically visualize and present objects and shapes in hyperspaces, i.e., in extensions of space beyond the third dimension. Currently, these are visualized only as mathematical abstractions, although there have been attempts to capture and
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Hyperspace Diagonal Counting (HSDC) for Multidimensional Database Visualization and Data Mining

This technology describes a new mathematical technique to graphically visualize and present objects and shapes in hyperspaces, i.e., in extensions of space beyond the third dimension. Currently, these are visualized only as mathematical abstractions, although there have been attempts to capture and
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Secure Fingerprint Matching by Hashing Localized Information

This invention discusses and discloses a unique method of protecting fingerprint biometric data. The method uses algorithms to determine a set of specialized points on a fingerprint, and then uses the pattern to hash (encrypt) the fingerprint recogn ition information. This invention is unique in tha
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Referent Tracking

Referent tracking is a simple yet powerful way to organize electronic data and coordinate databases. The ability to track not only information but also data relationships is invaluable in various fields including healthcare, intelligence, and digital media. Currently, the creation and flow of new an
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FieldXtract - a software toolkit for extraction and automated reading of machine printed and handwitten form fields for indexing and retrieval

FieldXtract - A software toolkit for extraction and automated reading of machine printed and handwitten form fields for indexing and retrieval
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In-Situ Stress-Strain Sensor

This invention describes a technology that provides a new class of strain/stress sensors. The sensors are short fiber composites. They provide a reversible electrical response to strain/stress application. The sensing material can function as the structure material at the same time, so no embedding
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Low Frequency Seismic Accelerometer

This invention describes a sensor for civil engineering applications in earthquake zones and for other applications where low frequency, large dynamic measurement range is required. Earlier technologies like high and "force-balance" acceleromet an deliver the frequency and dynamic range but are extr
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Low Power Solid-State Sensor Device

This invention describes the design of a novel sensor to quantify molecular Oxygen (O2) based entirely on solid-state electronics. A derivative compound of Ruthenium II has been found to exhibit luminescence of a very specific quality. Upon reacting with molecular O2, the characteristics of the lumi
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Detection and identification of buried, non-metallic landmines via acoustic sensing

This invention describes a technology appropriate for detection of buried objects such as landmines, buried structures and artifacts in soil beds and inhomogeneities in mass distribution of powders. It is a method and a system for detecting and imaging the shape, location, and material identity
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Micromachined Microsensor Arrays for Chemical Sensing Applications

Chemical sensor arrays are low cost, compact, robust and versatile alternatives to large analytical tools like optical spectrometers. This invention describes the rapid fabrication of reusable chemical sensor arrays for simultaneous multi-analyte qua ntification by machining a novel array on the fac
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