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Bone Implant Device and Methods of Using Same
A bone implant device comprising a plurality of interconnected plate members, at least one plate member defining a plurality of apertures therein adapted for permitting bone growth there through from an interior portion of the bone in which the device is implanted for aiding in securing the device w
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Protein Chip for Screening of Protein Activity
The present invention relates to protein chips useful for the large-scale study of protein function where the chip contains densely packed reaction wells. The invention also relates to methods of using protein chips to assay simultaneously the presence, amount, and/or function of proteins present in
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Identification of Cancer Protein Biomarker Using Proteome Technique
PROBLEM TO BE SOLVED: To provide a testing method capable of being used in order to diagnose the cancer of an ovary in an initial stage or an advanced stage. ; SOLUTION: There are disclosed a method for diagnosing the cancer or assisting the diagnosis of the cancer. The method is based on the identi
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Excitatory glycine receptors and methods
The invention provides isolated N-methyl-D-aspartate type 3B (NR3B) polypeptides, functional fragments and peptides, encoding nucleic acid molecules and polynucleotides, and specific antibodies. Also provided are excitatory glycine receptors, containing either NR3B or NR3A polypeptides. Further prov
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Methylation Biomarkers and Methods of Use
Disclosed are methods and compositions of assessing one or more statuses of a subject. Also disclosed are methods and compositions of identifying status biomarkers associated with a status of a subject. Also disclosed are sets of one or more status biomarkers. Also disclosed are methods and composit
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Diagnosis and Treatment of Age Related Macular Degeneration
Methods, compositions and kits for diagnosis and treatment of age related macular degeneration.
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Methods of Treating Hepatitis
The present invention relates to a method of treating hepatitis in a patient, which includes administering a pharmaceutical composition that includes carbon monoxide to the patient.
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C/CLP Antagonists and Methods of Use Thereof
The invention relates to the novel discovery that antagonizing a C/CLP can be useful for the treatment of diseases associated with the upregulation of one or more C/CLP such as Th2-driven and/or IL-13 mediated inflammatory diseases. Accordingly the present invention provides C/CLP antagonists and al
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Method and composition for treating immune complex associated disorders
The present invention provides methods and compositions for treating immune complex associated diseases (ICAD), such as SLE, rheumatoid arthritis, and hepatitis-C related immune complex disease (e.g., cryoglobulinemia) in a subject having an ICAD or at risk for developing ICAD. The invention is base
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Riboswitches and Methods and Compositions for Use of and with Riboswitches.
Riboswitches are targets for antibiotics and other small molecule therapies. Riboswitches and portions thereof can be used to regulate the expression or function of RNA molecules and other elements and molecules. Riboswitches and portions thereof can be used in a variety of other methods to, for exa
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Methods and Compositions Related to Riboswitches That Control Alternative Splicing and Rna Processing.
Disclosed are methods and compositions related to riboswitches that control alternative splicing.
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Inhibitors of Receptor Tyrosine Kinases and Methods of Use Thereof.
The present invention provides moieties that bind to an Ig-like domain, e.g., D4 or D5, of a human receptor tyrosine kinase, e.g., the human Kit RTK or the PDGFR RTK, or the D7 domain of a type V receptor tyrosine kinase wherein the moieties lock the ectodomain of the receptor tyrosine kinase in an
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Semaphorin 7A Plays a Critical Role in TGF-Beta1-Induced Pulmonary Fibrosis and Alveolar Destruction
The present invention provides methods of treating a subject diagnosed with, or at risk for developing, pathogenic fibrosis, particularly pulmonary fibrosis. The method of the invention comprises administering to the subject a compound or composition which inhibits semaphorin (SEMA) 7A, SEMA 7A rece
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Method of Assessing Blood Volume Using Photoelectric Plethysmography
A method and system for assessing blood volume within a subject includes generating a cardiovascular waveform representing physiological characteristics of a subject and determining blood volume of the subject by analyzing the cardiovascular waveform. The step of analyzing includes generating a firs
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Identification of cancer protein biomarkers using proteomic techniques
The claimed invention describes methods to diagnose or aid in the diagnosis of cancer. The claimed methods are based on the identification of biomarkers which are particularly well suited to discriminate between cancer subjects and healthy subjects. These biomarkers were identified using a unique an
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Ribosome structure and protein synthesis inhibitors
The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The i
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Apoptosis-Based Evaluation of Chemosensitivity in Cancer Patients
Induction of apoptosis in target cells is a key mechanism by which chemotherapy induces cell killing. An in vitro system has been established for determining carboplatin and paclitaxel (Taxol) chemosensitivity of epithelial ovarian cancer cells, where measurements of caspase-3 activation are surroga
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Detection, Isolation and Uses of Renalase (monoamine Oxidase C)
The present invention provides for the identification, isolation and uses of mammalian Monoamine Oxidase C (MAO-C), also known as renalase.
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Riboswitches, methods for their use, and compositions for use with riboswitches
It has been discovered that certain natural mRNAs serve as metabolite-sensitive genetic switches wherein the RNA directly binds a small organic molecule. This binding process changes the conformation of the mRNA, which causes a change in gene expression by a variety of different mechanisms. Modified
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Dynamic spine stabilizer
A dynamic spine stabilization device is provided that includes at least one force imparting member, e.g., a spring. The force imparting member is adapted to deliver a force of between about 150 lb/inch and 450 lbs/inch, and restrict the relative travel distance between said first and second pedicles
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Modulation of Sirt1 Expression
Methods are provided for reducing SIRT1 expression by administering a SIRT1 inhibitor. Also provided are methods for treating cardiovascular and metabolic disorders in a subject or delaying or preventing risk factors thereof through the reduction of SIRT1 expression. The present invention is also di
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Method for Controlling Flower Development in Plants
The present invention provides a method of controlling the sexuality of a plant comprising treating the plant with a composition comprising a compound selected from the group consisting of jasmonic acid, a jasmonic acid derivative, and a salt thereof.
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Compositions and Methods of Use of an Oncolytic Vesicular Stomatitis Virus
Oncolytic VSV viruses have been developed as a strategy for combating cancer. The present invention includes mutant VSV that have one or more mutations in the nucleic acid sequence encoding the viral genome that increase the oncolytic potential of the virus. Pharmaceutical compositions including onc
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Activated Wnt-beta-catenin Signaling in Melanoma
The present invention is directed to a method of determining the prospects for survival of a melanoma patient. This method involves providing a biological sample from a patient diagnosed with melanoma, determining the level of an indicator of Wnt/ss-catenin activation in the sample, comparing the le
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Volume Status Monitor: Peripheral Venous Pressure, Hypervolemia and Coherence Analysis
Systems and methods are provided for monitoring changes in blood volume using waveforms in the peripheral vasculature. In particular, the systems and methods relate to detecting ventilation-induced variation (VIV) of waveforms in the peripheral vasculature. Advantageously, the systems and methods ma
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Novel Markers for Detection of Complications Resulting from in Utero Encounters
Described herein are biomarkers, such as protein biomarkers, which are diagnostic of and predictive for complications that result from an in utero encounter, such as an infection by the fetus, that can lead to premature birth (PTB). The biomarkers can be used to identify fetuses and newborns at risk
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Methods and Compositions for the Detection and Treatment of Preeclampsia
Methods, kits and compounds are provided that relate to the diagnosis, treatment, and/or prevention of preeclampsia.
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Tissue Engineering of Lung
The present invention relates to compositions comprising a decellularized tissue. The present invention also provides an engineered three dimensional lung tissue exhibiting characteristics of a natural lung tissue. The engineered tissue is useful for the study of lung developmental biology and patho
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Compounds and Methods for Treating Viral Encephalitis
The invention includes compositions, methods, and techniques for influencing or otherwise altering or regulating signaling that emanates from ligands, receptors, or pathways of TLR7, and/or IL- 12, and/or IL-23, and/or IL- 17, singly or in any combination. The invention includes inhibiting ligands,
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Parallel Magnetic Resonance Imaging Using Nonlinear Gradient Encoding
In MRI by excitation of nuclear spins and measurement of RF signals induced by these spins in the presence of spatially-varying encoding magnetic fields, signal localization is performed through recombination of measurements obtained in parallel by each coil in an encircling array of RF receiver coi
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A Snp Marker of Breast and Ovarian Cancer Risk
The invention provides methods for predicting an increased risk or probability of developing breast or ovarian cancer in a patient based upon the patient's KRAS-Variant and BRCA status.
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Physiologic Sample Preparation for Nanosensors
The present invention provides a microfluidic purification chip for capturing a biomarker from a physiological solution. The present invention also provides a method of capturing and releasing a biomarker, wherein the biomarker is originally in a physiological solution. The present invention further
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Treatment and Prevention of White Matter Injury with Katp Channel Activators
The present invention includes a method of treating or preventing a CNS white matter injury in a patient in need thereof. The invention also includes a method of stimulating proliferation of a CNS cell in a patient in need thereof.
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Methods and Compositions Related to Riboswitches That Control Alternative Splicing.
Disclosed are methods and compositions related to riboswitches that control alternative splicing.
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Rock Inhibitors and Uses Thereof
The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are compounds that inhibit Rho-protein associated kinase function. Compounds of the invention include piperazinyl pyridine
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Nanoelectronic-enzyme Linked Immunosorbent Assay System and Method
The present invention relates to a device and method for determining the presence of a specific compound in solution. The device includes a nanosensor having an electrically conducting pathway between at least a first and second contact. The device also includes a first receptor, suitable for bindin
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Osmotic Desalination Process
An energy efficient desalination process that does not produce waste products involves the extraction of water from a first solution, such as seawater, by using a second concentrated solution to draw the water from the first solution across a semi-permeable membrane. By manipulating the equilibrium
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Use of the Combination of Phy906 and a Tyrosine Kinase Inhibitor As a Cancer Treatment Regimen
This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of cancer
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Osmotic Heat Engine.
A method of converting thermal energy into mechanical work that uses a semi- permeable membrane to convert osmotic pressure into electrical power. A closed cycle pressure-retarded osmosis (PRO) process known as an osmotic heat engine (OHE) uses a concentrated ammonia-carbon dioxide draw solution to
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Chimeric Small Molecules for the Recruitment of Antibodies to Cancer Cells
The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalentl
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A Method for Preventing Or Alleviating the Noxious Effects Resulting from Toxicant Exposure
The present invention provides a method of using agents which can modulate TRPAl function as counteragents to inhibit the physical effects of chemical irritants/toxicants when given prior to exposure or to lessen the physical effects when administered post exposure, and more specifically, to a metho
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Intrauterine Fallopian Tube Occlusion Device
An intrauterine device for occluding orifices of fallopian tubes includes a resilient body having an elongated member with a first end and a second end. The elongated member further includes a first leg ending with the first end of the elongated member, a second leg ending with the second end of the
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Porous Expansion Bolt
A biocompatible expansion bolt includes a central screw and an expansion shell positioned about the central screw. The expansion shell is shaped and dimensioned for controlled expansion between a first diameter and a larger, second diameter, wherein die expansion shell is composed of porous material
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Method of Blow Molding a Bulk Metallic Glass
A very low pressure gas or blow forming process for shaping a bulk metallic glass (BMG) in its supercooled liquid state that avoids the fractional stick forces experienced by conventional shaping techniques by engineering the expansion of a pre- shape or parison of BMG material such that substantial
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Compositions with Enhanced Bioavailability and Fast Acting Inhibitor of Gastric Acid Secretion
The present invention relates to the use of pharmaceutically acceptable zinc salts, preferably water soluble zinc salts alone or optionally, in combination with one or more of a protein pump inhibitor (PPI), H2 blocker, anti-H. pylori antibiotic/antimicrobial, cytoprotective agent or a combination a
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Methods for a Predictive Diagnostic Test for Tamoxifen
A method for determining the likelihood that a therapy involving administration of tamoxifen to a patient afflicted with an estrogen receptor positive breast cancer will provide a therapeutic benefit to the patient which comprises determining the level of expression of epidermal growth factor recept
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Suspension/retraction Device for Surgical Manipulation
A device that can be delivered into a body cavity to manipulate tissue intracorporeally while being controlled extracorporeally and a method of using the device to perform a single-port laparoscopic or natural orifice surgery. The device is being capable of being passed through an interior diameter
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Methods of Using Mir-199a As a Marker and Sequences of Mir-199a As a Therapeutic for Cancer
The invention relates to methods of measuring the level of expression of differentially expressed microRNAs (miRNAs), such as for example hsa-mir-199a, in a cancer cell as an indicator of the level of chemoresistance of the cancer cell. The invention further relates to methods of administering a nuc
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Mutations in Contaction Associated Protein 2 (cntnap2) Are Associated with Increased Risk for Ideopathic Autism
The present invention provides compositions and methods for the examination of cells, tissues, and fluids, collectively known as body samples, to identify human subjects at-risk of developing Autism Spectrum Disorder by detecting a chromosomal abnormality or variant in the CNTNAP2 gene, the AUTS2 ge
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Methods for Differential Diagnosis of Melanocytic Lesions
The invention provides a method for determining whether a melanocytic lesion in a patient is malignant which comprises determining a quantity of gp100 present within a nuclear compartment in stained cells in a tissue sample from the melanocytic lesion; determining a quantity of gp100 present within
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Microna Compositions in the Treatment of Vegf-mediated Disorders
The invention provides methods of treating diseases caused by the over-production of a VEGF polypeptide by administering miRNA or miRNA inhibitor compositions to decrease at least one activity of a VEGF polypeptide.
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Optical System That Selectively Provides Either of a Collimated Light Beam Or a Convergent Light Beam
There is provided a method that includes projecting a collimated light beam from an optical system to a plane during a first mode of operation of the optical system, and projecting a convergent light beam from the optical system to the plane during a second mode of operation of the optical system. T
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Improved Complementary Metal Oxide Semiconductor Devices
Improvements in Complementary Metal Oxide Semiconductor (CMOS) devices; in particular, field effect transistors (FETs) and devices using said transistors which are able to take advantage of the higher carrier mobility of electrons compared to holes by replacing the conventional p-channel transistor
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Carbon Nanotube Compositions and Methods of Use Thereof
Carbon nanotube (CNT)-based compositions for activating cellular immune responses are provided. The CNTs function as high surface area scaffolds for the attachment of T cell ligands and/or antigens. The CNT compositions function as artificial antigen-presenting cells (aAPCs) or as modular vaccines.
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Nanomechanical Photonic Devices
The present invention relates to devices which operate on gradient optical forces, in particular, nanoscale mechanical devices which are actuable by gradient optical forces. Such a device comprises a waveguide and a dielectric body, with at least a portion of the waveguide separated from the dielect
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Nanoparticles for Use As Synthetic Platelets and Therapeutic Agent Delivery Vehicles
The invention relates to synthetic platelet compositions and methods useful in diminishing bleeding and blood loss. The synthetic platelets of the invention can comprise a biocompatible, biodegradable polymer, including, for example, a poly(lactic-co-glycolic acid)-poly-L-lysine (PLGA-PLL) block cop
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Irf As a Tumor Suppressor and Uses Thereof
The invention relates to methods for treating BCR/ ABL mediated disorders. The methods of the invention also include monitoring progression of or sensitivity to treatment of BCR/ ABL mediated disorders as well as identifying subjects for the treatment methods of the invention. Screening assays and r
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Reagents and methods for improving reproducibility and reducing mispriming in PCR amplification
An additive for preventing mispriming in polymerase chain reaction (PCR) amplifications and assays comprising a hairpin oligonucleotide having a stem duplex greater than six nucleotides in length and a stabilized stem terminus. The additive improves PCR amplifications, including LATE-PCR amplificati
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Direction Sensitive Neutron Detector
A neutron detector includes a pressure vessel, an electrically conductive field cage assembly within the pressure vessel and an imaging subsystem. A pressurized gas mixture of CF4, 3He and 4He at respective partial pressures is used. The field cage establishes a relatively large drift region of low
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Methods of Insect Control By Inhibiting Or Modulating the Trpa1 Ion Gated Channel Or Family Members
The present invention is directed towards methods of inhibiting thermo- and chemo-sensing in insects and pests by inhibiting TRPA1 ion gated channel or family members. The present invention is also directed towards methods of insect control by modulating the TRPA1 ion gated channel or family members
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Conjugate Addition Reactions Using Bifunctional Cinchona-alkaloid-based Catalysts
One aspect of the present invention relates to quinine-based and quinidine-based catalysts. Another aspect of the present invention relates to a method of preparing a chiral, non-racemic compound from a prochiral electron-deficient alkene, comprising the step of: reacting a prochiral electron-defici
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Reagents and Methods for Pcr
Modified double-stranded oligonucleotides that have terminal regions on each of their strands, that have a hybrid length of 6-50 nucleotides long, that have a melting temperature Tm of at least 32 DEG C, and that include 2-4 modifying groups, each covalently attached to a different terminal region,
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Compounds and Methods for Treating Mammalian Gastrointestinal Microbial Infections
Described herein are compounds, and pharmaceutically acceptable salts and prodrugs thereof, which are useful as inhibitors of IMPDH. In certain embodiments, a compound of the invention selectively inhibits a parasitic IMPDH versus a host IMPDH. Further, the invention provides pharmaceutical composit
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Prepared Foods Containing Triglyceride-recrystallized Non-esterified Phytosterols
A dietary supplement is provided which includes at least one triglyceride-based edible fat and between 3% and 50% by weight of triglyceride recrystallized phytosterols. The dietary supplement can be in the form of a capsule, pill or wafer. Additionally, the dietary supplement can be combined with pr
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Cross-linking of Superoxide Dismutase Monomers
A stabilized superoxide dismutase (SOD1 ) analogue, wherein the side chains of two amino acids on two different SOD1 monomers are connected is provided. A method of producing a stabilized superoxide disumutase (SOD1) analogue comprises reacting a first SOD 1 monomer, a second SOD1 monomer, and a cro
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Systems and Methods for Determining Process Conditions in Confined Volumes
Systems and methods for the determination of properties in confined volumes are generally described. Generally, a gradient in at least one parameter (e.g., temperature) may be established across a plurality of confined volumes. In addition, at least one property (e.g., whether a crystal has been for
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Primers, Probes and Methods for Nucleic Acid Amplification
Homogenous detection during or following PCR amplification, preferably LATE-PCR, utilizing fluorescent DNA dye and indirectly excitable labeled primers and probes, improves reproducibility and quantification. Low-temperature homogeneous detection during or following non-symmetric PCR amplification,
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Nucleic Acid Processing Methods, Kits and Devices
Biological samples containing nucleic acids, RNA and DNA, are freed from bound proteins by incubation with a chaotropic agent such as a guanidium salt, and the mixture is readied for further processing by dilution of such agent to a concentration below 0.05 M without physical isolation of RNA and DN
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Methods for the Treatment Or Prevention of Diabetes Mellitus and Other Metabolic Imbalances
The invention relates to methods for treatment and prevention of a metabolic imbalance, including diabetes mellitus and other related diseases or disorders, using an extract from a fruit of genus Elaeis.
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Single Probe, Multiple Temperature, Nucleic Acid Detection Methods, Kits, and Compositions
Provided herein are methods, kits, and compositions related to nucleic acid detection assays that allow discrimination of multiple target sequences with a single probe. In particular, provided herein are methods kits, and compositions that include single-probe target sequence discrimination where di
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Staphylococcus Detection Assays
Provided herein are methods, kits, and compositions related to nucleic acid detection that allow the detection and discrimination of various Staphylococcus species and types. In particular, provided herein are assays that allow the detection of MSSA, MSSE, MRSA, MRSE, VRSA, VRSE, and MRSA community
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Methods for Making Embryonic Cells, Embryos, and Animals Sensitized to Stress
Embodiments of the invention are based upon the discovery that exposure of cleavage-stage embryos to a stress inducer, e.g. heat shock or chemical, renders the exposed embryos more sensitive to a secondary treatment with a stress inducer, e.g. heat shock or chemical inducer. Accordingly, the present
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Antineoplastic Hydrogels, and Enzyme-instructed Preparations Thereof
Disclosed is a general methodology to create nano fibers of therapeutic molecules that have a dual role, as both the delivery vehicle and the drug itself. It is shown that with proper molecular design, the integration of enzymatic reaction and self-assembly provides a powerful method to create molec
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Sn-2 Myristate-containing Edible Oil
A nutritional fat or oil-based composition for increasing HDL cholesterol, decreasing LDL cholesterol and decreasing the LDL/HDL cholesterol ratio in human plasma is described. The composition can advantageously include at least 1 % by weight myristic acid esterified at the sn-2 position in triglyce
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Complement Factor H-based Assays for Serum Bactericidal Activity Against Neisseria Meningitidis
Assays for detection of bactericidal anti-Neisserial antibodies using a factor H polypeptide having a human amino acid sequence that mediates binding to Neisserial factor H binding protein (fhBp) are provided, as well as non-human animal models of Neisserial infection.
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Multipurpose Microfluidic Device for Mimicking a Microenvironment Within a Tumor
The present application relates generally to a novel microfluidic device for the in it propagation of neoplastic cellagregates under conditions that mimic the physiological microenvironment found in tumors. The invention also describes methods of screening for therapeutic test agents and protocols t
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Detection of Human Immunodeficiency Virus Co-receptor Tropism in Aviremic Subjects
Methods for detecting human immunodeficiency virus (HIV) co-receptor tropism or replication-competent virus in aviremic subjects, and methods of selecting optimal therapies for aviremic subjects.
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Methods and Compositions for Improving the Production of Products in Microorganisms
Methods and compositions are provided for improving the production of products, such as fuel products like ethanol, in microorganisms. In particular, methods and compositions are described for improving ethanol production utilizing genes identified in Clostridium phytofermentans.
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Methods and compositions for enhancing the efficacy and specificity of RNAi
A method of enhancing the efficacy of an siRNA duplex, or promoting entry of an antisense strand of an siRNA duplex into a RISC complex, the siRNA duplex comprising the antisense strand and a complementary strand, the strands each having 5' and 3' ends, the method comprising enhancing the asymmetry
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Tumour-specific P450 Protein
The discovery that CYP1B1 protein is detectable in a wide range of human cancers of different histogenetic types, but is not detectable in non-cancerous tissues, gives rise to diagnostic methods for detecting tumours based on this protein as a marker, and to the possibility of tumour therapies invol
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Methods for Microbial Production of Terpenoids
The invention relates to recombinant expression of terpenoid synthase enzymes and geranylgeranyl diphosphate synthase (GGPPS) enzymes in cells and the production of diterpenoids.
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Methods for Treating Glioblastoma
Described are methods for treating cancers, e.g., glioblastoma, including administering an inhibitor of Notch signalling, e.g., a gamma secretase inhibitor, in combination with a chemotherapeutic agent.
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Cell Division Marker
This application relates to a newly identified animal cell structure, the midbody scar. This structure is a remnant of the midbody that is retained by one daughter cell following cytokinesis and persists through multiple subsequent cell cycles. The midbody scar can be useful as a marker of dividing
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Spectroscopic Sensors
Disclosed herein are sensors that include: (a) a circuit board that includes an electronic processor; (b) a plurality of radiation sources, each source being attached to the circuit board; and (c) a spectral detector attached to the circuit board, the spectral detector being configured to analyze ra
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A System for Producing Patterned Silicon Carbide Structures
The invention is directed to methods of forming ceramic pattern structures of silicon carbide film. In one method, an electron-beam resist or a photo-resist is deposited onto a substrate. A portion of the resist is selectively removed from the substrate to form a resist pattern on the substrate. A f
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Compounds for Modulating Tlr2
The present invention is directed to methods, kits, and uses of inhibitors of LCMV mediated NF-?B activation to treat viral infections and inflammatory conditions.
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Enzymatic Synthesis of Polymers
The invention relates to new methods of enzymatic synthesis of polymers such as polyorganosilicones and polyesters, and new polymers made by these methods.
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Superhydrophobic Surfaces for Drag Reduction
Superhydrophobic surfaces according to the invention contain micro or nanoscale hydrophobic features which can support a shear-free air-water interface between peaks in the surface topology. The surface of an engineered structure is patterned with a plurality of parallel ridges extending from the su
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Toll-Like Receptor 9 Modulators
TLR9 is localized to endoplasmic reticulum and upon stimulation with a TLR9 ligand, is transported to a tubular lysosomal compartment as is CpG-DNA. Furthermore, it is shown that TLR9 and CpG-DNA directly bind. It was also found that the MyD88 translocates in response to activation of TLR9-mediated
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Geobacteraceae Strains and Methods
Embodiments of the present invention provide a method of producing genetically modified strains of electricigenic microbes that are specifically adapted for the production of electrical current in microbial fuel cells, as well as strains produced by such methods and fuel cells using such strains. In
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Methods and compositions for controlling efficacy of RNA silencing
Based at least in part on an understanding of the mechanisms by which small RNAs (e.g., naturally-occurring miRNAs) mediate RNA silencing in plants, rules have been established for determining, for example, the degree of complementarity required between an RNAi-mediating agent and its target, i.e.,
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Systems and Methods of All-Optical Fourier Phase Contrast Imaging Using Dye Doped Liquid Crystals
An assembly for converting a microscope into a phase contrast microscope includes a first optical Fourier element that Fourier transforms light from a coherent light source, a cell in the Fourier plane arranged to receive light from the first optical Fourier element, a second optical Fourier element
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Universal Visualization Platform
The invention relates to a framework system and methods for connecting a plurality of tools. The system comprises a plug-in mechanism configured to dynamically load the plurality of tools, a data pool having storage space configured to store data sets associated with the plurality of tools, a linkin
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Antimicrobial Polymers
The invention generally relates to novel polymers (SMAMPs) and their syntheses and use. The polymers exhibit promising properties of AMPs, In particularly, for example, a ring-opening metathesis polymerization (ROMP) platform was developed that allows syntheses of SMAMPs that employ a minimum number
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Particle Stabilized Emulsions for Extraction of Hydrocarbons from Oil Sands and Oil Shale
article-stabilized emulsions, of the sort which can utilize liquid carbon dioxide and/or supercritical carbon dioxide as a continuous or a dispersed phase, for hydrocarbon extraction
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Polysaccharide-containing Block Copolmer Particles and Uses Thereof
The invention relates to new amphiphilic linear block copolymers of polysaccharides and polymers. The amphiphilic linear block copolymers do not form a true solution in water and are able to form micelles in selective solvents. Also disclosed are particles, each of which has a shell and a core, and
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Methods and Compositions for Treating Neurological Disease
This invention relates to methods and compositions for treating neurological disease, and more particularly to methods of delivering iRNA agents to neural cells for the treatment of neurological diseases.
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A Method to Reduce Sludge Generation in Wastewater Treatment Systems
The systems and methods described provide for reducing sludge generation, and thus sludge wasting and handling, by including an anaerobic completely stirred tank reactor (CSTR) as a bioreactor in a side-stream. The CSTR provides a significant simplification of side-stream treatment design, enhanced
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Compounds for Modulating Rna Binding Proteins and Uses Therefor
The invention relates to compositions and methods for inhibiting RNA binding proteins (e.g., MEX-3, MEX-5 and POS-1), as well as methods for treating and preventing disorders associated with parasitic infections and inflammatory disorders.
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Rapid Cell Block Embedding Method and Apparatus
PROBLEM TO BE SOLVED: To provide a method and apparatus for rapidly embedding cells that utilizes a flow-through embedding technique. ; SOLUTION: The apparatus 10 includes a cell flow pathway 16 defined by an inflow tube 20 for delivering cell fragment from a cell sample 14 to a sample port 26. The
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