PATENTS
For Sale or License
Notify me of New Entries
Receive an email whenever a new patent is added.
You can unsubscribe at any time.
Platform for Metrology Instruments and Use Thereof
The invention relates to a platform for metrology instruments, comprising a base and an upper plate that rotates on the base by means of rolling spheres, as well as kinematic couplings for anchoring the upper plate in pre-determined positions and sensors for obtaining highly precise measurements of
...
Liposomes Covered with the Extracellular Domain of the Apo2l/trail Protein
The invention relates to the field of biotechnology and medicine. The invention specifically relates to a compound comprising a liposome covered or decorated at least with the extracellular domain of the APO2L/TRAIL protein, and to the use thereof for developing a medicament preferably for the treat
...
Method for the Dehalogenation and Hydrogenation of Halogenated Aromatic Molecules
Method for the consecutive dehalogenation and hydrogenation of halogenated aromatic molecules under mild temperature and pressure conditions in the presence of a catalyst of rhodium complexes with bis(imino)pyridine ligands. Furthermore, the invention relates to said complexes.
...
Cell-culture Flow Bioreactor
Cell-culture flow bioreactor that comprises an incubator (1), the receptacle (14) of which, to which access is gained via a hermetically sealed door (13), is defined by thermally insulating walls, and which is provided with a system for pumping fluid that circulates via the interior of a plurality o
...
Object Authentication System and Method
The invention relates to an identification and verification system and to an associated method for the identification and verification of documents, based on the use of nanoparticles embedded or absorbed in the medium forming the document, whereby the different optical reflectance characteristics of
...
Suprapubic Instrument Used Specifically in Endoscopic Prostate Surgery
The invention relates to a single tool that complements the technique performed by a resectoscope (4), which combines puncturing and subsequently extracting the irrigation liquid and remains of the extracted tissues, optimising said processes and increasing the intervention time, being suitable for
...
System for Machining Plastic Parts
The invention concerns a device for machining plastic parts, essentially burrs on parts formed using plastic injection, which comprises: a rotating rod (2); several arms (3a, 3b), connected to the rotating rod (2) that rock around several axes perpendicular to the axis of rotation of the rod (2), su
...
Spiropiperidyl Rifamycins for the Treatment of Microbacterial Infections
The compounds of formula (1), their pharmaceutically acceptable salts and their solvates, wherein R 1 is a radical selected between hydrogen and alkyl; R 2 is selected from hydroxyalkyl, phenyl, phenyl mono-substituted and phenyl di-substituted in positions 3 and 4; R 3 is selected from phenyl, phen
...
In-line Sensor and System for Obtaining the Fat Content of Milk
The invention relates to an in-line sensor and a system for obtaining the fat content of milk, respectively: a hollow device similar to any pipe through which the milk can flow and provided with a light-transparent hole and a plate located at a short distance from, and parallel to said hole, such th
...
Wavefront Aberration and Distance Measurement Phase Camera
A system consisting of a phase camera with microlenses placed in the focal point of a converging lens, wherein the camera data, processed using a combined Fourier "Slice" and 10 fast Fourier transform edge detection technique, provide both a three-dimensional wavefront map and a real scene depth map
...
System for Generating Energy from Marine Dynamics
The invention relates to a system for generating energy from marine dynamics by means of compressing the air housed in contained inside conductor pipes and turbines, through a unit with a spherical geometry in the surface of which various holes are made, capturing the energy which is produced in the
...
Oviedomycin Derivatives, Method for Obtaining Same and Use Thereof
The invention relates to oviedomycin derivatives, the method for obtaining same and the use thereof. The invention relates to oviedomycin derivatives obtained by fermentation of recombinant bacterial strains. The invention also relates to the methods used to obtain the recombinant strains and to pro
...
Glycosylated Indolecarbazoles, Method for Obtaining Same and Uses Thereof
Glycosylated indolecarbazoles, method for obtaining same and uses thereof. This invention relates to rebeccamycin and staurosporine derivatives obtained by means of fermentation of recombinant bacterial strains. The invention also relates to the methods used to obtain the recombinant strains and to
...
Method for Marking and Identifying Manufactured Articles, Substances and Organisms, and Uses Thereof
The present invention comprises a method for marking and identifying manufactured articles, substances and organisms (referred to below as "products"), based on the addition to the product to be marked of a known mixture of two or more isotropic profiles of a single chemical element that are enriche
...
Enzymatic Synthesis of Enantiomerically Enriched Derivatives of Cis- and Trans-cyclopentane-1,2-diamines
The invention relates to the enzymatic resolution of derivatives of cis- and trans-cyclopentane-1,2-diamines in order to obtain enantiomerically pure or enriched compounds, a method for preparing the starting materials for this method, the products of said method and the transformation thereof into
...
Use of Menadione to Increase Saline Stress Tolerance in Plants
The invention relates to the use of compositions containing menadione (vitamin K3 or pro-vitamin K) and/or some of the water-soluble derivatives thereof in order to improve saline stress tolerance in affected plants. The treatment comprises the application of solutions containing the aforementioned
...
Method and Camera for the Real-time Acquisition of Visual Information from Three-dimensional Scenes
The invention relates to a method for calculating the focal stack associated with an object space from the plenoptic function thereof, using a sum transform along the length of constrained planes in discrete hypercubes, enabling the calculation time to be considerably reduced. The invention also rel
...
Trangenic mice used as model for human pathologies originating from stem cells
Transgenic non-human mammals that reproduce the human pathology that is of stem cell origin, for example, chromosomal anomalies associated with chronic myeloid leukaemia, B-cell acute lymphoblastic leukaemia, T-cell acute lymphoblastic leukaemia, or with the migration of haematopoietic or embryonic
...
Use of Hsp90 Protein Inhibiting Compounds and Pharmaceutical Composition Intended for Anti-tumour Therapy
The invention relates to a method for designing an individual anti-tumour therapy for a patient based on the detection of the levels of the Hsp90 protein responsible for resistance to a drug or a mixture of anti-tumour drugs that inhibit receptors IGF1R/KIT. The invention also relates to the use of
...
Use of a Casein-derived Peptide and Compositions Thereof As Antihypertensive
Use of a casein-derived peptide with antioxidant and ACE-inhibitory activity in vitro and antihypertensive activity in mammals, and compositions thereof. This peptide may be use as active ingredient in pharmaceutical, cosmetic and/or dermatological compositions, dietary supplements or as food ingred
...
Urinary Gm2 Activator Protein As a Marker of Acute Renal Failure Or the Risk of Developing Acute Renal Failure
The invention relates to a method of determining the risk of developing acute renal failure (ARF) in an individual, or of determining an ARF, and a method of predicting the progression of an ARF, by detecting and/or quantifying the protein Ganglioside GM2 Activator Protein (GM2AP). The failure can b
...
Biphasic calcium phosphate and method for obtaining same from fish bones
The present invention relates to a biphasic calcium phosphate comprising between 5 and 40% by weight of beta-tricalcium phosphate; between 0.1 and 0.6% by weight of Mg; between 0.2 and 0.8% by weight of Na; between 0.1 and 0.5% by weight of Sr; between 0.01 and 0.1% by weight of K; the remaining par
...
Method and System for Identifying Shellfish
The invention relates to a method which allows identifying shellfish by- forming a mark (6) on the carapace or shell of the animal (5) to be identified by means of applying a laser beam (4). By means of this method it is possible to identify crustaceans, mollusks or any other animal provided with a
...
Procedure for Verifying the Integrity of Documents
Procedure for verifying the integrity of documents which comprises a characterization of the original document to obtain a hash (508) and a stage of integrity verification, this stage comprising in turn, representing (601) the digital document to be verified in a matrix format; adapting (602) said d
...
EstÉrase Thermophile De Thermus Thermophilus
The invention relates to a thermophilic protein with esterase activity. Said protein, of the Thermus thermophilus organism, is expressed in recombinant yeasts and bacteria, in particular E.coli, K.lactis and S.cerevisiae. The esterase is expressed in fusion protein form with a signal sequence that e
...
Synthesis of Catalytic Subnanometric Au Particles Supported on Surfaces Having Amine Groups
The present invention refers to structures comprising particles of Au of subnanometric size (
...
Method for Cell Identification and Quantification with Gold Nanoparticles Through Hydrogen Ion Reduction
The method for cell identification and quantification comprises bonding specific surface proteins of cells immobilised on the surface of the electrochemical transducer with specific antibodies conjugated with gold nanoparticles, and subsequent nanoparticle detection and quantification through hydrog
...
Method for Removal of Wax from Porous Stones in Historical Monuments
Disclosed embodiments include methods for cleaning wax, substantially equivalent impurities, and other contaminants from porous stones in historical monuments and artworks using nondestructive means. According to one embodiment the method for removal of contaminants from porous stones using laser co
...
Dual Stream Device/ Statistical Data Tracker
An Interactive Web-feed/television broadcast dual display system that enables a user to access any information currently available on the Internet without disrupting a television broadcast he/she may be currently watching. Web-based content is selected at the will of the viewer and is displayed on a
...
Quantized Indexing
A Data Compression Patent, applying the power of combinatorial mathematics
to enumerative coding by uncovering a method which solves the problem of arithmetic
precision in Enumerative Coding, the underlying problem which has long
prevented it from being used for general purpose entropy coding, a
...
Compositions Comprising Antioxidant and Mitoprotective Flavonoids with Neuroprotective Properties
The present invention discloses compositions comprising phenolic compounds present in plant extracts with therapeutic activity against neuronal excitotoxicity, oxidative stress and mitochondrial dysfunction. When used individually or in a formula composition quercetin, kaempferol and biapigenin sign
...
Braided Corrugated Textile Vascular Prosthesis and Process of Producing Same
The present invention relates to a braided corrugated vascular prosthesis with a textile structure consisting of at least two types of biocompatible fibres, of which one is absorbable by the human body, and to the process of producing same using conventional braiding equipment, by combining previous
...
Method for the Determination of Phospholipids in Amniotic Fluid Samples
The present invention refers to a fast method for the determination of phospholipids in amniotic fluid samples by HPTLC (high performance thin layer chromatography). This innovative method presents high sensitivity, reproducibility and resolution. It has also the advantage of being of easy laborator
...
Smart Device for Absorbing Solar Energy and Controling Sunlight Admission
The present invention provides a process for absorbing solar energy and, simultaneously having a continuous control of the light admission making it possible to install the device in external openings of buildings and equipment, such as windows, shutters or skylights. The system comprises two frames
...
Aav-mediated Delivery of Dna to Cells of Nervous System
PROBLEM TO BE SOLVED: To provide a method of delivering a DNA exogenous to both an adeno-associated virus (AAV) and a target cell of the mammalian nervous system. ; SOLUTION: The method includes the step of supplying AAV-derived vectors modified to comprise the DNA exogenous to both AAV and the targ
...
Growth of Boron Nanostructures with Controlled Diameter
A process for growth of boron-based nanostructures, such as nanotubes and nanowires, with a controlled diameter and with controlled chemical (such as composition, doping) as well as physical (such as electrical and superconducting) properties is described. The boron nanostructures are grown on a met
...
Hydroxyapatite and Bioglass-based Pellets, Production Process and Applications of Thereof
The present invention refers to hydroxyapatite and bioglass-based pellets of homogeneous size and spherical shape, whose interconnective porous structure, in the micrometer range, allows for an enhanced osteoconductivity and osteointegratioh, with specific application as a synthetic bone graft and t
...
Device to Separate Olefins from Paraffins and to Purify Olefins and Use Thereof
The present invention discloses a device, which uses membranes, capable of separating olefins from paraffins. The device (1) considers an ultramicroporous ceramic membrane module, zeolite or silicate based, containing a fixed carrier of copper I or silver ions (#-complexant ions) inserted by ion exc
...
Glass Sealing of Dye-sensitized Solar Cells
The present invent describes a new sealing process of a specific type of photovoltaic cells named dye-sensitized solar cells. Currently, the sealing of these cells is made by means of a polymer, which connects the two electrode substrates made of glass, isolating the cell's inner content from the ou
...
Chiral Stationary Phases Based on Xanthone Derivatives
The present invention relates to the development of new chiral stationary phases (CSPs), named chiral xanthone stationary phases (CXSPs), and to the use thereof for the enantiomeric resolution by high-performance liquid chromatography (HPLC). More specifically, it relates to the invention of new xan
...
Device for Measuring and Analysing the Colour of the Outer Ear and Ear Canal
The present invention concerns a device for measurement and analysis of the middle ear and ear channel colour. This device allows thus automatic patient middle ear colour measurement and intends to be auxiliary equipment for health professionals in the diagnosis of ear infections. The device is comp
...
Guidance, Navigation and Information System Especially Adapted for Blind Or Partially Sighted People
The present invention concerns an orientation, navigation and information system, especially adapted for blind or visually impaired people. It is essentially a system that allows blind or visually impaired people to access information usually made available only to public transportation users visual
...
Portable Device and Method for Measurement and Calculation of Dynamic Parameters of Pedestrian Locomotion
The invention relates to a portable and autonomous device and corresponding method for the measurement, recording and calculation of dynamic parameters of the pedestrian locomotion of its bearer (1). The method hereby disclosed allows determining the distance effectively travelled, the velocity of d
...
Aqueous Extract of Pieris Brassicae Larvae and Its Use As Antioxidant
The present research respects to the aqueous extract of Pieris brassicae larvae fed with tronchuda cabbage, which possesses antioxidant activity against radical species prejudicial to health and has capacity to inhibit xanthine oxidase, an enzyme involved in gout development. The compounds present i
...
Smart Structures for Bone Prosthesis
This invention relates to structures to be applied in bone prostheses and it refers to a multi-network concept of biosensors and bioactuators that continually and actively monitor the performance and integrity of bone implants inside living organisms. The biosensors network contemplates different se
...
Transducer for Measuring Vertical Displacements
The present invention relates to a transducer for measuring vertical displacement in civil engineering structures, such as bridges and overpasses. For that purpose, the transducer carries out hydrostatic levelling over the structure being observed, from a fixed reference position, thus enabling the
...
Hygro-adjustable Wall Base Ventilation System for the Treatment of Rising Damp'
This patent of invention relates to a hygro- adjustable wall base ventilation system (3) intended both for accelerating the process of transporting humidity outwards and decreasing the level reached by the rising damp. The said system comprises a mechanical ventilation device (8) which is activated
...
Simulated Moving Bed Membrane Reactor, New Hybrid Separation Process and Uses Thereof
The present invention consists in a new technology, a simulated moving bed, absorbent membrane reactor. This technology comprises a reactor that integrates two different separation techniques: i) chromatography (simulated moving bed - SMB); ii) permeable membrane (namely, pervaporation and permeatio
...
Method and Apparatus for Efficient Direct Generation and Delivery of Ultrashort Laser Pulses
A method and apparatus are disclosed for the direct generation and efficient non-dispersive delivery of broadband few-cycle femtosecond laser pulses by temporal solitonic compression of low-energy ultrashort laser pulses in nonlinear waveguides with constant (spatially independent) negative dispersi
...
Device for Propelling Vehicles
The system disclosed in this patent application makes it possible to move one or more driving wheels for propelling a vehicle, by actuating two pedals with an alternating linear movement. The system comprises a structure (1) for carrying the remaining components, and pedals (9 and 23) supported on s
...
Compositions and Methods for Treating Cancer with Attenuated Oncolytic Viruses
Compositions including attenuated oncolytic viruses and methods of their use for the treatment of cancer are disclosed. Some attenuated virus exhibit potential as tumor therapies by exhibiting characteristics including, but not limited to, high selectivity, infectivity, cytotoxicity, or replication
...
Amphiphilic Compositions and Methods for Preparing and Using Same
The invention relates to amphiphilic C-glycoside derivatives, to methods of using them and to processes for synthesizing them. Specifically, the invention relates to novel cyclic and linear enone-glycolipids and cyclic ketone-glycolipids.
...
Microrna Signatures Differentiating Uterine and Ovarian Papillary Serous Tumors
The invention provides a papillary serous miRNA signature and methods for determining the identity, origin, and stage, of concurrent endometrial and ovarian papillary serous tumors. Exemplary origins of concurrent endometrial and ovarian tumors include, but are not limited to, the uterus, ovary, fal
...
Small Molecule Inhibitors of Autotaxin and Methods of Use
Autotaxin (ATX) is a prometastatic enzyme initially isolated from the conditioned media of human melanoma cells that stimulates a myriad of biological activities including angiogenesis and the promotion of cell growth, survival, and differentiation through the production of lysophosphatidic acid (LP
...
Riboswitches, methods for their use, and compositions for use with riboswitches
It has been discovered that certain natural mRNAs serve as metabolite-sensitive genetic switches wherein the RNA directly binds a small organic molecule. This binding process changes the conformation of the mRNA, which causes a change in gene expression by a variety of different mechanisms. Modified
...
Reactivation of Axon Growth and Recovery in Chronic Spinal Cord Injury
Disclosed are methods of treating chronic nervous system diseases or injuries, e.g., chronic spinal cord injury, using Nogo receptor antagonists, including Nogo receptor-1 (NgR1) polypeptides, Nogo receptor-1 antibodies and antigen-binding fragments thereof, soluble Nogo receptors and fusion protein
...
Neovascular-Targeted Immunoconjugates
Immunoconjugates for treating diseases associated with neovascularization such as cancer, rheumatoid arthritis, the exudative form of macular degeneration, and atherosclerosis are described. The immunoconjugates typically consist of the Fc region of a human IgG1 immunoglobulin including the hinge, o
...
Systems, Devices and Methods for Cartilage and Bone Grafting
Disclosed are systems, methods, devices and products to identify suitable donor sites for harvesting bone-cartilage grafts and to implant such bone-cartilage grafts. In some embodiments, a method includes providing a computer having access to a donor database, the donor database comprising informati
...
Mif Modulators
The invention provides novel heterocyclic compounds, pharmaceutical compositions and methods of treatment that modulate levels of MIF expression and treat disorders associated with high or low levels of MIF expression.
...
Survivin, a protein that inhibits cellular apoptosis, and its modulation
The present invention provides the amino acid of a protein that inhibits cellular apoptosis, herein termed the Survivin protein and nucleic acid molecules that encode Survivin. Based on this disclosure, the present invention provides isolated Survivin protein, isolated Survivin encoding nucleic acid
...
Targeting TGF-beta as a Therapy for Alzheimer's Disease
The invention includes compositions and methods for enhancing peripheral macrophage A[beta] phagocytosis activity. The invention includes inhibiting a component of TGF-[beta] signaling pathway in peripheral macrophages to promote central nervous system infiltration and beneficial cerebral A[beta] cl
...
High Flux Thin-film Composite Forward Osmosis and Pressure-retarded Osmosis Membranes
One aspect of the invention relates to customized thin-film composite membranes comprising: a porous support; a selective barrier; and one or more polymeric additives dispersed in the porous support in an amount from at least about 1% and about 50% by weight of the porous support. Another aspect of
...
Dynamic Spine Stabilizer
A dynamic spine stabilizer moves under the control of spinal motion providing increased mechanical support within a central zone corresponding substantially to the neutral zone of the injured spine. The dynamic spine stabilizer includes a support assembly and a resistance assembly associated with th
...
Methods for Modulating Expression of Creb
Methods are provided for modulating CREB by administering a CREB-specific modulator. Also provided are methods for treating cardiovascular and metabolic disorders in a subject or delaying or preventing risk factors thereof through the modulation of CREB. The present invention is also directed to met
...
Nogo Receptor Binding Small Molecules to Promote Axonal Growth
The present invention provides a method for identifying compounds which modulate the interaction of Nogo and Nogo receptor (NgR). The present invention also provides compounds that modulate the interaction of Nogo and Nogo receptor (NgR), the use of such compounds and compositions in the treatment o
...
Anti-hepatitis C Activity of Meso-tetrakis-porphyrin Analogues
The present invention relates to porphyrin analogues, their use in pharmaceutical compositions alone, or combination with other agents and in the treatment and/or prophylaxis of flaviviridae viral infections, especially hepatitis C viral infection, and secondary disease states and/or conditions asso
...
Toll-like Receptor 4 Deficiency and Downstream Effectors Cause Pulmonary Emphysema
The present invention provides compositions and methods for the detection, treatment, and prevention of emphysema/COPD. Compositions of the present invention comprise TLR4 activators, Nox3 inhibitors, and Cathepsin E inhibitors useful in the treatment or prevention of emphysema/COPD. Cathepsin E is
...
Immunization to Reduce Neurotoxicity During Treatment with Cytolytic Viruses
Methods for protecting the brain and other tissues from virus- associated toxicity are provided. Patients are treated with a first immunizing virus prior to administration of a second, therapeutic cytolytic virus. The immunizing virus is preferably administered peripherally, and initiates an adaptiv
...
Targeted Oligonucleotide Compositions for Modifying Gene Expression
The invention comprises compositions and methods for modifying gene expression. Modified oligos of the invention restore the lost function of let- 7 wild type miRNA molecules that are prevented from silencing target genes by mutations occurring within their binding sites. Administration of a particu
...
Anti-viral nucleoside analogs and methods for treating viral infections, especially hiv infections
The present invention relates to novel compounds according to the general Formulae (I, II, III, IV or V); wherein B is nucleoside base according to the structure Formula (VI); R is H, F, Cl, Br, I, C 1 -C 4 alkyl (preferably CH 3 ), -C N, -C C-R a , Formula (VII); X is H, C 1 -C 4 alkyl (preferably
...
Regulation of oncogenes by microRNAs
Naturally occurring miRNAs that regulate human oncogenes and methods of use thereof are described. Suitable nucleic acids for use in the methods and compositions described herein include, but are not limited to, pri-miRNA, pre-miRNA, mature miRNA or fragments of variants thereof that retain the biol
...
Anti-inflammatory Compounds and Uses Thereof
The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-[kappa]B-dependent targ
...
Spiral Wound Membrane Module for Forward Osmotic Use.
A spiral wound membrane module for forward osmotic use is disclosed. The membrane module may generally include a forward osmosis membrane in a spiral wound configuration. The module may include two inlets and two outlets, and may define first and second fluid flow paths. The inlets to each of the fl
...
Uveoscleral Drainage Device
An ophthalmic shunt implantable in an eye having an elongate body (10) and a branched conduit (40) for conducting aqueous humor from an anterior chamber of the eye to the suprachoroidal space of the eye and the subconjunctival space, and a plate extending from an upper surface of the elongate body.
...
Immunogenic Epitopes As Targets for Universal Cancer Vaccines
The present invention provides a peptide having an amino acid sequence as set forth in SEQ ID NOs: 1 through 95 and any combination there of. The peptide or combination of peptides possess 0CT4 specific inducibility. The peptide or combination of peptides can further be used as a vaccine.
...
Method for Implanting Intraocular Pressure Sensor
Methods of implanting an intraocular pressure sensor and systems tbr sensing intraocular pressure are disclosed. An intraocular pressure sensor, including, a top surface, may be placed through the sclera of an eye of a patient. The intraocular pressure sensor may be caused to be inserted into the sc
...
Methods of Regulating Renalase (monoamine Oxidase C)
The present invention provides methods of using Monoamine Oxidase C (MAO-C), also known as renalase, as a therapeutic protein in its active and inactive forms. Administering inactive renalase protein to individuals with lower renalase levels can be used to provide them with an adequate pool of the p
...
Compositions and Methods for Inhibiting Inflammation from and Rejection of Biomaterials and Other Methods
The present invention relates, inter alia, to methods and compositions for regulating the host response to biomaterials, including inhibiting inflammation from and rejection of biomaterials using salicylate compounds and/or TLR7/TLR9 antagonists as described herein.
...
Pseudocomplementary Oligonucleotides for Targeted Gene Therapy
Compositions and methods for targeted gene therapy are disclosed. Compositions containing double duplex-forming pseudocomplementary oligonucleotides are administered in combination with a donor oligonucleotide that is homologous to a target sequence on a double-stranded DNA molecule in need of repai
...
Ferroelectric Devices Including a Layer Having Two Or More Stable Configurations
Ferroelectric semiconductor devices are provided by including a ferroelectric layer in the device that is made of a material that is not ferroelectric in bulk. Such layers can be disposed at interfaces to promote ferroelectric switching in a semiconductor device. Switching of conduction in the semic
...
An Objective, Quantitative Method to Predict Histological Subtype in Non-small Cell Lung Cancer
The invention provides a method for determining the histotype of a non-small cell lung cancer tumor which comprises (a) determining the levels of expression of each of thyroid transcription factor-1 cytokeratm 5 cytokeratm-13 and epidermal growth factor receptor in a sample from the non-small cell l
...
Anti-inflammatory compounds and uses thereof
The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF- B-dependent target gen
...
A Melanoma Prognostic Model Using Tissue Microarrays and Genetic Algorithms
Provided is a method for determining the risk that a patient diagnosed with melanoma will develop a recurrence of melanoma comprising: a) determining the level of expression for each marker of a panel of markers, wherein the panel comprises activating transcription factor 2, p21V1AF1, p16NK4A, beta-
...
Polymeric Materials Loaded with Mutagenic and Recombinagenic Nucleic Acids
Polymeric rnicroparticles are used to deliver recombinagenic or mutagenic nucleic acid molecules such as donor nucleic acid alone, or in combination with triplex forming molecules, to induce a site-specific mutation in the target DNA. Target cells endocytose the particles, releasing the nucleic acid
...
Methods of Treating Cancer and Other Conditions Or Disease States Using Lfmau and Ldt
The present invention relates to the use of the compound according to formula (I), below for the treatment of tumors, cancer and hyperproliferative diseases, among other conditions or disease states: Where X is H or F; R1 and R2 are independently H, an acyl group, a C1-C20 alkyl or ether group, a ph
...
Herbal Composition Phy906 and Its Use in Chemotheraphy
This invention provides herbal compositions useful for increasing the therapeutic index of drugs, including those used in the treatment of disease, especially viral infections and neoplasms of cancer. This invention provides methods useful for improving the quality of life of an individual undergoin
...
Forward Osmosis Separation Processes
Separation processes using engineered osmosis are disclosed generally involving the extraction of solvent from a first solution to concentrate solute by using a second concentrated solution to draw the solvent from the first solution across a semi-permeable membrane. One or both of the solute and so
...
Carbon Molds for Use in the Fabrication of Bulk Metallic Glass Parts and Molds
Novel molds and methods for Bulk Metallic Glass (BMG) molding using carbon templates obtained from pyrolyzed materials are provided. The method employs the Carbon MEMS (C-MEMS) technique to derive molds of different geometries and dimensions. The resultant carbon structures are stable at very high t
...
Carbon Nanotube Filters
Filters comprising a layer of multiwall carbon nanotubes dispersed on a porous substrate, with or without a layer of single wall carbon nanotubes dispersed on top of the layer of multiwall carbon nanotubes, have been fabricated and shown to be useful for removing constituents from fluids.
...
Compositions and Methods for Treating Or Inhibiting Liver Injury
The present invention relates to the discovery that acetylsalicylic acid (ASA or aspirin), salicylic acid (SA) and related salicylate esters and their pharmaceutically acceptable salts, when coadministered in effective amounts with a drug or other bioactive agent which typically (in the absence of t
...
Jnk3 Modulator and Method for Using the Same
PROBLEM TO BE SOLVED: To provide a method for screening a molecule and compound reducing the expression or activity of the c-Jun NH2terminal kinase (JNK) group of a MAP kinase. ; SOLUTION: The method for identifying a JNK3 expression-modulating compound includes: incubating the expressing cells of t
...
Compostions and Methods for Targeted Gene Therapy
Compositions containing molecules that bind to duplex DNA in a sequence-specific manner to form a triple-stranded structure are disclosed. Triplex-forming molecules facilitate strand displacement and triplex formation, referred to as a "clamp," in which one molecule binds to the target strand by Hoo
...
Diagnosis of Preeclampsia
The present invention provides methods and compositions related to the detection and/or monitoring of the levels of angiogenic factors, specifically VEGF, PlGF and sFlt-1, in urine samples obtained from pregnant women and the effects of such levels on the risk of developing complications of pregnanc
...
Access Device
A device may include a hollow needle, a dilator mounted coaxially on the needle, and a sheath mounted coaxially on the dilator. The dilator may be slideably displaceable relative to the sheath.
...
Apparatus, Systems and Methods Utilizing Plethysmographic Data
Disclosed are apparatus, systems and methods utilizing attributes of the cardiac signal to calibrate/normalize components of the plethysmographic (PG) waveform indicating changes in venous and arterial blood volume. In the time-domain, amplitudes of respiratory-induced variations of the DC and AC co
...
Single Nucleotide Polymorphisms in Brca1 and Cancer Risk
The invention provides methods for identifying mutations, such as single nucleotide polymorphisms (SNPs), within breast and ovarian cancer associated genes that modify the binding efficacy of micro RNAs (miRNAs). In a preferred embodiment, methods of the invention identify a SNP that decreases expre
...
Controlling Absorption of Light in a Cavity
Described is a method of controlling the absorption of light in a cavity, a system in which absorption is so controlled, and an interferometer embodying the underlying physical concept. Materials can be made to completely absorb incident light when the light is imposed in a specific pattern of illum
...
Instruments, Methods and Systems for Harvesting and Implanting Cartilage Materials
The present disclosure provides instruments and systems for accessing and removing hyaline cartilage from desired donor sites. The present disclosure also provides instruments/systems for implantation of hyaline cartilage grafts, e.g., to fill osteochondral defects. The apparatus/systems may be used
...
Method for suppressing immune system response to transplanted tissue or cells
Methods are provided for suppressing the immune system response in recipients of transplanted organs, tissues or cells. An extracorporeal quantity of blood from the intended transplant recipient is treated to induce monocytes contained in the blood to differentiate and form dendritic cells. The matu
...
Nucleotide and Protein Sequence of Vertebrate Serrate Gene, and Method Based Thereon
PROBLEM TO BE SOLVED: To provide a nucleotide sequence of vertebrate Serrate gene, to provide the amino acid sequence of the protein encoded thereby, and further, to provide a derivative thereof (e.g. fragment) and an analogue thereof. ; SOLUTION: A refined vertebrate Serrate protein is provided. In
...
Page: 1 - <10 - 76 77 78 79 80 81 82 - 10> - 118 Next»