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High-speed and Large-scale Microscope Imaging
An imaging system generates an image of a specimen by acquiring images of individual portions of the specimen and combining the images to form a composite image. The system moves the specimen to a set of predetermined locations such that all portions of the specimen are captured into images. At each
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Functionalized Nanodiamond Reinforced Biopolymers
The present invention includes a composition for implantation in a patient, comprising surface-functionalized nanodiamonds and at least one biodegradable biocompatible polymer. The present invention also includes a surgical fixation device for use in a patient.
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Control of Mucus Membrane Bleeding with Cold Plasma
The use of non-thermal plasma to treat mucus membrane bleeding is described herein. A non-thermal plasma is generated using an apparatus having a first electrode that receives alternating electrical potentials from a power supply. When placed in an appropriate location proximate to tissue, a non-the
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Crosslinked Hydrogels
The present invention preferably provides for a method of forming and the resulting solid polymer gel composition comprising polyethylene imine and at least one hydrogen bonding polymer. The composition has a greater viscosity than either of the polyethylene imine or the hydrogen bonding polymer alo
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Small Diameter Vascular Graft Produced By a Hybrid Method
The present invention relates to a hybrid graft and methods of generating the hybrid graft. The hybrid graft comprises an exterior surface and a luminal surface. The luminal surface comprises a micropattern of grooves to which cells adhere and orient along. The exterior surface comprises electrospun
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Compositions and Methods for Treating a Disorder Or Defect in Soft Tissue
The present invention encompasses methods and compositions for generating a biomimetic proteoglycan. The invention includes methods of treating a disease, disorder, or condition of soft tissue using a biomimetic proteoglycan.
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Supercapacitor Compositions, Devices, and Related Methods
Disclosed are supercapacitor materials comprising compositions having pores that are optimally sized to maximize capacitance. Also disclosed are related methods for fabricating such supercapacitors.
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Enhanced Detection Sensitivity with Piezoelectric Microcantilever Sensors
A method for enhancing the detection sensitivity of a piezoelectric microcantilever sensor. The method may involve providing a piezoelectric microcantilever and inducing a change in the Young's modulus during detection of a species of interest. The change in the Young's modulus may be induced or enh
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Flow-based Enhancement of Specificity for Label-free Biochemical Assays
A label-free biochemical assay, in which label-free interrogation of a target-receptor layer is performed while the target-receptor layer is subjected to a relatively strong flow of an analyte-containing fluid. The volumetric flow rate for the assay is selected based on calibration data correspondin
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Physical Therapy Systems and Methods
The invention is directed to a physical therapy system including a glove with a set of acoustic sensors and a positive feedback system and method for teaching finger extension. The system may also include a pair of gloves with a set of acoustic sensors and a positive feedback system to teach clappin
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Method of Making Mixed Metal Oxide Ceramics
A method of making dielectric ceramics containing mixed metal oxides is provided. The method comprises the steps of at least partially coating a metal oxide powder with a metal hydroxide or metal oxide, compacting the coated powder with one or more additional metal compounds or metal compound precur
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Devices for Intracellular Surface-enhanced Raman Spectroscopy
Provided are surface-enhanced Raman spectroscopy (SERS) devices suitable for intra-subject (e.g., intracellular) observation, which devices may be of nanoscale size. Also provided are related SERS analysis methods.
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Freestanding Films with Electric Field-enhanced Piezoelectric Coefficients
A method to produce low-temperature sinterable powders which are then subsequently used to fabricate freestanding piezoelectric films with very large electric-field-enhanced piezoelectric response is provided. The -d31 coefficient for PMN-PT layers can be as high as 2000 pm/V, larger than that of co
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All Electric Piezoelectric Finger Sensor (pefs) for Soft Material Stiffness Measurement
A PEFS (Piezoelectric Finger Sensor) acts as an "electronic finger" capable of accurately and non-destructively measuring both the Young's compression modulus and shear modulus of tissues with gentle touches to the surface. The PEFS measures both the Young's compression modulus and shear modulus var
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Water Soluble Nanocrystalline Quantum Dots
An economic, direct synthetic method for producing water soluble QDs that are ready for bioconjugation is provided. The method can produce aqueous QDs with emission wavelengths varying from 400 nm to 700 nm. Highly luminescent metal sulfide (MS) QDs are produced via an aqueous synthesis route. MS QD
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System and Method for Evaluating Tissue
A sensor system for measuring an elastic modulus and a shear modulus and a method for evaluating a tissue. The invention pertains to a method for determining the presence of and/or characterizing abnormal growths, using a piezoelectric finger sensor (PEFS) system. The PEFS system may be particularly
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Articles and Methods for Repairing Damaged Nervous Tissue
The invention concerns substrates comprising a biocompatible gel and at least one of a plurality of cells, said cells being capable of producing at least one therapeutic agent. Other aspects of the invention concern methods of making such substrates and methods of repairing and regenerating damaged
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Hydrogen Production from Hydrogen Sulfide
The present subject matter is directed to plasma dissociation of fluidic hydrogen sulfide to hydrogen and sulfur. A reactor is configured to have a plasma discharge and a vortex flow pattern. The plasma discharge provides energy to the hydrogen sulfide disassociation reaction and the vortex flow pat
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Cervical Spine Protection Apparatus and Methods of Use
The invention is directed to a cervical spine protection apparatus one or more composite bands attached to provide restraint of one or more motions of the cervical spine of a wearer. The apparatus is designed to protect a wearer from incurring cervical spinal injuries, and/or to reduce the severity
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Intracranial Pressure Sensor
An intracranial pressure device for measuring CSF pressure in a skull includes a housing located between the scalp and the skull containing pressure device circuitry and a conduit extending downwardly from the housing to the vicinity of the CSF. A pressure sensor is coupled to the conduit and locate
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Plasma Reactor
A plasma reactor (10) is provided. The plasma reactor (10) includes a reaction chamber (12) formed by a wall (13). Proximate to the first end of the reaction chamber, the plasma reactor includes a feed gas inlet (14) for creating a reverse vortex gas flow (16) in the reaction chamber. The plasma rea
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Mimo Antenna Arrays Built on Metamaterial Substrates
A magnetic permeability enhanced metamaterial is used to enhance the antenna array of a Multiple Input Multiple Output (MIMO) communication system. A rectangular patch antenna array is formed including a stack of a plurality of unit cells, where each unit cell includes an inductive loop of magnetic
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Ferroelectric Nanoshell Devices
Disclosed herein are nanoscale devices comprising one or more ferroelectric nanoshells characterized as having an extreme curvature in at least one spatial dimension. Also disclosed are ferroelectric field effect transistors and metal ferroelectric metal capacitors comprising one or more ferroelectr
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Apparatus and Methods for Detecting Inflammation Using Quantum Dots
Apparatus and methods for detecting an a biomarker indicative of an inflammatory condition, including a capillary tube adapted for one or more biomarkers to adhere to an interior surface thereof, a light source for energizing quantum dots conjugated with the biomarkers within the capillary tube, and
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Systems and Methods for Selecting Reconfigurable Antennas in Mimo Systems
A method allows reconfigurable multi-element antennas to select the antenna configuration in MIMO, SIMO and MISO communication system. This selection scheme uses spatial correlation, channel reciprocal condition number, delay spread and average Signal to Noise Ratio (SNR) information to select the a
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Tubular Floating Electrode Dielectric Barrier Discharge for Applications in Sterilization and Tissue Bonding
Disclosed is a device and method for contacting a biological substrate. A non-thermal plasma device delivers a non-thermal plasma discharge using a dielectric conduit, an igniter electrode and a RF electrode. The dielectric conduit fluidicly communicates a gas therethrough and an igniter electrode i
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Apparatus for Atmospheric Pressure Pin-to-hole Spark Discharge and Uses Thereof
Disclosed herein are atmospheric pressure pin-to-hole pulsed spark discharge devices and methods for creating plasma. The devices include a conduit for fluidically communicating a gas, a plasma, or both, therethrough, portion of the conduit capable of being connected to a gas supply, and a second po
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Plasma Treatment for Growth Factor Release from Cells and Tissues
Aspects of the present invention are related to methods comprising contacting an endothelial cell in an endothelial cell population with a non-thermal plasma to release an angiogenic growth factor. The released angiogenic growth factor may induce endothelial cell proliferation. In certain embodiment
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Methods and Devices for Treating Surfaces with Surface Plasma
Methods and devices for treating surfaces of objects using a non-thermal plasma are disclosed herein. The non-thermal plasma is generated through the use of an apparatus configured to generate a non-thermal plasma on its surface. The apparatus is comprised of a substrate that contains one or more el
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Poly(ethylene Glycol) and Poly(ethylene Oxide) By Initiated Chemical Vapor Deposition
A method for ionic polymerization of ethylene oxide. In the first step of the method, a gaseous monomer composition comprising ethylene oxide at a first flow rate is mixed with a gaseous ionic polymerization initiator at a second flow rate, thereby forming a mixture. The formed mixture is then heate
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Encapsulation of Microbubbles Within the Aqueous Core of Microcapsules
The present invention includes a construct that comprises at least one microbubble encapsulated within the aqueous core of a microcapsule. The present invention also includes a pharmaceutical composition comprising a construct comprising at least one microbubble encapsulated within the aqueous core
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Transparent Conformal Polymer Antennas for Rfid and Other Wireless Communications Applications
An optically transparent conformal polymer antenna and a method for producing the antenna from optically transparent conductive polymers. The method includes selecting an antenna design; providing an optically transparent conductive polymer material capable of being printed using an ink-jet printer
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Detection and Measurement of Mass Change Using an Electromechanical Resonator
A change in impedance of a electromechanical resonating sensor is utilized to detect and/or measure a change in mass accumulated on the sensor. The impedance is monitored at a fixed frequency. The fixed frequency may be at or near the resonance frequency of the sensor. In various configurations, the
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Methods for Low Temperature Hydrogen Sulfide Dissociation
A method Of H2S dissociation comprises generating radicals or ions. H2S dissociation is initiated at relatively low temperature, e.g., of less than 1875 K. The residence time for dissociation generally ranges from about 0.01 s to 10 s. In one embodiment, plasmas are used to generate ions for use in
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Reflective Surface
The invention relates to a reflective surface substantially perpendicular to a vector field described by the equation: W (x,y,z) = T ( proj(x,y,z)) - (x,y,z) + proj(x,y,z) - (x,y,z) ¦¦T(proj(x,y,z)) - (x,y,z)¦¦¦¦proj(x,y,z) - (x,y,z)¦¦ and a method for forming the reflective surface. The reflective
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Lead-free Piezoelectric Ceramic Films and a Method for Making Thereof
his invention relates to lead-free piezoelectric ceramic films and a method of making thereof. Specifically, the invention is directed to a method for fabricating lead-free piezoelectric free standing films having enhanced piezoelectric properties. The films may be used for a number of applications
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Bioadhesive Hydrogels
A method of forming and the resulting bioadhesive hydrogel composition for repairing or supplementing a nucleus pulposus of an intervertebral disc comprises at least a first component, a second component and a third component, wherein the first component, the second component and the third component
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Detecting and Measuring Live Pathogens Utilizing a Mass Detection Device
Extremely minute amounts of live pathogens are rapidly detected using a piezoelectric cantilever sensor. A single pathogen is detectable in about 30 minutes. Pathogen-specific antibodies are immobilized on the sensor surface. The sensor is exposed to a medium that potentially contains the target pat
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Piezoelectric Stun Projectile
The present invention provides a non-lethal projectile for delivering an electric pulse to a target. In one aspect of the invention, the projectile utilizes a piezoelectric device and an electrical oscillating circuit in order to generate a pulse. In another aspect of the invention, the projectile u
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Methods and Devices For
The 'Smart Tool' includes a 'Smart Tool Probe' and two processing modules. The Smart Tool Probe is a hand held, wired or wireless, device that a surgeon utilizes for interrogating and identifying a tissue site, such as the entrance to a pedicle. The processing units, an Electro-Optical Control (EOC)
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Intelligent Modeling and Control of Automation
A system and method for advanced device specific knowledge based modeling as well as intelligent control to yield high performance, low cost automation for optoelectronic design, packaging and assembly. The control loop design is based on knowledge based model predictive control. A knowledge model,
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Method for Making Carbon Nanotubes with Embedded Nanoparticles
The invention concerns methods for producing carbon nanotubes with embedded nanoparticles comprising providing a template comprising an anodized aluminum oxide membrane with a pore diameter of 20-200 nm; contacting the template with a solution containing nanoparticles; exposing the template and solu
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Electrowetting Microarray Printing System and Methods for Bioactive Tissue Construct Manufacturing
Apparatuses and methods for manufacturing three-dimensional, bioactive, tissue scaffold fabrications with embedded cells and bioactive materials, such as growth factors, using biomimetic structure modeling, solid freeform fabrication, biocompatible hydrogel material, and electrowetting on dielectric
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Desalination System and Process
The present invention pertains to an effective system and method for reducing or eliminating the formation of scale in desalination systems. The system utilizes at least one pair of electrodes in direct contact with a liquid to induce an oscillating electric field directly in a portion of the liquid
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Method for the Formation of Sers Substrates
A method for the formation of surface enhanced Raman scattering substrates. The method produces thin substrates that have a nanoparticle ink deposited thereon. The nanoparticle ink may be any suitable nanoparticle ink such as silver, gold or copper nanoparticle ink which includes stabilized nanopart
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Dual Inhibitors of HIV-1 GP-120 Interactions
Compounds, which inhibit the binding of gp120 to CD4 as well as 17b and methods for their use in inhibiting the HIV fusion process, are provided.
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Local Delivery System for the Chemotherapeutic Drug Paclitaxel
The present invention provides methods for producing a semi-degradable polymeric composite drug delivery device for localized delivery of chemotherapeutic agents to be used in conjunction with total vertebral body replacement surgery that requires placement of a vertebral replacement cage for the tr
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Water Soluble Nanocrystalline Quantum Dots Capable of Near Infrared Emissions
A novel quantum dot capable of near infrared emissions at wavelengths of 750-1100 is made by forming solid solutions of metal sulfide, metal selenide or metal sulfide selenide by incorporating a suitable amount of an additional metallic element or elements to provide an emission wavelength in the ra
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Tissue Joining Device and Instrument for Enabling Use of a Tissue Joining Device
A tissue joining device and a surgical instrument for employing the tissue joining device are provided. The tissue joining device may be designed such that a first member may be inserted into a second member in discrete increments so that two lumen structures can properly be combined.
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Microreactor for Solution Deposition and Method of Use
A novel microreactor producing customized deposition products and a method for optimizing the deposition process. The microreactor has a unique design with high surface-to-volume ratio that produces high deposition yield with a minimal amount of waste. The invention may be particularly applicable to
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Non-contact Frequency Domain Near Infrared Absorption (inir) Device for Assessing Tissue Damage
A device for measuring the progress of healing of a wound over time includes at least one diode laser source that provides respective input wavelengths into at least one source fiber, a first optical switch that sequentially switches wavelengths among the respective input wavelengths into the at lea
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Functional Near-infrared Spectroscopy As a Monitor for Depth of Anesthesia
Disclosed are methods and devices for measuring a state of anesthesia in a noninvasive manner. Optical techniques may be used to measure changes in a functional near-infrared (fNIR) signal, where the fNIR signal is received in response to directing wavelengths of light in a near-infrared range on a
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Titania Dispersion and Method for Making
A novel method for preparing a titania dispersion by blending two different titania dispersions synthesized by a solvothermal process and a hydrolysis process. The titania dispersion has a plurality of titania particles substantially uniformly dispersed therein and can be blended to provide a high c
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Production and Uses of Carbon Suboxides
Methods for the reduction of gaseous carbon dioxide emissions from combustion or oxidation reactions are provided. The various methods involve the formation of carbon suboxides and/or polymerized carbon suboxides (PCS), preferentially over gaseous carbon oxides to thereby reduce gaseous carbon dioxi
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Automated Learning of Model Classifications
A method of providing an automated classifier for 3D CAD models wherein the method provides an algorithm for learning new classifications. The method enables existing model comparison algorithms to adapt to different classifications that are relevant in many engineering applications. This ability to
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Max-based Metal Matrix Composites
Disclosed are compositions comprising a MAX phase material having the formula Mn+1AXn, wherein M is an early transition metal, A is an A-group element, X one or both of C and N, and n=1-3, wherein the MAX phase material defines a plurality of pores; and, a metal component comprising a low melting po
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Nanodiamond Manufacture and Process for Making Thereof
Disclosed are novel coatings and other components of articles of manufacture featuring the inclusion of nanodiamonds therein. Also disclosed are methods of achieving such inclusion and methods of utilizing the resultant, improved articles.
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Polyamide Nanofibers and Methods Thereof
Provided are methods for dissolving polyamides under ambient conditions and for forming polyamide nanofibers by electrospinning. Also provided are methods for incorporating nanoparticles, including nanotubes, into such nanofibers.
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Fibrous Mats Containing Chitosan Nanofibers
The invention relate to fibrous mats comprising chitosan nanofibers and, optionally, at least one filler material, at least one additive, or both. The invention also relates to methods of making same, and devices that include a fibrous mat comprising chitosan nanofibers.
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Two-piece Lightweight Litter System
This invention is directed to a durable, compact, two-piece, light weight, load sustaining litter system for the transport of humans, animals or objects. The litter system comprises a litter frame, a fabric disposed between the structure of the frame, at least one hinge and at least one coupling mec
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Method for Structural Health Monitoring Using a Smart Sensor System
The structural health monitoring method of the present invention utilizes a sensor system to determine information about deformation, stress and/or damage in structural elements. The sensor system and the method employ at least one sensor which comprises a material having fully-reversible nonlinear
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Detection and Quantification of Biomarkers Via a Piezoelectric Cantilever Sensor
Quantification of a target analyte is performed using a single sample to which amounts of the target analyte are added. Calibration is performed as part of quantification on the same sample. The target analyte is detectable and quantifiable using label free reagents and requiring no sample preparati
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Detection of Nucleic Acids Using a Cantilever Sensor
Detection of miniscule amounts of nucleic acid is accomplished via binding of target nucleic acid to probe material, composed of nucleic acid, which is bound to a sensor configured to sense mass. The sensor is prepared by immobilizing a probe material to a surface of the sensor, wherein the probe ma
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Nanodiamond Compositions and Methods of Making and Using Thereof
Provided are functionalized nanodiamonds. Also provided are methods for fabricating such functionalized nanodiamonds. Also provided are composites including nanodiamonds and polymers. Also provided are methods for fabricating such composites including nanodiamonds and polymers. Also provided are ele
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Novel Method for Zero Point Detection
The present invention relates to a method for the simple, objective and accurate determination the zero point or effective zero point of a material, the point of first contact between an indenter tip and the surface of a material. The zero point is determined by using a sensor having a tip and capab
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Plasma Discharge Self-cleaning Filtration System
The present invention is directed to a novel method for cleaning a filter surface using a plasma discharge self-cleaning filtration system. The method involves utilizing plasma discharges to induce short electric pulses of nanoseconds duration at high voltages. These electrical pulses generate stron
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Fatty Acid Monomers to Reduce Emissions and Toughen Polymers
Novel fatty acid monomers and methods for their synthesis are provided for use in polymerization reactions. Fatty acid monomers are employed as reactive diluents in the polymerization of vinyl esters and polyesters for one or more purposes selected from improving the fracture resistance, lowering th
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Electrocatalysts for Fuel Cells
Disclosed are metallized carbonaceous materials, processes for forming such materials, and electrodes and fuel cells comprising the disclosed materials.
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Piezoelectric Powered Vehicles and Motors
One or more piezoelectric elements are employed to generate electrical energy from one or both of the mechanical energy of a moving part of a conventional engine or vehicle or the combustion energy of an internal combustion engine. The generated electrical energy can be stored and used to power an e
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Nano Discharges in Liquids
The present invention is direct to a nano-probe corona tool and uses thereof. A nano-probe corona tool is disclosed having a tip with a diameter in the nano-scale, typically around lOOnm. The nano-probe corona tool is constructed of electrically conductive material. On the other end of the tool, a p
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Metal Or Metal Oxide Deposited Fibrous Materials
A method for electrospraying nanosized metal or metal oxide particles onto a substrate. A metal oxide deposited fibrous material comprising a substrate, fibers and metal oxide particles may be made using the method. The material may be a flexible and porous fibrous matrix on which metal oxide partic
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Polymer Dispersed Liquid Crystal Photovoltaic Device and Method for Making
A novel photovoltaic device including a polymer dispersed liquid crystal (PDLC) material that is capable of converting solar energy to electrical energy and method for making. The device may optionally include a conductive container for holding the PDLC material. In an exemplary embodiment, the inve
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Method and Apparatus for Braiding Micro Strands
A method and apparatus for fabricating microbraided structures is provided. A microbraiding device includes first and second carrier members that are movable with respect to each other. Each carrier includes a plurality of shelters. Spool-less strands of microfiber are retained in shuttles that are
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Vertical Axis Wind Turbine
A vertical axis wind turbine is disclosed, including an axle and a plurality of blades circumferentially spaced about the axle and coupled to the axle. Each blade can include an outer surface and an inner surface, the outer surface and inner surface meeting at a leading edge and a trailing edge. Eac
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Fluorous reaction systems
The present invention provides a method for carrying out a chemical reaction comprising the steps of forming an organic/fluorous solubilizing liquid phase comprising a solvent system. The solvent system is selected or adapted to substantially solubilize a fluorous reaction component or components (t
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Paracorporeal respiratory assist lung
A paracorporeal respiratory assist lung (900), comprising a housing (920) having an outer body including an upper portion and a lower portion; an upper gas port (945) located on the upper portion; a lower gas port (940) located on the lower portion; an upper blood inlet (930) located on the upper po
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Engineered Microparticles for Macromolecule Delivery
A method for making a modified release composition, comprising: selecting a desired active agent and polymer matrix for formulating into a modified release composition; assessing degradation effect on release of the active agent from the composition including plotting polymer molecular weight (Mwr)
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Bone Substitute Compositions, Methods of Preparation and Clinical Applications
The present invention relates to bone substitute compositions and methods of their preparation, and their use in a wide variety of clinical applications. The compositions include calcium phosphate, acidic calcium salt, basic calcium salt, sodium hydrogen phosphate and porogen. The compositions furth
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Wortmannin Analogs and Method of Using Same
Wortmannin analogs and their use in inhibiting PI-3-kinase activity in mammals and the treatment of cancer and tumour formation in a subject are described herein. The wortmannin analogs have utility in the treatment of cancer, in particular, lung cancer.
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Method for Treating Alcoholic Hepatitis
Disclosed is a method for treating acute alcoholic hepatitis in a subject. The method comprises the step of administering to the subject an effective amount of an ester of an alpha-ketoalkanoic acid or an amide of an alpha-ketoalkanoic acid.
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Non-invasive Method to Treat Urological and Gastrointestinal Disorders
Provided herein are methods and devices useful for inhibiting or treating urological conditions, such as overactive bladder (OAB) symptoms including bladder overactivity, urinary frequency, urinary urgency, urinary incontinence, interstitial cystitis (IC), urinary retention, and pelvic pain; gastroi
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Devices, Systems and Methods for Cell Modification
A method of modifying cells includes removing fluid including cells from a patient, contacting the removed fluid from the patient with at least one surface upon which at least one agent to interact at least one cell receptor is immobilized to modify cells in the fluid, and returning the fluid to the
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Matricryptic Ecm Peptides for Tissue Reconstruction
Chemoattractant polypeptide compounds for progenitor cells and compositions and drug products comprising the compounds are provided herein. Methods for attracting progenitor cells to a location in or on a patient also are provided along with methods of growing and repairing bone.
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Oxygen Depletion Devices and Methods for Removing Oxygen from Red Blood Cells
An oxygen depletion device. The device has a cartridge; a plurality of hollow fibers extending within the cartridge from an entrance to an exit thereof; an amount of an oxygen scavenger packed within the cartridge and contiguous to and in between the plurality of hollow fibers. The hollow fibers are
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Use of Endostatin Peptides for the Treatment of Fibrosis
C-terminal endostatin polypeptides are disclosed herein. These polypeptides include or consist of at least at least 40 consecutive amino acids of the amino acid sequence set forth as amino acids 133-180 of SEQ ID NO: 2 or SEQ ID NO: 13 with at most 5 amino acid substitutions, wherein the polypeptide
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Porous Biomolecule-Containing Metal-Organic Frameworks
The present invention relates to compositions including porous biomolecule-containing metal-organic frameworks and methods for their preparation. The porous biomolecule-containing metal-organic frameworks can include a metal component and a biomolecule component. The pores located within the framewo
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Compositions and Methods for Detecting Cancer
The present invention provides methods and compositions involving detecting the presence of and/or assessing the risk of cancer in a subject. These methods include methods of detecting and diagnosing cancer in an individual; methods of identifying individuals at risk of developing a cancer; and meth
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Methods and Apparatus for Switching a Transponder to an Active State, and Asset Management Systems Employing Same
A transponder that may be used as an RFID tag includes a passive circuit to eliminate the need for an "always on" active RF receiving element to anticipate a wake-up signal for the balance of the transponder electronics. This solution allows the entire active transponder to have all circuit elements
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Methods of Treating Disorders Associated with Protein Aggregation
The present invention relates to methods of treatment of clinical disorders associated with protein aggregation comprising administering, to a subject, an effective amount of an anti- protein aggregate ("APA") compound selected from the group consisting of pimozide, fluphenazine (e.g., fluphenazine
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Bioerodible Wraps and Uses Therefor
A tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous
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Biomarkers for Prognosis of Pulmonary Diseases
The present invention relates to biomarkers that may be used to evaluate the prognoses of patients suffering from pulmonary diseases and assist in the determination of appropriate therapeutic regimens. It is based, at least in part, on the discovery that a number of T-cell antigens are differentiall
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Monoclonal Antibodies for Cspg4 for the Diagnosis and Treatment of Basal Breast Carcinoma
It is disclosed herein that condroitin sulfate proteoglycan 4 (CSPG4), also known as high molecular weight melanomal associated antigen, is overexpressed on basal breast carcinoma cells (BBC), specifically triple negative basal breast carcinoma cells (TNBC). Methods for detecting basal breast cancer
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Urinary Biomarkers for Predicting Long-term Dialysis
This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term dialysis. For example, prediction of long-term dialysis treatment can be determined by monitoring urine
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Targeted Nitroxide Agents
Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activit
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Bone Augmentation Utilizing Muscle-derived Progenitor Compositions in Biocompatible Matrix, and Treatments Thereof
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non- soft tissue (e.g. bone) when
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Methods to Diagnose and Immunize Against the Virus Causing Human Merkel Cell Carcinoma
The present invention provides isolated or substantially purified polypeptides, nucleic acids, and virus-like particles (VLPs) derived from a Merkel cell carcinoma virus (MCV), which is a newly-discovered virus. The invention further provides monoclonal antibody molecules that bind to MCV polypeptid
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Magnetic Device for Guiding Catheter and Method of Use Therefor
One or more external magnets that are suitable for placement on the back or front of a patient's neck and methods for using the external magnet(s) to guide a feeding tube containing one or more internal magnets through the esophagus are described herein. The external magnet is applied to the back or
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Wireless Energy Transfer System
A wireless energy transfer system includes a first energy transfer unit having at least one resonant frequency, a second energy transfer unit having the at least one resonant frequency, and a load. The first wireless energy transfer unit includes a first coil magnetically coupled to a first wireless
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Anticancer Vaccine and Diagnostic Methods and Reagents
The invention provides a method for vaccinating a patient against a malignancy comprising introducing a protein or peptide comprising of all or an immunogenic fragment of a cyclin protein into the patient. The invention further provides a method of identifying tumor antigens.
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Stable Lipid-comprising Drug Delivery Complexes and Methods for their Production
Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture method and upon
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