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Mounted Optical Component, Method for the Production Thereof and Use of Same
The invention relates to a mounted optical component and to a method for producing mounted optical components. The invention also relates to the use of mounted optical components.
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Nanochannel-based Sensor System with Controlled Sensitivity
Disclosed are sensors, devices, systems, arrays of sensors and methods, including a sensing device that includes a sensor including one or more nanochannels constructed from semiconductor material and connected at their opposite ends to electrodes, the one or more nanochannels having at least one el
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Chemical Functionalization of Solid-state Nanopores and Nanopore Arrays and Applications Thereof
Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof. Nanopores are extremely sensitive single-molecule sensors. Recently, electron beams have been used to fabricate synthetic nanopores in thin solid-state membranes with sub-nanometer resolution. A new cla
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Low Cost Disposable Medical Forceps to Enable a Hollow Central Channel for Various Functionalities
The present invention relates to an endoscopic biopsy forceps (10) with an open central channel. The forceps include a sheath (20) having a proximal end and a distal end, a housing (50) connected with the distal end of the outer sheath, an open channel actuator control means (30) having a proximal e
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Label-free Sensing of Pna-dna Complexes Using Nanopores
Embodiments disclosed herein relate to a method of detecting specific DNA sequences and the application of this method in the detection of pathogens, viruses, drug-resistant pathogens, genomic variations associated with disease/disorder susceptibility etc. based on specific signature sequences uniqu
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High Throughput Multichannel Reader and Uses Thereof
The present invention relates generally to the field of high content screening of particles, e.g., cells in a flow cytometric system. In particular, the present invention relates to devices, methods and systems to obtain line-scan images of particles, e.g., cells, of a plurality of different samples
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Lipoxin Analogs and Methods for the Treatment of Periodontal Disease
This invention provides new lipoxin analogs, compositions containing analogs, and methods of using these compounds and compositions for treating and preventing oral inflammation, including gingivitis, periodontitis, and other forms of periodontal disease. The invention also provides for methods of t
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Compositions for the treatment of blood disorders
The invention relates to compositions containing chemical compounds and compositions containing steel factor which stimulate the expression of hemoglobin or globin protein such as embryonic or fetal globin, or the proliferation of hemoglobin expressing and other cells. These compositions can be used
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Electro-mechanical Oscillating Devices and Associated Methods
Electro-mechanical oscillating devices designed to convert the frequency of electrical signal(s) and methods associated with the same are described. One example of such a frequency converting device is a mixer.
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Compliant Composites for Application of Drug-eluting Coatings to Tissue Surfaces
A compliant composite for delivering a bioactive agent including a scaffolding material and a polymer coating that together can be attached to compliant tissue surfaces is disclosed, along with methods for constructing and applying these composites. In some embodiments, the composite further compris
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Methods for Treating Viral Disorders
Disclosed are methods of treating viral disorders via the administration of an inducing agent and an anti-viral agent. In one embodiment, the inducing agent and the anti-viral agent are administered for about five days, and the anti-viral agent is subsequently administered without the inducing agent
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Glutamine Endopeptidases D'espÈce Rothia Et Utilisation De Celles-ci
Disclosed are glutamine endopeptidase enzymes from Rothia sp. bacteria that are naturally associated with the oral cavity, formulations comprising the glutamine endopeptidase enzymes and the use thereof for the treatment, prevention of allergic reaction and diagnosis of gluten allergy related diseas
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Method for Detecting and Quantifying Rare Mutations/polymorphisms
The present invention is directed to a method for detecting and quantifying rare mutations in a nucleic acid sample. The nucleic acid molecules under investigation can be either DNA or RNA. The rare mutation can be any type of functional or non-functional nucleic acid change or mutation, such as del
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In Vivo Gene Sensors
Described are methods and compositions for the detection of target genes. The inventors have developed a synthetic nucleic acid sensor-effector gene circuit. In cells without a target gene, the circuit suppresses e.g., effector production, but in the presence of the target gene the suppression is su
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Melanoma Biomarker and Methods of Uses
The present invention relates to the use of TROY, also called tumor necrosis factor receptor superfamily, member 19 (TNFRSF19) also called toxicity and JNK inducer (TAJ), in diagnosis and therapy of non-epithelial cancers, such as melanoma. Accordingly, the invention provides in vitro and in vivo di
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Nanoantenna Arrays for Nanospectroscopy, Methods of Use and Methods of High-throughput Nanofabrication
The present invention generally relates to nanoantenna arrays and methods of their fabrication. In particular, one aspect relates to nanoantenna arrays comprising nanostructures of predefined shapes in predefined patterns, which results in collective excitement of surface plasmons. In some embodimen
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Fully automated control system for type 1 diabetes
An augmented, adaptive algorithm utilizing model predictive control (MPC) is developed for closed-loop glucose control in type 1 diabetes. A linear empirical input-output subject model is used with an MPC algorithm to regulate blood glucose online, where the subject model is recursively adapted, and
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Antimicrobial Ionic Liquids
Certain aspects of the present invention relate to compositions, formulations, and use of ionic liquids as antimicrobial agent (e.g. as antibacterial and/or antifungal agents). In certain embodiments, the ionic liquids can be pared with one or more singly charge species or with one or more multi-cha
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Small Molecule Inhibitors of Hepatitis C Virus
The invention provides derivatives and analogues of triazatetracyclo[7.7.0.01,13,.02,7]-hexadeca-2,4,6,10,12-pentaenes, 5,7,11-triazatetracyclo[8.7.0.01,6.012,17] -heptadeca- 6,8,12,14,16-pentaenes, pharmaceutical compositions comprising these compounds and methods for treatment of hepatitis C viral
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S Isomers of Alpha-methyl Hydrocinnamic Acid for the Treatment of Blood Disorders
The present intervention generally relates to compositions comprising S-isomer of alpha-methyl- hydrocinnamic acid for the treatment and/or prevention of blood disorders and blood deficiencies, as well as methods for treating blood disorders and/or blood deficiency in a subject by administering a co
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System for Wave Energy Harvesting Employing Transport of Stored Energy
A system employs wave energy harvesting apparatus and a water vessel (e.g., a ship) carrying an energy storage apparatus (e.g., array of batteries). The energy harvesting apparatus is preferably also carried by the water vessel, but may be fixed or carried by a separate water vessel. The water vesse
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Thods and Compositions for Preventing Adhesion
This invention provides methods and compositions for preventing post-surgical adhesion formation based on use of an interleukin-16 (IL-16) antagonist, including an IL-16 antagonist peptide and/or an IL-16 antagonist antibody.
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Bioreactive Agents
This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily fluids, and nascent proteins from translation reactions. Agents comprise a detectable moiety bound to a phot
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Biological Analog-to-digital and Digital-to-analog Converter Switches
Described herein are novel biological converter switches that utilize modular components, such as genetic toggle switches and single invertase memory modules (SIMMs), for converting analog inputs to digital outputs, and digital inputs to analog outputs, in cells and cellular systems. Flexibility in
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Biological Circuit Chemotactic Converters
Described herein are novel biological circuit chemotactic converter that utilize modular components, such as genetic toggle switches and single invertase memory modules (SIMMs), for detecting and converting external inputs, such as chemoattractants, into outputs that allow for autonomous chemotaxis
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Delivery of H2 Antagonists
The present invention provides improved systems and methods for the local delivery of H2 antagonists. The inventive methods include topical administration of an effective amount of a H2 antagonist encapsulated in liposomes. In certain embodiments, the H2 antagonist, for example, Cimetidine, is encap
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TREATMENT OF IgE-MEDIATED DISEASE
The methods and compositions described herein are based, in part, on the discovery of a polypeptide of soluble CD23 (sCD23) that binds and sequesters IgE. Thus, the sCD23 peptides, polypeptides and derivatives described herein are useful for treating conditions or disorders involving increased IgE l
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Tetrahydropyranonaphthyridines Derivatives, Pharmaceutical Compositions and Therapeutic Treatment Thereof
This invention relates to tetrahydropyranonaphthyridines derivatives having formula (III) or IV: and analogues of the tetrahydropyranonaphthyridines derivatives. The invention also relates to pharmaceutical compositions comprising these compounds and methods for treatment of tuberculosis using these
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Compositions and Methods for the Treatment of Cystic Fibrosis
The invention is directed to novel pharmaceutical compositions comprising chemicals agents that are useful in the treatment and prevention of cystic fibrosis and the prevention of signs and symptoms of this disease. These pharmaceutical compositions are surprisingly successful in the treatment disor
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Labeled Skin Lesion Biopsy Punch and Uses Thereof
The present invention relates to a biopsy device, methods, kits and systems for marking the location of a biopsy site in order to later identify the location of a biopsy or surgery in a subject, where the marker is a dye or tattoo which is not visible to the naked eye under normal (white) light, but
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Compositions and Methods for Silencing Ebola Virus Gene Expression
The present invention provides compositions comprising therapeutic nucleic acids (e.g., interfering RNA such as siRNA) that target Ebola virus (EBOV) gene expression and methods of using such compositions to silence EBOV gene expression. More particularly, the invention provides unmodified and chemi
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Bacteriophages Expressing Amyloid Peptides and Uses Thereof
The present invention generally relates to engineered bacteriophages which express amyloid peptides for the modulation (e.g. increase or decrease) of protein aggregates and amyloid formation. In some embodiments, the engineered bacteriophages express anti-amyloid peptides for inhibiting protein aggr
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Method for de novo detection of sequences in nucleic acids:target sequencing by fragmentation
The present invention provides a method for determining nucleic acid sequences of a template nucleic acid that requires no prior knowledge of the nucleic acid sequence present in the template nucleic acid. The method is based on combining information about the mass of a fragment, the mass of any one
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Glucose Sensor Employing Semiconductor Nanoelectronic Device
A glucose sensor employs a programmable glucose sensor array of a relatively large number of nanoelectronic devices (e.g. semiconductor field-effect devices) having control surfaces functionalized with a glucose-reactive substance and generating sensing signals indicative of sensed glucose level of
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Crystal Structure of a MarR Family Polypeptide
The crystal structure of the product, crystals of the MarR protein, a regulator of multiple antibiotic resistance in Escherichia coli, and methods of crystallization of the MarR protein are described.
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Pimap39 Modulates Inflammatory Response
The present invention relates to a novel peptide sequence named PIMAP39 (herein referred to as SEQ ID NO.: 1 ) and methods of use of the novel sequence and functional variants thereof. The present invention also relates to methods for reducing and/or modulating inflammatory responses by administrati
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Switching Devices and Related Methods
A mechanical device capable of switching between two states is described. The device may include a micromechanical resonator with two distinct states in the hysteretic nonlinear regime. The devices can be used as a low-power, high-speed mechanical switch integrated on-chip with silicon circuitry.
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Nucleic Acid Cloning
The present invention provides an improved system for linking nucleic acids to one another. In particular, the present invention provides techniques for producing DNA product molecules that may be easily and directly ligated to recipient molecules. The product molecules need not be cleaved with rest
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Methods for prenatal diagnosis of chromosomal abnormalities
Chromosomal abnormalities are responsible for a significant number of birth defects, including mental retardation. The present invention is related to methods for non-invasive and rapid, prenatal diagnosis of chromosomal abnormalities based on analysis of a maternal blood sample. The invention explo
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Sequence Preserved Dna Conversion
Described herein are inexpensive high throughput methods to convert a target single stranded DNA (ssDNA) such that each nucleotide (or base) adenine (A), thymine (T), guanine (G) and cytosine (C) is converted to a pre-determined oligonucleotide code, with the sequential order preserved in the conver
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Integrated Mems and Ic Systems and Related Methods
An integrated MEMS and IC system (MEMSIC), as well as related methods, are described herein. According to some embodiments, a mechanical resonating structure is coupled to an electrical circuit (e.g., field-effect transistor). For example, the mechanical resonating structure may be coupled to a gate
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Apparatus and Method of Analyzing Arterial Plaque
A method of identifying arterial plaque analyzes arterial plaque using one or more non-invasive tests to determine if the plaque has any of a plurality of hallmarks that are predictive of disruption. The one or more tests do, in fact, test the plaque for the plurality of the hallmarks. The method th
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Isolation of Rna
Disclosed herein are methods for purification of RNA from a sample. The method involves preparing the sample in a solution of lysis buffer, depositing it into a first end of a lysis straw such that the sample solution flows through the matrix of the lysis straw and is eluted from its opposite end, a
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Nucleic Acid Supported Protein Complementation
The present invention is directed to novel methods for in vitro and in vivo detection of target nucleic acid molecules, including DNA and RNA targets, as well as nucleic acid analogues. The present invention is based on protein complementation, in which two individual polypeptides are inactive. When
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Modular Nucleic Acid-based Circuits for Counters, Binary Operations, Memory, and Logic
We have created novel engineered genetic counter designs and methods of use thereof that utilize DNA recombinases to provide modular systems, termed single invertase memory modules (SIMMs), for encoding memory in cells and cellular systems. Our designs are easily extended to compute to high numbers,
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Engineered Sers Substrates Employing Nanoparticle Cluster Arrays with Multiscale Signal Enhancement
Defined nanoparticle cluster arrays (NCAs) with total lateral dimensions of up to 25.4 [mu]m by 25.4 [mu]m have been fabricated on top of a 10 nm thin gold film using template guided self-assembly. This approach provides precise control of the structural parameters in the arrays allowing a systemati
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Chemical/biological Sensor Employing Scattered Chromatic Components in Nano-patterned Aperiodic Surfaces
A label-free multiplexed sensing platform is based on light interaction with aperiodic photonic structures with an advantage of a broadband operation. Multiple-scattering-induced "fingerprinting" colorimetric signatures can be used as a transduction mechanism. Aperiodic sensing platforms can operate
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Haplotype Analysis
The present invention provides an efficient way for high throughput haplotype analysis. Several polymorphic nucleic acid markers, such as SNPs, can be simultaneously and reliably determined through multiplex PCR of single nucleic acid molecules in several parallel single molecule dilutions and the c
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Bacteriophages Expressing Antimicrobial Peptides and Uses Thereof
The present invention is generally related to engineered bacteriophages expressing antimicrobial peptides or lytic enymes or fragments thereof for targeting a broad spectum of bacterial hosts, and for the long-term suppression of bacterial phage resistance for reducing bacterial infections. In some
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Virtual Interactive System for Ultrasound Training
A virtual interactive ultrasound training system for training medical personnel in the practical skills of performing ultrasound scans, including recognizing specific anatomies and pathologies.
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Classification Techniques for Medical Diagnostics Using Optical Spectroscopy
Mathematical/statistical pattern-recognition systems and methods to distinguish between different pathologies and benign conditions (e.g., normal or cancerous tissue) given spectra measured using optical spectroscopy such as elastic-scattering spectroscopy.
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Method for Imaging on Thin Solid-state Interface Between Two Fluids
Described herein is a fluid cell for an optical microscopy tool having a solid state membrane having a first side and a second, opposing side; a first fluid chamber comprising a first fluid having a first refractive index located on the first side of the membrane; and, a second fluid chamber compris
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Reservoir-buffered Mixers and Remote Valve Switching for Microfluidic Devices
The present invention relates generally to the control of fluid flow rate and direction on a microfluidic device. In particular, the present invention provides an integrated valveless microfluidic device, where directional fluid control is controlled using off-chip remote valve switching and fluid f
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System for Assessing the Efficacy of Stored Red Blood Cells Using Microvascular Networks
A system for assessing the microvascular fitness of a sample of stored red blood cells. The system has a network device having at least one network unit. The network unit has a single inlet and a single outlet for the sample and a plurality of microchannels. The plurality of microchannels receive th
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Disposal Separator/concentrator Device and Method of Use
The present invention relates to methods, devices and systems for separation and concentration of particles from liquid and fluid samples. In some embodiments, the separation/concentration is achieved by sequential centrifugation steps. In particular, one aspect of the invention relates to a separat
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High Magnification Spectral Reflectance Biosensing with Discrete Light Sources
A spectral reflectance imaging device for detecting biomolecular targets includes an illumination source that illuminates a substrate with a plurality of separate wavelengths of incoherent light. The substrate includes an oxide layer and a binding agent to selectively bind biomolecular targets to th
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Method and Device for Rapid Detection of Bacterial Antibiotic Resistance/susceptibility
Described herein is a method and a device for expediting delivery of an agent to a damaged bacterial cell. In one embodiment, the methods and devices are useful for screening candidate antibiotics. In another embodiment, the methods and devices described herein are used to determine susceptibility o
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Manufacture of Nanoparticles Using Nanopores and Voltage-driven Electrolyte Flow
Disclosed are methods of manufacturing nanoparticles such as quantum dots at desired nanopore locations in a membrane. The methods disclosed use voltage-driven electrolyte flow to drive the nanoparticle formation.
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Device and Method for Angularly Resolved Scattered Light Measurement
The invention relates to a device for angularly resolved scattered light measurement, comprising an illuminating device having a light source (1) for illuminating a sample (6) with light at a non-vanishing angle of incidence (? i) and a detector (7) for registering a proportion of the light scattere
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Single-mode Propagation in Microstructured Optical Fibers
The invention relates to an optical fiber as an optical waveguide for the single-mode operation. The present invention proposes a fiber having a microstructure, by which the propagation of modes of a higher order are selectively suppressed in the optical waveguide. At the same time, the propagation
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High Definition Scintillation Detector for Medicine, Homeland Security, and Non-destructive Evaluation
A bundle of drawn fibers that have X-ray scintillating unagglommerated nanocrystallite particles in plastic or glass cores of down to 0.1 micron spacing and claddings of X-ray absorbing compounds in the cladding composition. Optional is a cover to the bundle that blocks light from leaving the bundle
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Method for Identifying in Particular Unknown Substances By Mass Spectrometry
The problem was to be able to use the mass spectrometrical analysis at the same time to determine the structure and/or families and/or the chemical properties of said substances, free of subjective evaluation, in the shortest amount of time, in an automatable fashion and with high accuracy, without
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Method for Bacterial Lysis
The present invention is directed to a microfluidic device for lysis of cells, such as bacteria and microorganisms. In particular, the present invention relates to microfluidic devices and methods of manufacture of such microfluidic devices comprising a substrate with at least one channel packed wit
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Cell-specifically Effective Molecules on the Basis of Sirna and Application Kits for the Production Thereof and Use Thereof
1. Cell-specifically effective molecules on the basis of siRNA and application kits for the production thereof and use thereof. 2.1. The aim of the invention is to create a link between siRNA and one or more peptides, wherein the siRNA is activated after peptide separation, without the remaining lin
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Antifungal Formulation and Method of Preparation
A pharmaceutical preparation for treating a microbial infection such as a fungal or bacterial infection in an individual comprises a peptide or a pharmaceutically acceptable salt thereof, wherein said peptide has an amino acid sequence of at least 8 amino acids selected from the group of amino acid
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Alien Sequences
The present invention provides sequences and reagents for preparing microarrays with internal controls. Specifically, the present invention defines and provides sequences that are not present in the hybridizing mRNA or cDNA, and therefore can be used both as hybridization controls and for inter-spot
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Method for comparing three-dimensional surface triangulations of e.g. dinosaur, involves comparing three dimensional surface triangulation are based on three dimensional-moment invariants that are cal
The method involves computing three dimensional-moment invariants for location description of relevant vertices of three dimensional-surface triangulations within defined local areas. Numerical characteristics are determined in a form of accurate surface momentum of the three dimensional-surface tri
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Reca Inhibitors and their Uses As Microbial Inhibitors Or Potentiators of Antibiotic Activity
The present invention provides RecA inhibitors, compositions containing them, systems for identifying or characterizing them, and methods of using them.
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Knee Brace with Expandable Members and Method of Using the Same
A knee brace (300) has a body (310) supporting first, second, and third expandable members (330). When expanded, the first, second, and third expandable members are positioned on the brace body to provide a counteracting force to the adduction moment of the knee.
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Method for improving positioning accuracy of table, involves guiding-away gas from direct surrounding of gas bearing elements over selective influence of flow conditions in area surrounding sliding su
The method involves generating bearing force of gas bearing elements (1) through supplying of compressed gas for formation of a pressurized cushion between a sliding surface (4) and a counter surface (7). The gas is guided-away from the direct surrounding of the bearing elements over selective influ
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Method and Device for Gravity Like Simulation of Natural Balance Movements
We present a tool that can enhance the concept of BWS training by allowing natural APAs to occur mediolaterally. While in a supine position in a 90 degree tilted environment built around a modified hospital bed, subjects wear a backpack frame that is freely moving on air-bearings, as a puck on an ai
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Protective Oxide Coatings for Sofc Interconnections
A dense and well adhered spinel coating such as CuMn1.8O4, when deposited on a stainless steel substrate by electrophoretic deposition, significantly reduces the oxidation rate of the steel compared to the uncoated steel at elevated temperature. The protective oxide spinel coating is useful for prep
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Heterocyclic Inhibitors of Necroptosis
The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-a) induced necroptosis. The heterocyclic compounds of the invention are described by Formulas (I) and (Ia)-(Ie) and are shown to inhibit TNF-a induced necroptosis in FADD-deficient variant of hu
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Identification of Novel Pathways for Drug Development for Lung Disease
The invention provides the identification of oncogenic pathways activated in cytologically normal airway cells of individuals having or at risk of having lung disease, as well as specific gene expression patterns (biomarkers) associated with pathway activation. These biomarkers and pathways may prov
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Video Processing System Employing Behavior Subtraction Between Reference and Observed Video Image Sequences
An image processing method includes calculating sequences of motion labels from each of first and second sequences of images, each sequence of motion labels including motion label values indicating levels of motion activity in corresponding regions of the corresponding sequence of images. First and
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Metabolic and Cardioprotection By the Myokine Follistatin-like 1 Polypeptide
Described herein are methods and compositions related to the discovery that the Follistatin-like 1 protein (Fstl-1) has metabolic and cardioprotective effects in vivo. Fstl-1 and portions and derivatives or variants thereof can be used to treat or prevent metabolic diseases or disorders and to treat
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Nanochannel-based Sensor System for Use in Detecting Chemical Or Biological Species
A sensor system for detecting a chemical or biological species includes a sensing element and a bias and measurement circuit. The sensing element includes nanochannels, each having an outer surface functionalized to chemically interact with the species to create a corresponding surface potential, an
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Supramolecular Bioconjugates
The invention relates to supramolecular bioconjugates and to methods for assembling and utilizing supramolecular bioconjugates. Supramolecular bioconjugates comprise a plurality of first nucleic acids and a plurality of mediators wherein each mediator comprises a second nucleic acid complementary to
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Engineered Enzymatically Active Bacteriophage and Methods for Dispersing Biofilms
The present invention is directed to engineered enzymatically active bacteriophages that are both capable of killing the bacteria by lysis and dispersing the bacterial biofilm because they have been also engineered to express biofilm-degrading enzymes, particularly dispersin B (DspB), an enzyme that
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Polymeric Biolubricants for Medical Use
The present invention provides branched polymers which can be used as lubricants or shock absorbers in vivo. For example, the inventive polymers can be used as viscosupplements, viscoelastics, tissue space fillers, and/or anti-adhesive agents. Also provided are pharmaceutical compositions comprising
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Pre-or Post-exposure Treatment for Filovirus Or Arenavirus Infection
The compositions and methods of the invention described herein provide pre- or post-exposure treatments against filovirus or arenavirus infection by expressing one or more genes (e.g., two ore more genes) from filoviruses or arenaviruses in a delivery vehicle (e.g., a recombinant viral vector or a l
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Compositions and Methods for Treating Ebola Virus Infection
The compositions and methods of the invention described herein provide treatments against Ebola virus infection by expressing gene(s) from the Ivory Coast ebolavirus (ICEBOV) species in a recombinant viral vector.
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Cationic Contrast Agents and Methods of Use Thereof
The present invention provides compounds useful as contrast agents, such as for the CT imaging of cartilage tissue. The contrast agents are generally iodinated organic molecules that are positively charged under physiological environments. Also provided are compositions containing contrast agents an
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Multivalent Vaccine Vector for the Treatment and Inhibition of Viral Infection
The present invention features compositions and methods for the treatment or inhibition of one or more viruses using a recombinant viral vector that encodes and expresses at least one viral gene from two or more viruses. The viral genes encoded within the recombinant viral vector may be gene sequenc
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Multifactorial Methods for Detecting Lung Disorders
Described herein are multifactorial methods for detecting, diagnosing or aiding in the diagnosis of lung disorders or disease, e.g., lung cancer. The methods disclosed utilize multiple diagnostic paradigms, for example, to improve diagnostic sensitivity, specificity, negative predictive value and/or
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Fabrication of Silk Fibroin Photonic Structures By Nanocontact Imprinting
A method of manufacturing a nanopatterned biophotonic structure includes forming a customized nanopattern mask on a substrate using E-beam lithography, providing a biopolymer matrix solution, depositing the biopolymer matrix solution on the substrate, and drying the biopolymer matrix solution to for
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Optical Devices Featuring Nonpolar Textured Semiconductor Layers
A semiconductor emitter, or a precursor therefor, has a substrate and one or more textured semiconductor layers deposited onto the substrate in a nonpolar orientation. The textured layers enhance light extraction, and the use of nonpolar orientation greatly enhances internal quantum efficiency compa
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Acoustic Mobility Aid for the Visually Impaired
A wide-band sonar system can be used as a mobility aid by the visually impaired. The system includes an acoustic source and a pair of miniature microphone arrays with frequency-dependent beam patterns designed to mimic the properties of the human ear. Each microphone is preferably mounted near a res
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Methods for Diagnosis of Clostridium Diffcile and Methods and Vectors for Recombinant Toxin Expression
Cell-based methods for rapid real time assay of a presence of Clostridium difficile toxin and/or cells are provided, using an assay having a toxin-enhancing antibody and a sensitive cell line carrying Fc?R receptors, and kits for this assay. An ultrasensitive cell- based immunocytotoxicity assay for
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Silk Biomaterial and Method of Use Thereof
The present invention provides an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer, such as poly(ethylene oxide) (PEO) (a well-documented biocompatible material), was blended with the silk
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Matrix for the production of ligaments, tendons and other tissue
The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for implantation into a recipient in need thereof. The invention further provides the novel silk-fiber-based matri
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Interactive Digital Workbook System and Method
A digital workbook program, method, and system include a program interface module configured to communicate with a set of applications and a workbook module configured to generate a digital workbook from a master digital workbook. The digital workbook includes content and mechanisms that enable inpu
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Methods, compositions and kits for vegetative cell-based vaccines and spore-based vaccines
Methods for immunizing a subject to an antigen of an infectious agent, a tumor, or an allergen are provided, using vegetative cytoplasmic expression of the antigen or spore surface display of the antigen, and contacting the subject with a composition including a spore or a vegetative cell or both wi
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Wound Healing Peptides and Methods of Use Thereof
Methods and compositions for the treatment of wounds in a mammalian subject are provided. Particularly, novel polypeptides and encoding nucleic acids that stimulate keratinocyte and endothelial cell motility and/or proliferation are provided.
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Neonatal Salivary Genomics
The present invention provides systems for assessing neonatal development and/or conditions by analyzing neonatal saliva RNA. Methods of identifying genes involved in neonatal development and/or conditions affecting neonates, are provided. Methods of determining a diagnosis of a neonate comprising d
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Shear Sensors and Uses Thereof
The present invention relates to shear sensors. In particular, the present invention relates to deformable sensors for measurement of shear forces during chemical mechanical polishing.
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Inhibitors of Extracellular Hsp90
The present invention describes the inhibitors of extracellular Hsp90. The inhibition of extracellular Hsp90 leads to a reduction of the invasiveness of the tumor cells. Furthermore, the invention relates to the use of molecules inhibiting extracellular Hsp90 function for the manufacture of a medica
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Anti-apoptotic Agents and Uses Thereof
The invention generally relates to the use of parasite-derived neurotrophic factor (PDNF), or a fragment of PDNF, to reduce cell apoptosis. The PDNF or PDNF fragment is provided in the cytoplasm of a cell so that it can bind to Akt kinase and induce Akt kinase activation.
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Sulfur-tolerant Water-gas Shift Catalysts
A method for oxidizing carbon monoxide by a water-gas shift (WGS) reaction and a method for reducing carbon dioxide by a reverse water-gas shift (RWGS) reaction, both using a catalyst of the formula xMZLn2O2SOy, in which M, Ln, x, and y are as defined herein. Also disclosed are novel compositions fo
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Atoxic Recombinant Holotoxins of Clostridium Difficile As Immunogens
Atoxic Clostridium difficile toxin proteins were expressed in an endotoxin-free Bacillus system top develop a vaccine to reduce incidence and severity of C. difficile infection (CDI). Immunogens evaluated as potential vaccine candidates are mutated toxin A (encoded by TcdA) and toxin B (TcdB), and a
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