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Double-fed Asynchronous Generator and Method for Its Operation
The invention relates to a double-fed asynchronous generator, which is provided with a slipring rotor (1b), and to a method for its operation. In the normal manner, the asynchronous generator has a machine-side converter (5) and a network-side converter (6). According to the invention, the asynchron
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Active Head Support for Rear Bench Seats in a Passenger Vehicle
The present invention relates to a headrest to be installed in seats of vehicles that is moveable from a normal position to an accident position via a mechanism that is activated by sensor control.Thus, the head restraint is used and cared for an accident for impaired crash burden on individuals, su
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E2f As a Target for Treatment of Hormone Refractory Prostate Cancer
The instant invention provides amino acid sequences competing with E2F for DNA binding. Methods of using said amino acid sequences for treatment of hormone-refractory prostate cancer are also provided.
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Antimicrobial Agents
The invention provides a compound of formula (I): or a salt or prodrug thereof, wherein Y, W, Z, Z1, Z2, Z3, Z4, and R1- R12 have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as antibacterial agents.
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Rna Targeting in Alpha-synucleinopathies
Therapies and assays to screen for small molecules that can have therapeutic use in the control of neurodegenerative diseases such as Parkinson's and other alpha-synucleinopathies.
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Compositions and Methods Modulating Mg29 for the Treatment of Diabetes
Disclosed herein are compositions and methods for treatment of muscle dysfunction, including diabetes. In addition, the invention relates to therapeutic compositions comprising nucleotides and/or polypeptides of the invention in combination with a pharmaceutically acceptable carrier, wherein the com
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Novel Compounds for Inhibiting Eef2 Kinase Activity
The present invention discloses novel compounds for inhibiting eEF2 kinase and methods of use thereof.
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Strategy for Homo- Or Hetero-dimerization of Various Proteins in Solution and in Cell
The present invention describes a chimeric polypeptide comprising a first portion comprising a receptor domain, wherein the receptor domain comprises an intracellular region and a transmembrane region; and a second portion comprising a dimerization domain. The present invention also describes a chim
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Method of Treatment for Acute Myelogenous Leukemia
This invention relates to a method of treating acute myelogenous leukemia with TPA along with Dexamethasone and choline magnesium trisalicylate.
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Proteins Expressed By Mycobacterium Tuberculosis and Not By Bcg and their Use As Vaccines
The present invention is directed to proteins expressed by Mycobacterium tuberculosis and not by BCG and their use as vaccines.
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Genes As Diagnostic Tools for Autism
The homeobox transcription factor, ENGRAILED 2 EN2), was investigated for association with autism spectrum disorder (AS) by performing transmission/disequilibrium tests (TDT) for two SNPs (rs1861972 and rs1861973) and was identified as being a likely susceptibility locus for autism and related AS di
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Chemoprevention of Colorectal Cancer by Mesalamine/Sulfasalazine
A method for preventing or treating colorectal cancer in a patient possessing human tropomyocin isoform TC22 is presented. Also presented is a method for evaluating TC22 expression reduction activity of a compound.
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Tissue Engineered Fibrocartilage Replacement
Fibrocartilage implants characterized by circumferential fiber networks embedded in arcuate or torroidal scaffolds with orthogonal fiber networks embedded therein to prevent separation of the circumferential fiber networks. The fiber networks convert axial compressive forces on the scaffolds to tens
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Hemostatic Effects of Glucono-Delta-Lactone
Glucono-delta-lactone (GDL) can be used to mediate the human blood coagulation process. In particular, GDL can be used in an assay to determine an individual's risk potential for accelerated blood clotting or as a treatment for conditions related to accelerated clotting potential and/or inflammatory
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Compositions and methods for enzymatic detachment of bacterial and fungal biofilms
Isolated nucleic acid sequences and amino acid sequences for soluble -N-acetylglucosaminidase or active fragments or variants thereof which promote detachment of bacterial cells from a biofilm are provided. An isolated mutant bacteria which forms biofilm colonies which tightly adhere to surface but
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Medical use of mRNA interferase
The present invention is directed to the discovery of a novel family of enzymes designated herein as mRNA interferases that exhibit endoribonuclease activity. The novel finding of the present inventors, therefore, presents new applications for which mRNA interferase nucleic and amino acid sequences,
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Method for Treating Chronic Nerve Tissue Injury Using a Cell Therapy Strategy
A method for treating a degenerative or traumatic injury to a nerve tissue or the brain by administering at or near the injury site a composition containing adherent bone marrow stem cells suspended in a pharmaceutically acceptable liquid in an amount effective to elicit axonal regeneration or re-my
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Treatment and Diagnosis of Inflammatory Disorders
This invention concerns compositions and methods of treating or diagnosing inflammatory disorders and other disorders.
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Cold Shock Protein Compositions and Methods and Kits for the Use Thereof
The present invention provides cold shock protein-containing compositions for improved DNA synthesis reactions with improved reactivity, methods for synthesizing DNA using such compositions, kits for use in such methods, and DNA compositions yielded by such methods. The present invention further pro
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Multiplex Screening for Pathogenic Hypertrophic Cardiomyopathy Mutations
This invention relates to a new method of screening for hypertrophic cardiomyopathy. In certain embodiments, the invention comprises a method of screening for hypertrophic cardiomyopathy comprising detecting the presence or absence of at least one pathogenic HCM mutation by mutation detection assay
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Immunotherapy for Unresectable Pancreatic Cancer
The present invention provides a novel cancer immunotherapy comprising a vaccination schedule of both intratumoral and systemic injections followed by peripheral boost injection. The immunotherapy can then be followed by other standard treatment as is known in the art for locoregional or metastatic
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Anti-sense Microrna Expression Vectors
The present invention relates to an alternative strategy for expressing the antisense sequence of a miRNA. This system allows for continuous production of the antisense sequence and subsequently complete knockdown of the targeted miRNA.
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Compositions Comprising Mg29 Nucleic Acids, Polypeptides and Associated Methods of Use
Disclosed herein are compositions and methods for treatment of muscle dysfunction (including sarcopenia) and other diseases involving skeletal musle, including age-related muscle dysfunction. In addition, the invention relates to therapeutic compositions comprising nucleotides and/or polypeptides of
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IMAGING INDIVIDUAL mRNA MOLECULES USING MULTIPLE SINGLY LABELED PROBES
A method for probing a target sequence of messenger ribonucleic acid molecules (mRNA's) in a fixed, permeabilized cell, said target sequence including at least 30 non- overlapping probe binding regions of 15-100 nucleotides, comprising immersing said cell in an excess of at least 30 nucleic acid hyb
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Dentinal Drug Delivery Composition
The present invention is a dentinal drug delivery composition composed of cationic and/or neutral porous particles containing an effective amount of a therapeutic agent and a method for using the same to provide a dental treatment.
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Targeting Tumor Cells with Chemotherapeutic Agents Conjugated to Matriptase Antibodies
The present invention relates to matriptase antibodies and immunoconjugates of matriptase antibodies with cytotoxic agents and the use thereof for killing or inhibiting the growth of matriptase-expressing cancer cells, such as those of multiple myeloma and breast cancers. In particular, immunoconjug
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Treatment of Hiv Infection
This invention concerns compositions and methods of treating, inhibiting, or controlling HIV infection.
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Therapeutic Compounds
The invention provides compounds of formula (I) wherein u, d, v, m, n, R1, W, X, Y, and Z have any values defined herein, as well as salts thereof. The compounds have activity as anti-proliferative agents.
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Method for Treating Sepsis Or Septic Shock
The present invention is a method for treating sepsis or septic shock using Lipoxin A4.
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Closed System Separation of Adherent Bone Marrow Stem Cells for Regenerative Medicine Applications
A method for isolating and processing bone marrow derived stem cells, including the steps of: (a) collecting a biological sample containing adherent bone marrow stem cells in a receptacle with interior walls coated with a cell-adherent substrate; (b) incubating the bone marrow cells on the adherent
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The Use of Protein S Fusion for Protein Solubilization
The invention provides vectors containing a multiple cloning site comprising a PrS tag or a PrS2 tag from Myxococcus xanthus. Methods are provided for enhancing solubility of a target protein using Protein S tagged target fusion proteins. TM KIPO & WIPO 2009
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Targeting Bacterial Suicide Pathways for the Development of Novel Antibiotics
The invention provides methods for identifying an agent which prevents or partially prevents an antitoxin from forming a complex with its cognate toxin, comprising contacting a potential agent with a labeled substrate in solution, whereby detection of the label indicates presence of an agent that pr
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Telomerase Reverse Transcriptase Variant
The present invention relates to nucleic and amino acid sequences of a novel variant of the telomerase reverse transcriptase. More particularly, the present invention is directed to a novel variant of human telomerase reverse transcriptase, which displays properties distinct from those of wildtype t
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A Method of Using an Extracellular Matrix to Enhance Cell Transplant Survival and Differentiation
Provided is a matrix for promoting survival and differentiation of cells transplanted thereon, comprising a base matrix and a cell-made matrix thereon. Methods and means for making and using same are also provided.
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Use of Stem Cells for Wound Healing
Cells, compositions, and methods of cell therapy for administering a therapeutically effective amount of stem cells or cell concentrate to achieve accelerated wound healing of normal and chronic wounds, while minimizing the formation of scar tissue.
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Mechanism-based Small-molecule Parasite Inhibitors
Methods for preventing or treating an Apicomplexan parasite infection in a patient administering to a patient in need thereof an effective amount of a compound of Formulas I- IV.
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Compositions and Methods to Modulate Cell Membrane Resealing
Disclosed herein are compositions and methods for repairing cell membranes. In addition, the invention relates to therapeutic compositions comprising nucleotides and/or polypeptides of the invention in combination with a pharmaceutically acceptable carrier, wherein the composition facilitates the re
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Amniopunch and Uses Thereof
A tissue, such as an amniotic or chorionic membrane, harvesting device that integrates a system facilitating subsequent storage of tissue samples. The device cuts a sample of the target tissue and automatically deposits the sample in a storage vessel. A method of collecting and storing a sample from
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Novel Modification of Immunomodulatory Protein
Methods of inhibiting annexin I induced apoptosis by contacting a cell population containing a TRPM7/ChaK1 kinase with an effective amount of a composition containing an inhibitor for the kinase.
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Natural Polypeptides for Oral Health Care.
Tlic present invention relates generally to dental diseases, caries and periodontal disease. More specifically, the invention relates to Lactoferrin and Stathcrin fusion proteins (STAT-LF) along with therapeutic, diagnostic and research uses for these polypeptides. The present invention also provide
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Type 5 Adenylyl Cyclase Inhibitors for Providing Cardiac Protection
The invention provides a method of treating a cardiac disease by administering a pharmaceutically effective amount of at least one compound capable of inhibiting AC5 to a patient. The compound capable of inhibiting AC5 may be administered singly or in combination with another agent, such as, for ins
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Inhalable Particulate Environmental Robotic Sampler
A robotic sensor measures air quality characteristics as experienced by a toddler, such as a child of six to twelve months in age. The robot includes an air quality sensor, a terrain drive train, a sensor drive train and a control circuit that controls the terrain drive train and the sensor drive tr
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Methods and Compositions for Treating Cancer
The present invention provides methods of treating cancer using 2-amino-6-trifluoromethoxybenzothiazole (riluzole). In one aspect, the present invention provides methods of reducing cancer cell growth. In another aspect, the present invention provides a method of inducing apoptosis in a cancer cell.
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Salivary Bioassay for Early Detection of Bone Loss
The present invention is directed to methods to detect and diagnose osteoporosis and periodontal disease using salivary biomarkers.
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Novel oligonucleotide arrays and their use for sorting, isolating, sequencing, and manipulating nucleic acids
A method of sorting mixtures of nucleic acid strands comprising hybridizing the strands to an array of immobilized oligonucleotides, each of which includes a constant segment adjacent to a variable segment. The constant segment of the immobilized oligonucleotides can be made complementary to the end
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Methods and Compositions for Treating Alzheimer's Disease
A method is disclosed for inhibiting the build-up of amyloid plaques in the brain of a patient with at least one risk factor for, or a diagnosis of, Alzheimer's Disease by administering to the patient an amount of one or more compounds effective to inhibit the phosphoryla-tive activity of eEF2K, the
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Inhibiting Obesity Progression By Inhibiting Adipocyte Differentiation with a Pre-adipocyte Autophagy Inhibitor
The present invention relates to methods of mitigating, preventing or treating weight gain or obesity in patients by administering one or more autophagy inhibitors, thereby, preventing the differentiation process of pre-adipocyte cells into a mature adipocytes. Specifically, the present invention re
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Novel Toxin-antitoxin System
Disclosed in certain embodiments is a method of inhibiting cell function comprising inducing the expression of a mRNA interferase that cleaves mRNA at GCU.
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Type I Interferon Antagonists
Disclosed in certain embodiments is a method of preparing a Type 1 interferon antagonist comprising modifying a Type 1 interferon at the site of interaction with the interferon receptor subunit IFNAR-1 such that the binding affinity of the interferon to the IFNAR-1 subunit is reduced as compared to
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Independently Inducible System of Gene Expression
The present invention is directed to the improved methods for the temporal induction of proteins using the condensed single protein production (cSPP) system.
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Reconstituted Tumor Microenvironment for Anticancer Drug Development
Extracellular matrix bioscaffolds capable of supporting the formation and growth of tumors from tumor cells introduced thereto containing tumor associated macrophages and carcinoma-associated fibroblast-like cells cultured under conditions effective to provide a cellular matrix capable of supporting
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Bacterial Helicase Inhibitor Compounds and Uses Thereof
Organic compounds are described that inhibit bacterial helicase activity and growth of bacterial cells on surfaces.
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Methods and Compositions for Treating Obesity and Related Disorders
The invention provides methods for, and compositions effective for, treating obesity, inhibiting weight gain, treating diabetes mellitus, inhibiting atherosclerosis and treating related disorders and conditions comprising administering a pharmaceutically effective amount of at least one compound cap
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Benzo [c] Phenanthridines As Antimicrobial Agents
The present invention provides compounds of formula I: formula (I) wherein X1- X4 and R1-R12 have any of the values defined in the specification, as well as salts and prodrugs thereof, which inhibit major molecular mechanisms associated with bacterial cell division and proliferation so as to be usef
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Labeled Biomolecular Compositions and Methods for the Production and Uses Thereof
Disclosed herein is a set of E. coli single-protein production (SPP) technologies with protein NMR (SPP-NMR) for (i) using isotope-enriched membrane proteins produced with the SPP system in screening detergent conditions suitable for purification and/or three-dimensional structure analysis without t
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Novel Human Lysosomal Protein and Methods of Its Use
The gene associated and causative of classical late infantile neuronal ceroid lipofuscinosis (LINCL), CLN2, has been identified and characterized. The translation product of this gene is a novel protease and a deficiency in this activity results in LINCL. Identification of CLN2 will not only aid in
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Proteins, Nucleic Acids Encoding the Same, and Associated Methods of Use
Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypep
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Cytokines and Genes Differentially Affected by TNF Blockers
The present invention is directed to cytokines and genes that are differentially affected by TNF blockers and the use of these genes and cytokines to help asses the TB risks of new immunosuppressive therapies, to help evaluate the effects of new TB vaccines, and to help assess TB susceptibility in p
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Antitoxin Destabilization Technology
Disclosed are methods for purifying toxin proteins which avoid denaturation and renaturation procedures.
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Hiv-1 Gp41 Neutralization Domain and Use Thereof
The invention relates to a region of the HIV-I gp41 protein that contains, at least in part, an epitope that allows potent neutralization of resistant virus particles. This site is present in the C-terminal heptad repeat region of gp41 (HR2), and adjacent to, but distinct from the MPER. Vaccines con
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Modular Triple-helical Collagen-like Products
Recombinant bacterial triple-helical collagen-like proteins comprising two or more repetitive sequences of Gly-Xaa-Yaa yielding high-stability polymeric constructs without the need for post-translational modifications and which may incorporate one or more functional domains of biological or structur
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Combination Therapy to Improve Drug Efficiency
The instant invention provides methods for increasing drug bioavailability and/or preventing multi-drug resistance through inhibition of ABCG2 protein by caffeine or caffeine analogs.
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Methylenedioxybenzo [i] Phenanthridine Derivatives Used to Treat Cancer
The invention provides compounds of formula I: wherein A, B, X, and Y have any of the values defined in the specification, as well as pharmaceutical compositions comprising such compounds, processes for preparing such compounds, and therapeutic methods for treating cancer and other topoisomerase med
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Treatment of Cutaneous Hemangioma
This invention concerns a method of treating hemangiomas with a beta blocker by applying the beta blocker onto the hemangiomas directly. The invention also concerns a combination therapy by using a beta blocker along with a corticosteroid or an alpha adrenergic receptor agonist for the treatment of
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Pharmaceutical Preparations Having Individualized Dosage and Structure
A manufacturing device capable of creating individualized dosages of pharmaceutical preparations in which a metering system and a means of performing non-destructive chemical analysis of individual manufactured units are controlled by a microprocessor to precisely control the content and structure o
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Biocompatible Polymers for Medical Devices
The present invention relates to new classes of monomeric compounds, which may be polymerized to form novel biodegradable and bioresorble polymers and co-polymers. These polymers and co-polymers, while not limited thereto, may be adapted for radio- opacity and are useful for medical device applicati
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Nanocarrier and Nanogel Compositions
Novel classes of multi-arm polyalkylene oxide-based materials including PEG nanocarriers, nanogel particles, and aggregated nanogel particles are disclosed. These classes of compositions may be associated with therapeutic agents and targeting moieties, or visibility enhancing agents, and may have a
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Tilting/Tracking System for Solar Devices
A tracking system is provided for a roof-mounted solar array. The system includes a sensor mechanism for sensing an orientation of the sun relative to the solar array, and a controller connected to the sensor mechanism that generates a signal that represents an optimal tilt angle of the solar array
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Methods for Obtaining Bioactive Compounds from Phytoplankton
Phytoplankton represent a potential source of bioactive compounds. The present disclosure provides, inter alia, methods for identifying glycerolipids and apoptosis-inducing sphingosine-like lipids from virally-infected phytoplankton.
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Solubilized Topoisomerase Poisons
The invention provides compounds of formula I: wherein A, B, W, Y, Z, and R1 have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compound
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Multiple Phase Cross-linked Compositions and Uses Thereof
The present invention is directed to pharmaceutical compositions, and method for preparing pharmaceutical compositions, comprising a cross-linked matrix physically entrapping at least one therapeutic agent. The matrix may comprise one or more phases in addition to an aqueous phase, such as a solid a
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Expression System Compositions and Methods
The present invention relates to novel expression systems and methods for preparing samples for 3D structure determination of a protein based on a protein expression vector, E. coli host, and specific growth media.
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Snapin and Methods for Regulation of Microtubule Assembly and Dendrite Growth and Branching
Fragments of snapin important for interaction with cypin and thus regulating microtubule assembly are provided. Also provided are methods of use of said fragments and kits to facilitate said methods.
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Methods of Increasing Toughness of Immiscible Polymer Blends
An immiscible polymer blend that includes an amount of poly(trimethylene terephthalate) (PTT) and an amount of poly(methylmethacrylate) (PMMA). A method for preparing an immiscible polymer blend by (a) identifying a first polymeric component and a second polymeric component as immiscible when blende
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Metal Fluoride Compositions for Self Formed Batteries
The described invention provides compositions related to an electronically insulating amorphous or nanocrystalline mixed ionic conductor composition comprising a metal fluoride composite to which an electrical potential is applied to form 1) a negative electrode, and 2) a positive electrode, wherein
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Compounds, Compositions and Methods for Treatment of Protozoan Infections
Provided are compounds, compositions and methods for treating protozoan infections.
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Systems and Methods for Capture and Sequestration of Gases and Compositions Derived Therefrom
A method of sequestering a greenhouse gas is described, which comprises: (i) providing a solution carrying a first reagent that is capable of reacting with a greenhouse gas; (ii) contacting the solution with a greenhouse gas under conditions that promote a reaction between the at least first reagent
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Method of Hydrothermal Liquid Phase Sintering of Ceramic Materials and Products Derived Therefrom.
Provided here is a method of producing a monolithic body from a porous matrix, comprising: (i) providing a porous matrix having interstitial spaces and comprising at least a first reactant; (ii) contacting the porous matrix with an infiltrating medium that carries at least a second reactant; (iii) a
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Solubilized Topoisomerase Poison Agents
The invention provides compounds of formula I: wherein A, B, W, Y, Z, and R1 have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compound
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Compositions and Methods for Treating Ophthalmic Diseases.
Degradable polymeric compositions containing water-insoluble drugs blended with copolymers of biocompatible diphenol compound monomer units with pendant carboxylic acid groups polymerized with biocompatible diphenol corn-pound monomer units with pendant carboxylic acid ester groups and poly(alkylene
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Dressing Compositions and Methods
Described is a spray-on hydrogel comprising water-soluble PEG polymers that cross-link in situ to form a hydrogel such that the cross-links are reversible. The hydrogel can be useful as a drug delivery composition, wound dressing or surgery adjuvant. Polyethylene glycol polymer and cross-linker solu
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Low Temperature Metal Oxide Synthesis
A method for the decomposition of one or more metal oxide precursor compounds, at least one of which is a metal carboxylate salt, to a metal oxide or mixed metal oxide by contacting the metal oxide precursor compound or compounds with an aqueous reaction mixture at a pH, pressure and temperature eff
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Electrostatic Screen Device and Method for Emission Control
An electrostatic screen battery for emission control (ESBEC) system includes a plurality of screens. The screens are arranged in an alternating manner so that screens at a first electric potential are interposed with screens at a second electric potential. An ionizer is disposed upstream of the scre
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Disease Resistant Transgenic Plants
Provided are transgenic plants, seed and plant parts which display increased resistance to fungal disease or mycotoxin. Also provided are methods of making transgenic plants with increased resistance to fungal disease or mycotoxin.
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Apparatuses and Methods for Determining Protease Activity
The present invention relates to compositions and an apparatuses for determining protease activity. The compositions of the invention contain a reporter protein fused to at least one protease cleavage sequence, and linker for attaching the protease cleavage sequence to a solid support. Methods for d
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Moldable and Low-temperature Cure High-temperature Composites
A method for preparing a high-temperature heat-resistant composite material by combining a mixture of submicron alumina powder and submicron silica powder, wherein the ratio of alumina to silica is from about 4:1 to about 5:1, submicron Group II metal oxide powder, and a Group I metal silicate solut
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Systems and Methods for Identification of Ciliopathy Therapeutics
The invention provides systems and methods for identifying therapeutic targets for treating a disease including a ciliopathy. The invention further provides for drug discovery, and animal model systems related to drug discovery. The invention further relates to therapy of genetic disorders of the ce
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Radio-opaque Polymer Biomaterials
Iodinated and/or brominated derivatives of aromatic dihydroxy monomers are prepared and polymerized to form radio-opaque polymers. The monomers may also be copolymerized with other dihydroxy monomers. The iodinated and brominated aromatic dihydroxy monomers can be employed as radio-opacifying, bioco
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Compliant Biocompatible Polymer Compositions for Medical Uses
Phase-separated elastomeric biocompatible polymer compositions are disclosed that are bioresorbable and/or biodegradable, and are useful in a variety of medical applications in which a low modulus polymer is desired, such as in the fabrication of medical devices.
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Methods to Treat Cancer
The invention provides methods and pharmaceutical compositions for treating certain cancers with compounds of formula (I) wherein A, B, W, Y, Z, and R1 have any of the meanings defined in the specification and their pharmaceutically acceptable salts and prodrugs.
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Method and system for execution monitor-based trusted computing
A system and method of providing trusted service transactions includes associating a commitment with a remote service. The commitment includes a trusted list of runtime dependencies to execute a transaction. The method includes monitoring an actual list of runtime dependencies invoked during executi
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Bioresorbable Polymers Synthesized from Monomer Analogs of Natural Metabolites
New bioresorbable polymers are synthesized from monomer analogs of natural metabolites In particular, polymers are polymerized from analogs of amino acids that contribute advantageous synthesis, processing and material properties to the polymers prepared therefrom, including particularly advantageou
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Flame-retardant Coating
A flame-retardant coating composition, which includes a cross-linked thermosetting polymer and a metal hydroxide. A precursor composition for use in preparing the flame retardant-coating is also presented, wherein the precursor composition includes a cross-linked thermosetting polymer varnish, a met
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Interspecific cornus hybrid designated KF 111-1
An advanced generation interspecific hybrid of Cornus kousa and C. florida that is distinguished by its exceptionally high vigor, attractive foliage, very floriferous display of white floral bracts, high level of winter hardiness, tolerance of drought and shade, and high resistance to the incitants
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Oregano and Mint Anti-inflammatory Compositions and Methods
The present invention relates to bioactivity-guided isolation and identification of bioactive compounds from oregano and mint plants, in particular, rosmarinic acid, oleanolic acid and ursolic acid, and use of these compounds or combinations thereof as anti-inflammatory agents for the treatment of c
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Sterospecific Carbonyl Reductases
Stereospecific carbonyl reductases SCR1, SCR2, and SCR3 are described herein as are nucleotide sequences that encode these reductases. These stereospecific carbonyl reductases have anti-Prelog selectivity and have specificities that are useful for fine biochemical synthesis.
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Synthesis of Cyclic Diguanosine Monophosphate and Thiophosphate Analogs Thereof
The invention provides methods for the synthesis of cyclic dinucleotides and thiophosphate analogs thereof as well as a new family of analogs of cyclic diguanosine monophosphate that includes a series of seven phosphorothioate derivatives that includes diastereomers of mono-, di-, and trithiophospha
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Monomers and Phase-separated Biocompatible Polymer Compositions Prepared Therefrom for Medical Uses
The invention relates to novel monomers of Formula (I) useful for preparation of phase-separated biocompatible polymers or polymer compositions. These polymers or polymer compositions may be bioresorbable and/or biodegradable and have desirable mechanical properties, such as fracture and/or fatigue
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Compositions and Methods for Treatment of Neuropathic Pain
The present invention relates to compounds, compositions, methods, systems and kits for treating neuropathic pain regulated by SIP30. The present invention provides SIP30 antagonists for the treatment of neuropathic pain.
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High-throughput Biomarker Segmentation Utilizing Hierarchical Normalized Cuts
A method and apparatus for obtaining segmented images of the stained regions may comprise quantifying the extent of the presence of staining of a biomarker in an original image of a sample, which may comprise selecting a domain swatch of data based upon a user specified domain knowledge; clustering
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