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System and Method for Measuring Consumption in a Residential Or Commercial Building Via a Wall Socket
A system and method to measure power usage within a residence having a plurality of electrical circuits electrically connected to an over-current protection device may include measuring, by a power measurement device electrically connected to one of the electrical circuits by which power loads draw
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Biocompatible Polymers for Medial Devices
The present invention relates to new classes of monomeric compounds, which may be polymerized to form novel biodegradable and bioresorble polymers and copolymers. These polymers and co-polymers, while not limited thereto, may be adapted for radio-opacity and are useful for medical device application
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Virtual Flow Pipelining Processing Architecture
A computer system for embodying a virtual flow pipeline programmable processing architecture for a plurality of wireless protocol applications is disclosed. The computer system includes a plurality of functional units for executing a plurality of tasks, a synchronous task queue and a plurality of as
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Process for Designing Inhibitors of Influenza Virus Structural Protein-1
Disclosed are methods and compositions useful in identifying inhibitors of influenza virus, such as influenza A and B virus. Also disclosed are methods for preparing compositions for administration to animals, including humans infected with or to protect against influenza virus.
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Media Conditioning for Improving Gene Delivery Efficiency to Differentiating Embryonic Stem Cells
The present invention provides systems and methods for improving the efficiency of a transient gene delivery system to differentiating embryonic stem (ES) cells by serum starving the targeted cells for one to three days prior to transfection. Such a serum starvation surprisingly resulted in increase
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Radiopaque Polymeric Stents
The present invention relates to polymeric medical devices such as stents. More particularly the polymeric compositions disclosed herein comprise halogen-containing, tyrosine-derived diphenols, optionally in conjunction with other groups, such as dicarboxylic acids and/or poly(alkylene oxides), such
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Switch-region: Target and Method for Inhibition of Bacterial Rna Polymerase
The invention provides a target and methods for specific binding and inhibition of RNA polymerase from bacterial species. The invention provides methods for identifying agents that bind to a bacterial RNA polymerase, and that inhibit an activity of a bacterial RNA polymerase, through interactions wi
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Therapeutic Devices for Patterned Cell Growth
The invention provides therapeutic devices comprising a polymeric anti-inflammatory agent that biodegrades to release anti-inflammatory agents. The therapeutic devices are useful for repair and regeneration of a variety of injured tissues.
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Therapeutic Modulation of Autophagy
Methods for screening for modulators of autophagy are disclosed. Methods for identifying genes whose expression inhibits autophagy, as well as genes whose expression promotes autophagy, are disclosed. Also disclosed are methods for identifying compounds that stimulate autophagy, as well as compounds
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Method for Preparing Gallium Nitride Nanoparticles
A method for preparing gallium nitride nanoparticles includes providing a pair of electrodes; the pair of electrodes being opposedly disposed to one another. One electrode of the pair of electrodes is filled with gallium nitride powder. The pair of electrodes is dipped in a liquid. An arc discharge
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Therapeutic Compounds.
he invention provides compounds of formula (I) wherein A, B, R, F, G, n, n' and the dotted line have any values defined herein, as well as salts thereof. The compounds have activity as anti-proliferative agents.
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Method and Apparatus for Making and Detecting a Document Verification Indicator Using Optical Pattern Encryption
A method and apparatus for creating and detecting an optically encoded document having a uniquely designed document verification indicator is disclosed. One embodiment includes applying a spatially varying Brewster angle pattern on a substrate. Another embodiment includes an apparatus for detecting
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Polyarylates for Drug Delivery and Tissue Engineering
Biocompatible polyarylates of diphenol compounds and poly(alkylene oxide) dicarboxylic acids, articles formed therefrom and therapeutic uses are disclosed.
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Preparation and Use of Pouteria Lucuma Extract
A method of preparing Pouteria lucuma extract was developed which comprises extracting oil from the nut. The lucuma nut oil (LNO) was effective to induce cell migration, enhance tissue regeneration and enhance wound healing. The lucuma nut oil provides an agent that is useful for therapeutic or cosm
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Degradable Hydrogel Compositions and Methods
This invention concerns an in situ biodegradable hydrogel drug delivery system in which the components are assembled in a manner that provides a mechanism for the timed cleavage of a particular amide bond in a covalently linked active agent or of the hydrogel structure.
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Compositions and Methods for the Protection of Substrates from Heat Flux and Fire
A flame or heat flux protective coating composition, which includes a dispersion of fiberglass, hollow glass spheres, or a combination of both in silicone. A flame or heat flux protective sheet, which includes hollow glass spheres dispersed in silicone in a sheet form or fiberglass and silicone in a
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Polyhydrogen Fluoride Based Battery
The described invention relates to primary and secondary electrochemical energy storage systems, particularly to such systems as battery cells, which use materials that take up and release ions as a means of storing and supplying electrical energy, and methods of fabrication thereof.
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Image-based Risk Score-a Prognostic Predictor of Survival and Outcome from Digital Histopathology
The present invention relates to an image-based computer-aided prognosis (CAP) system and method that seeks to replicate the prognostic power of molecular assays in histopathology and pathological processes, including but not limited to cancer. Using only a tissue slide samples, a mechanism for digi
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Systems and Methods for the Detection of Malware
A system and method for distinguishing human input events from malware- generated events includes one or more central processing units (CPUs), one or more input devices and memory. The memory includes program code that when executed by the CPU causes the CPU to obtain a first set of input events fro
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Neuroprotective Compositions and Methods
This disclosure concerns novel methods for preventing or treating neurological or neurodegenerative diseases or disorders by using kombo butter acid enriched extracts derived from the seeds of African nutmeg, the main active compounds isolated from the extracts, namely sargaquinoic acid, sargachrome
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Toposiomerase Inhibitors
The invention provides compounds of formula (I): wherein A, B, W, Y, Z, R1, R3 and R4 have any of the meanings defined in the specification and their salts. The invention also provides pharmaceutical compositions comprising a compound of the invention, processes for preparing compounds of the invent
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Vehicular Information Systems and Methods
Disclosed is a method and system that receives sensor information from each of a plurality of sensors. Each sensor in the plurality is associated with a vehicle. The sensor information includes location coordinates of each vehicle in the plurality. The sensor information associated with each vehicle
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Nanocarrier Compositions and Methods
This invention provides multimeric nanocarrier for in vivo delivery of a bioactive agent, comprising at least two peptide monomers reversibly or irreversibly linked with one or more of said bioactive agents, wherein said two or more of said peptide monomers are covalently linked by a biodegradable d
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Soybean Oil Based Oxygen Carrying Emulsion for Massive Blood Loss
VivaSure is a new treatment for shock from massive blood loss. It is based on soybean oil and is therefore biodegradable. It refills lost vascular volume, protects from free radicals, absorbs toxins and provides nutrition to cells. Also it can deliver oxygen, nitric oxide or other gases to tissues.
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Device and method for the detection of biological material
Device for the detection of biological material, with a light (2) into an object (5) irradiating light source (1), where the object is brought into contact with a photonic crystal, and a photonic through the crystal (6) and the object light transmitted (7) and using a detector (8), characterized by
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Pharmaceutical Compositions for Treating Infections with Drug Resistant Mycobacteria
In a first aspect, the present invention relates to pharmaceutical compositions for the treatment of infections with mycobacteria wherein said mycobacteria are resistant to at least one of the following drugs: rifampicin, isoniazid, pyrazinamide, or ethambutol, in particular, said mycobacteria are M
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Method for Determining the Quality of Heparin
The invention relates to a method for determining contamination of heparin with other sulfated glycans, comprising the steps: incubating a predetermined amount of heparin together with a predetermined amount of an enzyme that specifically digests heparin for a predetermined duration, wherein the amo
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Electrode for Lithium-ion Accumulators
The invention relates to electrodes for lithium-ion accumulators comprising a metal film that is inert in relation to lithium ions and a plurality of silicon nanowires projecting from the film at least on a flat side of the film. Parts of the nanowires are surrounded by the metal film.
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Method and Arrangement for Reconstructing the Source of an Electromagnetic Field
The invention relates to a method for reconstructing the source (10, 23, 25) of an electromagnetic field. First, a measuring chamber (14) separate from the source (10, 23, 25) is selected so that the measuring space (14) is connected to the source (10, 23, 25) by means of a magnetically homogeneous
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Probabilistic Digital System for the Ultra-fast Mining of Huge Databases
This patent presents a new system that is able to achieve large performance values in the exploration of large datasets due to the huge parallelism that is achieved with probabilistic computing methodologies. The logic structures can be replicated hundred of times in a single FPGA in order to obtain
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Derivate Von N
The invention relates to physically-chemically and pharmacokinetically enhanced N ?-hydroxy-L-arginine (NOHA) derivatives and a method for producing the NOHA derivatives having enhanced physical-chemical and pharmacokinetic properties according to the invention.
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Inhibitors of Dimethylarginine Dimethylaminohydrolase
The invention relates to an inhibitor of dimethylarginine dimethylaminohydrolase (DDAH) of general structural formula (I), wherein B is a branched or unbranched, substituted or non-substituted, saturated or unsaturated hydrocarbon chain having a chain length of 1 to 6 and/or a substituted or non-sub
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Method for Producing Plant Tissues Suitable for Consumption and Having an Increased Content of Quercetin And/or Quercetin Derivatives
A method for producing a fruit that is suitable for consumption and has an increased content of quercetin and/or quercetin derivatives in the pulp, characterized by the following steps: cutting the fruit; immersing the cut fruit into an impregnating solution containing quercetin and/or quercetin der
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Laser Optical Beam Scanning Device
An optical beam scanning device is proposed for image recreation through optical beam scanning on a surface through the oscillation of piezoelectric actuators (A, B) and a spherical shaped mirror (R) according to horizontal and vertical sync signals. In a video display system, a laser beam (L) is re
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Mega-Catch Mosquito Traps
Innovative Mosquito Control Technology.
Mega-Catch™, maker of the world’s most advanced electronic mosquito traps, is seeking suitable licensees to manufacture and distribute its innovative products worldwide. Territories include: North, Central and South America, Europe, Africa, The Middle East,
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Transit Switching System for Monorail Vehicles
PATENT NUMBER 6,393,993
TRANSIT SWITCHING SYSTEM FOR MONORAIL VEHICLES relates to providing a monorail switching system for individually and selectively routing vehicles between a main track and merged tracks on a dedicated route.
Furthermore, vehicles can be public, business, or privately owned
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Environmental Energy Conversion Device
Present invention is related to energy conversion and using thermal energy spread
out in the outside environment it is the same energy which Sun, and other human
devices produce and release in the environment. It is modified process that used
for heat pumps; to pump-in the surrounding thermal ene
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Game of Spheres
The IP is for a board game to be played with small glass spheres. The board It's self uses a three dimensional grid system for the playing area, 55cm x 41cm.
The prototype of the board (see image) is also included in the price.
The lifetime of the UK IP expires 2026 and the HK I
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Method for Fast Macropore Etching in N-type Silicon
Electrochemical etching of macropores in n-type silicon wafers under illumination of wafer's rear side by use of an aqueous electrolyte, is claimed, where the electrolyte is an aqueous acetic acid solution of a composition comprising water:acetic acid in a ratio of 2:1 and 7:3 with a mixture of at l
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Measuring Method and Device for Characterizing a Semiconductor Component
The invention relates to a measuring method for characterizing a semiconductor component (1) having at least one pn junction and a measuring surface, which is the front and/or rear of the semiconductor component and which has at least one contacting subarea, which is covered by a metallization or is
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Method for the Production of a Nanostructure By Means of Spinodal Decrosslinking
Disclosed is a method for producing regularly arranged nanowires from a nanowire-forming material on a substrate. Said method is characterized by the following steps: a) the material is introduced into a carrier liquid at a load remaining at least three orders of magnitude below the loading capacity
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Method for Identifying an Increased Susceptibility to Ulcerative Colitis
A method is provided for detecting an increased susceptibility to ulcerative colitis by determining the presence of a polymorphism at position 256 of the nucleotide sequence of rs3024505 in which C is substituted by T or the presence of a polymorphism at position 501 of the nucleotide sequence of rs
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Treatment of Obesity
The present invention relates generally to a method of increasing lipid oxidation in a mammal and to agents useful for same. More particularly, the present invention relates to a method of increasing lipid oxidation in a mammal by administering a ligand which interacts with the IL-6 receptor and sig
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Method for the Depth Control of a Towfish
A method for the depth control of a towfish (6) examining the bottom (10) of a body of water, having a measuring boat (1), a magnetic floating body (3), which is towed by the measuring boat (1) at a certain distance, and a towfish (6) dependant on the floating body (3), wherein the profile of the bo
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Method for Generating Oxidic Nanoparticles from a Material Forming Oxide Particles
A method for generating oxidic nanoparticles from a material forming oxide particles, comprising the steps of: preparation of an aqueous solution containing ions of the material forming the oxide particles, film evaporation of the solution at a temperature above 200 DEG C., and skimming off the nano
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Basic Acetophenones as Inhibitors of No-Synthases
Use of the substance characterized by general structural formula (I) for the preparation of an agent inhibiting the enzymatic activity of NO-synthase, R1, R2, R3, R4 and/or R5 being hydrogen, an alkyl group, an aryl group or a heterocyclic group and n equals 2 or 3.
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Method for improved DEMON analysis using sub-band signals and local areas
The method involves subdividing a time-frequency-plane (9) into local regions (10), and separately evaluating demodulation of envelope modulation on noise (DEMON) spectrums, where each individual spectral value (11) consists of frequency and time points. Information carrying local regions of the spe
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Nanostructure production method in substrate used in microelectromechanical system (MEMS) or microchips, involves making drops of solution for nanostructure formation float on substrate, and heating s
The method involves adding drops of solution for nanostructure formation in water at a temperature above a predetermined temperature, in which the drops of solution floats to a substrate on a steam pad. The steam pad heats the substrate to evaporate the added drops, leaving and forming nanostructure
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Micelle Assemblies
The invention encompasses micelle assemblies, compositions having micelle assemblies, and methods for preparing micelle assemblies and compositions thereof. Also, the invention encompasses compounds of the formula: A-X-Y-Z-R1 wherein A is a carboxy group or is absent; X is a polyol, Y is -C(-O)-, -C
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Non-cytotoxic PAP mutants
Disclosed are PAP mutants that are less toxic than wild type PAP and that exhibit depurination activity. Also disclosed are transgenic plants that produce the PAP mutants, and methods for preparing the plants. Further disclosed are bioconjugates containing the PAP mutants, pharmaceutical composition
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Lily Plant Named 'bjm 006'
A new and distinct lily plant substantially as shown and described, characterized by 1) stem thickness supported by flower crown (8 to 10 mm in diameter); (2) straight stems with even leaf distribution from bottom to top (more than 50 leaves per plant); (3) flower crown compact (around 36 cm); and f
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Iodinated Polymers
The invention provides medical devices that comprise an iodinated polymer and that can be viewed using X-Ray imaging techniques. The invention also provides novel iodinated polymers that can be incorporated into or coated on medical devices.
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Broadcast Latency Optimization in Multihop Wireless Networks
A system and methodology that can optimize practical performance by reducing broadcast latency and collisions in a multihop wireless network is provided. The system includes an optimization component that determines a schedule for transmitting and/or receiving messages at nodes in the network during
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Power Junction Field Effect Power Transistor with Highly Vertical Channel and Uniform Channel Opening
A semiconductor vertical junction field effect power transistor formed by a semiconductor structure having top and bottom surfaces and including a plurality of semiconductor layers with predetermined doping concentrations and thicknesses and comprising at least a bottom layer as drain layer, a middl
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Compositions and Methods for the Protection of Substrates from Heat Flux and Fire.
A flame or heat flux protective coating composition, which includes a fiberglass dispersion in silicone. A flame or heat flux protective sheet, which includes fiberglass and silicone in a sheet form, wherein the fiberglass is dispersed in the silicone or the fiberglass is a woven cloth coated with t
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Transgenic plants expressing L3 delta proteins are resistant to trichothecene fungal toxins
Disclosed are specific mutants of L3 and transgenic plants that produce them. The plants exhibit increased resistance to fungal toxins that target ribosomal L3 protein. Also disclosed are transgenic plants that co-produce L3 mutant and an RIP protein, and exhibit increased resistance to various fung
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Compositions and Methods for Modulating Visceral Sensation and/or Gastrointestinal Reflex Activity
The invention relates to compositions capable of modulating visceral sensation and/or gastrointestinal activity obtained from botanical sources. More specifically, the invention relates to compositions comprising an extract product of an Asclepias plant, and methods of modulating visceral sensation
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Topoisomerase-targeting Agents
The invention provides compounds of formula I or formula II: wherein: the bond represented by is a single bond or a double bond, and R1-R5, X, and Y have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical composit
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Pharmaceutical Formulation for Regulating the Timed Release of Biologically Active Compounds Based on a Polymer Matrix
A formulation containing a biologically active compound having a structure with hydrogen bonding sites is blended with a polymer having a structure with complementary hydrogen bonding sites, the polymer forming hydrolytic degradation products that promote the release of the biologically active compo
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Lithium Stimulation of Cord Blood Stem Cell Proliferation and Growth Factor Production.
The present invention provides methods for expanding human umbilical cord blood stem cells and methods for stimulating growth factor production by cord blood stem cells using an in vitro cell culture system comprising a lithium salt. The present invention also provides in vivo methods for enhancing
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Biomarkers for Melanoma
The present invention relates to methods of determining melanoma status in a subject. The invention also relates to kits for determining melanoma status in a subject. The invention further relates to methods of identifying biomarkers and correlating biomarker expression to melanoma status or stage i
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Use of High-dose Oxazaphosphorine Drugs for Treating Immune Disorders
This disclosure relates, at least in part, to methods of eliminating adverse immune reactions in a subject in need thereof including those associated with autoimmune diseases, allergic reactions and transplant rejection, including administration of a lymphocytotoxic non-myeloablative amount of a oxa
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Reservoir device for intraocular drug delivery
A delivery device that allows for the sustained release of an agent, particularly useful for the sustained release of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. The delivery device is minimally invasive, refillable and may be easily fixed t
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High Molecular Weight Polymers, Devices and Method for Making and Using Same
Anhydride polymers that release active or activatable agent(s) have pre-selected properties such as molecular weight, flexibility, hardness, adhesiveness, and other valuable properties. The polymers are suitable for use in compositions, formulations, coatings, devices, and the like that benefit from
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Controlled Release of Actives in Skin.
Topical compositions are provided in which active compounds for topical delivery through the stratum corneum are complexed with nanospheres of a triblock copolymer having an A-B-A structure wherein each A end block is a water-soluble, hydrophilic and non-toxic polymer or oligomer; and the hydrophobi
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Preparation and Uses of Polyarylates
The present invention is directed to polyarylates comprising repeating units having the structure: as well as their preparation and use as cell growth substrates
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Uniform Shear Application System and Methods Relating Thereto
Disclosed herein is a shear application system for applying substantially uniform amounts of shear throughout a powder sample. The shear application system preferably includes a cylinder assembly having an inner cylinder, a housing, an inner set of lugs, and an outer set of lugs. The inner cylinder
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Graft Polymers for Enhanced Intracellular Delivery of Antisense Molecules
Innovative graft polymers designed for the efficient delivery of antisense molecules into biological cells and for maintaining the biological activity of these molecules while in serum and other aqueous environments are provided. Such polymers may comprise an anionic graft polymer comprising an anio
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Compositions and Methods for Treating Ophthalmic Diseases
Degradable polymeric compositions containing water-insoluble drugs blended with copolymers of biocompatible diphenol compound monomer units with pendant carboxylic acid groups polymerized with biocompatible diphenol corn-pound monomer units with pendant carboxylic acid ester groups and poly(alkylene
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Use of Tea-derived, Theaflavin Enriched Extract to Increase Exercise Performance and Reduce Exercise Recovery Time
This invention provides various methods such as a method for enhancing athletic exercise performance of a subject by administering to the subject a composition comprising a physiologically acceptable carrier and an extract of tea, wherein the extract comprises at least 20% by weight of theaflavins a
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Inhibition of Dcps
The disclosure relates to methods and compositions (e.g., compounds and pharmaceutical compositions thereof) useful for increasing expression of SMN in a cell (e.g., in vitro or in vivo). As a deficiency in SMN can result in the development of an SMA condition in a subject, the methods and compositi
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Compositions and Methods for Generating White Light
Crystalline inorganic-organic hybrid structures having a plurality of layers of a repeating unit characterized by a first organic ligand layer, a second organic ligand layer, and a two- dimensional semiconducting inorganic double layer having two opposing surfaces therebetween, wherein the two-dimen
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Methods and Related Devices for Continuous Sensing Utilizing Magnetic Beads
A fluidic device including a main channel, wherein a first inlet fluidly connects to an upstream end of the main channel and introduces magnetic beads into a first side of the main channel A second inlet is fluidly connected to the upstream end of the main channel and introduces a sample stream into
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Hcv E2 Construct Compositions and Methods
The invention provides a construct comprising the ectodomain of the Hepatitis C virus (HCV) E2 sequence and a mammalian expression system therefore. More particularly, the invention relates to a construct comprising the CMV promoter, prolactin signal sequence, the ectodomain of HCV E2 sequence trunc
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Endorphin Therapy Compositions and Methods
In certain embodiments, the invention provides methods of isolating and culturing neuronal stem cells from hypothalmi, methods of differentiating the neuronal cells into beta-endorphin neurons, and methods of treatment of various diseases comprising administering agents to differentiate endogenous n
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Fluorescent Excimer Lamps
Excimers are formed in a high pressure gas by applying a potential between a first electrode (14, 214) and a counter electrode (25, 226) so as to impose an electric field within the gas, or by introducing high energy electrons into the gas using an electron beam. A phosphor for converting the wavele
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Iron Oxyfluoride Electrodes for Electochemcial Energy Storage
The present invention provides electrochemical energy storage systems comprising metallolyte composites, iron fluoride composites and iron oxyfluoride composites. The present invention further provides methods for fabricating metallolyte composites.
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Methods for Obtaining Bioactive Compounds from Phytoplankton
Phytoplankton represent a potential source of bioactive compounds. The present disclosure provides, inter alia, methods for identifying glycerolipids and apoptosis- inducing sphingosine-like lipids from virally-infected phytoplankton.
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Compositions and Methods for Biofuel Crops
Using the natural variation of sweet and grain sorghum to uncover genes that are conserved in rice, sorghum, and sugarcane, but differently expressed in sweet versus grain sorghum by using a microarray platform and the syntenous alignment of rice and sorghum genomic regions containing these genes. I
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Target and Method for Inhibition of Bacterial Rna Polymerase
Target and method for inhibition of bacterial RNA polymerase disclosed are targets and methods for specific binding and inhibition of RNAP from bacterial species.
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Lily plant named 'BJM 004'
A new and distinct lily plant substantially as shown and described, characterized by (1) stem thickness supported by flower crown without bending (9 mm in diameter); (2) straight stems with even leaf distribution from bottom to top (102 leaves per plant); (3) flower crown compact (around 1212 cm); (
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Ampicillin and Amoxicillin-based Poly(anhydride-amides)
In one aspect the invention relates to an antibacterial compound of formula II: wherein n is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12; R is H or OH; or a salt thereof. In other aspects the invention also provides devices that include the compound as well as methods for producing an antibacterial eff
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Methods and Kits for Identification of Anti-excitotoxic Compounds
The instant invention provides methods and kits for screening for anti-excitotoxic compounds which increase the total amount of EAAT-I protein or the surface amount of EAAT-I protein.
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System and Method for Liver Cell Culture and Maturation
The present invention relates to systems and methods for maturation, proliferation and maintenance of function in cells presenting hepatocyte characteristics and differentiated from stem cells. The cells of the present invention may be generated from stem cell grown in collagen sandwich configuratio
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Nontoxic Shiga-like Toxin Mutant Compositions and Methods
Disclosed are nontoxic mutants of Shiga-like toxin (Stx1 or Stx2), nucleic acids encoding them, compositions containing the mutants and methods of using the mutants in connection with hemolytic euremic syndrome (HUS). Also disclosed are methods of treating HUS using L3 protein fragments, the nontoxi
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Compositions and Methods for Treating Cardiovascular Conditions
The invention provides amphiphilic macromolecule encapsulates that are useful for treating cardiovascular diseases including conditions related to or emanating from atherosclerosis.
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Pathways Underlying Pancreatic Tumorigenesis and an Hereditary Pancreatic Cancer Gene
There are currently few therapeutic options for patients with pancreatic cancers and new insights into the pathogenesis of this lethal disease are urgently needed. To this end, we performed a comprehensive analysis of the genes altered in 24 pancreatic tumors. First, we determined the sequences of 2
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Compositions and Methods for Enhancing Transport Through Mucus
The invention generally relates to compositions and methods for transporting substances across mucosal barriers. The invention also relates to methods of making and using such substances.
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Detection of Prostate Cancer Using Psa Glycosylation Patterns
The present invention features novel methods for determining if a subject has prostate cancer. The present invention is based on the development of lectin immunosorbant assays which analyze [alpha]2,6-linked sialylation of total serum PSA by sambucus nigra lectin (SNA) and [alpha]2,3-linked sialylat
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Ystem and Method for 3-dimensional Display of Image Data
Disclosed is a system for a 3-dimensional display that includes at least one eyepiece having first and second eyepiece sockets, having a first display contained in said first eyepiece socket associated with a first eye, two eye cameras mounted such that a first eye camera tracks eye reference points
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Trioxane Dimer Sulfur Compounds
The disclosure provides novel trioxane sulfur dimers having Formula I: methods for their preparation, pharmaceutical compositions containing these compounds, and methods for treating cancer, proliferative disorders, and/or malaria using these compounds and/or compositions.
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Protein Microarrays for Mass Spectrometry and Methods of Use Therefor
The present invention relates to the use of mass spectrometry to analyze arrays. The present invention provides methods for characterizing solutions comprising one or more proteins using arrays and mass spectrometry. The arrays of the present invention are coated with porous gold and utilize hydroph
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Methods for Promoting Fusion and Reprogramming of Somatic Cells
The invention features methods for reprogramming somatic cells by treating the cells with one or more agents to induce de-differentiation, in particular by targeting demethylase and methyltransferase genes. The invention also features methods of monitoring somatic cell fusion and reprogramming and m
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Prodrug Activation in Cancer Cells Using Molecular Switches
The present invention features a novel protein engineering strategy by combining the domains of two independent proteins into a molecular switch. The invention features polypeptides comprising a prodrug activating enzyme and a protein that binds a cancer specific marker, polynucleotides encoding the
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Methods and Compositions for Improving Cognitive Function
This invention relates to treating age-related cognitive impairment. This invention in particular relates to the use of inhibitors of synaptic vesicle protein 2A (SV2A), such as levetiracetam, seletracetam, and brivaracetam, in improving cognitive function in subjects that exhibit age-related cognit
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Albumin-bound Protein/peptide Complex As a Biomarker for Disease
Methods and kits for diagnosis and prognosis using biomarkers comprising albumin-bound protein/peptide complex (ABPPC).
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Psma-binding Agents and Uses Thereof
Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. The compounds allow ready i
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Adiabatic Multi-band Rf Pulses for Selective Signal Suppression in Magnetic Resonance Imaging
A magnetic resonance imaging (MRI) system, comprising: a magnetic resonance imaging scanner comprising: a main magnet providing a substantially uniform main magnetic field B0 for a subject under observation; and a radio frequency (RF) coil configured to irradiate a radio frequency (RF) pulse into a
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Citrullination of Human Peptidylarginine Deiminase 4 (pad-4) Regulates Its Function and Immunogenicity
The present invention provides peptidylarginine deiminase 4 (PAD-4) polypeptides comprising one or more citrullinated Arginine sites. In one embodiment, a PAD-4 polypeptide comprises a citrulline residue at the following sites: Arg-205, Arg-212, Arg-218, Arg-372, Arg-374, Arg-383, Arg-394, Arg-495,
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Compositions and Methods for Treatment of Cancer Using Tissue-specific Oncolytic Adenoviruses
The present invention includes the use of a nucleic acid sequence encoding an shRNA to target RNA interference against a cellular factor where such use can enhance oncolytic adenovius replication. The nucleic acid sequence encoding an shRNA can be introduced into an oncolytic adenovius construct via
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