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Female Reproductive Tract and Anal Prophylaxes
The present invention provides methods for boosting mucosal immunity in the female reproductive tract of pre- and post -menopausal women using a TGF-beta inhibitor, a Selective Estrogen Receptor Modulator, and/or a recombinant commensal bacterium that expresses endogenous microbicides into the intes
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System and Method for Calibration for Image-guided Surgery
A method of calibrating a transformation of ultrasound data in an imaging system from a first coordinate system into a second coordinate system, the method comprising applying a transformation having parameters. The parameters are calibrated by imaging a planar object, extracting points correspondin
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Prevention Or Treatment of Immune-relevant Disease By Modification of Microfloral Populations
The present invention is a method for preventing or treating an immune -relevant disease by modulating commensal microbiota populations via antibiotics, exogenous microbiota and/or probiotics.
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Molecular Signatures for Diagnosing Scleroderma
The present invention features methods for classifying, determining severity, and predicting clinical endpoints of scleroderma based upon the expression of selected biomarker genes.
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System and Method Using Coupler-resonators for Electron Paramagnetic Resonance Spectroscopy
A coupler-resonator for electron paramagnetic resonance (EPR) spectroscopy in subjects has a wire loop formed into a coupling loop, a central transmission portion, and sensor loops. The sensor loops hold EPR sensor materials and are coated with biocompatible plastic. The coupler-resonator is implant
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Compositions and Methods for Diagnosis and Treatment of Pancreatic Ductal Cancer
The present invention includes compositions and methods for diagnosing and treating pancreatic cancer. These compositions and methods are based on the finding that 14-3-3s protein is secreted from pancreatic cancer cells and is therefore a specific biomarker protein.
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System and Method for Post-exposure Dosimetry Using Electron Paramagnetic Resonance Spectroscopy
An apparatus and method for triaging patients according to radiation exposure operates by measuring electron paramagnetic resonance spectra of fingernails, toenails, and/or teeth. When operating in vivo, radiation induced spectra are obtained from intact fingernails, toenails, or teeth placed within
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Method for Selectively Inhibiting the Activity of Acat1 in the Treatment of Alzheimer's Disease
The present invention features methods for decreasing the size and density of amyloid plaques, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by selectively inhibiting the activity of Acyl -CoA: Cholesterol Acyltransferase 1, but not Acyl -CoA: Chole
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Selection of Cellulolytic Microbes with High Growth Rates
Methods for obtaining cellulolytic microbes with high growth rates are disclosed. For example, C. thermocellum colonies with growth rates higher than 0.17 hr " 1 have been obtained by the present methods. In realizing higher growth rates, better bioprocessing efficiency can be achieved resulting in
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Compositions and Methods for Inhibiting the Interaction Between Cftr and Cal
The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention provides peptides and peptidomimetics that selectively inhibit the interaction between CAL and mutant CFTR p
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Betulinic Acid Derivatives and Methods of Use Thereof
This invention features betulinic acid derivatives having the formula: wherein the variables are defined herein. The invention also provides related compounds and intermediates thereof, as well as pharmaceutical compositions, kits, and articles of manufacture comprising such compounds. Treatment met
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System and Method for Smoothly Inverting One Or More Faces of a Cubical Device
A system and method for inverting a cubical device 100 that inverts one or more faces of the cubical device 100 in a single fluid motion. In an embodiment, the cube faces are split in two face piece assemblies 210, in an alternative embodiment faces have only one invertible section 802, 702. The fac
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Refrigerant Evaporators with Pulse-electrothermal Defrosting
An pulse electro thermal defrost evaporator system has multiple refrigerant tubes formed from an electrically conductive metal and connected in parallel for refrigerant flow. These tubes are, however, connected electrically in series. A controller is capable of detecting ice accumulation and connect
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Apparatus and Method for Modulating Neurochemical Levels in the Brain
A treatment for Parkinson's Disease uses a stimulus electrode implanted in a subthalamic nucleus with a chemosensor implanted in a globus pallidus pars interna (GPi) of the subject. A level of a neurochemical is sensed with the chemosensor, and compared to a desired level. When the level of the neur
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Peptides and Nanoparticles for Therapeutic and Diagnostic Applications
Provided herein are peptides and nanoparticles conjugates thereof useful for the treatment of diseases and disorders mediated by GIPC/synectin, such as cancer.
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Cddo-compounds and Combination Therapies Thereof
CDDO-compounds in combination with other chemotherapeutic agents induce and potentiate cytotoxicity and apoptosis in cancer cell. One class of chemotherapeutic agents include retinoids. Cancer therapies based on these combination therapies are provided. Also provided are methods to treat graft versu
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Methods for diagnosing and treating neuroendocrine cancer
The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2. Methods for preventing and treating neuroendocrine cancers are also disclosed.
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Pulse Electrothermal Deicing of Complex Shapes
A pulse electrothermal deicing apparatus comprises at least one complex shape characterized by a thickness profile configured to generate uniform power per unit area to melt an interfacial layer of ice. A method of optimizing thicknesses of complex shapes for a pulse electrothermal deicing system in
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Pulse Electrothermal Mold Release Icemaker for Refrigerator Having Interlock Closure and Baffle for Safety
The present document relates to an icemaker having a pulse electrothermal ice release system for separating ice bodies from an ice mold. The pulse electrothermal ice release system operates by applying an electric current through the ice mold through two wires. Safety apparatus for preventing electr
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Pulse Electrothermal Mold Release Icemaker with Safety Baffles for Refrigerator
An icemaker and a refrigerator having an icemaker are discussed. The icemaker has pulse-electrothermal ice release and includes an ice-making tray having several ice forming portions in which water is stored and ice is formed; and a housing surrounding the ice-making tray provided with at least one
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Compositions and methods for inhibiting the synthesis or expression of MMP-1
The present invention relates to the specific inhibition of matrix metalloproteinase 1 (MMP-1) using agents which inhibit the synthesis or expression of MMP-1. Such agents are useful for suppressing invasion or metastasis of a tumor cell and in the treatment, prevention and management of cancer.
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Compositions and Methods for Regulating Rna Translation Via Cd154 Ca-dinucleotide Repeat
Compositions and methods for regulating CD154 gene expression are provided that rely on the interaction of hnRNP L with the CA-dinucleotide rich sequence of the 3 ' - untranslated region of CD154.
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System and Method for Injecting Sensed Presence Into Social Networking Applications
A method for injecting sensed presence into social networking applications includes receiving sensor data associated with a user, inferring a presence status of the user based upon analysis of the sensor data, storing the sensor data and presence status within a database, and sending the presence st
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Pulse Electrothermal and Heat-storage Ice Detachment Apparatus and Methods
Systems and methods for pulse electrothermal and heat-storage ice detachment. A pulse electrothermal ice detachment apparatus includes one or more coolant tubes, and optionally, fins in thermal contact with the coolant tubes. The tubes and/or fins form a resistive heater. Apparatus applies electrica
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Attenuated Uracil Auxotroph of an Apicomplexan and Use Thereof
Uracil auxotroph mutants of apicomplexans are provided which lack a functional carbamoyl phosphate synthase II (CPSII) enzyme. Also provided are T. gondii autoxtroph mutants which express exogenous antigens, and methods of protecting an animal against a T. gondii and non-T. gondii disease.
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Modification of Hydrogenase Activities in Thermophilic Bacteria to Enhance Ethanol Production
Bacteria consume a variety of biomass-derived substrates and produce ethanol. Hydrogenase genes have been inactivated m Thermoanaerobacterium saccharolyticum to generate mutant strains with reduced hydrogenase activities. One such mutant strain with both the ldh and hydtrA genes inactivated shows a
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Synthetic Triterpenoids and Methods of Use in the Treatment of Disease
The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease using synthetic triterpenoids, optionally in combination with a second treatment or prophylaxis.
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Angular Extrusion for Polymer Consolidation
Angular extrusion (AE) methods for creating monolithic polymers with high entanglement density, but small crystallite size, are disclosed. The methods involve consolidating granular polymer in an extrusion channel having at least one strain-imposing feature.
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Microrna-10 Antagonists and Microrna-10 Targets for Use in the Treatment of a Glioma
The present invention embraces microRNA-antagonists and activators of homeobox D10 protein; Zinc finger, MYND domain containing 11 protein; or RB1-inducible coiled-coil 1 protein for use in decreasing glial tumor cell proliferation and treating glioma.
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Nutraceutical Composition and Methods for Preventing Or Treating Multiple Sclerosis
The present invention embraces nutraceutical compositions containing isolated Bacteroides fragilis capsular polysaccharide A for use in methods of preventing or treating multiple sclerosis.
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T Cell Receptor-deficient T Cell Compositions
The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In one embodiment, this invention broadly relates to TCR-deficient T cells, isolated populations thereof, an
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System and Method for Coupling a Multi-mode Optical Fiber to a Single Mode Optical Fiber
A multi-mode to single mode optical interface device includes an optically pumped edge emitting semiconductor laser device and a lens. The optically pumped edge emitting semiconductor laser device includes (1) a gain area, and (2) an edge located single mode output. The lens focuses a multi-mode opt
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Nanoscale Interconnects Fabricated By Electrical Field Directed Assembly of Nanoelements
The invention provides a fast, scalable, room temperature process for fabricating metallic nanorods from nanoparticles or fabricating metallic or semiconducting nanorods from carbon nanotubes suspended in an aqueous solution. The assembled nanorods are suitable for use as nanoscale interconnects in
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Method for Treating And/or Preventing Drug Seeking Behavior
A dynorphin-A analog can be used for treatment, inhibition, and/or prevention of cocaine seeking behavior, and or the drug seeking behavior for a cocaine derivative or other structurally related substance. The dynorphin-A analog can be a cyclic dynorphin-A analog having sufficient systemic stability
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Patterned Nanosubstrates Made By Directed Self Assembly of Amphiphilic Molecules
Nanoscale patterns prepared by lithography are used to direct the self-assembly of amphiphilic molecules to form patterned nanosubstrates having a desired distribution of chemical functional moieties. These patterns can be fabricated over a large area and require no special limitations on the chemis
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Methods of Targeting Cells for Diagnosis and Therapy
Methods of making bispecific binding complexes and nanopolymers coupled to detection and/or therapeutic agents are disclosed. Also disclosed are methods of using such bispecific binding complexes and nanopolymers for detecting and treating cells.
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Patient Specific Ankle-foot Orthotic Device
The unique advantages of computer-controlled fabrication of a patient-specific orthotic device using an automated fabrication machine capable of following computer instructions to create 3D surface contours and new developments in non-invasive three-dimensional (3D) scanning have made it possible to
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Variable Resistance Hand Rehabilitation Device with Linear Smart Fluid Damper and Dynometer Capabilities
A variable resistance hand rehabilitation device and corresponding system. Improvements over the prior art include: a new damping system or damper design, to reduce friction and increase maximum force output; a dynometer feature that enables converting the dynamic device to a static grip force measu
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Intensified Neutral Loss Tags and Use Thereof in Mass Spectrometry
Ultrasensitive detection of a chemical substance (analyte) by mass spectrometry is achieved by employing a molecular tag that yields an intense parent ion and then an intense daughter ion in a multi-stage mass spectrometer.
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Dual Interleaved Flyback Converter for High Input Voltage
An integrated magnetic flyback converter includes interleaved phases that can be connected in series for an input stage and in parallel for an output stage. An integrated magnetic core has legs with gaps that may weaken a coupling between a primary and secondary of the associated transformer. The pr
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Methods of Treating Fungal Infections
Methods of identifying compounds that potentiate the activity of antifungal agents, potentiators identified by these methods, and methods of using potentiators are disclosed.
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Dielectric and magnetic particles based metamaterials
RF-optical metamaterials with (+-epsilon, +-mu) figures-of-merit of interest are constructed from coupled magnetic and dielectric multi-resonant multi-disks (finite-size cylinders) or multi-sphere lattices arranged in a periodic or a random fashion to offer tailored magnetic and electric dipole mome
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Anisotropic metal-dielectric metamaterials for broadband all-angle negative refraction and superlens imaging
A metamaterial comprises a plurality of metallic nanowires embedded in a dielectric matrix. The metamaterial composite media provide broadband all-angle negative refraction and flat lens, superlens and curved hyperlens imaging in specific spectral regions over a wide range of frequencies including,
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System and Method for Virtual Server Migration Across Networks Using Dns and Route Triangulation
A first virtual server is moved from a first network location to a second network location without interrupting service to users of the first virtual server. The state and data of the first virtual server are copied and transmitted to the second network location to create a copy of the first virtual
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Affinity Control of Tagging Noise
Analytical methodology is disclosed in which a trace analyte in a sample is tagged to increase its signal strength for measurement, and an affinity substance is used at least after the tagging step (late in the method) to separate the tagged analyte from tagging noise, wherein the affinity substance
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Therapeutic Stable Nanoparticles
Stable colloid nanoparticles comprising poorly soluble drugs are disclosed, as well as methods of making and methods of using such nanoparticles, e.g., as therapeutics and diagnostics.
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Antibiotic Compounds
Methods for identifying prodrug antibiotic compounds and direct inhibitory antibiotic compounds utilizing various screens are provided. Also provided are methods for treating infections using these compounds.
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Methods and Compounds for Modulating Cannabinoid Activity
Disclosed are compounds and compositions that inhibit the action of monoacylglycerol lipase (MGL) and fatty acid amide hydrolase (FAAH), methods of inhibiting MGL and FAAH, methods of modulating cannabinoid receptors, and methods of treating various disorders related to the modulation of cannabinoid
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Biomarkers for Diabetes, Obesity, and/or Hypertension
Methods of identifying subjects having, or at risk of developing, diabetes, obesity, and/or hypertension are disclosed, as well as methods of identifying biomarkers for diabetes, obesity, and/or hypertension, and biomarkers identified by such methods.
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Multifunctional Self-assembling Polymeric Nanosystems
Libraries of nanoparticles comprising therapeutic agents and/or imaging agents are disclosed, as well as methods of making, customizing, and using such libraries of nanoparticles.
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Methods for Forming Metal-polymer Hybrid Tooling for Forming Parts Having Micro Features
A method for forming metal-polymer hybrid tooling includes patterning a surface of a member such as a silicon wafer, stainless steel, nickel or nickel alloy, engaging a polymer layer with the patterned features of the surface of the silicon wafer to form the polymer layer having a reverse of the pat
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Methods of Treating Fungal Infections.
Methods of identifying compounds that potentiate the activity of antifungal agents, potentiators identified by these methods, and methods of using potentiators to treat fungal infections are disclosed.
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Multi-biomarker Biosensor
Nanosubstrates as biosensors, methods of making such nanosubstrates, and methods of using such nanosubstrates to detect biomarkers are described.
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Method of Reconstituting Cellular Spectra Useful for Detecting Cellular Disorders
Embodiments of the present disclosure provides improved methods for determining the presence of abnormalities in exfoliated cells. In one embodiment, the present disclosure provides methods for reconstructing cellular spectrum of a cell sample by creating a spectral map of the cellular sample, gener
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Modulators of Nuclear Receptor Co-regulatory Protein Binding
Disclosed are novel compounds and compositions for inhibition of androgen and estrogen receptor signaling, methods for inhibiting androgen signaling, methods for inhibiting estrogen signaling, methods for inhibiting the interaction between a co-regulatory protein and an androgen or estrogen receptor
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Conjugated Nanodelivery Vehicles
Anti-angiogenesis agent-linked liposomes and micelles, methods of making such liposomes and micelles, and methods of using such liposomes and micelles, such as for delivery of therapeutic and detection agents to tumor cells, are described.
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Universal Spherical Turbine with Skewed Axis of Rotation
A universal spherical reaction turbine for any flowing fluid at any depths or elevation that is capable of unidirectional rotation under reversible flow conditions. The turbine includes a rotatable shaft that is adapted to rotate about an axis of rotation; turbine blade support members that are fixe
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Ecological Comprehensive Component Construction System
An ecological comprehensive component construction system that is man transportable and erectable without the need of heavy lifting equipment. The system includes a plurality of exterior and interior panels or courses that are interconnectable to provide walls of variable heights, ceiling/flooring c
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Collapsible Reaction Turbine
A collapsible reaction turbine is disclosed. The turbine includes a rotatable shaft, a plurality of hub portions that are fixedly attached to the rotatable shaft, a plurality of turbine blades, and upper and lower pluralities of spokes. An upper spoke and a lower spoke from each of the spoke plurali
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Antimicrobial Compounds
This disclosure relates to compositions including certain compounds identified by a quantitative, high throughput assay to be effective in inhibiting the ability of a bacterium to kill a host organism, as well as methods for using these compounds for treating bacterial infections.
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Angiogenic Resorcinol Derivatives
Novel resorcinol derivatives and methods of preparation and use are presented. These compounds can stimulate angiogenesis as a biological function triggered by the activation of one cannabinoid receptor distinct from CB1 and CB2. Thus, these compounds are specific ligands for one cannabinoid recepto
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Sequential Planetary Stack Transmission System
A sequential planetary stack transmission system is provided. The system includes a stack of planetary gear sets, each gear set including a sun gear engageable with a rotatable central shaft, and freely rotatable concentrically about the central input or output shaft when not engaged with the centra
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Polycyclic Compounds for Use in Treating Ocular Neurodegenerative Diseases
Described herein are various compounds for treatment of ocular neurodegenerative diseases, including but not limited to glaucoma and diabetic retinopathy. The compounds described herein can act to attenuate and/or block calcium release from external neuronal environments as well as intracellular sto
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A Vmm-based Intrusion Detection System
An intrusion detection system collects architectural level events from a Virtual Machine Monitor where the collected events represent operation of a corresponding Virtual Machine. The events are consolidated into features that are compared with features from a known normal operating system. If an am
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Direct Chemical Synthesis of Rare Earth-transition Metal Alloy Magnetic Materials
A direct chemical synthesis scheme for the fabrication of isotropic and anisotropic rare earth (RE) -transition metal (TM)- based permanent magnets is disclosed. The method according to the invention permits the synthesis of, e.g., particles, films and coatings with controlled particle sizes, shapes
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Large Scale Nanoelement Assembly Method for Making Nanoscale Circuit Interconnects and Diodes
Nanoelements such as single walled carbon nanotubes are assembled in three dimensions into a nanoscale template on a substrate by means of electrophoresis and dielectrophoresis at ambient temperature. The current-voltage relation indicates that strong substrate-nanotube interconnects carrying mA cur
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Collagen Fibrillar Construction
Methods and compositions are described for organizing collagen into fibrillar networks, e.g, short and long-range organization. Collagen produced by the disclosed methods can be used for tissue engineering.
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Imaging Neuroleptic Compounds
A method for identifying typical and atypical antipsychotics based on their ability to reduce neuronal/glial activity in specific brain regions upon dopaminergic neurotransmission is disclosed.
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Method of Preparing Adenosine-resistant Anti-tumor T Lymphocytes for Adoptive Immunotherapy
In the past, adoptive immunotherapy often failed because the transferred immune cells were inactive in vivo. This disclosure provides a method of producing immune cells that are highly active in vivo. The immune cells may be expanded in vitro in the presence of an adenosine receptor agonist or an an
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Bistable Nanoswitch
A non-volatile bistable nano-electromechanical switch is provided for use in memory devices and microprocessors. The switch employs carbon nanotubes as the actuation element. A method has been developed for fabricating nanoswitches having one single-walled carbon nanotube as the actuator. The actuat
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Mixed Micelles Including Amphipathic Conjugates of Rna Agents, and Uses Thereof
Disclosed are improved pharmaceutical formulations for the delivery of RNA interference agents, such as antisense RNA, micro-RNA and siRNA. The formulations employ mixed micelles including amphipathic conjugates of the iRNA agents and amphipathic micelle- forming molecules with extended hydrophilic
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Tunable Negative Permeability Based Devices
Negative permeability metamaterials and devices based on negative permeability metamaterials are described. The invention presents a new paradigm for realizing electromagnetic devices utilizing naturally available magnetic materials operating in their negative permeability spectrum. The superior adv
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Multi-user Smartglove for Virtual Environment-based Rehabilitation
A low-cost, virtual environment, rehabilitation system and a glove input device for patients suffering from stroke or other neurological impairments for independent, in-home use, to improve upper extremity motor function, including hand and finger control. The system includes a low-cost input device
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Steroidal Anti-hormone Hybrids
Disclosed are novel compounds and compositions for inhibition of androgen and estrogen receptor signaling, methods for inhibiting androgen signaling, methods for inhibiting estrogen signaling, methods for inhibiting the interaction between a co-regulatory protein and an androgen or estrogen receptor
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SiRNA PHOSPHOLIPID CONJUGATE
siRNA-conjugated liposomes and micelles, methods of making such conjugates, and methods of using such conjugates, such as for the delivery of siRNA to cells to reduce expression of target polypeptides in such cells, are described.
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Initiator-tightened Compositions
Disclosed herein are gel and plastic compositions comprising tightened layers of polymerized vinyl monomers, as well as methods of making the same, where the layers are tightened in having smaller pores. The tightened layers comprise tightened inner layers and exterior layers, and the compositions c
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Cobalt Carbide-based Nanoparticle Permanent Magnet Materials
A composition of a crystalline ferromagnetic material based upon nanoscale cobalt carbide particles and to a method of manufacturing the ferromagnetic material of the invention via a polyol reaction are disclosed. The crystalline ferromagnetic cobalt carbide nanoparticles of the invention are useful
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Low-aspect Ratio Nanostructures
Low-aspect ratio nanostructures, such as nanocups, nanorings, and arrays of nanocups and nanorings, methods of fabrication of nanostructures, and methods of using nanostructures are disclosed.
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Device and Method for Organic Vapor Jet Deposition
A device and a method for facilitating the deposition and patterning of organic materials onto substrates utilizing the vapor transport mechanisms of organic vapor phase deposition is provided. The device includes one or more nozzles, and an apparatus integrally connected to the one or more nozzles,
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Sensors
The invention provides sensors that are useful for detecting and measuring chemical characteristics and physical properties of compositions containing analytes. The invention further provides, among other things, methods for making the sensors and for using them, as well as modified cells having sen
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Method and Apparatus for Depositing Material Using a Dynamic Pressure
A method of depositing organic material is provided. A carrier gas carrying organic material is ejected from a nozzle at a flow velocity that is at least 10% of the thermal velocity of the carrier gas, such that the organic material is deposited onto a substrate. In some embodiments, the dynamic pre
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Printed Electronics
Printed electronic device comprising a substrate onto at least one surface of which has been applied a layer of an electrically conductive ink comprising functionalized graphene sheets and at least one binder. A method of preparing printed electronic devices is further disclosed.
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Thermally Exfoliated Graphite Oxide
A modified graphite oxide material contains a thermally exfoliated graphite oxide with a surface area of from about 300 m2/g to 2600 m2/g, wherein the thermally exfoliated graphite oxide displays no signature of the original graphite and/or graphite oxide, as determined by X-ray diffraction.
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Coatings Containing Functionalized Graphene Sheets and Articles Coated Therewith
Coatings comprising functionalized graphene sheets and at least one binder. In one embodiment, the coatings are electrically conductive.
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High Efficiency Multi-color Electro-phosphorescent Oleds
The present invention relates to efficient organic light emitting devices (OLEDs) doped with multiple light-emitting dopants, at least one dopant comprising a phosphorescent emitter, in a thin film emissive layer or layers. The present invention is directed to an efficient phosphorescent organic lig
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Increased open-circuit-voltage organic photosensitive devices
The invention relates to a photosensitive device comprising: an anode and a cathode; and a first organic material and a second organic material forming a donor-acceptor heterojunction electrically connected between the anode and the cathode, wherein the first and second organic materials, as arrange
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Hybrid Dielectric Material for Thin Film Transistors
Thin-film transistors are made using a hybrid silica-silicone material as an insulating material. The hybrid silica-silicone material may be deposited by plasma-enhanced chemical vapor deposition from siloxanes and oxygen. These hybrid materials may be employed as the gate dielectric, as a subbing l
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Controlled growth of larger heterojunction interface area for organic photosensitive devices
An optoelectronic device and a method of fabricating a photosensitive optoelectronic device includes depositing a first organic semiconductor material on a first electrode to form a continuous first layer having protrusions, a side of the first layer opposite the first electrode having a surface are
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Self-assembling Micelle-like Nanoparticles for Systemic Gene Delivery.
Nanoparticles containing nucleic acid and suitable for use as in vivo delivery agents for nucleic acids are provided. The nanoparticles use a covalent conjugate of a polycation such as polyethylenimine and phospholipids. The final DNA- containing nanoparticle has a vesicular structure with a polyple
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Hybrid Layers for Use in Coatings on Electronic Devices Or Other Articles
A method for protecting an electronic device comprising an organic device body. The method involves the use of a hybrid layer deposited by chemical vapor deposition. The hybrid layer comprises a mixture of a polymeric material and a non-polymeric material, wherein the weight ratio of polymeric to no
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Bump Array Device Having Asymmetric Gaps for Segregation of Particles
The disclosure relates to obstacle array devices (also known as bump array devices) for separating populations of particles by size. Improvements over previous obstacle array devices are realized by causing the fluid velocity profile across gaps between obstacles to be asymmetrical with respect to t
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Method of fabricating devices by stamping
The invention relates to a method of fabricating an organic device, comprising: depositing a first organic layer onto a patterned, soft elastomeric stamp; and transferring the first organic layer from the patterned, soft elastomeric stamp onto a substrate.
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Very high efficiency organic light emitting devices based on electrophosphorescence
The invention relates to an organic light emitting device comprising an anode, a cathode, and an emissive layer, wherein the emissive layer is located between the anode and the cathode, and the emissive layer comprises a phosphorescent organometallic compound, wherein the phosphorescent organometall
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Enhanced Bonding Layers on Titanium Materials
The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based c
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A Multiple Degree of Freedom Rehabilitation System Having a Smart Fluid-based, Multi-mode Actuator
A rehabilitation system that combines robotics and interactive gaming to facilitate performance of task- specific, repetitive, upper extremity/hand motor tasks, to enable individuals undergoing rehabilitation to improve the performance of coordinated movements of the forearm and hand is disclosed. M
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Stable Polyelectrolyte Coated Nanoparticles
Stable nanoparticles comprising poorly soluble drugs are disclosed, as well as methods of making and methods of using such nanoparticles, e.g., as therapeutics and diagnostics.
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Ascorbate-linked Nanosystems for Brain Delivery
Ascorbate-conjugated liposomes and micelles, methods of making such liposomes and micelles, and methods of using such liposomes and micelles, such as for delivery of therapeutic and detection agents to the brain, are described.
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Carbon Nanostructures from Pyrolysis of Organic Materials
Methods and apparatus to generate carbon nanostructures from organic materials are described. Certain embodiments provide solid waste materials into a furnace, that pyrolyzes the solid waste materials into gaseous decomposition products, which are then converted to carbon nanostructures. Methods and
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Microparticle Organization
Methods and compositions are described for organizing nanoparticles or microparticles into nanostructures or microstructures using collagen as a template.
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Compositions and Methods for Modulating Immunogenic Responses By Activating Dendritic Cells
The conjugated peptide constructs described herein can be used to induce production of dendritic cells that generate cytokines. The vaccine-bearing dendritic cells can be administered to induce T cell mediated immune modulating responses.
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