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Novel Albumin-free Factor Viii Formulation
PROBLEM TO BE SOLVED: To provide a factor VIII formulation for a treatment that is stable in the absence of albumin or other proteins. ; SOLUTION: The factor VIII composition formulated without adding albumin comprises the following excipients in addition to the factor VIII: 4-10% of a filler select
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Manganese Oxide Nanowires, Films, and Membranes and Methods of Making
Nanowires, films, and membranes comprising ordered porous manganese oxide-based octahedral molecular sieves and methods of making the same are disclosed. A method for forming nanowires includes hydrothermally treating a chemical precursor composition in a hydrothermal treating solvent to form the na
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Complexes of alpha (2) macroglobulin and antigenic molecules for immunotherapy
The present invention relates to complexes of alpha (2) macroglobulin associated with antigenic molecules for use in immunotherapy. The invention relates to methods for using such compositions in the diagnosis and treatment of immune disorders, proliferative disorders, and infectious diseases.
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Process Intensification in Microreactors
The present disclosure provides for a chemical reactor which includes elongate chambers defining an arrangement and including first, second, and third elongate chambers adapted to support respective distinct first, second, and third reactor functions associated with respective first, second, and thi
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Methods of Identifying Insect-specific Spider Toxin Mimics.
Disclosed herein are methods of identifying a candidate molecule that mimics at least a portion of the three-dimensional structure of a rU-ACTX-Hvla insecticidal toxin, the method comprising providing a molecular model made from the atomic co-ordinates for the rU-ACTX- HvIa insecticidal toxin as dis
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Method and System for Recognition of a Target in a Three Dimensional Scene
A method for three-dimensional reconstruction of a three-dimensional scene and target object recognition may include acquiring a plurality of elemental images of a three-dimensional scene through a microlens array; generating a reconstructed display plane based on the plurality of elemental images u
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Methods for Separating Carbon Nanotubes
Disclosed herein too is a method that includes dispersing nanotubes in media that comprises flavin moieties substituted with solubilizing side chains, and/or non-flavin containing molecular species; self-assembling the flavin moieties and other non-flavin containing molecular species in a pattern th
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Bacteriorhodopsin Protein Variants and Methods of Use for Long Term Data Storage
Bacteriorhodopsin protein variants and methods using the bacteriorhodopsin variants for performance in holographic and three-dimensional (3D) memory storage devices are described. The amino acid and chemical modifications of bacteriorhodopsin provided herein achieve greatly enhanced protein performa
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Protein-Based Photovoltaics and Methods of Use
Protein-based photovoltaic cells and the manufacture and use of protein-based photovoltaic cells are described. In one embodiment, bacteriorhodopsin from Halobacterium salinarum, which undergoes structural transitions when irradiated with a given wavelength of light, is used as the protein in the pr
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Distributed Fault Diagnosis
A distributed diagnosis algorithm based on a multi-signal digraph model of an overall system is provided. In addition, a model enables the generation of a fault-test dependency matrix (D-matrix), which summarizes the detection capabilities of tests designed for faults associated with each node. Each
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Thyristor radiation detector array and applications thereof
An array of thyristor detector devices is provided having an epitaxial growth structure with complementary types of modulation doped quantum well interfaces located between a P+layer and an N+ layer. The thyristor detector devices operate over successive cycles that each include a sequence of two di
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Transgenic plants overexpressing a plant vacuolar Pyrophosphatase
Transgenic plants are described which are engineered to overexpress vacuolar H+-PPase. Plants such as tobacco and petunia transformed with A. Thaliana AVP-1 are shown to have increased meristematic activity resulting in larger leaves, stem, flower, fruit, root structures, increased salt tolerance, e
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Methods and Systems for Pretreatment of an Oil Stream
In one embodiment, a method for pre-treating an oil comprises: introducing a oil, an alcohol, and an acid catalyst to a first continuous stirred tank reactor vessel, wherein the oil comprises free fatty acids; selectively reacting the oil and the alcohol to convert the free fatty acids to alkyl este
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Therapeutic Applications of Fatty Acid Amide Hydrolase Inhibitors
Fatty acid amide hydrolase (FAAH) is an enzyme responsible for the degradation of oleamide (an endogenous sleep-inducing lipid) and anandamide (an endogenous ligand for cannabinoid receptors). Disclosed herein are potent inhibitors of FAAH and methods for their use for treating a variety of disorder
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Apparatus, Systems and Methods for Enhanced Multi-carrier Based Underwater Acoustic Communications
Advantageous OFDM-based underwater acoustic (UWA) apparatus, systems and methods are provided according to the present disclosure. In general, OFDM transmissions over UWA channels encounter frequency-dependent Doppler drifts that destroy the orthogonality among OFDM subcarriers. The disclosed appara
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Ceramic/structural Protein Composites and Method of Preparation Thereof
Ceramic/structural protein composites and methods of preparation are disclosed, including coatings and films. Ceramic/structural protein coatings can be fabricated on the surface of substrates, including the surface of implantable medical devices.
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Dialysis Adapter Cell and Method of Use
A dialysis adapter cell includes a housing comprising a plurality of pillars extending between and attached to a top plate and a bottom plate to form a hollow receptacle, wherein the top plate comprises an aperture configured to provide access to the hollow receptacle; a dialysis membrane disposed a
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Protein-based Artificial Retinas
Multilayer protein films are provided, which comprise native bacteriorhodopsin and/or specialized bacteriorhodopsin mutants as the photoactive element. Also provided are artificial subretinal and epiretinal implants carrying such bacteriorhodopsin films, as well as methods for making and using the s
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Synergetic Functionalized Spiral-in-tubular Bone Scaffolds
An integrated scaffold for bone tissue engineering has a tubular outer shell and a spiral scaffold made of a porous sheet. The spiral scaffold is formed such that the porous sheet defines a series of spiral coils with gaps of controlled width between the coils to provide an open geometry for enhance
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Sh2 Domain Profiling to Characterize Tyrosine Phosphorylation Signaling in Cancer
A phosphoproteomic method termed SH2 profiling to characterize phosphotyrosine (pTyr) signaling in lung cancer. This method provides quantitative values for the phosphorylated binding sites for Src Homology 2 (SH2) domains, which the cell uses to relay signals from tyrosine kinases. Lung cancer cell
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Methods and Apparatus for the Synthesis of Useful Compounds
The present invention relates to methods and apparatus for activation of a low reactivity, non-polar chemical compound, hi one example embodiment, the method comprises introducing the low reactivity chemical compound to a catalyst. At least one of (a) an oxidizing agent or a reducing agent and (b) a
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Nucleic Acid-based Photovoltaic Cell
Photovoltaic cells containing nucleic acid materials and methods of production and use are provided. The nucleic acid materials have photovoltaic donor and acceptor molecules incorporated therein and define a spatial organization and orientation for these molecules that inhibits recombination of exc
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Conjugated Polymers from Substituted 3,4-propylenedioxythiophene, Compositions, Method of Making, and Use Thereof
Polymers and copolymers having units derived from substituted 3,4-propylenedioxythiophene are disclosed. Also provided are methods of making and using the same.
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Novel Hetero Pyrrole Analogs Acting on Cannapinoid Receptors
Disclosed are biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CB1 and/or CB2 cannabinoid receptors. Aspects disclose hetero pyrrole analogs acting as CB1 and/or CB 1 receptor antagonists, having selectivity for the CB 1
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Method and Apparatus for Generating Electricity While a User Is Moving
The present disclosure provides for systems and methods for generating electricity while a user is moving. More particularly, the present disclosure provides for improved systems and methods for generating electricity while a user is walking or running. In exemplary embodiments, the present disclosu
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Flexible Electrochromic Device, Electrodes Therefor, and Method of Manufacture
An electrochromic fiber or fabric using electrochromic fiber electrodes (72, 74) is disclosed. The fiber or fabric includes a flexible, electrically- conductive fiber (76, 78), and a layer (80, 92) comprising an electrochromic material disposed on and surrounding the flexible, electrically conductiv
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Multiple Excitation Capacitance Polling for Enhanced Electronic Capacitance Tomography
Disclosed herein is a novel sensing technique, termed Multiple Excitation Capacitance Polling (MECaP), that improves the efficiency of Electrical Capacitance Tomography (ECT). Unlike traditional alternating current techniques, where excitation signal is applied to an electrode one at a time, MECaP i
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Systems and Methods for Key Generation in Wireless Communication Systems
A system and a method for providing a secure wireless ad-hoc network in a wireless communication system having at least two transceivers coupled by a wireless transmission link are disclosed. The method includes receiving a data transmission at a first transceiver from a second transceiver, wherein
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Apparatus and methods for solar energy conversion using nanocoax structures
An apparatus and method for solar conversion using nanocoax structures are disclosed herein. A nano-optics apparatus for use as a solar cell comprising a plurality of nano-coaxial structures comprising an internal conductor surrounded by a semiconducting material coated with an outer conductor; a fi
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Apparatus and methods for solar energy conversion using nanoscale cometal structures
An apparatus and methods for solar conversion using nanoscale cometal structures are disclosed herein. The cometal structures may be coaxial and coplanar. A nanoscale optics apparatus (100) for use as a solar cell comprises a plurality of nanoscale cometal structures each including a photovoltaic ma
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Apparatus and methods for manipulating light using nanoscale cometal structures
An apparatus and methods for manipulating light using nanoscale cometal structures are disclosed. A nanoscale optics apparatus for manipulating light includes a plurality of nanoscale cometal structures each comprising a dielectric material located between a first electrical conductor and a second e
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Nanoscale optical microscope
Nanoscale optical probes for use with nanoscale optical microscopy are disclosed herein. A nanoscale optical probe for use with a near-field scanning optical microscope includes an inner conductor having a top end, a bottom end, and a body; a dielectric material engaging the inner conductor; and an
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Apparatus and methods for nanolithography using nanoscale optics
An apparatus and methods for nanolithography using nanoscale optics are disclosed herein. Submicron-scale structures may be obtained using standard photolithography systems with a de-magnifying lens. A de-magnifying lens for use in a standard photolithography system includes a film having a top surf
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Apparatus and methods for optical switching using nanoscale optics
An apparatus and methods for optical switching using nanoscale optics are disclosed herein. A nano-optics apparatus for use as an optical switch includes a metallic film having a top surface, a bottom surface and a plurality of cylindrical channels containing a dielectric material, the metallic film
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Device and method for achieving enhanced field emission utilizing nanostructures grown on a conductive substrate
A device and method is presented for achieving a high field emission from the application of a low electric field. More specifically, the device includes a substrate wherein a plurality of nanostructures are grown on the substrate. The relationship of the nanostructures and the substrate (the relati
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Solar Thermoelectric Conversion
Systems and methods utilizing solar-electrical generators are discussed. Solar- electrical generators are disclosed having a radiation-capture structure and one or more thermoelectric converters. Heat produced in a capture structure via impingement of solar radiation can maintain a portion of a ther
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Inhibitors of Cyclic Amp Phosphodiesterases
Recombinant fission yeast cells and methods of using them are described, which provide for identification of chemical and biological inhibitors or activators of a target exogenous phosphodiesterase (PDE). The invention provides, in some aspects, compounds that inhibit cAMP PDE activity and compositi
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Methods of Fabricating Complex Two-dimensional Conductive Silicides
The embodiments disclosed herein relate to the fabrication of complex two-dimensional conductive silicide nanostructures, and methods of fabricating the nanostructures. In an embodiment, a conductive silicide includes a plurality of connected and spaced-apart nanobeams linked together at an about 90
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Apparatus and Methods for Visual Perception Using an Array of Nanoscale Waveguides
Nanoscale photovoltaic devices fabricated from nanoscale waveguides that receive, propagate, and convert incident light into electrical neural signals, and methods of using these photovoltaic devices for visual perception are disclosed herein. A visual neuroprosthetic device includes an array of nan
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Inhibitors of Fructose 1,6-bisphosphatase and Methods of Use Thereof
The invention is directed to a compound according to formula (I). The compounds of formula (I) include prodrugs, pharmaceutically acceptable salts, stereoisomer mixtures, and enantiomers thereof. The invention is also directed to a pharmaceutical composition comprising a compound according to formul
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Nanoscopically Thin Photovoltaic Junction Solar Cells
Nanoscopically thin photovoltaic junction solar cells are disclosed herein. In an embodiment, there is provided a photovoltaic film 100 that includes a p-doped region 102, an n-doped region 106, and an intrinsic region 104 positioned between the p-doped region 102 and the n-doped region 106, wherein
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Nanostructures and Methods for Chemically Synthesizing Nanostructures
The present invention generally relates to nanostructure compositions, as well as methods for the controlled synthesis of nanostructures, such as carbon nanotubes. In some embodiments, methods involving iterative growth of a nanostructure template to homogeneously produce nanostructure compositions
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Molecular Imprinted Nanosensors
An apparatus for detecting the presence of a target molecule is disclosed which includes a conductive nanostructure, a non-conductive polymer coating on at least a portion of the nanostructure, and a cavity formed in the polymer coating having a shape corresponding to the shape of the target molecul
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Hetero-nanostructure Materials for Use in Energy-storage Devices and Methods of Fabricating Same
The embodiments disclosed herein relate to hetero-nanostructure materials for use in energy-storage devices, and more particularly to the fabrication of hetero-nanostructure materials and the use of the hetero-nanostructure materials as battery electrodes. In an embodiment, a Si/TiSi2 electrode 1000
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Wireless Passive Radio-frequency Strain and Displacement Sensors
Wireless strain and displacement sensors wirelessly monitor structural health and integrity, and are made by printing inductor-interdigital capacitor sensing circuits on a variety of substrates, including ceramic substrates, with thermally processable conductive inks. Sensors of the invention can be
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Methods for forming copolymers comprising olefin and protected or unprotected hydroxystyrene units
Novel methods for forming copolymers, including block copolymers, which comprise one or more olefin units and one or more protected or unprotected hydroxystyrene units are provided.
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Organometallic-Polyisomonoolefin Block Copolymers
The present invention provides copolymers which include a plurality of constitutional units that correspond to at least one cationically polymerizable isomonoolefin species and a plurality of constitutional units that correspond to at least one anionically polymerizable monomer species selected from
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Functional Hydrocarbon Polymers and Process for Producing Same
A method of synthesizing a compound of formula (IIIe), comprising a step of reacting a compound of formula (IIIc): A functional polymer of formula (XXXa): The variables in formulas (IIIc), (IIIe), and (XXXa) are defined herein.
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Polymeric antioxidants
Antioxidant polymers of the present invention comprise repeat units that include one or both of Structural Formulas (I) and (II): wherein: R is -H or a substituted or unsubstituted alkyl, acyl or aryl group; Ring A is substituted with at least one tert-butyl group or substituted or unsubstituted n-a
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Compositions and Methods for Treating Cancer with Dacarbazine Nanoemulsions
A uniform microfluidized nanoemulsion is disclosed containing an anti-cancer agent, such as dacarbazine. The microfluidized nanoemulsion improves the combination's cell membrane permeability by at least four-fold over conventional nanoemulsion compositions, which significantly increases the intracel
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Chiral Metamaterials
A metamaterial includes a dielectric substrate and an array of discrete resonators at the dielectric substrate, wherein each of the discrete resonators has a shape that is independently selected from: an F-type shape; an E-type shape; or a y-type shape. A parameter of a chiral metamaterial is determ
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Polymerization of aromatic monomers using derivatives of hematin
Hematin, a hydroxyferriprotoporphyrin, is derivatized with one or more non-proteinaceous amphipathic groups. The derivatized hematin can serve as a mimic of horseradish peroxidase in polymerizing aromatic monomers, such as aromatic compounds. These derivatized hematins can also be used as catalysts
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End-capped Polymer Chains and Products Thereof
Methods are described herein for converting carbocationically terminated polymers to anionically terminated polymers. These methods comprise: (a) providing a carbocationically terminated polymeric moiety; (b) reacting the carbocationically terminated polymeric moiety with a heterocyclic compound of
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Method for Fabricating a Sensor, a Sensor, and a Method for Sensing
A method for fabricating a sensor, a sensor so fabricated, and a method for sensing a stimulus are provided. The method includes providing an elongated open channel, such as, a V-groove, in a substrate, the open channel providing a first surface; removing at least some material from at least a porti
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Copolymers Having Polyisobutylene and Biodegradable Polymer Segments
The present invention pertains to copolymers having one or more polyisobutylene segments and one or more biodegradable polymer segments, to methods of making such copolymers, to medical articles that contain such copolymers, and to methods of making such medical articles. According to certain aspect
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Biological Particle Collector, and Methods of Use Thereof
One aspect of the invention relates to the devices and methods for the collection of bioaerosols (such as viruses, bacteria, and proteins) from the exhaled breath of humans and/or animals, for the purpose of determining, for example, particle size, generation rate, diseases and interventions for par
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System and Method for Identification of Fingerprints and Mapping of Blood Vessels in a Finger
In accordance with an embodiment of the invention, there is provided an apparatus for characterizing and identifying a human. The apparatus comprises a light imaging device that images topography of a surface of a portion of human anatomy, and an infrared imaging device that images infrared radiatio
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Methods for Forming Injected Molded Parts and In-mold Sensors Therefor
A method for use in forming a molded part includes providing a mold having a cavity and a movable pin, injecting a moldable material into the cavity, biasing the movable pin to maintain an end of the movable pin in contact with the moldable material in the cavity during the curing of the moldable ma
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Modified Polymers and Methods for Making and Using the Same
The present invention provides block copolymers, e.g., thermoplastic elastomers, having at least one monomer that is covalently bonded to a sulfonate moiety. The present invention also provides block copolymers, e.g., thermoplastic elastomers, having at least one monomer that is covalently bonded to
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CELL CULTURE HYDROGEL WITH pH INDICATOR
The invention provides devices, compositions and methods for maintaining conditions in a cell culture and for measurement of conditions in the cell culture. In particular, the invention provides hydrogel materials, apparatus and methods for several non-invasive techniques of maintaining glucose and
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Methods for Forming Metal-polymer Hybrid Tooling for Forming Parts Having Micro Features
A method (10, 100) for forming metal-polymer hybrid tooling includes patterning a surface of a silicon wafer (20, 420), depositing a polymer material (30, 430) onto the patterned features of the surface of the silicon wafer to form a polymer layer having a reverse of the patterned surface the silico
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Device and Method for Forming Multilayered Laminates
Methods and devices for forming a vertically-oriented multilayer laminates, for example, a vertically-oriented multilayer laminates, are provided. The laminates may be fabricated by hardenable fluids, for example, polymers that are directed along flow paths (80) to divide, repossession, and combine
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Polyisobutylene-based Polyurethanes
An elastomeric polymer, comprising (1) a hard segment in the amount of 10% to 60% by weight of the elastomeric polymer, wherein the hard segment includes a urethane, urea or urethaneurea; and (2) a soft segment in the amount of 40% to 90% by weight of the elastomeric polymer. The soft segment compri
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Thiophene-based Conjugated Polymers for Detection of Explosives
A device comprises a sensing element, wherein the sensing element includes a polymer or a copolymer having at least one unit of structural formula (I) having particular substituents for R' and R, formula (I): A method of detecting certain chemical compounds in a sample that includes exposing the dev
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Functional Polysobutylene Based Macromonomers and Methods for Making and Using the Same
A method of synthesizing a functionalized polymer represented by the structural formula (I) comprising a step of reacting a polymer represented by structural formula (II) with a compound Nu1 -M to nucleophilically substitute moiety X1 with moiety Nu1. Values and preferred values of the variables in
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Absorbable Bone Adhesive Applicator
The instant invention provides of a novel method for repairing bone defects using a polymer blend as well as apparatus for performing such a method. The method includes dispensing a polymer blend either directly on the bone tissue as the fixation means; or secondly in combination with a bone plate,
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Conductive Formulations for Use in Electrical, Electronic and Rf Applications
Metal flakes, an organic metal precursor, an organic solvent and either no binder, or a volatile or a thermally decomposable binder are combined to form a paste. The paste is deposited in a circuit pattern on a substrate and the circuit pattern is cured. While curing, the organic metal precursor dec
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Optical Fiber Pressure Sensor with Uniform Diaphragm and Method of Fabricating Same
An optical fiber sensor (100) can be used to measure pressure with high sensitivity and fine resolution. As a cavity (108) at the end of the sensor expands or contracts, the spectrum of a beam reflected from the end of fiber shifts, producing a change linked to pressure exerted on the sensor. Novel
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Electroencephalography Monitoring Device Having a Self-adaptive Analog-to-digital Converter
An EEG monitoring device, contains at least one electrode, a non-linear analog signal processor, a variable resolution analog-to-digital converter, a storage, and a power source. The non-linear analog signal processor receives a signal from the at least one electrode and determines whether the signa
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Systems and Methods for Combined Ultrasound and Electrical Impedance Imaging
A dual imaging probe 300 for obtaining both ultrasound and electrical impedance data is disclosed along with methods of using the dual imaging probe 300 to interrogate tissue. An electrical impedance imaging overlay 330 is adapted to be positioned on a transducer window 304 of an ultrasound probe 32
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Eutectic Alloys of the Type FE 25-35 NI 15-25 MN 30-40 AL 10-20 M 0-5 and Methods for Production Thereof
Alloys, formed by a eutectic transformation of the type Fe25-35 Ni15-25 Mn30-40 Al10-20 MO-5, are disclosed. M is selected from chromium, molybdenum, carbon and combinations thereof. The alloys have high strength and ductility. The alloys are prepared from readily available transition metals, and ca
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Animal model and compounds identified via this model for treatment of chronic pain
An animal model for chronic pain, and in particular lower back pain, is provided. Methods of identifying agents and reducing chronic pain with identified agents such as methotrexate are also provided.
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Joining of Parts Via Magnetic Heating of Metal-Aluminum Powders
A method of joining at least two parts includes steps of dispersing a joining material comprising a multi-phase nanocrystalline magnetic metal-aluminum powder at an interface between the at least two parts to be joined and applying an alternating magnetic field (AMF). The AMF has a magnetic field st
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Methods for diagnosing and treating neuroendocrine cancer
The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2. Methods for preventing and treating neuroendocrine cancers are also disclosed.
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Monocyclic Cyanoenones and Methods of Use Thereof
The present invention features monocyclic cyanoenone compositions and methods for using the same in the treatment of diseases such as cancer, inflammatory diseases and neurodegenerative diseases.
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Compositions and methods for preventing or treating a viral infection
The present invention is a composition for enhancing the immunogenicity of viral vaccine. The composition encompasses a viral vaccine in combination with at least one toll-like receptor and, in particular embodiments, an anti-CD40 antibody. The compositions of the instant invention find application
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System and Method for Use of Nanoparticles in Imaging and Diagnosis
A method for diagnosing certain types of cancers provides a nanoparticle agent to be uptaken by cancer cells for diagnosis and treatment of certain cancers. A compound containing nanoparticles is directed toward a tumor site, and then a predetermined time period passes to allow the nanoparticles to
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Pulse Systems and Methods for Detaching Ice
A pulse system for detaching ice includes a power supply for applying a high-power heating pulse to the interface between ice and an object such as a cold plate of an ice making system, an ice-container, a heat-exchanger, a refrigerator surface or an airplane wing. Pulse heating may be generated wit
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Microrna-21 antagonists and its target PDCD4 for use in the treatment of a glioma
The present invention embraces microRNA-21 antagonists and activators of Programmed Cell Death 4 for use in decreasing glial tumor cell proliferation and treating glioma.
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Yeast Strain and Method for Using the Same to Produce Nicotinamide Riboside
The present invention embraces a fungal strain deficient in nicotinamide riboside import and salvage and use thereof for producing nicotinamide riboside. Methods for producing nicotinamide riboside and a nicotinamide riboside- supplemented food product using the strain of the invention are also prov
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Hybrid Prokaryotic-eukaryotic Tubulins and Use Thereof
The present invention embraces hybrid Prosthecobacter- eukaryotic tubulin proteins and use thereof for identifying agents that modulate the activity of tubulin.
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Modified Cipa Gene from Clostridium Thermocellum for Enhanced Genetic Stability
Bacteria consume a variety of biomass-derived substrates and produce ethanol. The scaffoldin gene cipA from Clostridium thermocellum is modified to generate a mutated gene with enhanced genetic stability. This mutated cipA gene can be introduced into a heterologous host, such as Thermoanaerobacteriu
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Caveolin 1-reporter Protein Knock-in Mouse
The present invention embraces a transgenic mouse whose genome harbors a nucleic acid molecule encoding caveolin-1 fused in-frame with a reporter. To control expression of the Cavl-reporter, the nucleic acid molecule further includes a selectable marker expression cassette flanked by recombinase tar
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Compositions and Methods for Treating Pancreatic Cancer
The present invention provides a method of treating pancreatic cancer by inhibiting the activity cyclin D1 activity in tumor cells. The invention is based on the finding that cyclin D1 shRNA molecules are capable of attenuating tumor growth and interfering with tumor angiogenesis.
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Methods for Screening for Antibiotic Compounds
The present invention is a method for screening drugs for antibiotic activity by screening a drug for activity to disrupt a toxin-antitoxin complex in a bacterial cell.
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Compositions for Treating Bacterial Infections
The present invention is antibiotic compositions having the ability to disrupt a MazEF complex in S. aureus. The compositions also have the ability to inhibit growth of S. aureus and as such are useful as antibiotic compounds.
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Method for Identifying an Agent That Inhibits Candida Albicans -mediated Host Cell Differentiation
The present invention features a method for identifying an agent that inhibits Candida albicans- mediated differentiation of keratinocytes. Agents identified by the screening assay of the invention find application in the prevention and treatment of candidiasis.
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System and Method for Providing Patient Registration Without Fiducials
A method for providing patient registration without fiducials comprises the steps of: spatially placing an ultrasound image of a patient randomly at different starting positions relative to a preoperative image; creating an independent registration corresponding to each different starting positions,
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Compositions and Methods for Treating Cancer
The present invention embraces bis-acridine and bis- quinoline intercalators having a bis (4-aminophenyl) ether tether, and diglycolate salts thereof, for selectively decreasing colon cancer and glial cell proliferation and preventing or treating colon cancers and gliomas.
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System and method for deicing of power line cables
A system and method for deicing power transmission cables divides the cable into sections. Switches are provided at each end of a section for coupling the conductors together in parallel in a normal mode, and at least some of the conductors in series in an anti-icing mode. When the switches couple t
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Thermophillic Organisms for Conversion of Lignocellulosic Biomass to Ethanol
Mutant thermophilic organisms that consume a variety of biomass derived substrates are disclosed herein. Strains of Thermoanaerobacterium saccharolyticum with acetate kinase and phosphotransacetylase expression eliminated are disclosed herein. Further, strain ALK1 has been engineered by site directe
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Microrna Biomarkers for Human Breast and Lung Cancer
The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
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Bis-carbazole DNA intercalating agents for antitumor therapy
The present invention is a DNA intercalating agent represented by the structure Y-Z-Y, wherein Y is an anti-tumor bis-carbazole and Z is a linear arrangement of multiple aromatic rings, containing at least two aromatic rings, or at least two alicyclic rings, said rings being linked in a 1,4 or 1,3 m
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Systems and Methods for Windshield Deicing.
Cost efficient, lightweight and rapid windshield deicing systems and methods are disclosed. The systems utilize step-up converters or inverters, or dual-voltage batteries, to provide a voltage high enough to deice a windshield in less than thirty seconds.
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Compact Helical Heat Exchanger with Stretch to Maintain Airflow
A heat exchanger for exchanging heat between gasses such as air and a liquid or gaseous coolant has narrow spacing between exchanger surfaces for high efficiency. To avoid undue obstruction of gas flow due to ice buildup on the exchanger surfaces, the heat exchanger is equipped with sensors to monit
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Multilayer Foil-wound Inductors Having Alternating Layers
A multilayer foil winding in a foil-wound magnetic circuit component (200) has conductors (202, 204, 402, 408) that alternate at various points such that the conductors share current more effectively than multiple non-alternating conductors. AC resistance of the multilayer winding is therefore decre
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Bioactive Molecules Produced By Probiotic Bacteria and Methods for Isolating and Using the Same
The present invention is a method for isolating bioactive molecules secreted by probiotic bacteria such as Lactobacillus rhamnosus, and methods for using such bioactive molecules to decrease replication of human immunodeficiency virus, expression of inflammatory cytokines and chemokines, expression
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Rotary Frog Systems and Methods
Systems and methods determining amplitude and phase versus frequency of an incoming beam of pulsed laser light. An apparatus is set to an initial configuration to split the incoming beam into two beams of substantially equal intensity, delay one of the two split beams for a delay period t and recomb
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System, Optode and Cap for Near-infrared Diffuse-optical Functional Neuroimaging
An optode for a functional infrared diffuse optical neuroimaging system uses a GRIN lens and prism for coupling to an optical fiber at a right-angle to the lens. The lens is inserted into a grommet for attachment to an elastomeric cap worn by a subject. In an embodiment, the cap also has an array of
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Electrical Impedance Sensing Biopsy Sampling Device and Method
A biopsy sampling device has an inner trocar having a sharpened tip and a sampling opening. The trocar is slideably engaged in a central cavity of an outer needle with its sharpened tip and sampling opening protruding from an end of the outer needle. Impedance measuring apparatus measures impedance
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