Veterinary Science Patents for Sale or License

Fluid Delivery Micropump

Infu-Disk™ , developed and manufactured by Med-e-Cell, is a commercially available fluid administration pump currently used in a variety of applications particularly veterinary medicine, toxicology/pharmacokinetic studies, and preclinical research, with the exception of human use. Infu-Disk™ fluid delivery pumps are a unique group of accurate, single use pumps, operating at any flow rate between 0.03 and 4.0 mL/hour. The flow rate is factory set. Infu-Disk™ is a totally autonomous, dis
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Methods of Inhibiting Tumor Cell Proliferation

The invention provides methods for inhibiting tumor cell proliferation by inhibiting FoxM1B activity, expression, or nuclear localization in a tumor cell. The invention also provides methods for preventing tumor progression in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization. Furthermore, the invention provides methods for inhibiting tumor cell growth in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization in tumor cells in the
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Antimicrobial/preservative Compositions Comprising Botanicals

The present invention relates to a preservative or antimicrobial compositions which comprise low concentrations of botanical extracts, in synergistic combinations with alkanediols in a solvent system, optionally with fruit acids. Additionally, the present invention relates to a preservative or antimicrobial compositions which comprise a silver compound, an essential oil or individual constituent, one or more zinc salts, and one or more alkanediol. The compositions of the invention may be used in
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Piscine Reovirus Immunogenic Compositions

The invention is directed to immunogenic compositions and methods for inducing an immune response against Piscine reoviruses in an animal. In another aspect, the invention relates to antibodies that bind Piscine reovirus poplypeptides. In yet another aspect, the invention relates to methods for preventing, or reducing PRV infection in an animal.
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Systems, Apparatus and Devices for Use in Animal Studies

Featured are various devices, apparatuses and systems for use in connection with animal studies or experimentation as well as methods related thereto. Such devices, apparatuses and systems include a scalable animal enclosure that is easily customized for a given application; a scalable and easily customizable sound attenuation chamber that can be used with such an animal enclosure; an olfactory discrimination system which can quickly delivery an odor to an animal while minimizing the potential f
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Peptide Analogs Capable of Enhancing Stimulation of a Glioma-specific Ctl Response

The invention provides a peptide derived from the interleukin-13 receptor alpha2, which serves as a HLA-A2-restricted cytotoxic T lymphocyte (CTL) epitope. The invention can be used as a vaccine for glioma and can be formulated into compositions for medical or veterinary use. In addition, the invention provides the use of a peptide derived from the Eph family of tyrosine kinase receptors which can be also used as a vaccine for glioma and can be formulated into compositions for medical or veterin
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Mechanically Competent Natural Polymer Based Porous Grafts for Bone Repair and Regeneration

The invention provides a scaffold for bone or cartilage replacement, in which the scaffold is fabricated from naturally derived polymers. In one embodiment the invention provides a bone replacement scaffold, wherein the scaffold comprises sintered polysaccharide microspheres. In a particular embodiment the invention provides a bone replacement scaffold, in which the scaffold comprises polysaccharide microspheres comprising ethyl cellulose microspheres and/ or cellulose acetate microspheres. The
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Cell Division Marker

This application relates to a newly identified animal cell structure, the midbody scar. This structure is a remnant of the midbody that is retained by one daughter cell following cytokinesis and persists through multiple subsequent cell cycles. The midbody scar can be useful as a marker of dividing cells or of a cell's replicative age.
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Microdrive for use in neurophysiological research of animals

Microdrive for use in neurophysiological research of animals, particulary for use in mice, comprising: - at least two elongate electrodes for measuring field potentials from nervous tissue; - electrode adjusting means for adjusting the depth of each of the electrodes in the nervous tissue; and - a body for holding the electrode adjusting means, wherein the electrodes comprise upper parts held in the electrode adjusting means and lower parts forming a bundle arranged for insertion in the animal,
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Use of Nucleoside Derivatives As Anti-koi Herpes Virus in Fish

The present invention relates to the use of N-phosphonylmethoxyethyl nucleoside analogs for manufacturing a medicament for the treatment or prevention of Koi Herpes virus infections in fish, especially in carps.
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Combined method for the sequential measurement of (1) the enzymatically active fraction and (2) the total amount of an enzyme

The present invention is related to a combined method and kit (or device) for the sequential measurement of the enzymatically active fraction and the total amount of an enzyme [(such as myeloperoxidase (MPO)] in a sample, and that find improved applications in veterinary and human health fields.
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Live Attenuated Salmonella Vaccine.

The present invention relates to attenuated guaB deletion mutants of a bacterium infecting veterinary species, more in particular Salmonella enterica, to their use and production. The present invention further relates to live attenuated vaccines based on such mutants for preventing bacterial infections, and more in particular Salmonellosis, in a veterinary species, more in particular poultry.
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Live Attenuated Salmonella Vaccine

The present invention is related to double and triple attenuated mutant strains of a bacterium infecting veterinary species such as Salmonella enterica and/or (a pathogenic) Escherichia coli. The mutants of the invention contain at least one first genetic modification and at least one second genetic modification, said first modification in one or more motility genes, and said second modification in one or more genes involved in the survival or the proliferation of the pathogen in the host. The p
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Immediate Release Pharmaceutical Granule Compositions and a Continuous Process for Making Them

A pharmaceutical or veterinary granule composition in the form of a mixture consisting essentially of: (i) at least one drug classifiable as Class II or Class IV of the Biopharmaceutical Classification System, wherein said drug (i) constitutes from 0.5% to 20% by weight of the composition, and excipients, said pharmaceutical or veterinary granule composition providing a drug release of at least 70% within 10 minutes in water, (ii) a first excipient being a maltodextrin representing from 40% by w
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Methods for reducing the incidence of mastitis by administration of keratin

Disclosed are methods of reducing the incidence of mastitis, inducing leucycytosis and of sealing a teat canal of a non-human animal such as a cow, including the step of introducing a composition including keratin into the teat canal of the animal, thereby reducing the incidence of mastitis in said animal. Also disclosed is a teat seal including keratin formulated for introduction into the teat canal of a non-human animal, wherein the composition is a solid or semi-solid.
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Transgenic Animals for Analyzing CYP3A4 Cytochrome P450 Gene Regulation

PROBLEM TO BE SOLVED: To provide non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional regulatory nucleic acid molecule from the human CYP3A4 gene. ; SOLUTION: The invention relates to the generation of the non-human transgenic animals comprising the reporter construct for producing the detectable amount of the reporter molecule operably linked to the transcriptional regulatory nucleic acid molec
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Sex-determination and Methods of Specifying Same

The present invention relates generally to the field of sex determination of animals. Provided are methods and agents to manipulate sex determination, particularly in avian animals such as chickens, through a male chromosome-linked testis (sex) regulatory gene. Expression or activity of the DMRT1 gene or protein is modulated to produce animals with displaying a phenotype sex that differs from their genotype.
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Antimicrobial Material

The invention relates to a method for preparing antimicrobial material. The method comprises heating material comprising wood or bark or material derived therefrom, under conditions sufficient to render the material antimicrobial. The invention also relates to antimicrobial materials prepared by such methods, and to various uses of the antimicrobial materials, for example in reducing microbial activity in animal bedding, such as that which is used in poultry farming.
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Identifying Sub-optimal Performance in a Race Animal

Apparatus for identifying sub-optimal performance in a race animal comprises means for measuring frequency of stride of the race animal, means for measuring speed of the animal and means for processing data. The data processing means is configured to receive and process said stride frequency and speed in a predetermined manner so as to identify a predetermined physiological condition in the race animal.
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Protection of an Animal Against Pestivirus Infection

This invention involves compositions and methods for protecting animals from pestivirus infection and for treating animals infected with pestivirus. Pharmaceutical compositions containing E2 and NS3 from a pestivirus are used to protect animals or treat animals.
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Vaccine Composition for Vaccinating Dogs Against Canine Infectious Respiratory Disease (CIRD)

A vaccine composition for vaccinating dogs comprising any one or more of (a) an agent capable of raising an immune response against Streptococcus equi sub species zooepidemicus in a dog, (b) an agent capable of raising an immune response against Mycoplasma cynos in a dog, and (c) an agent capable of raising an immune response against a Chlamydophila in a dog.
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Antigen Delivery System

A compound for vaccination of an animal comprising (i) a moiety which selectively binds to a dendritic cell in the animal but which does not naturally occur in the animal and (ii) an antigen. Typically, the moiety which selectively binds as said binds to DC-SIGN. The moiety maybe HIV-1 gp 120. The compound of the invention may be used to vaccinate animals and, following vaccination, they may be distinguished from naturally infected animals.
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Methods and Compositions

A method of inducing relaxation of the cervix of a female mammal, the method comprising administering at least one pharmaceutical agent selected from follicle stimulating hormone or a beta-subunit thereof, luteinizing hormone or a beta- subunit thereof, thyroid stimulating hormone or a beta-subunit thereof, and chorionic gonadotrophin or a beta-subunit thereof, topically to the cervix of the mammal. The method can be used to facilitate artificial insemination of the female mammal. Also provided
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Method for Enhancing Sperm Survival

A spermatozoa diluent comprising isolated Hsc70 protein, in which the Hsc70 has sperm viability improving and/or prolonging activity. Also disclosed are compositions comprising the diluent, methods of prolonging/improving sperm viability and use of the diluent to prolong/improve sperm viability.
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Method of Inhibiting Clostridium Difficile By Administration of Oritavancin

Glycopeptide antibiotics, such as oritavancin, demonstrate significant activity against both a vegetative form of C. difficile and C. difficile spores. Methods for the treatment, prophylaxis and prevention of C. difficile infection and disease in animals, including humans, are described.
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Murine Endometriosis Modelled By K-RAS Activation of Menstruating Endometrium

This invention relates to the production of rodent endometriosis models by implanting into wild type recipient rodents menstruating endometrium from donor rodents in which an oncogene, such as K-ras, has been activated. Rodent endometriosis models and methods of production and use of such models in screening for therapeutics are provided.
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A Composite Comprising At Least One Type of Perfluoroalkyl-perfluoro-phthalocyanine

The present invention relates to a composite comprising at least one type of perfluoroalkyl-perfluoro-phthalocyanine, and to a method of producing such composite. The present invention also relates to a method of generating singlet oxygen, a method of killing eukaryotic or prokaryotic cells and a method of sterilization, cleaning and/or decontamination. Moreover, the present invention relates to a composite or a device for use in a method of sterilization, cleaning and/or decontamination.
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Koret School of Veterinary Medicine

Objective/function With two sites - the campus of the Faculty of Agricultural, Food and Environmental Quality Sciences in Rehovot and the Veterinary Teaching Hospital in Bet Degan - the Koret School of Veterinary Medicine trains veterinarians and researchers in modern clinical and research modalities in variety of related specialties. It also provides continuing education and specialist training for veterinarians. It is the only veterinary school in Israel. Service provided The Veterina
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Animal Model of Gaucher’s Disease

Disruptions or mutations in the glucocerebrosidase gene (GBA) are responsible for Gaucher’s disease, a rare inherited autosomal recessive disorder. Until now, the study of sphingolipid metabolism in Gaucher’s disease has been limited to cell culture and in vitro investigations due to the absence of an appropriate animal model. Previous attempts at producing a mouse model for Gaucher’s disease through mutation of the GBA gene have resulted in a non-viable, perinatal lethal phenotype. Resear
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Fertility Control Agent for Targeted Treatment of Animal Species

Background Annually, about $30 billion is lost due to food and property damage caused by rodents and other mammalian pests worldwide. In the United States alone, rats and mice destroy almost $2 billion worth of foodstuffs and property annually. Insurance companies and government agencies spend hundreds of millions of dollars annually due to health complications and property loss caused by exposure to the pest. Currently, traps and poisons are used to control rats and mice. Poisons consist mainly
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A Bench-top Image Guided Conformal Irradiation System for Laboratory Animals

The present technology is a bench top small animal research platform designed for focused delivery of radiation to laboratory animals. The system is equipped with CT image guidance and a robotic stage for positioning of the animal. High quality CT reconstructions are possible with the prototype. The novel acquisition geometry enables the employment of a single x-ray source for both imaging and radiation delivery. Current systems on the market do not have guidance capabilities or utilize a CT gan
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A Method for the Efficient Functional Examination of Mammalian Noncoding Sequences in Transgenic Zebrafish

sequence conservation is recognized as a reliable indicator of both coding and non-coding functional sequences. Consistent with this hypothesis, coding sequences may be readily identified based on evolutionary conservation. However, of the 5% of the human genome that is predicted to be functional based on conservation alone, less than a third actually encodes protein. The remaining conserved non-coding sequences probably regulate temporal, spatial, and quantitative aspects of gene expression. Co
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Unexpected Cross-neutralization of Cutaneous & Mucosal Papillomavirus Types with Anti-Sera to a Novel Epitopes

High risk Human Papillomavirus (HPV) infection is a common cause of cervical cancer. Researchers at JHU have found that vaccination with the N terminus of HPV16 and bovine papillomavirus 1 can induce cross neutralizing antibodies that inhibit in vitro generated pseudovirus infection of both cutaneous and genital types that infect both humans and animals. Description (Set) Proposed Use (Set) The invention could be developed into a simple protein-based vaccine to broadly prevent genital and c
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O/E2 and O/E3 Knockout Mice

The mammalian Olf1/EBF (O/E) family of repeated helix-loop-helix (rHLH) transcription factors has been implicated in olfactory system gene regulation, nervous system development and B-cell differentiation. Ebf (O/E1) mutant animals showed defects in B-cell lineage and brain regions where it is the only O/E family member expressed, but the olfactory epithelium appeared unaffected and olfactory marker expression was grossly normal in these animals. In order to further study the mammalian O/E prote
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High-Resolution X-Ray Crystal Structures of Tritrichomonas Foetus Inosine Monophosphate Dehydrogenase as Lead Compound for Structure-Based Drug Design

Background: Trichomoniasis is a venereal disease of cattle caused by a protozoan parasite, Tritrichomonas foetus. The disease has been reported worldwide with an estimated economic loss to the U.S. beef industry exceeding $100 million annually due to reduced conception rates, lowered weaning weights and increased culling. Currently there is no treatment for T. foetus. Technology: University of California, Irvine researchers utilized high-resolution x-ray crystallography to study the structur
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Use of Infectious and Pathogenic Clone of a Lung Cancer-Inducing Retrovirus for Generation of Therapeutic Reagents and Diagnostic Tests

Background: Jaagsiekte sheep retrovirus (JSRV) causes broncheolo-alveolar carcinoma in sheep and is a significant veterinary problem world-wide. Clinically and histopathologically, this disease has strong resemblance to broncheolo-alveolar carcinoma (BAC) in humans which accounts for approximately 25% of human lung cancers. Technology: Researchers at the University of California, Irvine have isolated the first infectious molecular clone of JSRV and have developed techniques for production of
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